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Items: 1 to 50 of 732

1.

Hepatic carboxylesterases are differentially regulated in PPARα-null mice treated with perfluorooctanoic acid.

Wen X, Baker AA, Klaassen CD, Corton JC, Richardson JR, Aleksunes LM.

Toxicology. 2019 Mar 15;416:15-22. doi: 10.1016/j.tox.2019.01.014. Epub 2019 Jan 24.

PMID:
30685356
2.

RNA-Seq provides new insights on the relative mRNA abundance of antioxidant components during mouse liver development.

Wu KC, Cui JY, Liu J, Lu H, Zhong XB, Klaassen CD.

Free Radic Biol Med. 2019 Jan 16;134:335-342. doi: 10.1016/j.freeradbiomed.2019.01.017. [Epub ahead of print]

PMID:
30659941
3.

Editorial.

Aschner M, Autrup HN, Cohen SM, Dekant W, Eisenbrand G, Galli CL, Gori GB, Kaminski NE, Klaassen CD, Klaunig JE, Levy L, Lotti M, Marquardt HW, Pelkonen O, Schrenk DF, Yamazaki H.

Regul Toxicol Pharmacol. 2019 Feb;101:A1-A2. doi: 10.1016/j.yrtph.2018.12.015. No abstract available.

PMID:
30642615
4.

Safety Assessment of PEGs Cocamine and Related Ingredients as Used in Cosmetics.

Boyer I, Burnett CL, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Gill LJ, Heldreth B.

Int J Toxicol. 2018 Sep/Oct;37(2_suppl):10S-60S. doi: 10.1177/1091581818794417.

PMID:
30235961
5.

Safety Assessment of PEG-150 Pentaerythrityl Tetrastearate as Used in Cosmetics.

Johnson W Jr, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Andersen FA, Heldreth B.

Int J Toxicol. 2018 Sep/Oct;37(2_suppl):5S-9S. doi: 10.1177/1091581818794457.

PMID:
30235960
6.

Safety Assessment of Tocopherols and Tocotrienols as Used in Cosmetics.

Fiume MM, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Andersen FA, Heldreth B.

Int J Toxicol. 2018 Sep/Oct;37(2_suppl):61S-94S. doi: 10.1177/1091581818794455.

PMID:
30235959
7.

Activation of Nrf2 in the liver is associated with stress resistance mediated by suppression of the growth hormone-regulated STAT5b transcription factor.

Rooney J, Oshida K, Vasani N, Vallanat B, Ryan N, Chorley BN, Wang X, Bell DA, Wu KC, Aleksunes LM, Klaassen CD, Kensler TW, Corton JC.

PLoS One. 2018 Aug 16;13(8):e0200004. doi: 10.1371/journal.pone.0200004. eCollection 2018.

8.

Oleanolic acid reprograms the liver to protect against hepatotoxicants, but is hepatotoxic at high doses.

Liu J, Lu YF, Wu Q, Xu SF, Shi FG, Klaassen CD.

Liver Int. 2019 Mar;39(3):427-439. doi: 10.1111/liv.13940. Epub 2018 Aug 27. Review.

PMID:
30079536
9.

Obfuscating transparency?

Aschner M, Autrup H, Berry CL, Boobis AR, Cohen SM, Dekant W, Galli CL, Goodman JI, Gori GB, Greim HA, Kaminski NE, Klaassen CD, Klaunig JE, Lotti M, Marquardt HW, Moretto A, Pelkonen O, Sipes IG, Wallace KB, Yamazaki H.

Regul Toxicol Pharmacol. 2018 Aug;97:A1-A3. doi: 10.1016/j.yrtph.2018.07.004. Epub 2018 Jul 11.

PMID:
30017904
10.

Safety Assessment of Polyether Lanolins as Used in Cosmetics.

Becker LC, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Andersen FA, Heldreth B.

Int J Toxicol. 2018 May/Jun;37(1_suppl):19S-27S. doi: 10.1177/1091581817740120.

PMID:
29761732
11.

Safety Assessment of Alkyl Betaines as Used in Cosmetics.

Burnett CL, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Andersen FA, Heldreth B.

Int J Toxicol. 2018 May/Jun;37(1_suppl):28S-46S. doi: 10.1177/1091581818773354.

PMID:
29761731
12.

Safety Assessment of Tromethamine, Aminomethyl Propanediol, and Aminoethyl Propanediol as Used in Cosmetics.

Becker LC, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Gill LJ, Heldreth B.

Int J Toxicol. 2018 May/Jun;37(1_suppl):5S-18S. doi: 10.1177/1091581817738242.

PMID:
29761730
13.

Safety Assessment of Magnesium Sulfate as Used in Cosmetics.

Johnson W Jr, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Andersen FA, Heldreth B.

Int J Toxicol. 2018 May/Jun;37(1_suppl):47S-54S. doi: 10.1177/1091581818773355.

PMID:
29761729
14.

Safety Assessment of Hydrolyzed Wheat Protein and Hydrolyzed Wheat Gluten as Used in Cosmetics.

Burnett C, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Andersen FA, Heldreth B.

Int J Toxicol. 2018 May/Jun;37(1_suppl):55S-66S. doi: 10.1177/1091581818776013.

PMID:
29761728
15.

The Life and Times of John Doull, PhD, MD (1922-2017).

Klaassen CD.

Toxicol Sci. 2018 Mar 1;162(1):5-11. doi: 10.1093/toxsci/kfy009. No abstract available.

PMID:
29529316
16.

Aryl hydrocarbon receptor (AhR) mediated short-term effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on bile acid homeostasis in mice.

Csanaky IL, Lickteig AJ, Klaassen CD.

Toxicol Appl Pharmacol. 2018 Mar 15;343:48-61. doi: 10.1016/j.taap.2018.02.005. Epub 2018 Feb 13.

17.

Safety Assessment of Dimethiconol and Its Esters and Reaction Products as Used in Cosmetics.

Johnson W Jr, Heldreth B, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Andersen FA.

Int J Toxicol. 2017 Nov/Dec;36(3_suppl):31S-50S. doi: 10.1177/1091581817739429. Review.

PMID:
29243542
18.

Safety Assessment of Benzyl Alcohol, Benzoic Acid and its Salts, and Benzyl Benzoate.

Johnson W, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG, Shank RC, Slaga TJ, Snyder PW, Andersen FA.

Int J Toxicol. 2017 Nov/Dec;36(3_suppl):5S-30S. doi: 10.1177/1091581817728996. Review.

PMID:
29243541
19.

Safety Assessment of Plant-Derived Fatty Acid Oils.

Burnett CL, Fiume MM, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler D, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Alan Andersen F.

Int J Toxicol. 2017 Nov/Dec;36(3_suppl):51S-129S. doi: 10.1177/1091581817740569. Review.

PMID:
29243540
20.

Activation of PPARα decreases bile acids in livers of female mice while maintaining bile flow and biliary bile acid excretion.

Zhang Y, Lickteig AJ, Csanaky IL, Klaassen CD.

Toxicol Appl Pharmacol. 2018 Jan 1;338:112-123. doi: 10.1016/j.taap.2017.11.014. Epub 2017 Nov 22.

21.

Alteration of Bile Acid and Cholesterol Biosynthesis and Transport by Perfluorononanoic Acid (PFNA) in Mice.

Zhang Y, Zhang Y, Klaassen CD, Cheng X.

Toxicol Sci. 2018 Mar 1;162(1):225-233. doi: 10.1093/toxsci/kfx237.

PMID:
29112762
22.

From the Cover: Identification of Natural Products as Inhibitors of Human Organic Anion Transporters (OAT1 and OAT3) and Their Protective Effect on Mercury-Induced Toxicity.

Wang X, Han L, Li G, Peng W, Gao X, Klaassen CD, Fan G, Zhang Y.

Toxicol Sci. 2018 Feb 1;161(2):321-334. doi: 10.1093/toxsci/kfx216.

PMID:
29045746
23.

Safety Assessment of Diethanolamine and Its Salts as Used in Cosmetics.

Fiume MM, Heldreth B, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Andersen FA.

Int J Toxicol. 2017 Sep/Oct;36(5_suppl2):89S-110S. doi: 10.1177/1091581817707179.

PMID:
29025348
24.

Safety Assessment of Cross-Linked Alkyl Acrylates as Used in Cosmetics.

Fiume MM, Heldreth B, Boyer I, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Andersen FA.

Int J Toxicol. 2017 Sep/Oct;36(5_suppl2):59S-88S. doi: 10.1177/1091581817707927.

PMID:
29025328
25.

From Classical Toxicology to Tox21: Some Critical Conceptual and Technological Advances in the Molecular Understanding of the Toxic Response Beginning From the Last Quarter of the 20th Century.

Choudhuri S, Patton GW, Chanderbhan RF, Mattia A, Klaassen CD.

Toxicol Sci. 2018 Jan 1;161(1):5-22. doi: 10.1093/toxsci/kfx186. Review.

26.

Editor's Highlight: Clofibrate Decreases Bile Acids in Livers of Male Mice by Increasing Biliary Bile Acid Excretion in a PPARα-Dependent Manner.

Zhang Y, Lickteig AJ, Csanaky IL, Klaassen CD.

Toxicol Sci. 2017 Dec 1;160(2):351-360. doi: 10.1093/toxsci/kfx191.

27.

RNA-Seq Profiling of Intestinal Expression of Xenobiotic Processing Genes in Germ-Free Mice.

Fu ZD, Selwyn FP, Cui JY, Klaassen CD.

Drug Metab Dispos. 2017 Dec;45(12):1225-1238. doi: 10.1124/dmd.117.077313. Epub 2017 Sep 22.

28.

Safety Assessment of Amino Acid Alkyl Amides as Used in Cosmetics.

Burnett CL, Heldreth B, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Andersen FA.

Int J Toxicol. 2017 May/Jun;36(1_suppl):17S-56S. doi: 10.1177/1091581816686048.

PMID:
28553738
29.

Safety Assessment of Anthemis nobilis-Derived Ingredients as Used in Cosmetics.

Johnson W Jr, Heldreth B, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Andersen FA.

Int J Toxicol. 2017 May/Jun;36(1_suppl):57S-66S. doi: 10.1177/1091581817705620.

PMID:
28553737
30.

Amended Safety Assessment of Isethionate Salts as Used in Cosmetics.

Burnett CL, Heldreth B, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Andersen FA.

Int J Toxicol. 2017 May/Jun;36(1_suppl):5S-16S. doi: 10.1177/1091581816685552.

PMID:
28553736
31.

Regulation of drug metabolism and toxicity by multiple factors of genetics, epigenetics, lncRNAs, gut microbiota, and diseases: a meeting report of the 21st International Symposium on Microsomes and Drug Oxidations (MDO).

Yu AM, Ingelman-Sundberg M, Cherrington NJ, Aleksunes LM, Zanger UM, Xie W, Jeong H, Morgan ET, Turnbaugh PJ, Klaassen CD, Bhatt AP, Redinbo MR, Hao P, Waxman DJ, Wang L, Zhong XB.

Acta Pharm Sin B. 2017 Mar;7(2):241-248. doi: 10.1016/j.apsb.2016.12.006. Epub 2017 Feb 1.

32.

Persistent alterations in immune cell populations and function from a single dose of perfluorononanoic acid (PFNA) in C57Bl/6 mice.

Rockwell CE, Turley AE, Cheng X, Fields PE, Klaassen CD.

Food Chem Toxicol. 2017 Feb;100:24-33. doi: 10.1016/j.fct.2016.12.004. Epub 2016 Dec 8.

33.

Safety Assessment of Achillea millefolium as Used in Cosmetics.

Becker LC, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Andersen FA.

Int J Toxicol. 2016 Nov;35(3 suppl):5S-15S. Review.

PMID:
27913788
34.

Safety Assessment of Polyquaternium-22 and Polyquarternium-39 as Used in Cosmetics.

Johnson W Jr, Heldreth B, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Andersen FA.

Int J Toxicol. 2016 Nov;35(3 suppl):47S-53S.

PMID:
27913787
35.

Safety Assessment of Dialkyl Sulfosuccinate Salts as Used in Cosmetics.

Fiume MM, Heldreth B, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Andersen FA.

Int J Toxicol. 2016 Nov;35(3 suppl):34S-46S. Review.

PMID:
27913786
36.

Safety Assessment of Alumina and Aluminum Hydroxide as Used in Cosmetics.

Becker LC, Boyer I, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Andersen FA.

Int J Toxicol. 2016 Nov;35(3 suppl):16S-33S. Review.

PMID:
27913785
37.

Safety Assessment of Formic Acid and Sodium Formate as Used in Cosmetics.

Johnson W Jr, Heldreth B, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Andersen FA.

Int J Toxicol. 2016 Nov;35(2 suppl):41S-54S. Review.

PMID:
27913772
38.

Safety Assessment of Methyl Glucose Polyethers and Esters as Used in Cosmetics.

Johnson W Jr, Heldreth B, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Andersen FA.

Int J Toxicol. 2016 Nov;35(2 suppl):12S-40S. Review.

PMID:
27913771
39.

Dose-response effect of berberine on bile acid profile and gut microbiota in mice.

Guo Y, Zhang Y, Huang W, Selwyn FP, Klaassen CD.

BMC Complement Altern Med. 2016 Oct 18;16(1):394.

40.

Effect of nine diets on mRNAs of phase-II conjugation enzymes in livers of mice.

Guo Y, Cui JY, Lu H, Klaassen CD.

Xenobiotica. 2017 Aug;47(8):645-654. doi: 10.1080/00498254.2016.1213926. Epub 2016 Aug 10.

41.

Upholding science in health, safety and environmental risk assessments and regulations.

Aschner M, Autrup HN, Berry SC, Boobis AR, Cohen SM, Creppy EE, Dekant W, Doull J, Galli CL, Goodman JI, Gori GB, Greim HA, Joudrier P, Kaminski NE, Klaassen CD, Klaunig JE, Lotti M, Marquardt HW, Pelkonen O, Sipes IG, Wallace KB, Yamazaki H.

Toxicology. 2016 Sep 14;371:12-16. doi: 10.1016/j.tox.2016.09.005. Epub 2016 Sep 14.

42.

Safety Assessment of Hydroxypropyl Bis(N-Hydroxyethyl-p-Phenylenediamine) HCl as Used in Cosmetics.

Becker LC, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Andersen FA.

Int J Toxicol. 2016 Nov;35(2 suppl):5S-11S. Epub 2016 Aug 3. Review.

PMID:
27488826
43.

Safety Assessment of Alkyl PEG/PPG Ethers as Used in Cosmetics.

Fiume MM, Heldreth B, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Andersen FA.

Int J Toxicol. 2016 Jul;35(1 Suppl):60S-89S. doi: 10.1177/1091581816650626. Review.

PMID:
27383199
44.

Safety Assessment of Microbial Polysaccharide Gums as Used in Cosmetics.

Fiume MM, Heldreth B, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Andersen FA.

Int J Toxicol. 2016 Jul;35(1 Suppl):5S-49S. doi: 10.1177/1091581816651606. Review.

PMID:
27383198
45.

Safety Assessment of Nitrocellulose and Collodion as Used in Cosmetics.

Fiume MM, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Andersen FA.

Int J Toxicol. 2016 Jul;35(1 Suppl):50S-9S. doi: 10.1177/1091581816651607. Review.

PMID:
27383197
46.

RNA-Seq reveals common and unique PXR- and CAR-target gene signatures in the mouse liver transcriptome.

Cui JY, Klaassen CD.

Biochim Biophys Acta. 2016 Sep;1859(9):1198-1217. doi: 10.1016/j.bbagrm.2016.04.010. Epub 2016 Apr 23.

47.

RNA Sequencing Quantification of Xenobiotic-Processing Genes in Various Sections of the Intestine in Comparison to the Liver of Male Mice.

Fu ZD, Selwyn FP, Cui JY, Klaassen CD.

Drug Metab Dispos. 2016 Jun;44(6):842-56. doi: 10.1124/dmd.115.068270. Epub 2016 Apr 5.

48.

Activation of Constitutive Androstane Receptor (CAR) in Mice Results in Maintained Biliary Excretion of Bile Acids Despite a Marked Decrease of Bile Acids in Liver.

Lickteig AJ, Csanaky IL, Pratt-Hyatt M, Klaassen CD.

Toxicol Sci. 2016 Jun;151(2):403-18. doi: 10.1093/toxsci/kfw054. Epub 2016 Mar 16.

49.

Photodegradation of dispersants in colloidal suspensions of pristine graphene.

Hansen MJ, Rountree KS, Irin F, Sweeney CB, Klaassen CD, Green MJ.

J Colloid Interface Sci. 2016 Mar 15;466:425-31. doi: 10.1016/j.jcis.2015.10.027. Epub 2015 Oct 22.

PMID:
26771505
50.

Calorie Restriction Increases P-Glycoprotein and Decreases Intestinal Absorption of Digoxin in Mice.

Renaud HJ, Klaassen CD, Csanaky IL.

Drug Metab Dispos. 2016 Mar;44(3):366-9. doi: 10.1124/dmd.115.064766. Epub 2016 Jan 7.

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