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Items: 1 to 50 of 83

1.

MAIT cells protect against pulmonary Legionella longbeachae infection.

Wang H, D'Souza C, Lim XY, Kostenko L, Pediongco TJ, Eckle SBG, Meehan BS, Shi M, Wang N, Li S, Liu L, Mak JYW, Fairlie DP, Iwakura Y, Gunnersen JM, Stent AW, Godfrey DI, Rossjohn J, Westall GP, Kjer-Nielsen L, Strugnell RA, McCluskey J, Corbett AJ, Hinks TSC, Chen Z.

Nat Commun. 2018 Aug 22;9(1):3350. doi: 10.1038/s41467-018-05202-8.

2.

An overview on the identification of MAIT cell antigens.

Kjer-Nielsen L, Corbett AJ, Chen Z, Liu L, Mak JY, Godfrey DI, Rossjohn J, Fairlie DP, McCluskey J, Eckle SB.

Immunol Cell Biol. 2018 Jul;96(6):573-587. doi: 10.1111/imcb.12057. Epub 2018 May 15. Review.

PMID:
29656544
3.

Recipient mucosal-associated invariant T cells control GVHD within the colon.

Varelias A, Bunting MD, Ormerod KL, Koyama M, Olver SD, Straube J, Kuns RD, Robb RJ, Henden AS, Cooper L, Lachner N, Gartlan KH, Lantz O, Kjer-Nielsen L, Mak JY, Fairlie DP, Clouston AD, McCluskey J, Rossjohn J, Lane SW, Hugenholtz P, Hill GR.

J Clin Invest. 2018 May 1;128(5):1919-1936. doi: 10.1172/JCI91646. Epub 2018 Apr 9.

4.

Divergent T-cell receptor recognition modes of a HLA-I restricted extended tumour-associated peptide.

Chan KF, Gully BS, Gras S, Beringer DX, Kjer-Nielsen L, Cebon J, McCluskey J, Chen W, Rossjohn J.

Nat Commun. 2018 Mar 12;9(1):1026. doi: 10.1038/s41467-018-03321-w.

5.

Mucosal-associated invariant T cell receptor recognition of small molecules presented by MR1.

Awad W, Le Nours J, Kjer-Nielsen L, McCluskey J, Rossjohn J.

Immunol Cell Biol. 2018 Jul;96(6):588-597. doi: 10.1111/imcb.12017. Epub 2018 Feb 27. Review.

PMID:
29393543
6.

Drugs and drug-like molecules can modulate the function of mucosal-associated invariant T cells.

Keller AN, Eckle SB, Xu W, Liu L, Hughes VA, Mak JY, Meehan BS, Pediongco T, Birkinshaw RW, Chen Z, Wang H, D'Souza C, Kjer-Nielsen L, Gherardin NA, Godfrey DI, Kostenko L, Corbett AJ, Purcell AW, Fairlie DP, McCluskey J, Rossjohn J.

Nat Immunol. 2017 Apr;18(4):402-411. doi: 10.1038/ni.3679. Epub 2017 Feb 6.

PMID:
28166217
7.

Functional Heterogeneity and Antimycobacterial Effects of Mouse Mucosal-Associated Invariant T Cells Specific for Riboflavin Metabolites.

Sakala IG, Kjer-Nielsen L, Eickhoff CS, Wang X, Blazevic A, Liu L, Fairlie DP, Rossjohn J, McCluskey J, Fremont DH, Hansen TH, Hoft DF.

J Immunol. 2015 Jul 15;195(2):587-601. doi: 10.4049/jimmunol.1402545. Epub 2015 Jun 10.

8.

Mucosal-associated invariant T cell alterations in obese and type 2 diabetic patients.

Magalhaes I, Pingris K, Poitou C, Bessoles S, Venteclef N, Kiaf B, Beaudoin L, Da Silva J, Allatif O, Rossjohn J, Kjer-Nielsen L, McCluskey J, Ledoux S, Genser L, Torcivia A, Soudais C, Lantz O, Boitard C, Aron-Wisnewsky J, Larger E, Clément K, Lehuen A.

J Clin Invest. 2015 Apr;125(4):1752-62. doi: 10.1172/JCI78941. Epub 2015 Mar 9.

9.

An extensive antigenic footprint underpins immunodominant TCR adaptability against a hypervariable viral determinant.

Nivarthi UK, Gras S, Kjer-Nielsen L, Berry R, Lucet IS, Miles JJ, Tracy SL, Purcell AW, Bowden DS, Hellard M, Rossjohn J, McCluskey J, Bharadwaj M.

J Immunol. 2014 Dec 1;193(11):5402-13. doi: 10.4049/jimmunol.1401357. Epub 2014 Oct 29.

10.

A molecular basis underpinning the T cell receptor heterogeneity of mucosal-associated invariant T cells.

Eckle SB, Birkinshaw RW, Kostenko L, Corbett AJ, McWilliam HE, Reantragoon R, Chen Z, Gherardin NA, Beddoe T, Liu L, Patel O, Meehan B, Fairlie DP, Villadangos JA, Godfrey DI, Kjer-Nielsen L, McCluskey J, Rossjohn J.

J Exp Med. 2014 Jul 28;211(8):1585-600. doi: 10.1084/jem.20140484. Epub 2014 Jul 21.

11.

Recognition of distinct cross-reactive virus-specific CD8+ T cells reveals a unique TCR signature in a clinical setting.

Nguyen TH, Rowntree LC, Pellicci DG, Bird NL, Handel A, Kjer-Nielsen L, Kedzierska K, Kotsimbos TC, Mifsud NA.

J Immunol. 2014 Jun 1;192(11):5039-49. doi: 10.4049/jimmunol.1303147. Epub 2014 Apr 28.

12.

T-cell activation by transitory neo-antigens derived from distinct microbial pathways.

Corbett AJ, Eckle SB, Birkinshaw RW, Liu L, Patel O, Mahony J, Chen Z, Reantragoon R, Meehan B, Cao H, Williamson NA, Strugnell RA, Van Sinderen D, Mak JY, Fairlie DP, Kjer-Nielsen L, Rossjohn J, McCluskey J.

Nature. 2014 May 15;509(7500):361-5. doi: 10.1038/nature13160. Epub 2014 Apr 2.

PMID:
24695216
13.

MAITs, MR1 and vitamin B metabolites.

Birkinshaw RW, Kjer-Nielsen L, Eckle SB, McCluskey J, Rossjohn J.

Curr Opin Immunol. 2014 Feb;26:7-13. doi: 10.1016/j.coi.2013.09.007. Epub 2013 Oct 18. Review.

PMID:
24556396
14.

Antigen-loaded MR1 tetramers define T cell receptor heterogeneity in mucosal-associated invariant T cells.

Reantragoon R, Corbett AJ, Sakala IG, Gherardin NA, Furness JB, Chen Z, Eckle SB, Uldrich AP, Birkinshaw RW, Patel O, Kostenko L, Meehan B, Kedzierska K, Liu L, Fairlie DP, Hansen TH, Godfrey DI, Rossjohn J, McCluskey J, Kjer-Nielsen L.

J Exp Med. 2013 Oct 21;210(11):2305-20. doi: 10.1084/jem.20130958. Epub 2013 Oct 7.

15.

Recognition of vitamin B metabolites by mucosal-associated invariant T cells.

Patel O, Kjer-Nielsen L, Le Nours J, Eckle SB, Birkinshaw R, Beddoe T, Corbett AJ, Liu L, Miles JJ, Meehan B, Reantragoon R, Sandoval-Romero ML, Sullivan LC, Brooks AG, Chen Z, Fairlie DP, McCluskey J, Rossjohn J.

Nat Commun. 2013;4:2142. doi: 10.1038/ncomms3142.

PMID:
23846752
16.

MR1 presents microbial vitamin B metabolites to MAIT cells.

Kjer-Nielsen L, Patel O, Corbett AJ, Le Nours J, Meehan B, Liu L, Bhati M, Chen Z, Kostenko L, Reantragoon R, Williamson NA, Purcell AW, Dudek NL, McConville MJ, O'Hair RA, Khairallah GN, Godfrey DI, Fairlie DP, Rossjohn J, McCluskey J.

Nature. 2012 Nov 29;491(7426):717-23. doi: 10.1038/nature11605. Epub 2012 Oct 10.

PMID:
23051753
17.

Immune self-reactivity triggered by drug-modified HLA-peptide repertoire.

Illing PT, Vivian JP, Dudek NL, Kostenko L, Chen Z, Bharadwaj M, Miles JJ, Kjer-Nielsen L, Gras S, Williamson NA, Burrows SR, Purcell AW, Rossjohn J, McCluskey J.

Nature. 2012 Jun 28;486(7404):554-8. doi: 10.1038/nature11147.

PMID:
22722860
18.

Structural insight into MR1-mediated recognition of the mucosal associated invariant T cell receptor.

Reantragoon R, Kjer-Nielsen L, Patel O, Chen Z, Illing PT, Bhati M, Kostenko L, Bharadwaj M, Meehan B, Hansen TH, Godfrey DI, Rossjohn J, McCluskey J.

J Exp Med. 2012 Apr 9;209(4):761-74. doi: 10.1084/jem.20112095. Epub 2012 Mar 12.

19.

A structural basis for varied αβ TCR usage against an immunodominant EBV antigen restricted to a HLA-B8 molecule.

Gras S, Wilmann PG, Chen Z, Halim H, Liu YC, Kjer-Nielsen L, Purcell AW, Burrows SR, McCluskey J, Rossjohn J.

J Immunol. 2012 Jan 1;188(1):311-21. doi: 10.4049/jimmunol.1102686. Epub 2011 Dec 2.

20.

Vβ2 natural killer T cell antigen receptor-mediated recognition of CD1d-glycolipid antigen.

Patel O, Pellicci DG, Uldrich AP, Sullivan LC, Bhati M, McKnight M, Richardson SK, Howell AR, Mallevaey T, Zhang J, Bedel R, Besra GS, Brooks AG, Kjer-Nielsen L, McCluskey J, Porcelli SA, Gapin L, Rossjohn J, Godfrey DI.

Proc Natl Acad Sci U S A. 2011 Nov 22;108(47):19007-12. doi: 10.1073/pnas.1109066108. Epub 2011 Nov 7.

21.

A semi-invariant Vα10+ T cell antigen receptor defines a population of natural killer T cells with distinct glycolipid antigen-recognition properties.

Uldrich AP, Patel O, Cameron G, Pellicci DG, Day EB, Sullivan LC, Kyparissoudis K, Kjer-Nielsen L, Vivian JP, Cao B, Brooks AG, Williams SJ, Illarionov P, Besra GS, Turner SJ, Porcelli SA, McCluskey J, Smyth MJ, Rossjohn J, Godfrey DI.

Nat Immunol. 2011 Jun 12;12(7):616-23. doi: 10.1038/ni.2051.

22.

Rapid screening for the detection of HLA-B57 and HLA-B58 in prevention of drug hypersensitivity.

Kostenko L, Kjer-Nielsen L, Nicholson I, Hudson F, Lucas A, Foley B, Chen K, Lynch K, Nguyen J, Wu AH, Tait BD, Holdsworth R, Mallal S, Rossjohn J, Bharadwaj M, McCluskey J.

Tissue Antigens. 2011 Jul;78(1):11-20. doi: 10.1111/j.1399-0039.2011.01649.x. Epub 2011 Apr 19.

PMID:
21501118
23.

The structural bases of direct T-cell allorecognition: implications for T-cell-mediated transplant rejection.

Gras S, Kjer-Nielsen L, Chen Z, Rossjohn J, McCluskey J.

Immunol Cell Biol. 2011 Mar;89(3):388-95. doi: 10.1038/icb.2010.150. Epub 2011 Feb 8. Review.

PMID:
21301478
24.

Antigen-driven patterns of TCR bias are shared across diverse outcomes of human hepatitis C virus infection.

Miles JJ, Thammanichanond D, Moneer S, Nivarthi UK, Kjer-Nielsen L, Tracy SL, Aitken CK, Brennan RM, Zeng W, Marquart L, Jackson D, Burrows SR, Bowden DS, Torresi J, Hellard M, Rossjohn J, McCluskey J, Bharadwaj M.

J Immunol. 2011 Jan 15;186(2):901-12. doi: 10.4049/jimmunol.1003167. Epub 2010 Dec 15.

25.

The structural basis for autonomous dimerization of the pre-T-cell antigen receptor.

Pang SS, Berry R, Chen Z, Kjer-Nielsen L, Perugini MA, King GF, Wang C, Chew SH, La Gruta NL, Williams NK, Beddoe T, Tiganis T, Cowieson NP, Godfrey DI, Purcell AW, Wilce MC, McCluskey J, Rossjohn J.

Nature. 2010 Oct 14;467(7317):844-8. doi: 10.1038/nature09448.

PMID:
20944746
26.

The impact of human leukocyte antigen (HLA) micropolymorphism on ligand specificity within the HLA-B*41 allotypic family.

Bade-Döding C, Theodossis A, Gras S, Kjer-Nielsen L, Eiz-Vesper B, Seltsam A, Huyton T, Rossjohn J, McCluskey J, Blasczyk R.

Haematologica. 2011 Jan;96(1):110-8. doi: 10.3324/haematol.2010.030924. Epub 2010 Oct 7.

27.

Allelic polymorphism in the T cell receptor and its impact on immune responses.

Gras S, Chen Z, Miles JJ, Liu YC, Bell MJ, Sullivan LC, Kjer-Nielsen L, Brennan RM, Burrows JM, Neller MA, Khanna R, Purcell AW, Brooks AG, McCluskey J, Rossjohn J, Burrows SR.

J Exp Med. 2010 Jul 5;207(7):1555-67. doi: 10.1084/jem.20100603. Epub 2010 Jun 21.

28.

Hard wiring of T cell receptor specificity for the major histocompatibility complex is underpinned by TCR adaptability.

Burrows SR, Chen Z, Archbold JK, Tynan FE, Beddoe T, Kjer-Nielsen L, Miles JJ, Khanna R, Moss DJ, Liu YC, Gras S, Kostenko L, Brennan RM, Clements CS, Brooks AG, Purcell AW, McCluskey J, Rossjohn J.

Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10608-13. doi: 10.1073/pnas.1004926107. Epub 2010 May 18.

29.

The structure and stability of the monomorphic HLA-G are influenced by the nature of the bound peptide.

Walpole NG, Kjer-Nielsen L, Kostenko L, McCluskey J, Brooks AG, Rossjohn J, Clements CS.

J Mol Biol. 2010 Mar 26;397(2):467-80. doi: 10.1016/j.jmb.2010.01.052. Epub 2010 Feb 1.

30.

T cell allorecognition via molecular mimicry.

Macdonald WA, Chen Z, Gras S, Archbold JK, Tynan FE, Clements CS, Bharadwaj M, Kjer-Nielsen L, Saunders PM, Wilce MC, Crawford F, Stadinsky B, Jackson D, Brooks AG, Purcell AW, Kappler JW, Burrows SR, Rossjohn J, McCluskey J.

Immunity. 2009 Dec 18;31(6):897-908. doi: 10.1016/j.immuni.2009.09.025.

31.

Adaptability of the semi-invariant natural killer T-cell receptor towards structurally diverse CD1d-restricted ligands.

Florence WC, Xia C, Gordy LE, Chen W, Zhang Y, Scott-Browne J, Kinjo Y, Yu KO, Keshipeddy S, Pellicci DG, Patel O, Kjer-Nielsen L, McCluskey J, Godfrey DI, Rossjohn J, Richardson SK, Porcelli SA, Howell AR, Hayakawa K, Gapin L, Zajonc DM, Wang PG, Joyce S.

EMBO J. 2009 Dec 2;28(23):3781. doi: 10.1038/emboj.2009.348. No abstract available.

32.

Antigen recognition by CD1d-restricted NKT T cell receptors.

Godfrey DI, Pellicci DG, Patel O, Kjer-Nielsen L, McCluskey J, Rossjohn J.

Semin Immunol. 2010 Apr;22(2):61-7. doi: 10.1016/j.smim.2009.10.004. Epub 2009 Nov 28. Review.

PMID:
19945889
33.

Adaptability of the semi-invariant natural killer T-cell receptor towards structurally diverse CD1d-restricted ligands.

Florence WC, Xia C, Gordy LE, Chen W, Zhang Y, Scott-Browne J, Kinjo Y, Yu KO, Keshipeddy S, Pellicci DG, Patel O, Kjer-Nielsen L, McCluskey J, Godfrey DI, Rossjohn J, Richardson SK, Porcelli SA, Howell AR, Hayakawa K, Gapin L, Zajonc DM, Wang PG, Joyce S.

EMBO J. 2009 Nov 18;28(22):3579-90. doi: 10.1038/emboj.2009.286. Epub 2009 Oct 8. Erratum in: EMBO J. 2009 Dec 2;28(23):3781.

34.

Differential recognition of CD1d-alpha-galactosyl ceramide by the V beta 8.2 and V beta 7 semi-invariant NKT T cell receptors.

Pellicci DG, Patel O, Kjer-Nielsen L, Pang SS, Sullivan LC, Kyparissoudis K, Brooks AG, Reid HH, Gras S, Lucet IS, Koh R, Smyth MJ, Mallevaey T, Matsuda JL, Gapin L, McCluskey J, Godfrey DI, Rossjohn J.

Immunity. 2009 Jul 17;31(1):47-59. doi: 10.1016/j.immuni.2009.04.018.

35.

T cell receptor CDR2 beta and CDR3 beta loops collaborate functionally to shape the iNKT cell repertoire.

Mallevaey T, Scott-Browne JP, Matsuda JL, Young MH, Pellicci DG, Patel O, Thakur M, Kjer-Nielsen L, Richardson SK, Cerundolo V, Howell AR, McCluskey J, Godfrey DI, Rossjohn J, Marrack P, Gapin L.

Immunity. 2009 Jul 17;31(1):60-71. doi: 10.1016/j.immuni.2009.05.010.

36.

Antigen ligation triggers a conformational change within the constant domain of the alphabeta T cell receptor.

Beddoe T, Chen Z, Clements CS, Ely LK, Bushell SR, Vivian JP, Kjer-Nielsen L, Pang SS, Dunstone MA, Liu YC, Macdonald WA, Perugini MA, Wilce MC, Burrows SR, Purcell AW, Tiganis T, Bottomley SP, McCluskey J, Rossjohn J.

Immunity. 2009 Jun 19;30(6):777-88. doi: 10.1016/j.immuni.2009.03.018. Epub 2009 May 21.

37.

The shaping of T cell receptor recognition by self-tolerance.

Gras S, Burrows SR, Kjer-Nielsen L, Clements CS, Liu YC, Sullivan LC, Bell MJ, Brooks AG, Purcell AW, McCluskey J, Rossjohn J.

Immunity. 2009 Feb 20;30(2):193-203. doi: 10.1016/j.immuni.2008.11.011. Epub 2009 Jan 22.

38.

Human leukocyte antigen class I-restricted activation of CD8+ T cells provides the immunogenetic basis of a systemic drug hypersensitivity.

Chessman D, Kostenko L, Lethborg T, Purcell AW, Williamson NA, Chen Z, Kjer-Nielsen L, Mifsud NA, Tait BD, Holdsworth R, Almeida CA, Nolan D, Macdonald WA, Archbold JK, Kellerher AD, Marriott D, Mallal S, Bharadwaj M, Rossjohn J, McCluskey J.

Immunity. 2008 Jun;28(6):822-32. doi: 10.1016/j.immuni.2008.04.020. Erratum in: Immunity. 2008 Jul;29(1):165.

39.

A minimal binding footprint on CD1d-glycolipid is a basis for selection of the unique human NKT TCR.

Wun KS, Borg NA, Kjer-Nielsen L, Beddoe T, Koh R, Richardson SK, Thakur M, Howell AR, Scott-Browne JP, Gapin L, Godfrey DI, McCluskey J, Rossjohn J.

J Exp Med. 2008 Apr 14;205(4):939-49. doi: 10.1084/jem.20072141. Epub 2008 Mar 31.

40.

T-cell receptor bias and immunity.

Gras S, Kjer-Nielsen L, Burrows SR, McCluskey J, Rossjohn J.

Curr Opin Immunol. 2008 Feb;20(1):119-25. doi: 10.1016/j.coi.2007.12.001. Epub 2008 Jan 18. Review.

PMID:
18207719
41.

Structural insight into natural killer T cell receptor recognition of CD1d.

Borg NA, Kjer-Nielsen L, McCluskey J, Rossjohn J.

Adv Exp Med Biol. 2007;598:20-34. Review. No abstract available.

PMID:
17892202
42.

T cell allorecognition and MHC restriction--A case of Jekyll and Hyde?

Archbold JK, Ely LK, Kjer-Nielsen L, Burrows SR, Rossjohn J, McCluskey J, Macdonald WA.

Mol Immunol. 2008 Feb;45(3):583-98. Epub 2007 Sep 14. Review.

PMID:
17869342
43.

CD1d-lipid-antigen recognition by the semi-invariant NKT T-cell receptor.

Borg NA, Wun KS, Kjer-Nielsen L, Wilce MC, Pellicci DG, Koh R, Besra GS, Bharadwaj M, Godfrey DI, McCluskey J, Rossjohn J.

Nature. 2007 Jul 5;448(7149):44-9. Epub 2007 Jun 20.

PMID:
17581592
44.

Structural studies on HLA-G: implications for ligand and receptor binding.

Clements CS, Kjer-Nielsen L, McCluskey J, Rossjohn J.

Hum Immunol. 2007 Apr;68(4):220-6. Epub 2006 Oct 27. Review.

PMID:
17400055
45.

A T cell receptor flattens a bulged antigenic peptide presented by a major histocompatibility complex class I molecule.

Tynan FE, Reid HH, Kjer-Nielsen L, Miles JJ, Wilce MC, Kostenko L, Borg NA, Williamson NA, Beddoe T, Purcell AW, Burrows SR, McCluskey J, Rossjohn J.

Nat Immunol. 2007 Mar;8(3):268-76. Epub 2007 Jan 28.

PMID:
17259989
46.

TCR alpha genes direct MHC restriction in the potent human T cell response to a class I-bound viral epitope.

Miles JJ, Borg NA, Brennan RM, Tynan FE, Kjer-Nielsen L, Silins SL, Bell MJ, Burrows JM, McCluskey J, Rossjohn J, Burrows SR.

J Immunol. 2006 Nov 15;177(10):6804-14.

47.

Alloreactivity between disparate cognate and allogeneic pMHC-I complexes is the result of highly focused, peptide-dependent structural mimicry.

Archbold JK, Macdonald WA, Miles JJ, Brennan RM, Kjer-Nielsen L, McCluskey J, Burrows SR, Rossjohn J.

J Biol Chem. 2006 Nov 10;281(45):34324-32. Epub 2006 Sep 8.

48.

Disparate thermodynamics governing T cell receptor-MHC-I interactions implicate extrinsic factors in guiding MHC restriction.

Ely LK, Beddoe T, Clements CS, Matthews JM, Purcell AW, Kjer-Nielsen L, McCluskey J, Rossjohn J.

Proc Natl Acad Sci U S A. 2006 Apr 25;103(17):6641-6. Epub 2006 Apr 14.

49.

The production, purification and crystallization of a soluble form of the nonclassical MHC HLA-G: the essential role of cobalt.

Clements CS, Kjer-Nielsen L, Kostenko L, McCluskey J, Rossjohn J.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Jan 1;62(Pt 1):70-3. Epub 2005 Dec 16.

50.

A structural basis for selection and cross-species reactivity of the semi-invariant NKT cell receptor in CD1d/glycolipid recognition.

Kjer-Nielsen L, Borg NA, Pellicci DG, Beddoe T, Kostenko L, Clements CS, Williamson NA, Smyth MJ, Besra GS, Reid HH, Bharadwaj M, Godfrey DI, Rossjohn J, McCluskey J.

J Exp Med. 2006 Mar 20;203(3):661-73. Epub 2006 Feb 27.

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