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Items: 1 to 50 of 742

1.

The essential role of the transporter ABCG2 in the pathophysiology of erythropoietic protoporphyria.

Wang P, Sachar M, Lu J, Shehu AI, Zhu J, Chen J, Liu K, Anderson KE, Xie W, Gonzalez FJ, Klaassen CD, Ma X.

Sci Adv. 2019 Sep 18;5(9):eaaw6127. doi: 10.1126/sciadv.aaw6127. eCollection 2019 Sep.

2.

Safety Assessment of PCA (2-Pyrrolidone-5-Carboxylic Acid) and Its Salts as Used in Cosmetics.

Fiume MM, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Gill LJ, Heldreth B.

Int J Toxicol. 2019 Sep/Oct;38(2_suppl):5S-11S. doi: 10.1177/1091581819856568.

PMID:
31522652
3.

Safety Assessment of Sorbitan Esters as Used in Cosmetics.

Fiume MM, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Gill LJ, Heldreth B.

Int J Toxicol. 2019 Sep/Oct;38(2_suppl):60S-80S. doi: 10.1177/1091581819871877.

PMID:
31522651
4.

Safety Assessment of Citrus-Derived Peel Oils as Used in Cosmetics.

Burnett CL, Fiume MM, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Gill LJ, Heldreth B.

Int J Toxicol. 2019 Sep/Oct;38(2_suppl):33S-59S. doi: 10.1177/1091581819862504.

PMID:
31522650
5.

Safety Assessment of Alkyl Phosphates as Used in Cosmetics.

Fiume MM, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Gill LJ, Heldreth B.

Int J Toxicol. 2019 Sep/Oct;38(2_suppl):12S-32S. doi: 10.1177/1091581819856582.

PMID:
31522649
6.

Identification and Characterization of Efflux Transporters That Modulate the Subtoxic Disposition of Diclofenac and Its Metabolites.

Scialis RJ, Aleksunes LM, Csanaky IL, Klaassen CD, Manautou JE.

Drug Metab Dispos. 2019 Oct;47(10):1080-1092. doi: 10.1124/dmd.119.086603. Epub 2019 Aug 9.

PMID:
31399506
7.

Effects of Absence of Constitutive Androstane Receptor (CAR) on Bile Acid Homeostasis in Male and Female Mice.

Lickteig AJ, Zhang Y, Klaassen CD, Csanaky IL.

Toxicol Sci. 2019 Jun 21. pii: kfz143. doi: 10.1093/toxsci/kfz143. [Epub ahead of print]

PMID:
31225615
8.

Amended Safety Assessment of Methylisothiazolinone as Used in Cosmetics.

Burnett CL, Boyer I, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Gill LJ, Heldreth B.

Int J Toxicol. 2019 May/Jun;38(1_suppl):70S-84S. doi: 10.1177/1091581819838792.

PMID:
31170842
9.

Safety Assessment of Fatty Acid Amidopropyl Dimethylamines as Used in Cosmetics.

Burnett CL, Boyer I, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Gill LJ, Heldreth B.

Int J Toxicol. 2019 May/Jun;38(1_suppl):39S-69S. doi: 10.1177/1091581819836089.

PMID:
31170841
10.

Safety Assessment of Monosaccharides, Disaccharides, and Related Ingredients as Used in Cosmetics.

Fiume MM, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Gill LJ, Heldreth B.

Int J Toxicol. 2019 May/Jun;38(1_suppl):5S-38S. doi: 10.1177/1091581818814189.

PMID:
31170840
11.

Hepatic carboxylesterases are differentially regulated in PPARα-null mice treated with perfluorooctanoic acid.

Wen X, Baker AA, Klaassen CD, Corton JC, Richardson JR, Aleksunes LM.

Toxicology. 2019 Mar 15;416:15-22. doi: 10.1016/j.tox.2019.01.014. Epub 2019 Jan 24.

PMID:
30685356
12.

RNA-Seq provides new insights on the relative mRNA abundance of antioxidant components during mouse liver development.

Wu KC, Cui JY, Liu J, Lu H, Zhong XB, Klaassen CD.

Free Radic Biol Med. 2019 Apr;134:335-342. doi: 10.1016/j.freeradbiomed.2019.01.017. Epub 2019 Jan 16.

PMID:
30659941
13.

Editorial.

Aschner M, Autrup HN, Cohen SM, Dekant W, Eisenbrand G, Galli CL, Gori GB, Kaminski NE, Klaassen CD, Klaunig JE, Levy L, Lotti M, Marquardt HW, Pelkonen O, Schrenk DF, Yamazaki H.

Regul Toxicol Pharmacol. 2019 Feb;101:A1-A2. doi: 10.1016/j.yrtph.2018.12.015. No abstract available.

PMID:
30642615
14.

Safety Assessment of PEGs Cocamine and Related Ingredients as Used in Cosmetics.

Boyer I, Burnett CL, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Gill LJ, Heldreth B.

Int J Toxicol. 2018 Sep/Oct;37(2_suppl):10S-60S. doi: 10.1177/1091581818794417.

PMID:
30235961
15.

Safety Assessment of PEG-150 Pentaerythrityl Tetrastearate as Used in Cosmetics.

Johnson W Jr, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Andersen FA, Heldreth B.

Int J Toxicol. 2018 Sep/Oct;37(2_suppl):5S-9S. doi: 10.1177/1091581818794457.

PMID:
30235960
16.

Safety Assessment of Tocopherols and Tocotrienols as Used in Cosmetics.

Fiume MM, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Andersen FA, Heldreth B.

Int J Toxicol. 2018 Sep/Oct;37(2_suppl):61S-94S. doi: 10.1177/1091581818794455.

PMID:
30235959
17.

Activation of Nrf2 in the liver is associated with stress resistance mediated by suppression of the growth hormone-regulated STAT5b transcription factor.

Rooney J, Oshida K, Vasani N, Vallanat B, Ryan N, Chorley BN, Wang X, Bell DA, Wu KC, Aleksunes LM, Klaassen CD, Kensler TW, Corton JC.

PLoS One. 2018 Aug 16;13(8):e0200004. doi: 10.1371/journal.pone.0200004. eCollection 2018.

18.

Oleanolic acid reprograms the liver to protect against hepatotoxicants, but is hepatotoxic at high doses.

Liu J, Lu YF, Wu Q, Xu SF, Shi FG, Klaassen CD.

Liver Int. 2019 Mar;39(3):427-439. doi: 10.1111/liv.13940. Epub 2018 Aug 27. Review.

PMID:
30079536
19.

Obfuscating transparency?

Aschner M, Autrup H, Berry CL, Boobis AR, Cohen SM, Dekant W, Galli CL, Goodman JI, Gori GB, Greim HA, Kaminski NE, Klaassen CD, Klaunig JE, Lotti M, Marquardt HW, Moretto A, Pelkonen O, Sipes IG, Wallace KB, Yamazaki H.

Regul Toxicol Pharmacol. 2018 Aug;97:A1-A3. doi: 10.1016/j.yrtph.2018.07.004. Epub 2018 Jul 11.

PMID:
30017904
20.

Safety Assessment of Polyether Lanolins as Used in Cosmetics.

Becker LC, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Andersen FA, Heldreth B.

Int J Toxicol. 2018 May/Jun;37(1_suppl):19S-27S. doi: 10.1177/1091581817740120.

PMID:
29761732
21.

Safety Assessment of Alkyl Betaines as Used in Cosmetics.

Burnett CL, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Andersen FA, Heldreth B.

Int J Toxicol. 2018 May/Jun;37(1_suppl):28S-46S. doi: 10.1177/1091581818773354.

PMID:
29761731
22.

Safety Assessment of Tromethamine, Aminomethyl Propanediol, and Aminoethyl Propanediol as Used in Cosmetics.

Becker LC, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Gill LJ, Heldreth B.

Int J Toxicol. 2018 May/Jun;37(1_suppl):5S-18S. doi: 10.1177/1091581817738242.

PMID:
29761730
23.

Safety Assessment of Magnesium Sulfate as Used in Cosmetics.

Johnson W Jr, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Andersen FA, Heldreth B.

Int J Toxicol. 2018 May/Jun;37(1_suppl):47S-54S. doi: 10.1177/1091581818773355.

PMID:
29761729
24.

Safety Assessment of Hydrolyzed Wheat Protein and Hydrolyzed Wheat Gluten as Used in Cosmetics.

Burnett C, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Andersen FA, Heldreth B.

Int J Toxicol. 2018 May/Jun;37(1_suppl):55S-66S. doi: 10.1177/1091581818776013.

PMID:
29761728
25.

The Life and Times of John Doull, PhD, MD (1922-2017).

Klaassen CD.

Toxicol Sci. 2018 Mar 1;162(1):5-11. doi: 10.1093/toxsci/kfy009. No abstract available.

PMID:
29529316
26.

Aryl hydrocarbon receptor (AhR) mediated short-term effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on bile acid homeostasis in mice.

Csanaky IL, Lickteig AJ, Klaassen CD.

Toxicol Appl Pharmacol. 2018 Mar 15;343:48-61. doi: 10.1016/j.taap.2018.02.005. Epub 2018 Feb 13.

27.

Safety Assessment of Dimethiconol and Its Esters and Reaction Products as Used in Cosmetics.

Johnson W Jr, Heldreth B, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Andersen FA.

Int J Toxicol. 2017 Nov/Dec;36(3_suppl):31S-50S. doi: 10.1177/1091581817739429. Review.

PMID:
29243542
28.

Safety Assessment of Benzyl Alcohol, Benzoic Acid and its Salts, and Benzyl Benzoate.

Johnson W, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG, Shank RC, Slaga TJ, Snyder PW, Andersen FA.

Int J Toxicol. 2017 Nov/Dec;36(3_suppl):5S-30S. doi: 10.1177/1091581817728996. Review.

PMID:
29243541
29.

Safety Assessment of Plant-Derived Fatty Acid Oils.

Burnett CL, Fiume MM, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler D, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Alan Andersen F.

Int J Toxicol. 2017 Nov/Dec;36(3_suppl):51S-129S. doi: 10.1177/1091581817740569. Review.

PMID:
29243540
30.

Activation of PPARα decreases bile acids in livers of female mice while maintaining bile flow and biliary bile acid excretion.

Zhang Y, Lickteig AJ, Csanaky IL, Klaassen CD.

Toxicol Appl Pharmacol. 2018 Jan 1;338:112-123. doi: 10.1016/j.taap.2017.11.014. Epub 2017 Nov 22.

31.

Alteration of Bile Acid and Cholesterol Biosynthesis and Transport by Perfluorononanoic Acid (PFNA) in Mice.

Zhang Y, Zhang Y, Klaassen CD, Cheng X.

Toxicol Sci. 2018 Mar 1;162(1):225-233. doi: 10.1093/toxsci/kfx237.

32.

From the Cover: Identification of Natural Products as Inhibitors of Human Organic Anion Transporters (OAT1 and OAT3) and Their Protective Effect on Mercury-Induced Toxicity.

Wang X, Han L, Li G, Peng W, Gao X, Klaassen CD, Fan G, Zhang Y.

Toxicol Sci. 2018 Feb 1;161(2):321-334. doi: 10.1093/toxsci/kfx216.

PMID:
29045746
33.

Safety Assessment of Diethanolamine and Its Salts as Used in Cosmetics.

Fiume MM, Heldreth B, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Andersen FA.

Int J Toxicol. 2017 Sep/Oct;36(5_suppl2):89S-110S. doi: 10.1177/1091581817707179.

PMID:
29025348
34.

Safety Assessment of Cross-Linked Alkyl Acrylates as Used in Cosmetics.

Fiume MM, Heldreth B, Boyer I, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Andersen FA.

Int J Toxicol. 2017 Sep/Oct;36(5_suppl2):59S-88S. doi: 10.1177/1091581817707927.

PMID:
29025328
35.

From Classical Toxicology to Tox21: Some Critical Conceptual and Technological Advances in the Molecular Understanding of the Toxic Response Beginning From the Last Quarter of the 20th Century.

Choudhuri S, Patton GW, Chanderbhan RF, Mattia A, Klaassen CD.

Toxicol Sci. 2018 Jan 1;161(1):5-22. doi: 10.1093/toxsci/kfx186. Review.

36.

Editor's Highlight: Clofibrate Decreases Bile Acids in Livers of Male Mice by Increasing Biliary Bile Acid Excretion in a PPARα-Dependent Manner.

Zhang Y, Lickteig AJ, Csanaky IL, Klaassen CD.

Toxicol Sci. 2017 Dec 1;160(2):351-360. doi: 10.1093/toxsci/kfx191.

37.

RNA-Seq Profiling of Intestinal Expression of Xenobiotic Processing Genes in Germ-Free Mice.

Fu ZD, Selwyn FP, Cui JY, Klaassen CD.

Drug Metab Dispos. 2017 Dec;45(12):1225-1238. doi: 10.1124/dmd.117.077313. Epub 2017 Sep 22.

38.

Safety Assessment of Amino Acid Alkyl Amides as Used in Cosmetics.

Burnett CL, Heldreth B, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Andersen FA.

Int J Toxicol. 2017 May/Jun;36(1_suppl):17S-56S. doi: 10.1177/1091581816686048.

PMID:
28553738
39.

Safety Assessment of Anthemis nobilis-Derived Ingredients as Used in Cosmetics.

Johnson W Jr, Heldreth B, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Andersen FA.

Int J Toxicol. 2017 May/Jun;36(1_suppl):57S-66S. doi: 10.1177/1091581817705620.

PMID:
28553737
40.

Amended Safety Assessment of Isethionate Salts as Used in Cosmetics.

Burnett CL, Heldreth B, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Andersen FA.

Int J Toxicol. 2017 May/Jun;36(1_suppl):5S-16S. doi: 10.1177/1091581816685552.

PMID:
28553736
41.

Regulation of drug metabolism and toxicity by multiple factors of genetics, epigenetics, lncRNAs, gut microbiota, and diseases: a meeting report of the 21st International Symposium on Microsomes and Drug Oxidations (MDO).

Yu AM, Ingelman-Sundberg M, Cherrington NJ, Aleksunes LM, Zanger UM, Xie W, Jeong H, Morgan ET, Turnbaugh PJ, Klaassen CD, Bhatt AP, Redinbo MR, Hao P, Waxman DJ, Wang L, Zhong XB.

Acta Pharm Sin B. 2017 Mar;7(2):241-248. doi: 10.1016/j.apsb.2016.12.006. Epub 2017 Feb 1.

42.

Persistent alterations in immune cell populations and function from a single dose of perfluorononanoic acid (PFNA) in C57Bl/6 mice.

Rockwell CE, Turley AE, Cheng X, Fields PE, Klaassen CD.

Food Chem Toxicol. 2017 Feb;100:24-33. doi: 10.1016/j.fct.2016.12.004. Epub 2016 Dec 8.

43.

Safety Assessment of Achillea millefolium as Used in Cosmetics.

Becker LC, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Andersen FA.

Int J Toxicol. 2016 Nov;35(3 suppl):5S-15S. Review.

PMID:
27913788
44.

Safety Assessment of Polyquaternium-22 and Polyquarternium-39 as Used in Cosmetics.

Johnson W Jr, Heldreth B, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Andersen FA.

Int J Toxicol. 2016 Nov;35(3 suppl):47S-53S.

PMID:
27913787
45.

Safety Assessment of Dialkyl Sulfosuccinate Salts as Used in Cosmetics.

Fiume MM, Heldreth B, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Andersen FA.

Int J Toxicol. 2016 Nov;35(3 suppl):34S-46S. Review.

PMID:
27913786
46.

Safety Assessment of Alumina and Aluminum Hydroxide as Used in Cosmetics.

Becker LC, Boyer I, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Andersen FA.

Int J Toxicol. 2016 Nov;35(3 suppl):16S-33S. Review.

PMID:
27913785
47.

Safety Assessment of Formic Acid and Sodium Formate as Used in Cosmetics.

Johnson W Jr, Heldreth B, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Andersen FA.

Int J Toxicol. 2016 Nov;35(2 suppl):41S-54S. Review.

PMID:
27913772
48.

Safety Assessment of Methyl Glucose Polyethers and Esters as Used in Cosmetics.

Johnson W Jr, Heldreth B, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Andersen FA.

Int J Toxicol. 2016 Nov;35(2 suppl):12S-40S. Review.

PMID:
27913771
49.

Dose-response effect of berberine on bile acid profile and gut microbiota in mice.

Guo Y, Zhang Y, Huang W, Selwyn FP, Klaassen CD.

BMC Complement Altern Med. 2016 Oct 18;16(1):394.

50.

Effect of nine diets on mRNAs of phase-II conjugation enzymes in livers of mice.

Guo Y, Cui JY, Lu H, Klaassen CD.

Xenobiotica. 2017 Aug;47(8):645-654. doi: 10.1080/00498254.2016.1213926. Epub 2016 Aug 10.

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