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Items: 36


Use of Collagen Binding Domains to Deliver Molecules to the Cornea.

Klarlund JK, Callaghan JD, Stella NA, Kowalski RP, McNamara NA, Shanks RMQ.

J Ocul Pharmacol Ther. 2019 Oct 10. doi: 10.1089/jop.2019.0065. [Epub ahead of print]


Putting on the brakes: Bacterial impediment of wound healing.

Brothers KM, Stella NA, Hunt KM, Romanowski EG, Liu X, Klarlund JK, Shanks RM.

Sci Rep. 2015 Sep 14;5:14003. doi: 10.1038/srep14003.


Dual modes of motility at the leading edge of migrating epithelial cell sheets.

Klarlund JK.

Proc Natl Acad Sci U S A. 2012 Sep 25;109(39):15799-804. Epub 2012 Sep 10.


Extracellular ATP stimulates epithelial cell motility through Pyk2-mediated activation of the EGF receptor.

Block ER, Tolino MA, Klarlund JK.

Cell Signal. 2011 Dec;23(12):2051-5. doi: 10.1016/j.cellsig.2011.07.021. Epub 2011 Aug 4.


Brief treatment with heparin-binding EGF-like growth factor, but not with EGF, is sufficient to accelerate epithelial wound healing.

Tolino MA, Block ER, Klarlund JK.

Biochim Biophys Acta. 2011 Sep;1810(9):875-8. doi: 10.1016/j.bbagen.2011.05.011. Epub 2011 May 26.


Free edges in epithelia as cues for motility.

Klarlund JK, Block ER.

Cell Adh Migr. 2011 Mar-Apr;5(2):106-10. Epub 2011 Mar 1.


Free edges in epithelial cell sheets stimulate epidermal growth factor receptor signaling.

Block ER, Tolino MA, Lozano JS, Lathrop KL, Sullenberger RS, Mazie AR, Klarlund JK.

Mol Biol Cell. 2010 Jul 1;21(13):2172-81. doi: 10.1091/mbc.E09-12-1026. Epub 2010 May 12.


Pyk2 activation triggers epidermal growth factor receptor signaling and cell motility after wounding sheets of epithelial cells.

Block ER, Tolino MA, Klarlund JK.

J Biol Chem. 2010 Apr 30;285(18):13372-9. doi: 10.1074/jbc.M109.083089. Epub 2010 Mar 9.


Wounding sheets of epithelial cells activates the epidermal growth factor receptor through distinct short- and long-range mechanisms.

Block ER, Klarlund JK.

Mol Biol Cell. 2008 Nov;19(11):4909-17. doi: 10.1091/mbc.E08-01-0097. Epub 2008 Sep 17.


Activation of the epidermal growth factor receptor by hydrogels in artificial tears.

Lozano JS, Chay EY, Healey J, Sullenberger R, Klarlund JK.

Exp Eye Res. 2008 Mar;86(3):500-5. doi: 10.1016/j.exer.2007.12.003. Epub 2007 Dec 23.


Hepatocyte growth factor induces epithelial cell motility through transactivation of the epidermal growth factor receptor.

Spix JK, Chay EY, Block ER, Klarlund JK.

Exp Cell Res. 2007 Sep 10;313(15):3319-25. Epub 2007 Jun 27.


Epithelial cell motility is triggered by activation of the EGF receptor through phosphatidic acid signaling.

Mazie AR, Spix JK, Block ER, Achebe HB, Klarlund JK.

J Cell Sci. 2006 Apr 15;119(Pt 8):1645-54. Epub 2006 Mar 28.


Wounding induces motility in sheets of corneal epithelial cells through loss of spatial constraints: role of heparin-binding epidermal growth factor-like growth factor signaling.

Block ER, Matela AR, SundarRaj N, Iszkula ER, Klarlund JK.

J Biol Chem. 2004 Jun 4;279(23):24307-12. Epub 2004 Mar 23. Erratum in: J Biol Chem. 2004 Aug 20;279(34):36166.


Signaling complexes of the FERM domain-containing protein GRSP1 bound to ARF exchange factor GRP1.

Klarlund JK, Holik J, Chawla A, Park JG, Buxton J, Czech MP.

J Biol Chem. 2001 Oct 26;276(43):40065-70. Epub 2001 Jul 9.


A role for phospholipase D in GLUT4 glucose transporter translocation.

Emoto M, Klarlund JK, Waters SB, Hu V, Buxton JM, Chawla A, Czech MP.

J Biol Chem. 2000 Mar 10;275(10):7144-51.


ADP-ribosylation factor 6 as a target of guanine nucleotide exchange factor GRP1.

Langille SE, Patki V, Klarlund JK, Buxton JM, Holik JJ, Chawla A, Corvera S, Czech MP.

J Biol Chem. 1999 Sep 17;274(38):27099-104.


Regulation of GRP1-catalyzed ADP ribosylation factor guanine nucleotide exchange by phosphatidylinositol 3,4,5-trisphosphate.

Klarlund JK, Rameh LE, Cantley LC, Buxton JM, Holik JJ, Sakelis C, Patki V, Corvera S, Czech MP.

J Biol Chem. 1998 Jan 23;273(4):1859-62.


Signaling by phosphoinositide-3,4,5-trisphosphate through proteins containing pleckstrin and Sec7 homology domains.

Klarlund JK, Guilherme A, Holik JJ, Virbasius JV, Chawla A, Czech MP.

Science. 1997 Mar 28;275(5308):1927-30.


Regulation of phosphatidylinositol 3,4,5-trisphosphate 5'-phosphatase activity by insulin.

Guilherme A, Klarlund JK, Krystal G, Czech MP.

J Biol Chem. 1996 Nov 22;271(47):29533-6.


The rat T-cell surface protein RT6 is associated with src family tyrosine kinases and generates an activation signal.

Rigby MR, Bortell R, Greiner DL, Czech MP, Klarlund JK, Mordes JP, Rossini AA.

Diabetes. 1996 Oct;45(10):1419-26.


Role of the Raf/mitogen-activated protein kinase pathway in p21ras desensitization.

Klarlund JK, Cherniack AD, McMahon M, Czech MP.

J Biol Chem. 1996 Jul 12;271(28):16674-7.


Divergent mechanisms for homologous desensitization of p21ras by insulin and growth factors.

Klarlund JK, Cherniack AD, Czech MP.

J Biol Chem. 1995 Oct 6;270(40):23421-8.


Disassembly of Son-of-sevenless proteins from Grb2 during p21ras desensitization by insulin.

Cherniack AD, Klarlund JK, Conway BR, Czech MP.

J Biol Chem. 1995 Jan 27;270(4):1485-8.


Phosphorylation of the Ras nucleotide exchange factor son of sevenless by mitogen-activated protein kinase.

Cherniack AD, Klarlund JK, Czech MP.

J Biol Chem. 1994 Feb 18;269(7):4717-20.


Binding of the Ras activator son of sevenless to insulin receptor substrate-1 signaling complexes.

Baltensperger K, Kozma LM, Cherniack AD, Klarlund JK, Chawla A, Banerjee U, Czech MP.

Science. 1993 Jun 25;260(5116):1950-2.


Activation of protein kinases by insulin and non-hydrolyzable GTP analogs in permeabilized 3T3-L1 adipocytes.

Klarlund JK, Khalaf N, Kozma L, Czech MP.

J Biol Chem. 1993 Apr 15;268(11):7646-9.


Purification and characterization of a cytosolic insulin-stimulated serine kinase from rat liver.

Wolfe L, Bradford AP, Klarlund JK, Czech MP.

J Biol Chem. 1992 May 15;267(14):9749-56.


An insulin-stimulated kemptide kinase purified from rat liver is deactivated by phosphatase 2A.

Klarlund JK, Jaspers SR, Khalaf N, Bradford AP, Miller TB, Czech MP.

J Biol Chem. 1991 Mar 5;266(7):4052-5.


Purification of a novel insulin-stimulated protein kinase from rat liver.

Klarlund JK, Bradford AP, Milla MG, Czech MP.

J Biol Chem. 1990 Jan 5;265(1):227-34.


Numerous proteins phosphorylated on tyrosine and enhanced tyrosine kinase activities in vanadate-treated NIH 3T3 fibroblasts.

Klarlund JK, Latini S, Forchhammer J.

Biochim Biophys Acta. 1988 Aug 19;971(1):112-20.


Insulin receptor signaling. Activation of multiple serine kinases.

Czech MP, Klarlund JK, Yagaloff KA, Bradford AP, Lewis RE.

J Biol Chem. 1988 Aug 15;263(23):11017-20. Review. No abstract available.


Temperature-sensitive tumorigenicity of cells transformed by a mutant of Moloney sarcoma virus.

Klarlund JK, Forchhammer J.

Proc Natl Acad Sci U S A. 1980 Mar;77(3):1501-5.

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