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Items: 20

1.

The Discovery of 3-((4-Chloro-3-methoxyphenyl)amino)-1-((3R,4S)-4-cyanotetrahydro-2H-pyran-3-yl)-1H-pyrazole-4-carboxamide, a Highly Ligand Efficient and Efficacious Janus Kinase 1 Selective Inhibitor with Favorable Pharmacokinetic Properties.

Siu T, Brubaker J, Fuller P, Torres L, Zeng H, Close J, Mampreian DM, Shi F, Liu D, Fradera X, Johnson K, Bays N, Kadic E, He F, Goldenblatt P, Shaffer L, Patel SB, Lesburg CA, Alpert C, Dorosh L, Deshmukh SV, Yu H, Klappenbach J, Elwood F, Dinsmore CJ, Fernandez R, Moy L, Young JR.

J Med Chem. 2017 Dec 14;60(23):9676-9690. doi: 10.1021/acs.jmedchem.7b01135. Epub 2017 Dec 4.

PMID:
29156136
2.

Multiplexed quantification of proteins and transcripts in single cells.

Peterson VM, Zhang KX, Kumar N, Wong J, Li L, Wilson DC, Moore R, McClanahan TK, Sadekova S, Klappenbach JA.

Nat Biotechnol. 2017 Oct;35(10):936-939. doi: 10.1038/nbt.3973. Epub 2017 Aug 30.

PMID:
28854175
3.

Evaluation of JAK3 Biology in Autoimmune Disease Using a Highly Selective, Irreversible JAK3 Inhibitor.

Elwood F, Witter DJ, Piesvaux J, Kraybill B, Bays N, Alpert C, Goldenblatt P, Qu Y, Ivanovska I, Lee HH, Chiu CS, Tang H, Scott ME, Deshmukh SV, Zielstorff M, Byford A, Chakravarthy K, Dorosh L, Rivkin A, Klappenbach J, Pan BS, Kariv I, Dinsmore C, Slipetz D, Dandliker PJ.

J Pharmacol Exp Ther. 2017 May;361(2):229-244. doi: 10.1124/jpet.116.239723. Epub 2017 Feb 13.

4.

An accessible pharmacodynamic transcriptional biomarker for notch target engagement.

Tanis KQ, Podtelezhnikov AA, Blackman SC, Hing J, Railkar RA, Lunceford J, Klappenbach JA, Wei B, Harman A, Camargo LM, Shah S, Finney EM, Hardwick JS, Loboda A, Watters J, Bergstrom DA, Demuth T, Herman GA, Strack PR, Iannone R.

Clin Pharmacol Ther. 2016 Apr;99(4):370-80. doi: 10.1002/cpt.335. Epub 2016 Feb 17.

PMID:
26765077
5.

HCV genotyping from NGS short reads and its application in genotype detection from HCV mixed infected plasma.

Qiu P, Stevens R, Wei B, Lahser F, Howe AY, Klappenbach JA, Marton MJ.

PLoS One. 2015 Apr 1;10(4):e0122082. doi: 10.1371/journal.pone.0122082. eCollection 2015.

6.

Phenotypic responses of differentiated asthmatic human airway epithelial cultures to rhinovirus.

Bai J, Smock SL, Jackson GR Jr, MacIsaac KD, Huang Y, Mankus C, Oldach J, Roberts B, Ma YL, Klappenbach JA, Crackower MA, Alves SE, Hayden PJ.

PLoS One. 2015 Feb 23;10(2):e0118286. doi: 10.1371/journal.pone.0118286. eCollection 2015.

7.

Anti-inflammatory actions of Chemoattractant Receptor-homologous molecule expressed on Th2 by the antagonist MK-7246 in a novel rat model of Alternaria alternata elicited pulmonary inflammation.

Gil MA, Caniga M, Woodhouse JD, Eckman J, Lee HH, Salmon M, Naber J, Hamilton VT, Sevilla RS, Bettano K, Klappenbach J, Moy L, Correll CC, Gervais FG, Siliphaivanh P, Zhang W, Zhang-Hoover J, McLeod RL, Cicmil M.

Eur J Pharmacol. 2014 Nov 15;743:106-16. doi: 10.1016/j.ejphar.2014.09.021. Epub 2014 Sep 23.

8.

Mineralocorticoid receptor antagonists attenuate pulmonary inflammation and bleomycin-evoked fibrosis in rodent models.

Lieber GB, Fernandez X, Mingo GG, Jia Y, Caniga M, Gil MA, Keshwani S, Woodhouse JD, Cicmil M, Moy LY, Kelly N, Jimenez J, Crawley Y, Anthes JC, Klappenbach J, Ma YL, McLeod RL.

Eur J Pharmacol. 2013 Oct 15;718(1-3):290-8. doi: 10.1016/j.ejphar.2013.08.019. Epub 2013 Sep 5.

PMID:
24012780
9.

UGT2B17 genetic polymorphisms dramatically affect the pharmacokinetics of MK-7246 in healthy subjects in a first-in-human study.

Wang YH, Trucksis M, McElwee JJ, Wong PH, Maciolek C, Thompson CD, Prueksaritanont T, Garrett GC, Declercq R, Vets E, Willson KJ, Smith RC, Klappenbach JA, Opiteck GJ, Tsou JA, Gibson C, Laethem T, Panorchan P, Iwamoto M, Shaw PM, Wagner JA, Harrelson JC.

Clin Pharmacol Ther. 2012 Jul;92(1):96-102. doi: 10.1038/clpt.2012.20. Epub 2012 Jun 6.

10.

Unprecedented levels of horizontal gene transfer among spatially co-occurring Shewanella bacteria from the Baltic Sea.

Caro-Quintero A, Deng J, Auchtung J, Brettar I, Höfle MG, Klappenbach J, Konstantinidis KT.

ISME J. 2011 Jan;5(1):131-40. doi: 10.1038/ismej.2010.93. Epub 2010 Jul 1.

11.

The genome sequence of Psychrobacter arcticus 273-4, a psychroactive Siberian permafrost bacterium, reveals mechanisms for adaptation to low-temperature growth.

Ayala-del-Río HL, Chain PS, Grzymski JJ, Ponder MA, Ivanova N, Bergholz PW, Di Bartolo G, Hauser L, Land M, Bakermans C, Rodrigues D, Klappenbach J, Zarka D, Larimer F, Richardson P, Murray A, Thomashow M, Tiedje JM.

Appl Environ Microbiol. 2010 Apr;76(7):2304-12. doi: 10.1128/AEM.02101-09. Epub 2010 Feb 12.

12.

DNA-DNA hybridization values and their relationship to whole-genome sequence similarities.

Goris J, Konstantinidis KT, Klappenbach JA, Coenye T, Vandamme P, Tiedje JM.

Int J Syst Evol Microbiol. 2007 Jan;57(Pt 1):81-91.

PMID:
17220447
13.

Influence of dangling ends and surface-proximal tails of targets on probe-target duplex formation in 16S rRNA gene-based diagnostic arrays.

Stedtfeld RD, Wick LM, Baushke SW, Tourlousse DM, Herzog AB, Xia Y, Rouillard JM, Klappenbach JA, Cole JR, Gulari E, Tiedje JM, Hashsham SA.

Appl Environ Microbiol. 2007 Jan;73(2):380-9. Epub 2006 Nov 17.

14.

Respiratory nitrate ammonification by Shewanella oneidensis MR-1.

Cruz-García C, Murray AE, Klappenbach JA, Stewart V, Tiedje JM.

J Bacteriol. 2007 Jan;189(2):656-62. Epub 2006 Nov 10.

15.

Genetic and genomic insights into the role of benzoate-catabolic pathway redundancy in Burkholderia xenovorans LB400.

Denef VJ, Klappenbach JA, Patrauchan MA, Florizone C, Rodrigues JL, Tsoi TV, Verstraete W, Eltis LD, Tiedje JM.

Appl Environ Microbiol. 2006 Jan;72(1):585-95.

16.

Global transcriptome analysis of Shewanella oneidensis MR-1 exposed to different terminal electron acceptors.

Beliaev AS, Klingeman DM, Klappenbach JA, Wu L, Romine MF, Tiedje JM, Nealson KH, Fredrickson JK, Zhou J.

J Bacteriol. 2005 Oct;187(20):7138-45.

17.

Global profiling of Shewanella oneidensis MR-1: expression of hypothetical genes and improved functional annotations.

Kolker E, Picone AF, Galperin MY, Romine MF, Higdon R, Makarova KS, Kolker N, Anderson GA, Qiu X, Auberry KJ, Babnigg G, Beliaev AS, Edlefsen P, Elias DA, Gorby YA, Holzman T, Klappenbach JA, Konstantinidis KT, Land ML, Lipton MS, McCue LA, Monroe M, Pasa-Tolic L, Pinchuk G, Purvine S, Serres MH, Tsapin S, Zakrajsek BA, Zhu W, Zhou J, Larimer FW, Lawrence CE, Riley M, Collart FR, Yates JR 3rd, Smith RD, Giometti CS, Nealson KH, Fredrickson JK, Tiedje JM.

Proc Natl Acad Sci U S A. 2005 Feb 8;102(6):2099-104. Epub 2005 Jan 31.

19.

rRNA operon copy number reflects ecological strategies of bacteria.

Klappenbach JA, Dunbar JM, Schmidt TM.

Appl Environ Microbiol. 2000 Apr;66(4):1328-33.

20.

rrndb: the Ribosomal RNA Operon Copy Number Database.

Klappenbach JA, Saxman PR, Cole JR, Schmidt TM.

Nucleic Acids Res. 2001 Jan 1;29(1):181-4.

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