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The biogenesis, biology and characterization of circular RNAs.

Kristensen LS, Andersen MS, Stagsted LVW, Ebbesen KK, Hansen TB, Kjems J.

Nat Rev Genet. 2019 Aug 8. doi: 10.1038/s41576-019-0158-7. [Epub ahead of print] Review.


SMARTer single cell total RNA sequencing.

Verboom K, Everaert C, Bolduc N, Livak KJ, Yigit N, Rombaut D, Anckaert J, Lee S, Venø MT, Kjems J, Speleman F, Mestdagh P, Vandesompele J.

Nucleic Acids Res. 2019 Jun 19. pii: gkz535. doi: 10.1093/nar/gkz535. [Epub ahead of print]


Electrical stimulation of the ventral hippocampal commissure delays experimental epilepsy and is associated with altered microRNA expression.

Costard LS, Neubert V, Venø MT, Su J, Kjems J, Connolly NMC, Prehn JHM, Schratt G, Henshall DC, Rosenow F, Bauer S.

Brain Stimul. 2019 Jun 7. pii: S1935-861X(19)30260-8. doi: 10.1016/j.brs.2019.06.009. [Epub ahead of print]


Lipidoid-siRNA Nanoparticle-Mediated IL-1β Gene Silencing for Systemic Arthritis Therapy in a Mouse Model.

Song P, Yang C, Thomsen JS, Dagnæs-Hansen F, Jakobsen M, Brüel A, Deleuran B, Kjems J.

Mol Ther. 2019 Aug 7;27(8):1424-1435. doi: 10.1016/j.ymthe.2019.05.002. Epub 2019 May 15.


Cellular uptake of covalent and non-covalent DNA nanostructures with different sizes and geometries.

Raniolo S, Croce S, Thomsen RP, Okholm AH, Unida V, Iacovelli F, Manetto A, Kjems J, Desideri A, Biocca S.

Nanoscale. 2019 Jun 6;11(22):10808-10818. doi: 10.1039/c9nr02006c.


A self-assembled, modular nucleic acid-based nanoscaffold for multivalent theranostic medicine.

Andersen VL, Vinther M, Kumar R, Ries A, Wengel J, Nielsen JS, Kjems J.

Theranostics. 2019 Apr 13;9(9):2662-2677. doi: 10.7150/thno.32060. eCollection 2019.


Pluronic F127-Folate Coated Super Paramagenic Iron Oxide Nanoparticles as Contrast Agent for Cancer Diagnosis in Magnetic Resonance Imaging.

Vu-Quang H, Vinding MS, Nielsen T, Ullisch MG, Nielsen NC, Nguyen DT, Kjems J.

Polymers (Basel). 2019 Apr 25;11(4). pii: E743. doi: 10.3390/polym11040743.


Peptide-Directed DNA-Templated Protein Labelling for The Assembly of a Pseudo-IgM.

Nielsen TB, Thomsen RP, Mortensen MR, Kjems J, Nielsen PF, Nielsen TE, Kodal ALB, Cló E, Gothelf KV.

Angew Chem Int Ed Engl. 2019 Jul 1;58(27):9068-9072. doi: 10.1002/anie.201903134. Epub 2019 May 28.


Genetically Encoded, Functional Single-Strand RNA Origami: Anticoagulant.

Krissanaprasit A, Key C, Fergione M, Froehlich K, Pontula S, Hart M, Carriel P, Kjems J, Andersen ES, LaBean TH.

Adv Mater. 2019 May;31(21):e1808262. doi: 10.1002/adma.201808262. Epub 2019 Apr 10.


Isolating, Sequencing and Analyzing Extracellular MicroRNAs from Human Mesenchymal Stem Cells.

Yan Y, Chang CC, Venø MT, Mothershead CR, Su J, Kjems J.

J Vis Exp. 2019 Mar 8;(145). doi: 10.3791/58655.


Selective Delivery of Doxorubicin to EGFR+ Cancer Cells by Cetuximab-DNA Conjugates.

Liu T, Song P, Märcher A, Kjems J, Yang C, Gothelf KV.

Chembiochem. 2019 Apr 15;20(8):1014-1018. doi: 10.1002/cbic.201800685. Epub 2019 Mar 12.


Strontium functionalized scaffold for bone tissue engineering.

Prabha RD, Nair BP, Ditzel N, Kjems J, Nair PD, Kassem M.

Mater Sci Eng C Mater Biol Appl. 2019 Jan 1;94:509-515. doi: 10.1016/j.msec.2018.09.054. Epub 2018 Sep 25.


Enhanced Tailored MicroRNA Sponge Activity of RNA Pol II-Transcribed TuD Hairpins Relative to Ectopically Expressed ciRS7-Derived circRNAs.

Hollensen AK, Andersen S, Hjorth K, Bak RO, Hansen TB, Kjems J, Aagaard L, Damgaard CK, Mikkelsen JG.

Mol Ther Nucleic Acids. 2018 Dec 7;13:365-375. doi: 10.1016/j.omtn.2018.09.009. Epub 2018 Sep 21.


Small-Molecule Probes for Affinity-Guided Introduction of Biocompatible Handles on Metal-Binding Proteins.

Mortensen MR, Skovsgaard MB, Okholm AH, Scavenius C, Dupont DM, Rosen CB, Enghild JJ, Kjems J, Gothelf KV.

Bioconjug Chem. 2018 Sep 19;29(9):3016-3025. doi: 10.1021/acs.bioconjchem.8b00424. Epub 2018 Aug 23.


Dihydropyridine Fluorophores Allow for Specific Detection of Human Antibodies in Serum.

Domljanovic I, Rexen Ulven E, Ulven T, Thomsen RP, Okholm AH, Kjems J, Voss A, Taskova M, Astakhova K.

ACS Omega. 2018 Jul 31;3(7):7580-7586. doi: 10.1021/acsomega.8b00424. Epub 2018 Jul 10.


Enzyme-free digital counting of endogenous circular RNA molecules in B-cell malignancies.

Dahl M, Daugaard I, Andersen MS, Hansen TB, Grønbæk K, Kjems J, Kristensen LS.

Lab Invest. 2018 Dec;98(12):1657-1669. doi: 10.1038/s41374-018-0108-6. Epub 2018 Aug 7.


A Modified Monomeric Red Fluorescent Protein Reporter for Assessing CRISPR Activity.

Højland Knudsen C, Ásgrímsdóttir ES, Rahimi K, Gill KP, Frandsen S, Hvolbøl Buchholdt S, Chen M, Kjems J, Febbraro F, Denham M.

Front Cell Dev Biol. 2018 May 15;6:54. doi: 10.3389/fcell.2018.00054. eCollection 2018.


An RNA Origami Octahedron with Intrinsic siRNAs for Potent Gene Knockdown.

Høiberg HC, Sparvath SM, Andersen VL, Kjems J, Andersen ES.

Biotechnol J. 2019 Jan;14(1):e1700634. doi: 10.1002/biot.201700634. Epub 2018 Jun 13.


Caveolae-mediated mesenchymal stem cell labelling by PSS-coated PLGA PFOB nano-contrast agent for MRI.

Quang HV, Chang CC, Song P, Hauge EM, Kjems J.

Theranostics. 2018 Apr 3;8(10):2657-2671. doi: 10.7150/thno.23206. eCollection 2018.


Theranostic Niosomes for Efficient siRNA/MicroRNA Delivery and Activatable Near-Infrared Fluorescent Tracking of Stem Cells.

Yang C, Gao S, Song P, Dagnæs-Hansen F, Jakobsen M, Kjems J.

ACS Appl Mater Interfaces. 2018 Jun 13;10(23):19494-19503. doi: 10.1021/acsami.8b05513. Epub 2018 May 29.


Calcium-MicroRNA Complex-Functionalized Nanotubular Implant Surface for Highly Efficient Transfection and Enhanced Osteogenesis of Mesenchymal Stem Cells.

Song W, Yang C, Svend Le DQ, Zhang Y, Kjems J.

ACS Appl Mater Interfaces. 2018 Mar 7;10(9):7756-7764. doi: 10.1021/acsami.7b18289. Epub 2018 Feb 22.


Circular RNAs as novel regulators of β-cell functions in normal and disease conditions.

Stoll L, Sobel J, Rodriguez-Trejo A, Guay C, Lee K, Venø MT, Kjems J, Laybutt DR, Regazzi R.

Mol Metab. 2018 Mar;9:69-83. doi: 10.1016/j.molmet.2018.01.010. Epub 2018 Jan 31.


Novel Brassinosteroid-Modified Polyethylene Glycol Micelles for Controlled Release of Agrochemicals.

Pérez Quiñones J, Brüggemann O, Kjems J, Shahavi MH, Peniche Covas C.

J Agric Food Chem. 2018 Feb 21;66(7):1612-1619. doi: 10.1021/acs.jafc.7b05019. Epub 2018 Feb 7.


Global MicroRNA Profiling in Human Bone Marrow Skeletal-Stromal or Mesenchymal-Stem Cells Identified Candidates for Bone Regeneration.

Chang CC, Venø MT, Chen L, Ditzel N, Le DQS, Dillschneider P, Kassem M, Kjems J.

Mol Ther. 2018 Feb 7;26(2):593-605. doi: 10.1016/j.ymthe.2017.11.018. Epub 2017 Dec 5.


Circular RNAs are abundantly expressed and upregulated during human epidermal stem cell differentiation.

Kristensen LS, Okholm TLH, Venø MT, Kjems J.

RNA Biol. 2018 Feb 1;15(2):280-291. doi: 10.1080/15476286.2017.1409931. Epub 2017 Dec 28.


Circular RNA expression is abundant and correlated to aggressiveness in early-stage bladder cancer.

Okholm TLH, Nielsen MM, Hamilton MP, Christensen LL, Vang S, Hedegaard J, Hansen TB, Kjems J, Dyrskjøt L, Pedersen JS.

NPJ Genom Med. 2017 Nov 28;2:36. doi: 10.1038/s41525-017-0038-z. eCollection 2017.


Antibacterial isoeugenol coating on stainless steel and polyethylene surfaces prevents biofilm growth.

Nielsen CK, Subbiahdoss G, Zeng G, Salmi Z, Kjems J, Mygind T, Snabe T, Meyer RL.

J Appl Microbiol. 2018 Jan;124(1):179-187. doi: 10.1111/jam.13634. Epub 2017 Dec 18.


Control of enzyme reactions by a reconfigurable DNA nanovault.

Grossi G, Dalgaard Ebbesen Jepsen M, Kjems J, Andersen ES.

Nat Commun. 2017 Oct 19;8(1):992. doi: 10.1038/s41467-017-01072-8.


Circular RNAs in cancer: opportunities and challenges in the field.

Kristensen LS, Hansen TB, Venø MT, Kjems J.

Oncogene. 2018 Feb 1;37(5):555-565. doi: 10.1038/onc.2017.361. Epub 2017 Oct 9. Review.


The invasion of circRNAs.

Hansen TB, Kjems J.

RNA Biol. 2017 Aug 3;14(8):973-974. doi: 10.1080/15476286.2017.1360467. No abstract available.


Bioactive nano-fibrous scaffold for vascularized craniofacial bone regeneration.

Prabha RD, Kraft DCE, Harkness L, Melsen B, Varma H, Nair PD, Kjems J, Kassem M.

J Tissue Eng Regen Med. 2018 Mar;12(3):e1537-e1548. doi: 10.1002/term.2579. Epub 2017 Dec 4.


Theranostic poly(lactic-co-glycolic acid) nanoparticle for magnetic resonance/infrared fluorescence bimodal imaging and efficient siRNA delivery to macrophages and its evaluation in a kidney injury model.

Yang C, Vu-Quang H, Husum DMU, Tingskov SJ, Vinding MS, Nielsen T, Song P, Nielsen NC, Nørregaard R, Kjems J.

Nanomedicine. 2017 Nov;13(8):2451-2462. doi: 10.1016/j.nano.2017.08.007. Epub 2017 Aug 24.


Construction of a Polyhedral DNA 12-Arm Junction for Self-Assembly of Wireframe DNA Lattices.

Manuguerra I, Grossi G, Thomsen RP, Lyngsø J, Pedersen JS, Kjems J, Andersen ES, Gothelf KV.

ACS Nano. 2017 Sep 26;11(9):9041-9047. doi: 10.1021/acsnano.7b03538. Epub 2017 Aug 22.


Extracellular Vesicles Transfer the Receptor Programmed Death-1 in Rheumatoid Arthritis.

Greisen SR, Yan Y, Hansen AS, Venø MT, Nyengaard JR, Moestrup SK, Hvid M, Freeman GJ, Kjems J, Deleuran B.

Front Immunol. 2017 Jul 24;8:851. doi: 10.3389/fimmu.2017.00851. eCollection 2017.


New Fluorescent Nanoparticles for Ultrasensitive Detection of Nucleic Acids by Optical Methods.

Westergaard Mulberg M, Taskova M, Thomsen RP, Okholm AH, Kjems J, Astakhova K.

Chembiochem. 2017 Aug 17;18(16):1599-1603. doi: 10.1002/cbic.201700125. Epub 2017 Jul 6.


Fatty Acid-Modified Gapmer Antisense Oligonucleotide and Serum Albumin Constructs for Pharmacokinetic Modulation.

Hvam ML, Cai Y, Dagnæs-Hansen F, Nielsen JS, Wengel J, Kjems J, Howard KA.

Mol Ther. 2017 Jul 5;25(7):1710-1717. doi: 10.1016/j.ymthe.2017.05.009. Epub 2017 Jun 20.


A DNA-Programmed Liposome Fusion Cascade.

Löffler PMG, Ries O, Rabe A, Okholm AH, Thomsen RP, Kjems J, Vogel S.

Angew Chem Int Ed Engl. 2017 Oct 16;56(43):13228-13231. doi: 10.1002/anie.201703243. Epub 2017 Aug 23.


Complexes of DNA with fluorescent dyes are effective reagents for detection of autoimmune antibodies.

Domljanovic I, Carstens A, Okholm A, Kjems J, Nielsen CT, Heegaard NHH, Astakhova K.

Sci Rep. 2017 May 15;7(1):1925. doi: 10.1038/s41598-017-02214-0.


A microRNA-129-5p/Rbfox crosstalk coordinates homeostatic downscaling of excitatory synapses.

Rajman M, Metge F, Fiore R, Khudayberdiev S, Aksoy-Aksel A, Bicker S, Ruedell Reschke C, Raoof R, Brennan GP, Delanty N, Farrell MA, O'Brien DF, Bauer S, Norwood B, Veno MT, Krüger M, Braun T, Kjems J, Rosenow F, Henshall DC, Dieterich C, Schratt G.

EMBO J. 2017 Jun 14;36(12):1770-1787. doi: 10.15252/embj.201695748. Epub 2017 May 9.


Small RNA sequencing reveals metastasis-related microRNAs in lung adenocarcinoma.

Daugaard I, Venø MT, Yan Y, Kjeldsen TE, Lamy P, Hager H, Kjems J, Hansen LL.

Oncotarget. 2017 Apr 18;8(16):27047-27061. doi: 10.18632/oncotarget.15968.


Impact of PEG Chain Length on the Physical Properties and Bioactivity of PEGylated Chitosan/siRNA Nanoparticles in Vitro and in Vivo.

Yang C, Gao S, Dagnæs-Hansen F, Jakobsen M, Kjems J.

ACS Appl Mater Interfaces. 2017 Apr 12;9(14):12203-12216. doi: 10.1021/acsami.6b16556. Epub 2017 Apr 3.


Investigating the Cellular Specificity in Tumors of a Surface-Converting Nanoparticle by Multimodal Imaging.

Fay F, Hansen L, Hectors SJCG, Sanchez-Gaytan BL, Zhao Y, Tang J, Munitz J, Alaarg A, Braza MS, Gianella A, Aaronson SA, Reiner T, Kjems J, Langer R, Hoeben FJM, Janssen HM, Calcagno C, Strijkers GJ, Fayad ZA, Pérez-Medina C, Mulder WJM.

Bioconjug Chem. 2017 May 17;28(5):1413-1421. doi: 10.1021/acs.bioconjchem.7b00086. Epub 2017 May 5.


Cortical Morphogenesis during Embryonic Development Is Regulated by miR-34c and miR-204.

Venø MT, Venø ST, Rehberg K, van Asperen JV, Clausen BH, Holm IE, Pasterkamp RJ, Finsen B, Kjems J.

Front Mol Neurosci. 2017 Feb 9;10:31. doi: 10.3389/fnmol.2017.00031. eCollection 2017.


RNA sequencing of synaptic and cytoplasmic Upf1-bound transcripts supports contribution of nonsense-mediated decay to epileptogenesis.

Mooney CM, Jimenez-Mateos EM, Engel T, Mooney C, Diviney M, Venø MT, Kjems J, Farrell MA, O'Brien DF, Delanty N, Henshall DC.

Sci Rep. 2017 Jan 27;7:41517. doi: 10.1038/srep41517.


Circulating miRNAs as biomarkers for oral squamous cell carcinoma recurrence in operated patients.

Yan Y, Wang X, Venø MT, Bakholdt V, Sørensen JA, Krogdahl A, Sun Z, Gao S, Kjems J.

Oncotarget. 2017 Jan 31;8(5):8206-8214. doi: 10.18632/oncotarget.14143.


Insights into circular RNA biology.

Ebbesen KK, Hansen TB, Kjems J.

RNA Biol. 2017 Aug 3;14(8):1035-1045. doi: 10.1080/15476286.2016.1271524. Epub 2016 Dec 16. Review.


Effects of Tween 80 on Growth and Biofilm Formation in Laboratory Media.

Nielsen CK, Kjems J, Mygind T, Snabe T, Meyer RL.

Front Microbiol. 2016 Nov 22;7:1878. eCollection 2016.


The utility of DNA nanostructures for drug delivery in vivo.

Okholm AH, Kjems J.

Expert Opin Drug Deliv. 2017 Feb;14(2):137-139. doi: 10.1080/17425247.2017.1266335. Epub 2016 Dec 5. No abstract available.


Antimicrobial effect of emulsion-encapsulated isoeugenol against biofilms of food pathogens and spoilage bacteria.

Krogsgård Nielsen C, Kjems J, Mygind T, Snabe T, Schwarz K, Serfert Y, Meyer RL.

Int J Food Microbiol. 2017 Feb 2;242:7-12. doi: 10.1016/j.ijfoodmicro.2016.11.002. Epub 2016 Nov 9.


MicroRNAs in epilepsy: pathophysiology and clinical utility.

Henshall DC, Hamer HM, Pasterkamp RJ, Goldstein DB, Kjems J, Prehn JHM, Schorge S, Lamottke K, Rosenow F.

Lancet Neurol. 2016 Dec;15(13):1368-1376. doi: 10.1016/S1474-4422(16)30246-0. Review.


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