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Items: 1 to 50 of 931

1.

The essential role of the transporter ABCG2 in the pathophysiology of erythropoietic protoporphyria.

Wang P, Sachar M, Lu J, Shehu AI, Zhu J, Chen J, Liu K, Anderson KE, Xie W, Gonzalez FJ, Klaassen CD, Ma X.

Sci Adv. 2019 Sep 18;5(9):eaaw6127. doi: 10.1126/sciadv.aaw6127. eCollection 2019 Sep.

2.

Safety Assessment of PCA (2-Pyrrolidone-5-Carboxylic Acid) and Its Salts as Used in Cosmetics.

Fiume MM, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Gill LJ, Heldreth B.

Int J Toxicol. 2019 Sep/Oct;38(2_suppl):5S-11S. doi: 10.1177/1091581819856568.

PMID:
31522652
3.

Safety Assessment of Sorbitan Esters as Used in Cosmetics.

Fiume MM, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Gill LJ, Heldreth B.

Int J Toxicol. 2019 Sep/Oct;38(2_suppl):60S-80S. doi: 10.1177/1091581819871877.

PMID:
31522651
4.

Safety Assessment of Citrus-Derived Peel Oils as Used in Cosmetics.

Burnett CL, Fiume MM, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Gill LJ, Heldreth B.

Int J Toxicol. 2019 Sep/Oct;38(2_suppl):33S-59S. doi: 10.1177/1091581819862504.

PMID:
31522650
5.

Safety Assessment of Alkyl Phosphates as Used in Cosmetics.

Fiume MM, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Gill LJ, Heldreth B.

Int J Toxicol. 2019 Sep/Oct;38(2_suppl):12S-32S. doi: 10.1177/1091581819856582.

PMID:
31522649
6.

Glucocorticoids increase renal excretion of urate in mice by down-regulating urate transporter 1.

Li G, Han L, Ma R, Saeed K, Xiong H, Klaassen C, Lu Y, Zhang Y.

Drug Metab Dispos. 2019 Sep 13. pii: dmd.119.087700. doi: 10.1124/dmd.119.087700. [Epub ahead of print]

7.

Identification and Characterization of Efflux Transporters That Modulate the Subtoxic Disposition of Diclofenac and Its Metabolites.

Scialis RJ, Aleksunes LM, Csanaky IL, Klaassen CD, Manautou JE.

Drug Metab Dispos. 2019 Oct;47(10):1080-1092. doi: 10.1124/dmd.119.086603. Epub 2019 Aug 9.

PMID:
31399506
8.

Epidemiology and characterisation of carbapenem-non-susceptible Pseudomonas aeruginosa in a large intensive care unit in Jakarta, Indonesia.

Saharman YR, Pelegrin AC, Karuniawati A, Sedono R, Aditianingsih D, Goessens WHF, Klaassen CHW, van Belkum A, Mirande C, Verbrugh HA, Severin JA.

Int J Antimicrob Agents. 2019 Aug 7. pii: S0924-8579(19)30214-6. doi: 10.1016/j.ijantimicag.2019.08.003. [Epub ahead of print]

9.

Effects of Absence of Constitutive Androstane Receptor (CAR) on Bile Acid Homeostasis in Male and Female Mice.

Lickteig AJ, Zhang Y, Klaassen CD, Csanaky IL.

Toxicol Sci. 2019 Jun 21. pii: kfz143. doi: 10.1093/toxsci/kfz143. [Epub ahead of print]

PMID:
31225615
10.

Amended Safety Assessment of Methylisothiazolinone as Used in Cosmetics.

Burnett CL, Boyer I, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Gill LJ, Heldreth B.

Int J Toxicol. 2019 May/Jun;38(1_suppl):70S-84S. doi: 10.1177/1091581819838792.

PMID:
31170842
11.

Safety Assessment of Fatty Acid Amidopropyl Dimethylamines as Used in Cosmetics.

Burnett CL, Boyer I, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Gill LJ, Heldreth B.

Int J Toxicol. 2019 May/Jun;38(1_suppl):39S-69S. doi: 10.1177/1091581819836089.

PMID:
31170841
12.

Safety Assessment of Monosaccharides, Disaccharides, and Related Ingredients as Used in Cosmetics.

Fiume MM, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Gill LJ, Heldreth B.

Int J Toxicol. 2019 May/Jun;38(1_suppl):5S-38S. doi: 10.1177/1091581818814189.

PMID:
31170840
13.

The adequacy of aging techniques in vertebrates for rapid estimation of population mortality rates from age distributions.

Zhao M, Klaassen CAJ, Lisovski S, Klaassen M.

Ecol Evol. 2018 Dec 27;9(3):1394-1402. doi: 10.1002/ece3.4854. eCollection 2019 Feb.

14.

Hepatic carboxylesterases are differentially regulated in PPARα-null mice treated with perfluorooctanoic acid.

Wen X, Baker AA, Klaassen CD, Corton JC, Richardson JR, Aleksunes LM.

Toxicology. 2019 Mar 15;416:15-22. doi: 10.1016/j.tox.2019.01.014. Epub 2019 Jan 24.

PMID:
30685356
15.

RNA-Seq provides new insights on the relative mRNA abundance of antioxidant components during mouse liver development.

Wu KC, Cui JY, Liu J, Lu H, Zhong XB, Klaassen CD.

Free Radic Biol Med. 2019 Apr;134:335-342. doi: 10.1016/j.freeradbiomed.2019.01.017. Epub 2019 Jan 16.

PMID:
30659941
16.

Editorial.

Aschner M, Autrup HN, Cohen SM, Dekant W, Eisenbrand G, Galli CL, Gori GB, Kaminski NE, Klaassen CD, Klaunig JE, Levy L, Lotti M, Marquardt HW, Pelkonen O, Schrenk DF, Yamazaki H.

Regul Toxicol Pharmacol. 2019 Feb;101:A1-A2. doi: 10.1016/j.yrtph.2018.12.015. No abstract available.

PMID:
30642615
17.

Double Infection With Leishmania tropica and L. major in an HIV Patient Controlled With High Doses of Amphotericin B.

Al Balushi A, Khamis F, Klaassen CHW, Gangneux JP, Van Hellemond JJ, Petersen E.

Open Forum Infect Dis. 2018 Dec 7;5(12):ofy323. doi: 10.1093/ofid/ofy323. eCollection 2018 Dec.

18.

Safety Assessment of PEGs Cocamine and Related Ingredients as Used in Cosmetics.

Boyer I, Burnett CL, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Gill LJ, Heldreth B.

Int J Toxicol. 2018 Sep/Oct;37(2_suppl):10S-60S. doi: 10.1177/1091581818794417.

PMID:
30235961
19.

Safety Assessment of PEG-150 Pentaerythrityl Tetrastearate as Used in Cosmetics.

Johnson W Jr, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Andersen FA, Heldreth B.

Int J Toxicol. 2018 Sep/Oct;37(2_suppl):5S-9S. doi: 10.1177/1091581818794457.

PMID:
30235960
20.

Safety Assessment of Tocopherols and Tocotrienols as Used in Cosmetics.

Fiume MM, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Andersen FA, Heldreth B.

Int J Toxicol. 2018 Sep/Oct;37(2_suppl):61S-94S. doi: 10.1177/1091581818794455.

PMID:
30235959
21.

Activation of Nrf2 in the liver is associated with stress resistance mediated by suppression of the growth hormone-regulated STAT5b transcription factor.

Rooney J, Oshida K, Vasani N, Vallanat B, Ryan N, Chorley BN, Wang X, Bell DA, Wu KC, Aleksunes LM, Klaassen CD, Kensler TW, Corton JC.

PLoS One. 2018 Aug 16;13(8):e0200004. doi: 10.1371/journal.pone.0200004. eCollection 2018.

22.

Oleanolic acid reprograms the liver to protect against hepatotoxicants, but is hepatotoxic at high doses.

Liu J, Lu YF, Wu Q, Xu SF, Shi FG, Klaassen CD.

Liver Int. 2019 Mar;39(3):427-439. doi: 10.1111/liv.13940. Epub 2018 Aug 27. Review.

PMID:
30079536
23.

PME and Other ESBL-Positive Multiresistant Pseudomonas aeruginosa Isolated from Hospitalized Patients in the Region of Kurdistan, Iraq.

van Burgh S, Maghdid DM, Ganjo AR, Mansoor IY, Kok DJ, Fatah MH, Alnakshabandi AA, Asad D, Hammerum AM, Ng K, Klaassen C, Goessens WHF.

Microb Drug Resist. 2019 Jan/Feb;25(1):32-38. doi: 10.1089/mdr.2018.0036. Epub 2018 Aug 1.

PMID:
30067166
24.

Obfuscating transparency?

Aschner M, Autrup H, Berry CL, Boobis AR, Cohen SM, Dekant W, Galli CL, Goodman JI, Gori GB, Greim HA, Kaminski NE, Klaassen CD, Klaunig JE, Lotti M, Marquardt HW, Moretto A, Pelkonen O, Sipes IG, Wallace KB, Yamazaki H.

Regul Toxicol Pharmacol. 2018 Aug;97:A1-A3. doi: 10.1016/j.yrtph.2018.07.004. Epub 2018 Jul 11.

PMID:
30017904
25.

Unexpected mechanisms of resistance in Dutch Pseudomonas aeruginosa isolates collected during 14 years of surveillance.

Croughs PD, Klaassen CHW, van Rosmalen J, Maghdid DM, Boers SA, Hays JP, Goessens WHF; Dutch Antibiotic Resistance Surveillance Group.

Int J Antimicrob Agents. 2018 Sep;52(3):407-410. doi: 10.1016/j.ijantimicag.2018.05.009. Epub 2018 May 15.

PMID:
29772393
26.

Safety Assessment of Polyether Lanolins as Used in Cosmetics.

Becker LC, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Andersen FA, Heldreth B.

Int J Toxicol. 2018 May/Jun;37(1_suppl):19S-27S. doi: 10.1177/1091581817740120.

PMID:
29761732
27.

Safety Assessment of Alkyl Betaines as Used in Cosmetics.

Burnett CL, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Andersen FA, Heldreth B.

Int J Toxicol. 2018 May/Jun;37(1_suppl):28S-46S. doi: 10.1177/1091581818773354.

PMID:
29761731
28.

Safety Assessment of Tromethamine, Aminomethyl Propanediol, and Aminoethyl Propanediol as Used in Cosmetics.

Becker LC, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Gill LJ, Heldreth B.

Int J Toxicol. 2018 May/Jun;37(1_suppl):5S-18S. doi: 10.1177/1091581817738242.

PMID:
29761730
29.

Safety Assessment of Magnesium Sulfate as Used in Cosmetics.

Johnson W Jr, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Andersen FA, Heldreth B.

Int J Toxicol. 2018 May/Jun;37(1_suppl):47S-54S. doi: 10.1177/1091581818773355.

PMID:
29761729
30.

Safety Assessment of Hydrolyzed Wheat Protein and Hydrolyzed Wheat Gluten as Used in Cosmetics.

Burnett C, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Andersen FA, Heldreth B.

Int J Toxicol. 2018 May/Jun;37(1_suppl):55S-66S. doi: 10.1177/1091581818776013.

PMID:
29761728
31.

The Life and Times of John Doull, PhD, MD (1922-2017).

Klaassen CD.

Toxicol Sci. 2018 Mar 1;162(1):5-11. doi: 10.1093/toxsci/kfy009. No abstract available.

PMID:
29529316
32.

Aryl hydrocarbon receptor (AhR) mediated short-term effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on bile acid homeostasis in mice.

Csanaky IL, Lickteig AJ, Klaassen CD.

Toxicol Appl Pharmacol. 2018 Mar 15;343:48-61. doi: 10.1016/j.taap.2018.02.005. Epub 2018 Feb 13.

33.

Endemic carbapenem-nonsusceptible Acinetobacter baumannii-calcoaceticus complex in intensive care units of the national referral hospital in Jakarta, Indonesia.

Saharman YR, Karuniawati A, Sedono R, Aditianingsih D, Sudarmono P, Goessens WHF, Klaassen CHW, Verbrugh HA, Severin JA.

Antimicrob Resist Infect Control. 2018 Jan 12;7:5. doi: 10.1186/s13756-017-0296-7. eCollection 2018.

34.

Safety Assessment of Dimethiconol and Its Esters and Reaction Products as Used in Cosmetics.

Johnson W Jr, Heldreth B, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Andersen FA.

Int J Toxicol. 2017 Nov/Dec;36(3_suppl):31S-50S. doi: 10.1177/1091581817739429. Review.

PMID:
29243542
35.

Safety Assessment of Benzyl Alcohol, Benzoic Acid and its Salts, and Benzyl Benzoate.

Johnson W, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG, Shank RC, Slaga TJ, Snyder PW, Andersen FA.

Int J Toxicol. 2017 Nov/Dec;36(3_suppl):5S-30S. doi: 10.1177/1091581817728996. Review.

PMID:
29243541
36.

Safety Assessment of Plant-Derived Fatty Acid Oils.

Burnett CL, Fiume MM, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler D, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Alan Andersen F.

Int J Toxicol. 2017 Nov/Dec;36(3_suppl):51S-129S. doi: 10.1177/1091581817740569. Review.

PMID:
29243540
37.

Activation of PPARα decreases bile acids in livers of female mice while maintaining bile flow and biliary bile acid excretion.

Zhang Y, Lickteig AJ, Csanaky IL, Klaassen CD.

Toxicol Appl Pharmacol. 2018 Jan 1;338:112-123. doi: 10.1016/j.taap.2017.11.014. Epub 2017 Nov 22.

38.

Alteration of Bile Acid and Cholesterol Biosynthesis and Transport by Perfluorononanoic Acid (PFNA) in Mice.

Zhang Y, Zhang Y, Klaassen CD, Cheng X.

Toxicol Sci. 2018 Mar 1;162(1):225-233. doi: 10.1093/toxsci/kfx237.

39.

From the Cover: Identification of Natural Products as Inhibitors of Human Organic Anion Transporters (OAT1 and OAT3) and Their Protective Effect on Mercury-Induced Toxicity.

Wang X, Han L, Li G, Peng W, Gao X, Klaassen CD, Fan G, Zhang Y.

Toxicol Sci. 2018 Feb 1;161(2):321-334. doi: 10.1093/toxsci/kfx216.

PMID:
29045746
40.

Safety Assessment of Diethanolamine and Its Salts as Used in Cosmetics.

Fiume MM, Heldreth B, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Andersen FA.

Int J Toxicol. 2017 Sep/Oct;36(5_suppl2):89S-110S. doi: 10.1177/1091581817707179.

PMID:
29025348
41.

Safety Assessment of Cross-Linked Alkyl Acrylates as Used in Cosmetics.

Fiume MM, Heldreth B, Boyer I, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Andersen FA.

Int J Toxicol. 2017 Sep/Oct;36(5_suppl2):59S-88S. doi: 10.1177/1091581817707927.

PMID:
29025328
42.

From Classical Toxicology to Tox21: Some Critical Conceptual and Technological Advances in the Molecular Understanding of the Toxic Response Beginning From the Last Quarter of the 20th Century.

Choudhuri S, Patton GW, Chanderbhan RF, Mattia A, Klaassen CD.

Toxicol Sci. 2018 Jan 1;161(1):5-22. doi: 10.1093/toxsci/kfx186. Review.

43.

Editor's Highlight: Clofibrate Decreases Bile Acids in Livers of Male Mice by Increasing Biliary Bile Acid Excretion in a PPARα-Dependent Manner.

Zhang Y, Lickteig AJ, Csanaky IL, Klaassen CD.

Toxicol Sci. 2017 Dec 1;160(2):351-360. doi: 10.1093/toxsci/kfx191.

44.

Detection of azole-susceptible and azole-resistant Aspergillus coinfection by cyp51A PCR amplicon melting curve analysis.

Schauwvlieghe AFAD, Vonk AG, Buddingh EP, Hoek RAS, Dalm VA, Klaassen CHW, Rijnders BJA.

J Antimicrob Chemother. 2017 Nov 1;72(11):3047-3050. doi: 10.1093/jac/dkx262.

PMID:
28961889
45.

RNA-Seq Profiling of Intestinal Expression of Xenobiotic Processing Genes in Germ-Free Mice.

Fu ZD, Selwyn FP, Cui JY, Klaassen CD.

Drug Metab Dispos. 2017 Dec;45(12):1225-1238. doi: 10.1124/dmd.117.077313. Epub 2017 Sep 22.

46.

Safety Assessment of Amino Acid Alkyl Amides as Used in Cosmetics.

Burnett CL, Heldreth B, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Andersen FA.

Int J Toxicol. 2017 May/Jun;36(1_suppl):17S-56S. doi: 10.1177/1091581816686048.

PMID:
28553738
47.

Safety Assessment of Anthemis nobilis-Derived Ingredients as Used in Cosmetics.

Johnson W Jr, Heldreth B, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Andersen FA.

Int J Toxicol. 2017 May/Jun;36(1_suppl):57S-66S. doi: 10.1177/1091581817705620.

PMID:
28553737
48.

Amended Safety Assessment of Isethionate Salts as Used in Cosmetics.

Burnett CL, Heldreth B, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Andersen FA.

Int J Toxicol. 2017 May/Jun;36(1_suppl):5S-16S. doi: 10.1177/1091581816685552.

PMID:
28553736
49.

Regulation of drug metabolism and toxicity by multiple factors of genetics, epigenetics, lncRNAs, gut microbiota, and diseases: a meeting report of the 21st International Symposium on Microsomes and Drug Oxidations (MDO).

Yu AM, Ingelman-Sundberg M, Cherrington NJ, Aleksunes LM, Zanger UM, Xie W, Jeong H, Morgan ET, Turnbaugh PJ, Klaassen CD, Bhatt AP, Redinbo MR, Hao P, Waxman DJ, Wang L, Zhong XB.

Acta Pharm Sin B. 2017 Mar;7(2):241-248. doi: 10.1016/j.apsb.2016.12.006. Epub 2017 Feb 1.

50.

Regulation of hepatic microRNA expression by hepatocyte nuclear factor 4 alpha.

Lu H, Lei X, Liu J, Klaassen C.

World J Hepatol. 2017 Feb 8;9(4):191-208. doi: 10.4254/wjh.v9.i4.191.

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