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Items: 1 to 50 of 647

1.

A Semicentennial of Pancreatic Pathology: The Genetic Revolution Is Here, But Don't Throw the Baby Out With The Bath Water!

Hruban RH, Klimstra DS, Zamboni G, Klöppel G.

Hum Pathol. 2019 Sep 12. pii: S0046-8177(19)30164-9. doi: 10.1016/j.humpath.2019.08.024. [Epub ahead of print]

PMID:
31521627
2.

Classification and prognostic stratification of bronchopulmonary neuroendocrine neoplasms.

Oka N, Kasajima A, Konukiewitz B, Sakurada A, Okada Y, Kameya T, Weichert W, Ishikawa Y, Suzuki H, Sasano H, Klöppel G.

Neuroendocrinology. 2019 Aug 19. doi: 10.1159/000502776. [Epub ahead of print]

PMID:
31422400
3.

[Neuroendocrine neoplasms : Two families with distinct features unified in one classification (German version)].

Klöppel G.

Pathologe. 2019 May;40(3):211-219. doi: 10.1007/s00292-019-0594-3. German.

PMID:
30969346
4.

Clinicopathological Profiling of Lung Carcinoids with a Ki67 Index > 20.

Kasajima A, Konukiewitz B, Oka N, Suzuki H, Sakurada A, Okada Y, Kameya T, Ishikawa Y, Sasano H, Weichert W, Klöppel G.

Neuroendocrinology. 2019;108(2):109-120. doi: 10.1159/000495806. Epub 2018 Nov 28.

PMID:
30485860
5.

Molecular alterations associated with metastases of solid pseudopapillary neoplasms of the pancreas.

Amato E, Mafficini A, Hirabayashi K, Lawlor RT, Fassan M, Vicentini C, Barbi S, Delfino P, Sikora K, Rusev B, Simbolo M, Esposito I, Antonello D, Pea A, Sereni E, Ballotta M, Maggino L, Marchegiani G, Ohike N, Wood LD, Salvia R, Klöppel G, Zamboni G, Scarpa A, Corbo V.

J Pathol. 2019 Jan;247(1):123-134. doi: 10.1002/path.5180. Epub 2018 Nov 27.

6.

Unmet Needs in Functional and Nonfunctional Pancreatic Neuroendocrine Neoplasms.

Jensen RT, Bodei L, Capdevila J, Couvelard A, Falconi M, Glasberg S, Kloppel G, Lamberts S, Peeters M, Rindi G, Rinke A, Rothmund M, Sundin A, Welin S, Fazio N; The ENETS 2016 Munich Advisory Board Participants; ENETS 2016 Munich Advisory Board Participants.

Neuroendocrinology. 2019;108(1):26-36. doi: 10.1159/000494258. Epub 2018 Oct 3.

7.

The Combination of MiRNA-196b, LCN2, and TIMP1 is a Potential Set of Circulating Biomarkers for Screening Individuals at Risk for Familial Pancreatic Cancer.

Bartsch DK, Gercke N, Strauch K, Wieboldt R, Matthäi E, Wagner V, Rospleszcz S, Schäfer A, Franke FS, Mintziras I, Bauer C, Grote T, Figiel J, Di Fazio P, Burchert A, Reinartz S, Pogge von Strandmann E, Klöppel G, Slater EP.

J Clin Med. 2018 Sep 20;7(10). pii: E295. doi: 10.3390/jcm7100295.

8.

A common classification framework for neuroendocrine neoplasms: an International Agency for Research on Cancer (IARC) and World Health Organization (WHO) expert consensus proposal.

Rindi G, Klimstra DS, Abedi-Ardekani B, Asa SL, Bosman FT, Brambilla E, Busam KJ, de Krijger RR, Dietel M, El-Naggar AK, Fernandez-Cuesta L, Klöppel G, McCluggage WG, Moch H, Ohgaki H, Rakha EA, Reed NS, Rous BA, Sasano H, Scarpa A, Scoazec JY, Travis WD, Tallini G, Trouillas J, van Krieken JH, Cree IA.

Mod Pathol. 2018 Dec;31(12):1770-1786. doi: 10.1038/s41379-018-0110-y. Epub 2018 Aug 23.

9.

Incidentally detected pancreatic neuroendocrine microadenoma with lymph node metastasis.

Kwon JH, Kim HJ, Park DH, Lee YJ, Heaphy CM, Klöppel G, Hruban RH, Hong SM.

Virchows Arch. 2018 Nov;473(5):649-653. doi: 10.1007/s00428-018-2407-0. Epub 2018 Jul 12.

PMID:
30003325
10.

[Solitary Fibrous Tumor: a Rare Cause of Recurrent Severe Hypoglycemia].

Kühn-Velten U, Hohmann C, Strauss T, Heizmann O, Klöppel G.

Dtsch Med Wochenschr. 2018 Jun;143(11):824-829. doi: 10.1055/a-0594-8043. Epub 2018 May 28. German.

PMID:
29807385
11.

Frequent expression of somatostatin receptor 2a in olfactory neuroblastomas: a new and distinctive feature.

Czapiewski P, Kunc M, Gorczyński A, Haybaeck J, Okoń K, Reszec J, Lewczuk A, Dzierzanowski J, Karczewska J, Biernat W, Turri-Zanoni M, Castelnuovo P, Taverna C, Franchi A, La Rosa S, Sessa F, Klöppel G.

Hum Pathol. 2018 Sep;79:144-150. doi: 10.1016/j.humpath.2018.05.013. Epub 2018 May 25.

PMID:
29807052
12.

Pancreatic neuroendocrine carcinomas reveal a closer relationship to ductal adenocarcinomas than to neuroendocrine tumors G3.

Konukiewitz B, Jesinghaus M, Steiger K, Schlitter AM, Kasajima A, Sipos B, Zamboni G, Weichert W, Pfarr N, Klöppel G.

Hum Pathol. 2018 Jul;77:70-79. doi: 10.1016/j.humpath.2018.03.018. Epub 2018 Mar 26.

PMID:
29596894
13.

Evolutionary routes and KRAS dosage define pancreatic cancer phenotypes.

Mueller S, Engleitner T, Maresch R, Zukowska M, Lange S, Kaltenbacher T, Konukiewitz B, Öllinger R, Zwiebel M, Strong A, Yen HY, Banerjee R, Louzada S, Fu B, Seidler B, Götzfried J, Schuck K, Hassan Z, Arbeiter A, Schönhuber N, Klein S, Veltkamp C, Friedrich M, Rad L, Barenboim M, Ziegenhain C, Hess J, Dovey OM, Eser S, Parekh S, Constantino-Casas F, de la Rosa J, Sierra MI, Fraga M, Mayerle J, Klöppel G, Cadiñanos J, Liu P, Vassiliou G, Weichert W, Steiger K, Enard W, Schmid RM, Yang F, Unger K, Schneider G, Varela I, Bradley A, Saur D, Rad R.

Nature. 2018 Feb 1;554(7690):62-68. doi: 10.1038/nature25459. Epub 2018 Jan 24.

14.

MAFA missense mutation causes familial insulinomatosis and diabetes mellitus.

Iacovazzo D, Flanagan SE, Walker E, Quezado R, de Sousa Barros FA, Caswell R, Johnson MB, Wakeling M, Brändle M, Guo M, Dang MN, Gabrovska P, Niederle B, Christ E, Jenni S, Sipos B, Nieser M, Frilling A, Dhatariya K, Chanson P, de Herder WW, Konukiewitz B, Klöppel G, Stein R, Korbonits M, Ellard S.

Proc Natl Acad Sci U S A. 2018 Jan 30;115(5):1027-1032. doi: 10.1073/pnas.1712262115. Epub 2018 Jan 16.

15.

Appendiceal goblet cell carcinoids and adenocarcinomas ex-goblet cell carcinoid are genetically distinct from primary colorectal-type adenocarcinoma of the appendix.

Jesinghaus M, Konukiewitz B, Foersch S, Stenzinger A, Steiger K, Muckenhuber A, Groß C, Mollenhauer M, Roth W, Detlefsen S, Weichert W, Klöppel G, Pfarr N, Schlitter AM.

Mod Pathol. 2018 May;31(5):829-839. doi: 10.1038/modpathol.2017.184. Epub 2018 Jan 12.

16.

Inflammation and PD-L1 expression in pulmonary neuroendocrine tumors.

Kasajima A, Ishikawa Y, Iwata A, Steiger K, Oka N, Ishida H, Sakurada A, Suzuki H, Kameya T, Konukiewitz B, Klöppel G, Okada Y, Sasano H, Weichert W.

Endocr Relat Cancer. 2018 Mar;25(3):339-350. doi: 10.1530/ERC-17-0427. Epub 2018 Jan 11.

PMID:
29326364
17.

[Neuroendocrine neoplasms of the head and neck].

Konukiewitz B, Agaimy A, Weichert W, Klöppel G.

Pathologe. 2018 Feb;39(1):27-34. doi: 10.1007/s00292-017-0404-8. Review. German.

PMID:
29313083
18.

Correction to: Ki67 labeling index: assessment and prognostic role in gastroenteropancreatic neuroendocrine neoplasms.

Klöppel G, La Rosa S.

Virchows Arch. 2018 Mar;472(3):515. doi: 10.1007/s00428-017-2283-z.

PMID:
29280080
19.

IgG4-related disease: with emphasis on the biopsy diagnosis of autoimmune pancreatitis and sclerosing cholangitis.

Detlefsen S, Klöppel G.

Virchows Arch. 2018 Apr;472(4):545-556. doi: 10.1007/s00428-017-2275-z. Epub 2017 Dec 1. Review.

PMID:
29196804
20.

Neuroendocrine Neoplasms: Dichotomy, Origin and Classifications.

Klöppel G.

Visc Med. 2017 Oct;33(5):324-330. doi: 10.1159/000481390. Epub 2017 Oct 16. Review.

21.

Ki67 labeling index: assessment and prognostic role in gastroenteropancreatic neuroendocrine neoplasms.

Klöppel G, La Rosa S.

Virchows Arch. 2018 Mar;472(3):341-349. doi: 10.1007/s00428-017-2258-0. Epub 2017 Nov 13. Review. Erratum in: Virchows Arch. 2017 Dec 26;:.

PMID:
29134440
22.

Genome-wide genetic and epigenetic analyses of pancreatic acinar cell carcinomas reveal aberrations in genome stability.

Jäkel C, Bergmann F, Toth R, Assenov Y, van der Duin D, Strobel O, Hank T, Klöppel G, Dorrell C, Grompe M, Moss J, Dor Y, Schirmacher P, Plass C, Popanda O, Schmezer P.

Nat Commun. 2017 Nov 6;8(1):1323. doi: 10.1038/s41467-017-01118-x.

23.

Pancreatic Ductal Adenocarcinoma Subtyping Using the Biomarkers Hepatocyte Nuclear Factor-1A and Cytokeratin-81 Correlates with Outcome and Treatment Response.

Muckenhuber A, Berger AK, Schlitter AM, Steiger K, Konukiewitz B, Trumpp A, Eils R, Werner J, Friess H, Esposito I, Klöppel G, Ceyhan GO, Jesinghaus M, Denkert C, Bahra M, Stenzinger A, Sprick MR, Jäger D, Springfeld C, Weichert W.

Clin Cancer Res. 2018 Jan 15;24(2):351-359. doi: 10.1158/1078-0432.CCR-17-2180. Epub 2017 Nov 3.

24.

Molecular, morphological and survival analysis of 177 resected pancreatic ductal adenocarcinomas (PDACs): Identification of prognostic subtypes.

Schlitter AM, Segler A, Steiger K, Michalski CW, Jäger C, Konukiewitz B, Pfarr N, Endris V, Bettstetter M, Kong B, Regel I, Kleeff J, Klöppel G, Esposito I.

Sci Rep. 2017 Feb 1;7:41064. doi: 10.1038/srep41064.

25.

Somatostatin receptor expression related to TP53 and RB1 alterations in pancreatic and extrapancreatic neuroendocrine neoplasms with a Ki67-index above 20.

Konukiewitz B, Schlitter AM, Jesinghaus M, Pfister D, Steiger K, Segler A, Agaimy A, Sipos B, Zamboni G, Weichert W, Esposito I, Pfarr N, Klöppel G.

Mod Pathol. 2017 Apr;30(4):587-598. doi: 10.1038/modpathol.2016.217. Epub 2017 Jan 6.

26.

Colorectal mixed adenoneuroendocrine carcinomas and neuroendocrine carcinomas are genetically closely related to colorectal adenocarcinomas.

Jesinghaus M, Konukiewitz B, Keller G, Kloor M, Steiger K, Reiche M, Penzel R, Endris V, Arsenic R, Hermann G, Stenzinger A, Weichert W, Pfarr N, Klöppel G.

Mod Pathol. 2017 Apr;30(4):610-619. doi: 10.1038/modpathol.2016.220. Epub 2017 Jan 6.

27.

Intraductal Tubulopapillary Neoplasm of the Pancreas: A Clinicopathologic and Immunohistochemical Analysis of 33 Cases.

Basturk O, Adsay V, Askan G, Dhall D, Zamboni G, Shimizu M, Cymes K, Carneiro F, Balci S, Sigel C, Reid MD, Esposito I, Baldaia H, Allen P, Klöppel G, Klimstra DS.

Am J Surg Pathol. 2017 Mar;41(3):313-325. doi: 10.1097/PAS.0000000000000782.

28.

Characterization of pancreatic glucagon-producing tumors and pituitary gland tumors in transgenic mice overexpressing MYCN in hGFAP-positive cells.

Fielitz K, Althoff K, De Preter K, Nonnekens J, Ohli J, Elges S, Hartmann W, Klöppel G, Knösel T, Schulte M, Klein-Hitpass L, Beisser D, Reis H, Eyking A, Cario E, Schulte JH, Schramm A, Schüller U.

Oncotarget. 2016 Nov 15;7(46):74415-74426. doi: 10.18632/oncotarget.12766.

29.

[Histopathology of IgG4-related disease].

Detlefsen S, Klöppel G.

Z Rheumatol. 2016 Sep;75(7):666-74. doi: 10.1007/s00393-016-0130-2. Review. German.

PMID:
27405315
30.

Aberrant Menin expression is an early event in pancreatic neuroendocrine tumorigenesis.

Hackeng WM, Brosens LA, Poruk KE, Noë M, Hosoda W, Poling JS, Rizzo A, Campbell-Thompson M, Atkinson MA, Konukiewitz B, Klöppel G, Heaphy CM, Meeker AK, Wood LD.

Hum Pathol. 2016 Oct;56:93-100. doi: 10.1016/j.humpath.2016.06.006. Epub 2016 Jun 21.

PMID:
27342911
31.

Refinement of screening for familial pancreatic cancer.

Bartsch DK, Slater EP, Carrato A, Ibrahim IS, Guillen-Ponce C, Vasen HF, Matthäi E, Earl J, Jendryschek FS, Figiel J, Steinkamp M, Ramaswamy A, Vázquez-Sequeiros E, Muñoz-Beltran M, Montans J, Mocci E, Bonsing BA, Wasser M, Klöppel G, Langer P, Fendrich V, Gress TM.

Gut. 2016 Aug;65(8):1314-21. doi: 10.1136/gutjnl-2015-311098. Epub 2016 May 24.

PMID:
27222532
32.

Loss of Chromosome 18 in Neuroendocrine Tumors of the Small Intestine: The Enigma Remains.

Nieser M, Henopp T, Brix J, Stoß L, Sitek B, Naboulsi W, Anlauf M, Schlitter AM, Klöppel G, Gress T, Moll R, Bartsch DK, Heverhagen AE, Knoefel WT, Kaemmerer D, Haybaeck J, Fend F, Sperveslage J, Sipos B.

Neuroendocrinology. 2017;104(3):302-312. doi: 10.1159/000446917. Epub 2016 May 25.

PMID:
27222126
33.

HIF2A gain-of-function mutations detected in duodenal gangliocytic paraganglioma.

Zhuang Z, Yang C, Ryska A, Ji Y, Hou Y, Graybill SD, Bullova P, Lubensky IA, Klöppel G, Pacak K.

Endocr Relat Cancer. 2016 May;23(5):L13-6. doi: 10.1530/ERC-16-0148. Epub 2016 Apr 29. No abstract available.

34.

[Insulitis in type 1 diabetes].

In't Veld P, Klöppel G.

Pathologe. 2016 May;37(3):245-52. doi: 10.1007/s00292-016-0166-8. Review. German.

PMID:
27126249
35.

Benefit of Surveillance for Pancreatic Cancer in High-Risk Individuals: Outcome of Long-Term Prospective Follow-Up Studies From Three European Expert Centers.

Vasen H, Ibrahim I, Ponce CG, Slater EP, Matthäi E, Carrato A, Earl J, Robbers K, van Mil AM, Potjer T, Bonsing BA, de Vos Tot Nederveen Cappel WH, Bergman W, Wasser M, Morreau H, Klöppel G, Schicker C, Steinkamp M, Figiel J, Esposito I, Mocci E, Vazquez-Sequeiros E, Sanjuanbenito A, Muñoz-Beltran M, Montans J, Langer P, Fendrich V, Bartsch DK.

J Clin Oncol. 2016 Jun 10;34(17):2010-9. doi: 10.1200/JCO.2015.64.0730. Epub 2016 Apr 25.

PMID:
27114589
36.

Mixed acinar-neuroendocrine carcinoma of the pancreas: a case report and a review.

Jakobsen M, Klöppel G, Detlefsen S.

Histol Histopathol. 2016 Dec;31(12):1381-8. doi: 10.14670/HH-11-767. Epub 2016 Apr 15. Review.

PMID:
27081013
37.

ENETS Consensus Guidelines Update for the Management of Patients with Functional Pancreatic Neuroendocrine Tumors and Non-Functional Pancreatic Neuroendocrine Tumors.

Falconi M, Eriksson B, Kaltsas G, Bartsch DK, Capdevila J, Caplin M, Kos-Kudla B, Kwekkeboom D, Rindi G, Klöppel G, Reed N, Kianmanesh R, Jensen RT; Vienna Consensus Conference participants.

Neuroendocrinology. 2016;103(2):153-71. doi: 10.1159/000443171. Epub 2016 Jan 5. No abstract available.

38.

Intraductal tubulopapillary neoplasms of the bile ducts: clinicopathologic, immunohistochemical, and molecular analysis of 20 cases.

Schlitter AM, Jang KT, Klöppel G, Saka B, Hong SM, Choi H, Offerhaus GJ, Hruban RH, Zen Y, Konukiewitz B, Regel I, Allgäuer M, Balci S, Basturk O, Reid MD, Esposito I, Adsay V.

Mod Pathol. 2016 Jan;29(1):93. doi: 10.1038/modpathol.2015.106. No abstract available.

39.

Syndromic versus non-syndromic sporadic gastrin-producing neuroendocrine tumors of the duodenum: comparison of pathological features and biological behavior.

Rosentraeger MJ, Garbrecht N, Anlauf M, Raffel A, Knoefel WT, Wiedenmann B, Klöppel G.

Virchows Arch. 2016 Mar;468(3):277-87. doi: 10.1007/s00428-015-1890-9. Epub 2015 Dec 9.

PMID:
26649731
40.

A Revised Classification System and Recommendations From the Baltimore Consensus Meeting for Neoplastic Precursor Lesions in the Pancreas.

Basturk O, Hong SM, Wood LD, Adsay NV, Albores-Saavedra J, Biankin AV, Brosens LA, Fukushima N, Goggins M, Hruban RH, Kato Y, Klimstra DS, Klöppel G, Krasinskas A, Longnecker DS, Matthaei H, Offerhaus GJ, Shimizu M, Takaori K, Terris B, Yachida S, Esposito I, Furukawa T; Baltimore Consensus Meeting.

Am J Surg Pathol. 2015 Dec;39(12):1730-41. doi: 10.1097/PAS.0000000000000533.

41.

Potential role of Th17 cells in the pathogenesis of type 2 autoimmune pancreatitis.

Loos M, Lauffer F, Schlitter AM, Kleeff J, Friess H, Klöppel G, Esposito I.

Virchows Arch. 2015 Dec;467(6):641-648. Epub 2015 Oct 1.

PMID:
26427656
42.

Pathology, genetics and precursors of human and experimental pancreatic neoplasms: An update.

Esposito I, Segler A, Steiger K, Klöppel G.

Pancreatology. 2015 Nov-Dec;15(6):598-610. doi: 10.1016/j.pan.2015.08.007. Epub 2015 Sep 3. Review.

PMID:
26365060
43.

Intraductal tubulopapillary neoplasms of the bile ducts: clinicopathologic, immunohistochemical, and molecular analysis of 20 cases.

Schlitter AM, Jang KT, Klöppel G, Saka B, Hong SM, Choi H, Offerhaus GJ, Hruban RH, Zen Y, Konukiewitz B, Regel I, Allgäuer M, Balci S, Basturk O, Reid MD, Esposito I, Adsay V.

Mod Pathol. 2015 Sep;28(9):1249-64. doi: 10.1038/modpathol.2015.61. Epub 2015 Jun 26. Erratum in: Mod Pathol. 2016 Jan;29(1):93.

44.

Effects of the GLP-1 Receptor Agonist Dulaglutide on the Structure of the Exocrine Pancreas of Cynomolgus Monkeys.

Vahle JL, Byrd RA, Blackbourne JL, Martin JA, Sorden SD, Ryan T, Pienkowski T, Rosol TJ, Snyder PW, Klöppel G.

Toxicol Pathol. 2015 Oct;43(7):1004-14. doi: 10.1177/0192623315588999. Epub 2015 Jun 9.

PMID:
26059826
45.

Erratum to: Extensive multifocal branch duct IPMN of the pancreas after liver transplantation: is surgery justified?

Branchi V, Lingohr P, Willinek WA, Bölke E, Semaan A, Zhou H, Kristiansen G, Klöppel G, Kalff JC, Schäfer N, Matthaei H.

Eur J Med Res. 2015 May 20;20:53. doi: 10.1186/s40001-015-0143-3. No abstract available.

46.

[Neoplasms of the disseminated neuroendocrine cell system of the gastrointestinal tract].

Klöppel G.

Pathologe. 2015 May;36(3):237-45. doi: 10.1007/s00292-015-0015-1. Review. German.

PMID:
25947223
47.

Glucagon receptor gene mutations with hyperglucagonemia but without the glucagonoma syndrome.

Miller HC, Kidd M, Modlin IM, Cohen P, Dina R, Drymousis P, Vlavianos P, Klöppel G, Frilling A.

World J Gastrointest Surg. 2015 Apr 27;7(4):60-6. doi: 10.4240/wjgs.v7.i4.60.

48.

Extensive multifocal branch duct IPMN of the pancreas after liver transplantation: is surgery justified?

Branchi V, Lingohr P, Willinek WA, Bölke E, Semaan A, Zhou H, Kristiansen G, Klöppel G, Kalff JC, Schäfer N, Matthaei H.

Eur J Med Res. 2015 Mar 19;20:26. doi: 10.1186/s40001-015-0117-5. Erratum in: Eur J Med Res. 2015;20:53. Bölke, Edwin [added].

49.

Pathologic Evaluation and Reporting of Intraductal Papillary Mucinous Neoplasms of the Pancreas and Other Tumoral Intraepithelial Neoplasms of Pancreatobiliary Tract: Recommendations of Verona Consensus Meeting.

Adsay V, Mino-Kenudson M, Furukawa T, Basturk O, Zamboni G, Marchegiani G, Bassi C, Salvia R, Malleo G, Paiella S, Wolfgang CL, Matthaei H, Offerhaus GJ, Adham M, Bruno MJ, Reid MD, Krasinskas A, Klöppel G, Ohike N, Tajiri T, Jang KT, Roa JC, Allen P, Fernández-del Castillo C, Jang JY, Klimstra DS, Hruban RH; Members of Verona Consensus Meeting, 2013.

Ann Surg. 2016 Jan;263(1):162-77. doi: 10.1097/SLA.0000000000001173.

50.

Glucagon cell hyperplasia and neoplasia with and without glucagon receptor mutations.

Sipos B, Sperveslage J, Anlauf M, Hoffmeister M, Henopp T, Buch S, Hampe J, Weber A, Hammel P, Couvelard A, Höbling W, Lieb W, Boehm BO, Klöppel G.

J Clin Endocrinol Metab. 2015 May;100(5):E783-8. doi: 10.1210/jc.2014-4405. Epub 2015 Feb 19.

PMID:
25695890

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