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Items: 27


Physical, chemical and kinetic factors affecting prion infectivity.

Properzi F, Badhan A, Klier S, Schmidt C, Klöhn PC, Wadsworth JD, Clarke AR, Jackson GS, Collinge J.

Prion. 2016 May 3;10(3):251-61. doi: 10.1080/19336896.2016.1181250.


A systematic investigation of production of synthetic prions from recombinant prion protein.

Schmidt C, Fizet J, Properzi F, Batchelor M, Sandberg MK, Edgeworth JA, Afran L, Ho S, Badhan A, Klier S, Linehan JM, Brandner S, Hosszu LL, Tattum MH, Jat P, Clarke AR, Klöhn PC, Wadsworth JD, Jackson GS, Collinge J.

Open Biol. 2015 Dec;5(12):150165. doi: 10.1098/rsob.150165.


Identification of a gene regulatory network associated with prion replication.

Marbiah MM, Harvey A, West BT, Louzolo A, Banerjee P, Alden J, Grigoriadis A, Hummerich H, Kan HM, Cai Y, Bloom GS, Jat P, Collinge J, Klöhn PC.

EMBO J. 2014 Jul 17;33(14):1527-47. doi: 10.15252/embj.201387150. Epub 2014 May 19.


In vitro screen of prion disease susceptibility genes using the scrapie cell assay.

Brown CA, Schmidt C, Poulter M, Hummerich H, Klöhn PC, Jat P, Mead S, Collinge J, Lloyd SE.

Hum Mol Genet. 2014 Oct 1;23(19):5102-8. doi: 10.1093/hmg/ddu233. Epub 2014 May 15.


Exosome release from infected dendritic cells: a clue for a fast spread of prions in the periphery?

Klöhn PC, Castro-Seoane R, Collinge J.

J Infect. 2013 Nov;67(5):359-68. doi: 10.1016/j.jinf.2013.07.024. Epub 2013 Jul 31. Review.


IBC's 23rd Annual Antibody Engineering, 10th Annual Antibody Therapeutics international conferences and the 2012 Annual Meeting of The Antibody Society: December 3-6, 2012, San Diego, CA.

Klöhn PC, Wuellner U, Zizlsperger N, Zhou Y, Tavares D, Berger S, Zettlitz KA, Proetzel G, Yong M, Begent RH, Reichert JM.

MAbs. 2013 Mar-Apr;5(2):178-201. doi: 10.4161/mabs.23655.


Plasmacytoid dendritic cells sequester high prion titres at early stages of prion infection.

Castro-Seoane R, Hummerich H, Sweeting T, Tattum MH, Linehan JM, Fernandez de Marco M, Brandner S, Collinge J, Klöhn PC.

PLoS Pathog. 2012 Feb;8(2):e1002538. doi: 10.1371/journal.ppat.1002538. Epub 2012 Feb 16.


PrP antibodies do not trigger mouse hippocampal neuron apoptosis.

Klöhn PC, Farmer M, Linehan JM, O'Malley C, Fernandez de Marco M, Taylor W, Farrow M, Khalili-Shirazi A, Brandner S, Collinge J.

Science. 2012 Jan 6;335(6064):52. doi: 10.1126/science.1215579.


Assaying prions in cell culture: the standard scrapie cell assay (SSCA) and the scrapie cell assay in end point format (SCEPA).

Mahal SP, Demczyk CA, Smith EW Jr, Klohn PC, Weissmann C.

Methods Mol Biol. 2008;459:49-68. doi: 10.1007/978-1-59745-234-2_4.


Transcriptional stability of cultured cells upon prion infection.

Julius C, Hutter G, Wagner U, Seeger H, Kana V, Kranich J, Klöhn PC, Weissmann C, Miele G, Aguzzi A.

J Mol Biol. 2008 Feb 1;375(5):1222-33. Epub 2007 Nov 12. Erratum in: J Mol Biol. 2009 Apr 24;388(1):207. Klöhn, Peter [corrected to Klöhn, Peter-Christian].


Disease-related prion protein forms aggresomes in neuronal cells leading to caspase activation and apoptosis.

Kristiansen M, Messenger MJ, Klöhn PC, Brandner S, Wadsworth JD, Collinge J, Tabrizi SJ.

J Biol Chem. 2005 Nov 18;280(46):38851-61. Epub 2005 Sep 12.


Chronic lymphocytic inflammation specifies the organ tropism of prions.

Heikenwalder M, Zeller N, Seeger H, Prinz M, Klöhn PC, Schwarz P, Ruddle NH, Weissmann C, Aguzzi A.

Science. 2005 Feb 18;307(5712):1107-10. Epub 2005 Jan 20.


Depleting neuronal PrP in prion infection prevents disease and reverses spongiosis.

Mallucci G, Dickinson A, Linehan J, Klöhn PC, Brandner S, Collinge J.

Science. 2003 Oct 31;302(5646):871-4.


A quantitative, highly sensitive cell-based infectivity assay for mouse scrapie prions.

Klöhn PC, Stoltze L, Flechsig E, Enari M, Weissmann C.

Proc Natl Acad Sci U S A. 2003 Sep 30;100(20):11666-71. Epub 2003 Sep 22.


Early resistance to cell death and to onset of the mitochondrial permeability transition during hepatocarcinogenesis with 2-acetylaminofluorene.

Klöhn PC, Soriano ME, Irwin W, Penzo D, Scorrano L, Bitsch A, Neumann HG, Bernardi P.

Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):10014-9. Epub 2003 Aug 7.


Transmission of prions.

Weissmann C, Enari M, Klöhn PC, Rossi D, Flechsig E.

J Infect Dis. 2002 Dec 1;186 Suppl 2:S157-65. Review.


Molecular biology of prions.

Weissmann C, Enari M, Klöhn PC, Rossi D, Flechsig E.

Acta Neurobiol Exp (Wars). 2002;62(3):153-66. Review.


Transmission of prions.

Weissmann C, Enari M, Klöhn PC, Rossi D, Flechsig E.

Proc Natl Acad Sci U S A. 2002 Dec 10;99 Suppl 4:16378-83. Epub 2002 Aug 14.


Redox regulation in mammalian signal transduction.

Gulati P, Klöhn PC, Krug H, Göttlicher M, Markova B, Böhmer FD, Herrlich P.

IUBMB Life. 2001 Jul;52(1-2):25-8. Review. No abstract available.


Dose response of early effects related to tumor promotion of 2-acetylaminofluorene.

Bitsch A, Hadjiolov N, Klöhn PC, Bergmann O, Zwirner-Baier I, Neumann HG.

Toxicol Sci. 2000 May;55(1):44-51.


New insights into carcinogenesis of the classical model arylamine 2-acetylaminofluorene.

Bitsch A, Klöhn PC, Hadjiolov N, Bergmann O, Neumann HG.

Cancer Lett. 1999 Sep 1;143(2):223-7.


Mitochondrial permeability transition is altered in early stages of carcinogenesis of 2-acetylaminofluorene.

Klöhn PC, Bitsch A, Neumann HG.

Carcinogenesis. 1998 Jul;19(7):1185-90.


Impairment of respiration and oxidative phosphorylation by redox cyclers 2-nitrosofluorene and menadione.

Klöhn PC, Neumann HG.

Chem Biol Interact. 1997 Aug 29;106(1):15-28.


The dual role of 2-acetylaminofluorene in hepatocarcinogenesis: specific targets for initiation and promotion.

Neumann HG, Bitsch A, Klöhn PC.

Mutat Res. 1997 May 12;376(1-2):169-76.


Genotoxic and chronic toxic effects in the carcinogenicity of aromatic amines.

Bitsch A, Fecher J, Jost M, Klöhn PC, Neumann HG.

Recent Results Cancer Res. 1997;143:209-23. No abstract available.


A metabolite of carcinogenic 2-acetylaminofluorene, 2-nitrosofluorene, induces redox cycling in mitochondria.

Klöhn PC, Massalha H, Neumann HG.

Biochim Biophys Acta. 1995 May 10;1229(3):363-72.

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