Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 108

1.

A highly efficient modality to block the degradation of tryptophan for cancer immunotherapy: locked nucleic acid-modified antisense oligonucleotides to inhibit human indoleamine 2,3-dioxygenase 1/tryptophan 2,3-dioxygenase expression.

Klar R, Michel S, Schell M, Hinterwimmer L, Zippelius A, Jaschinski F.

Cancer Immunol Immunother. 2019 Dec 4. doi: 10.1007/s00262-019-02438-1. [Epub ahead of print]

PMID:
31802183
2.

Induction of Articular Chondrogenesis by Chitosan/Hyaluronic-Acid-Based Biomimetic Matrices Using Human Adipose-Derived Stem Cells.

Huang Y, Seitz D, König F, Müller PE, Jansson V, Klar RM.

Int J Mol Sci. 2019 Sep 11;20(18). pii: E4487. doi: 10.3390/ijms20184487.

3.

Publisher Correction: ER stress-induced mediator C/EBP homologous protein thwarts effector T cell activity in tumors through T-bet repression.

Cao Y, Trillo-Tinoco J, Sierra RA, Anadon C, Dai W, Mohamed E, Cen L, Costich TL, Magliocco A, Marchion D, Klar R, Michel S, Jaschinski F, Reich RR, Mehrotra S, Cubillos-Ruiz JR, Munn DH, Conejo-Garcia JR, Rodriguez PC.

Nat Commun. 2019 Aug 15;10(1):3680. doi: 10.1038/s41467-019-11563-5.

4.

Key Features Relevant to Select Antigens and TCR From the MHC-Mismatched Repertoire to Treat Cancer.

Audehm S, Glaser M, Pecoraro M, Bräunlein E, Mall S, Klar R, Effenberger M, Albers J, Bianchi HO, Peper J, Yusufi N, Busch DH, Stevanović S, Mann M, Antes I, Krackhardt AM.

Front Immunol. 2019 Jun 28;10:1485. doi: 10.3389/fimmu.2019.01485. eCollection 2019.

5.

Anti-Niemann Pick C1 Single-Stranded Oligonucleotides with Locked Nucleic Acids Potently Reduce Ebola Virus Infection In Vitro.

Sadewasser A, Dietzel E, Michel S, Klüver M, Helfer M, Thelemann T, Klar R, Eickmann M, Becker S, Jaschinski F.

Mol Ther Nucleic Acids. 2019 Jun 7;16:686-697. doi: 10.1016/j.omtn.2019.04.018. Epub 2019 Apr 25.

6.

Evaluation of pneumococcal and tetanus vaccine responses in patients with rheumatoid arthritis receiving baricitinib: results from a long-term extension trial substudy.

Winthrop KL, Bingham CO 3rd, Komocsar WJ, Bradley J, Issa M, Klar R, Kartman CE.

Arthritis Res Ther. 2019 Apr 18;21(1):102. doi: 10.1186/s13075-019-1883-1.

7.

Traditional and Nontraditional Collaborations to Improve Population Health Using Geospatial Information SystemMaps: Analysis of the Opioid Crisis.

Hallas D, Klar RT, Baldyga JA, Rattner I, Waingortin R, Fletcher J.

J Pediatr Health Care. 2019 May - Jun;33(3):309-322. doi: 10.1016/j.pedhc.2018.10.006. Epub 2019 Mar 20.

PMID:
30902507
8.

ER stress-induced mediator C/EBP homologous protein thwarts effector T cell activity in tumors through T-bet repression.

Cao Y, Trillo-Tinoco J, Sierra RA, Anadon C, Dai W, Mohamed E, Cen L, Costich TL, Magliocco A, Marchion D, Klar R, Michel S, Jaschinski F, Reich RR, Mehrotra S, Cubillos-Ruiz JR, Munn DH, Conejo-Garcia JR, Rodriguez PC.

Nat Commun. 2019 Mar 20;10(1):1280. doi: 10.1038/s41467-019-09263-1. Erratum in: Nat Commun. 2019 Aug 15;10(1):3680.

9.

Antisense oligonucleotide targeting CD39 improves anti-tumor T cell immunity.

Kashyap AS, Thelemann T, Klar R, Kallert SM, Festag J, Buchi M, Hinterwimmer L, Schell M, Michel S, Jaschinski F, Zippelius A.

J Immunother Cancer. 2019 Mar 12;7(1):67. doi: 10.1186/s40425-019-0545-9.

10.

Gene activated adipose tissue fragments as advanced autologous biomaterials for bone regeneration: osteogenic differentiation within the tissue and implications for clinical translation.

Ren B, Betz VM, Thirion C, Salomon M, Klar RM, Jansson V, Müller PE, Betz OB.

Sci Rep. 2019 Jan 18;9(1):224. doi: 10.1038/s41598-018-36283-6.

11.

Health Professional Training and Capacity Strengthening Through International Academic Partnerships: The First Five Years of the Human Resources for Health Program in Rwanda.

Cancedda C, Cotton P, Shema J, Rulisa S, Riviello R, Adams LV, Farmer PE, Kagwiza JN, Kyamanywa P, Mukamana D, Mumena C, Tumusiime DK, Mukashyaka L, Ndenga E, Twagirumugabe T, Mukara KB, Dusabejambo V, Walker TD, Nkusi E, Bazzett-Matabele L, Butera A, Rugwizangoga B, Kabayiza JC, Kanyandekwe S, Kalisa L, Ntirenganya F, Dixson J, Rogo T, McCall N, Corden M, Wong R, Mukeshimana M, Gatarayiha A, Ntagungira EK, Yaman A, Musabeyezu J, Sliney A, Nuthulaganti T, Kernan M, Okwi P, Rhatigan J, Barrow J, Wilson K, Levine AC, Reece R, Koster M, Moresky RT, O'Flaherty JE, Palumbo PE, Ginwalla R, Binanay CA, Thielman N, Relf M, Wright R, Hill M, Chyun D, Klar RT, McCreary LL, Hughes TL, Moen M, Meeks V, Barrows B, Durieux ME, McClain CD, Bunts A, Calland FJ, Hedt-Gauthier B, Milner D, Raviola G, Smith SE, Tuteja M, Magriples U, Rastegar A, Arnold L, Magaziner I, Binagwaho A.

Int J Health Policy Manag. 2018 Nov 1;7(11):1024-1039. doi: 10.15171/ijhpm.2018.61.

12.

Recommendations for improving accuracy of gene expression data in bone and cartilage tissue engineering.

He T, Huang Y, Chak JC, Klar RM.

Sci Rep. 2018 Oct 5;8(1):14874. doi: 10.1038/s41598-018-33242-z.

13.

Effectiveness of 3-dimensional shoulder ultrasound in the diagnosis of rotator cuff tears: A meta-analysis.

Teng A, Liu F, Zhou D, He T, Chevalier Y, Klar RM.

Medicine (Baltimore). 2018 Sep;97(37):e12405. doi: 10.1097/MD.0000000000012405. Review.

14.

Dose reduction of baricitinib in patients with rheumatoid arthritis achieving sustained disease control: results of a prospective study.

Takeuchi T, Genovese MC, Haraoui B, Li Z, Xie L, Klar R, Pinto-Correia A, Otawa S, Lopez-Romero P, de la Torre I, Macias W, Rooney TP, Smolen JS.

Ann Rheum Dis. 2019 Feb;78(2):171-178. doi: 10.1136/annrheumdis-2018-213271. Epub 2018 Sep 7.

15.

The meaning of "capacity building" for the nurse workforce in sub-Saharan Africa: An integrative review.

Ridge LJ, Klar RT, Stimpfel AW, Squires A.

Int J Nurs Stud. 2018 Oct;86:151-161. doi: 10.1016/j.ijnurstu.2018.04.019. Epub 2018 May 5.

PMID:
30029056
16.

The Induction of Bone Formation: The Translation Enigma.

Klar RM.

Front Bioeng Biotechnol. 2018 Jun 7;6:74. doi: 10.3389/fbioe.2018.00074. eCollection 2018. Review.

17.

Effects of baricitinib on radiographic progression of structural joint damage at 1 year in patients with rheumatoid arthritis and an inadequate response to conventional synthetic disease-modifying antirheumatic drugs.

van der Heijde D, Dougados M, Chen YC, Greenwald M, Drescher E, Klar R, Xie L, de la Torre I, Rooney TP, Witt SL, Schlichting DE, de Bono S, Emery P.

RMD Open. 2018 May 8;4(1):e000662. doi: 10.1136/rmdopen-2018-000662. eCollection 2018.

18.

Macrocognition in the Healthcare Built Environment (mHCBE): A Focused Ethnographic Study of "Neighborhoods" in a Pediatric Intensive Care Unit.

O'Hara S, Klar RT, Patterson ES, Morris NS, Ascenzi J, Fackler JC, Perry DJ.

HERD. 2018 Apr;11(2):104-123. doi: 10.1177/1937586717728484. Epub 2017 Dec 15.

PMID:
29243506
19.

In-depth Characterization of a TCR-specific Tracer for Sensitive Detection of Tumor-directed Transgenic T Cells by Immuno-PET.

Yusufi N, Mall S, Bianchi HO, Steiger K, Reder S, Klar R, Audehm S, Mustafa M, Nekolla S, Peschel C, Schwaiger M, Krackhardt AM, D'Alessandria C.

Theranostics. 2017 Jun 15;7(9):2402-2416. doi: 10.7150/thno.17994. eCollection 2017.

20.

Direct identification of clinically relevant neoepitopes presented on native human melanoma tissue by mass spectrometry.

Bassani-Sternberg M, Bräunlein E, Klar R, Engleitner T, Sinitcyn P, Audehm S, Straub M, Weber J, Slotta-Huspenina J, Specht K, Martignoni ME, Werner A, Hein R, H Busch D, Peschel C, Rad R, Cox J, Mann M, Krackhardt AM.

Nat Commun. 2016 Nov 21;7:13404. doi: 10.1038/ncomms13404.

21.

Cementogenesis and osteogenesis in periodontal tissue regeneration by recombinant human transforming growth factor-β3 : a pilot study in Papio ursinus.

Ripamonti U, Parak R, Klar RM, Dickens C, Dix-Peek T, Duarte R.

J Clin Periodontol. 2017 Jan;44(1):83-95. doi: 10.1111/jcpe.12642. Epub 2016 Dec 1.

PMID:
27783845
22.

Redundancy and Molecular Evolution: The Rapid Induction of Bone Formation by the Mammalian Transforming Growth Factor-β3 Isoform.

Ripamonti U, Duarte R, Parak R, Dickens C, Dix-Peek T, Klar RM.

Front Physiol. 2016 Sep 8;7:396. doi: 10.3389/fphys.2016.00396. eCollection 2016. Review.

23.

The synergistic induction of bone formation by the osteogenic proteins of the TGF-β supergene family.

Ripamonti U, Parak R, Klar RM, Dickens C, Dix-Peek T, Duarte R.

Biomaterials. 2016 Oct;104:279-96. doi: 10.1016/j.biomaterials.2016.07.018. Epub 2016 Jul 20.

PMID:
27474964
24.

Transgenic antigen-specific, HLA-A*02:01-allo-restricted cytotoxic T cells recognize tumor-associated target antigen STEAP1 with high specificity.

Schirmer D, Grünewald TG, Klar R, Schmidt O, Wohlleber D, Rubío RA, Uckert W, Thiel U, Bohne F, Busch DH, Krackhardt AM, Burdach S, Richter GH.

Oncoimmunology. 2016 Apr 25;5(6):e1175795. doi: 10.1080/2162402X.2016.1175795. eCollection 2016 Jun.

25.

Immuno-PET Imaging of Engineered Human T Cells in Tumors.

Mall S, Yusufi N, Wagner R, Klar R, Bianchi H, Steiger K, Straub M, Audehm S, Laitinen I, Aichler M, Peschel C, Ziegler S, Mustafa M, Schwaiger M, D'Alessandria C, Krackhardt AM.

Cancer Res. 2016 Jul 15;76(14):4113-23. doi: 10.1158/0008-5472.CAN-15-2784. Epub 2016 Jun 28.

26.

Human HLA-A*02:01/CHM1+ allo-restricted T cell receptor transgenic CD8+ T cells specifically inhibit Ewing sarcoma growth in vitro and in vivo.

Blaeschke F, Thiel U, Kirschner A, Thiede M, Rubio RA, Schirmer D, Kirchner T, Richter GHS, Mall S, Klar R, Riddell S, Busch DH, Krackhardt A, Grunewald TG, Burdach S.

Oncotarget. 2016 Jul 12;7(28):43267-43280. doi: 10.18632/oncotarget.9218.

27.

Tissue segregation restores the induction of bone formation by the mammalian transforming growth factor-β(3) in calvarial defects of the non-human primate Papio ursinus.

Ripamonti U, Klar RM, Parak R, Dickens C, Dix-Peek T, Duarte R.

Biomaterials. 2016 Apr;86:21-32. doi: 10.1016/j.biomaterials.2016.01.071. Epub 2016 Feb 2.

PMID:
26874889
28.

Allosteric activation of M4 muscarinic receptors improve behavioral and physiological alterations in early symptomatic YAC128 mice.

Pancani T, Foster DJ, Moehle MS, Bichell TJ, Bradley E, Bridges TM, Klar R, Poslusney M, Rook JM, Daniels JS, Niswender CM, Jones CK, Wood MR, Bowman AB, Lindsley CW, Xiang Z, Conn PJ.

Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):14078-83. doi: 10.1073/pnas.1512812112. Epub 2015 Oct 27.

29.

Activation of Metabotropic Glutamate Receptor 7 Is Required for Induction of Long-Term Potentiation at SC-CA1 Synapses in the Hippocampus.

Klar R, Walker AG, Ghose D, Grueter BA, Engers DW, Hopkins CR, Lindsley CW, Xiang Z, Conn PJ, Niswender CM.

J Neurosci. 2015 May 13;35(19):7600-15. doi: 10.1523/JNEUROSCI.4543-14.2015.

30.

The discovery and characterization of a centrally penetrant (ML396) and a peripherally restricted (ML397) pan-Group III mGlu positive allosteric modulators.

Jalan-Sakrikar N, Roper-Field J, Klar R, Mattman M, Walker AG, Zamorano R, Xiang Z, Byers CF, Blobaum AL, Engers D, Weaver CD, Days E, Utley TJ, Melancon B, Daniels JS, Wood MR, Lindsley CW, Conn PJ, Hopkins CR, Niswender CM.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2014 Apr 15 [updated 2015 Jan 16].

31.

[Benefit assessment of medical interventions].

Klar R, Vach W.

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2015 Mar;58(3):219. doi: 10.1007/s00103-015-2137-2. German. No abstract available.

PMID:
25676451
32.

Identification of positive allosteric modulators VU0155094 (ML397) and VU0422288 (ML396) reveals new insights into the biology of metabotropic glutamate receptor 7.

Jalan-Sakrikar N, Field JR, Klar R, Mattmann ME, Gregory KJ, Zamorano R, Engers DW, Bollinger SR, Weaver CD, Days EL, Lewis LM, Utley TJ, Hurtado M, Rigault D, Acher F, Walker AG, Melancon BJ, Wood MR, Lindsley CW, Conn PJ, Xiang Z, Hopkins CR, Niswender CM.

ACS Chem Neurosci. 2014 Dec 17;5(12):1221-37. doi: 10.1021/cn500153z. Epub 2014 Oct 9.

33.

Therapeutic targeting of naturally presented myeloperoxidase-derived HLA peptide ligands on myeloid leukemia cells by TCR-transgenic T cells.

Klar R, Schober S, Rami M, Mall S, Merl J, Hauck SM, Ueffing M, Admon A, Slotta-Huspenina J, Schwaiger M, Stevanović S, Oostendorp RA, Busch DH, Peschel C, Krackhardt AM.

Leukemia. 2014 Dec;28(12):2355-66. doi: 10.1038/leu.2014.131. Epub 2014 Apr 16.

PMID:
24736212
34.

The induction of bone formation by the recombinant human transforming growth factor-β3.

Klar RM, Duarte R, Dix-Peek T, Ripamonti U.

Biomaterials. 2014 Mar;35(9):2773-88. doi: 10.1016/j.biomaterials.2013.12.062. Epub 2014 Jan 15.

PMID:
24438909
35.

Calcium ions and osteoclastogenesis initiate the induction of bone formation by coral-derived macroporous constructs.

Klar RM, Duarte R, Dix-Peek T, Dickens C, Ferretti C, Ripamonti U.

J Cell Mol Med. 2013 Nov;17(11):1444-57. doi: 10.1111/jcmm.12125. Epub 2013 Sep 23.

36.

Norepinephrine transporter heterozygous knockout mice exhibit altered transport and behavior.

Fentress HM, Klar R, Krueger JJ, Sabb T, Redmon SN, Wallace NM, Shirey-Rice JK, Hahn MK.

Genes Brain Behav. 2013 Nov;12(8):749-59. doi: 10.1111/gbb.12084. Epub 2013 Oct 9.

37.

Norepinephrine transporter variant A457P knock-in mice display key features of human postural orthostatic tachycardia syndrome.

Shirey-Rice JK, Klar R, Fentress HM, Redmon SN, Sabb TR, Krueger JJ, Wallace NM, Appalsamy M, Finney C, Lonce S, Diedrich A, Hahn MK.

Dis Model Mech. 2013 Jul;6(4):1001-11. doi: 10.1242/dmm.012203. Epub 2013 Apr 4.

38.

Working hard: women's self-care practices in Ghana.

Theroux R, Klar RT, Messenger L.

Health Care Women Int. 2013;34(8):651-73. doi: 10.1080/07399332.2012.736574. Epub 2013 Mar 28.

PMID:
23537401
39.

Targeting selective activation of M(1) for the treatment of Alzheimer's disease: further chemical optimization and pharmacological characterization of the M(1) positive allosteric modulator ML169.

Tarr JC, Turlington ML, Reid PR, Utley TJ, Sheffler DJ, Cho HP, Klar R, Pancani T, Klein MT, Bridges TM, Morrison RD, Blobaum AL, Xiang Z, Daniels JS, Niswender CM, Conn PJ, Wood MR, Lindsley CW.

ACS Chem Neurosci. 2012 Nov 21;3(11):884-95. doi: 10.1021/cn300068s. Epub 2012 Jul 18.

40.

Isolation of human MHC class II-restricted T cell receptors from the autologous T-cell repertoire with potent anti-leukaemic reactivity.

Weigand LU, Liang X, Schmied S, Mall S, Klar R, Stötzer OJ, Salat C, Götze K, Mautner J, Peschel C, Krackhardt AM.

Immunology. 2012 Nov;137(3):226-38. doi: 10.1111/imm.12000.

41.

Biomimetic matrices self-initiating the induction of bone formation.

Ripamonti U, Roden LC, Ferretti C, Klar RM.

J Craniofac Surg. 2011 Sep;22(5):1859-70. doi: 10.1097/SCS.0b013e31822e83fe. Review.

PMID:
21959451
42.

Bone Induction: Regeneration through Chaos.

Klar RM.

Front Physiol. 2011 May 31;2:21. doi: 10.3389/fphys.2011.00021. eCollection 2011. No abstract available.

43.

[Quality control in medicine].

Klar R, Selbmann HK.

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2011 Feb;54(2):145-7. doi: 10.1007/s00103-010-1211-z. German. No abstract available.

PMID:
21290266
44.

[Biomedical techniques, chances and risks].

Klar R, Stieglitz T.

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2010 Aug;53(8):757-8. doi: 10.1007/s00103-010-1104-1. German. No abstract available.

PMID:
20700773
45.

Synergistic induction of bone formation by hOP-1, hTGF-beta3 and inhibition by zoledronate in macroporous coral-derived hydroxyapatites.

Ripamonti U, Klar RM, Renton LF, Ferretti C.

Biomaterials. 2010 Sep;31(25):6400-10. doi: 10.1016/j.biomaterials.2010.04.037. Epub 2010 May 21.

PMID:
20493522
46.
47.

[Health risks: assessment, knowledge, and perceptions ].

Klar R, Hensel A, Schmidt S.

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2009 Dec;52(12):1119-21. doi: 10.1007/s00103-009-0981-7. German. No abstract available.

PMID:
20012565
48.

Bridging from medical informatics, biometry and epidemiology to medical engineering.

Zöllner I, Klar R.

Methods Inf Med. 2009;48(5):397-8. No abstract available.

PMID:
19866509
49.

Fibrotest or Fibroscan for evaluation of liver fibrosis in haemophilia patients infected with hepatitis C.

Maor Y, Halfon P, Bashari D, Pénaranda G, Morali G, Klar R, Bar-Meir S, Martinowitz U, Oren R.

Haemophilia. 2010 Jan;16(1):148-54. doi: 10.1111/j.1365-2516.2009.02092.x. Epub 2009 Sep 4.

PMID:
19702631
50.

Kawasaki disease lacks association with human coronavirus NL63 and human bocavirus.

Lehmann C, Klar R, Lindner J, Lindner P, Wolf H, Gerling S.

Pediatr Infect Dis J. 2009 Jun;28(6):553-4. No abstract available.

PMID:
19504744

Supplemental Content

Support Center