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Items: 1 to 50 of 69

1.

Changing climate both increases and decreases European river floods.

Blöschl G, Hall J, Viglione A, Perdigão RAP, Parajka J, Merz B, Lun D, Arheimer B, Aronica GT, Bilibashi A, Boháč M, Bonacci O, Borga M, Čanjevac I, Castellarin A, Chirico GB, Claps P, Frolova N, Ganora D, Gorbachova L, Gül A, Hannaford J, Harrigan S, Kireeva M, Kiss A, Kjeldsen TR, Kohnová S, Koskela JJ, Ledvinka O, Macdonald N, Mavrova-Guirguinova M, Mediero L, Merz R, Molnar P, Montanari A, Murphy C, Osuch M, Ovcharuk V, Radevski I, Salinas JL, Sauquet E, Šraj M, Szolgay J, Volpi E, Wilson D, Zaimi K, Živković N.

Nature. 2019 Sep;573(7772):108-111. doi: 10.1038/s41586-019-1495-6. Epub 2019 Aug 28.

PMID:
31462777
2.

Peripherally delivered hepatopreferential insulin analog insulin-406 mimics the hypoglycaemia-sparing effect of portal vein human insulin infusion in dogs.

Gregory JM, Kraft G, Scott MF, Neal DW, Farmer B, Smith MS, Hastings JR, Madsen P, Kjeldsen TB, Hostrup S, Brand CL, Fledelius C, Nishimura E, Cherrington AD.

Diabetes Obes Metab. 2019 Oct;21(10):2294-2304. doi: 10.1111/dom.13808. Epub 2019 Jul 8.

PMID:
31183936
3.

Targeting insulin to the liver corrects defects in glucose metabolism caused by peripheral insulin delivery.

Edgerton DS, Scott M, Farmer B, Williams PE, Madsen P, Kjeldsen T, Brand CL, Fledelius C, Nishimura E, Cherrington AD.

JCI Insight. 2019 Feb 26;5. pii: 126974. doi: 10.1172/jci.insight.126974.

4.

Chronic lymphocytic leukemia patients with heterogeneously or fully methylated LPL promotor display longer time to treatment.

Daugaard I, Hussmann D, Kristensen L, Kristensen T, Kjeldsen TE, Nyvold CG, Larsen TS, Møller MB, Hansen LL, Wojdacz TK.

Epigenomics. 2018 Sep;10(9):1155-1166. doi: 10.2217/epi-2018-0020. Epub 2018 Sep 5.

PMID:
30182737
5.

A Vector Flow Imaging Method for Portable Ultrasound Using Synthetic Aperture Sequential Beamforming.

Di Ianni T, Villagomez Hoyos CA, Ewertsen C, Kjeldsen TK, Mosegaard J, Nielsen MB, Jensen JA.

IEEE Trans Ultrason Ferroelectr Freq Control. 2017 Nov;64(11):1655-1665. doi: 10.1109/TUFFC.2017.2742599. Epub 2017 Aug 21.

PMID:
28841555
6.

Changing climate shifts timing of European floods.

Blöschl G, Hall J, Parajka J, Perdigão RAP, Merz B, Arheimer B, Aronica GT, Bilibashi A, Bonacci O, Borga M, Čanjevac I, Castellarin A, Chirico GB, Claps P, Fiala K, Frolova N, Gorbachova L, Gül A, Hannaford J, Harrigan S, Kireeva M, Kiss A, Kjeldsen TR, Kohnová S, Koskela JJ, Ledvinka O, Macdonald N, Mavrova-Guirguinova M, Mediero L, Merz R, Molnar P, Montanari A, Murphy C, Osuch M, Ovcharuk V, Radevski I, Rogger M, Salinas JL, Sauquet E, Šraj M, Szolgay J, Viglione A, Volpi E, Wilson D, Zaimi K, Živković N.

Science. 2017 Aug 11;357(6351):588-590. doi: 10.1126/science.aan2506.

PMID:
28798129
7.

The association between miR-34 dysregulation and distant metastases formation in lung adenocarcinoma.

Daugaard I, Knudsen A, Kjeldsen TE, Hager H, Hansen LL.

Exp Mol Pathol. 2017 Jun;102(3):484-491. doi: 10.1016/j.yexmp.2017.05.012. Epub 2017 May 13.

PMID:
28512015
8.

Small RNA sequencing reveals metastasis-related microRNAs in lung adenocarcinoma.

Daugaard I, Venø MT, Yan Y, Kjeldsen TE, Lamy P, Hager H, Kjems J, Hansen LL.

Oncotarget. 2017 Apr 18;8(16):27047-27061. doi: 10.18632/oncotarget.15968.

9.

Identification and validation of candidate epigenetic biomarkers in lung adenocarcinoma.

Daugaard I, Dominguez D, Kjeldsen TE, Kristensen LS, Hager H, Wojdacz TK, Hansen LL.

Sci Rep. 2016 Oct 26;6:35807. doi: 10.1038/srep35807.

10.

Detection and attribution of urbanization effect on flood extremes using nonstationary flood-frequency models.

Prosdocimi I, Kjeldsen TR, Miller JD.

Water Resour Res. 2015 Jun;51(6):4244-4262. Epub 2015 Jun 16.

11.

An empirical investigation of climate and land-use effects on water quantity and quality in two urbanising catchments in the southern United Kingdom.

Putro B, Kjeldsen TR, Hutchins MG, Miller J.

Sci Total Environ. 2016 Apr 1;548-549:164-172. doi: 10.1016/j.scitotenv.2015.12.132. Epub 2016 Jan 21.

PMID:
26802345
12.

Estimating the microbiological risks associated with inland flood events: Bridging theory and models of pathogen transport.

Collender PA, Cooke OC, Bryant LD, Kjeldsen TR, Remais JV.

Crit Rev Environ Sci Technol. 2016;46(23-24):1787-1833. doi: 10.1080/10643389.2016.1269578. Epub 2016 Dec 9.

13.

The influence of DNA degradation in formalin-fixed, paraffin-embedded (FFPE) tissue on locus-specific methylation assessment by MS-HRM.

Daugaard I, Kjeldsen TE, Hager H, Hansen LL, Wojdacz TK.

Exp Mol Pathol. 2015 Dec;99(3):632-40. doi: 10.1016/j.yexmp.2015.11.007. Epub 2015 Nov 6.

PMID:
26551081
14.

Quantitative Neuroimaging Software for Clinical Assessment of Hippocampal Volumes on MR Imaging.

Ahdidan J, Raji CA, DeYoe EA, Mathis J, Noe KØ, Rimestad J, Kjeldsen TK, Mosegaard J, Becker JT, Lopez O.

J Alzheimers Dis. 2016;49(3):723-32. doi: 10.3233/JAD-150559.

15.

The road to the first, fully active and more stable human insulin variant with an additional disulfide bond.

Vinther TN, Kjeldsen TB, Jensen KJ, Hubálek F.

J Pept Sci. 2015 Nov;21(11):797-806. doi: 10.1002/psc.2822. Epub 2015 Sep 18. Review.

PMID:
26382042
16.

Extended spectrum β-lactamase-producing Escherichia coli forms filaments as an initial response to cefotaxime treatment.

Kjeldsen TS, Sommer MO, Olsen JE.

BMC Microbiol. 2015 Mar 8;15:63. doi: 10.1186/s12866-015-0399-3.

17.

Expression, receptor binding, and biophysical characterization of guinea pig insulin desB30: a monomeric insulin variant.

Engholm E, Hansen TH, Johansson E, Strauss HM, Vinther TN, Jensen KJ, Hubálek F, Kjeldsen TB.

Chembiochem. 2015 Apr 13;16(6):954-8. doi: 10.1002/cbic.201402688. Epub 2015 Mar 5.

PMID:
25754940
18.

Additional disulfide bonds in insulin: Prediction, recombinant expression, receptor binding affinity, and stability.

Vinther TN, Pettersson I, Huus K, Schlein M, Steensgaard DB, Sørensen A, Jensen KJ, Kjeldsen T, Hubalek F.

Protein Sci. 2015 May;24(5):779-88. doi: 10.1002/pro.2649. Epub 2015 Mar 16.

19.

CTX-M-1 β-lactamase expression in Escherichia coli is dependent on cefotaxime concentration, growth phase and gene location.

Kjeldsen TS, Overgaard M, Nielsen SS, Bortolaia V, Jelsbak L, Sommer M, Guardabassi L, Olsen JE.

J Antimicrob Chemother. 2015 Jan;70(1):62-70. doi: 10.1093/jac/dku332. Epub 2014 Sep 1.

PMID:
25182062
20.

Changes in glucose and fat metabolism in response to the administration of a hepato-preferential insulin analog.

Edgerton DS, Moore MC, Winnick JJ, Scott M, Farmer B, Naver H, Jeppesen CB, Madsen P, Kjeldsen TB, Nishimura E, Brand CL, Cherrington AD.

Diabetes. 2014 Nov;63(11):3946-54. doi: 10.2337/db14-0266. Epub 2014 Jun 19.

21.

Investigation of MGMT and DAPK1 methylation patterns in diffuse large B-cell lymphoma using allelic MSP-pyrosequencing.

Kristensen LS, Treppendahl MB, Asmar F, Girkov MS, Nielsen HM, Kjeldsen TE, Ralfkiaer E, Hansen LL, Grønbæk K.

Sci Rep. 2013 Sep 27;3:2789. doi: 10.1038/srep02789.

22.

Insulin analog with additional disulfide bond has increased stability and preserved activity.

Vinther TN, Norrman M, Ribel U, Huus K, Schlein M, Steensgaard DB, Pedersen TÅ, Pettersson I, Ludvigsen S, Kjeldsen T, Jensen KJ, Hubálek F.

Protein Sci. 2013 Mar;22(3):296-305. doi: 10.1002/pro.2211. Epub 2013 Jan 17.

23.

Competitive amplification of differentially melting amplicons (CADMA) improves KRAS hotspot mutation testing in colorectal cancer.

Kristensen LS, Kjeldsen TE, Hager H, Hansen LL.

BMC Cancer. 2012 Nov 23;12:548. doi: 10.1186/1471-2407-12-548.

24.

Systematic evaluation of the metabolic to mitogenic potency ratio for B10-substituted insulin analogues.

Glendorf T, Knudsen L, Stidsen CE, Hansen BF, Hegelund AC, Sørensen AR, Nishimura E, Kjeldsen T.

PLoS One. 2012;7(2):e29198. doi: 10.1371/journal.pone.0029198. Epub 2012 Feb 22.

25.

Novel covalently linked insulin dimer engineered to investigate the function of insulin dimerization.

Vinther TN, Norrman M, Strauss HM, Huus K, Schlein M, Pedersen TÅ, Kjeldsen T, Jensen KJ, Hubálek F.

PLoS One. 2012;7(2):e30882. doi: 10.1371/journal.pone.0030882. Epub 2012 Feb 17.

26.

Identification of anchor points for chemical modification of a small cysteine-rich protein by using a cysteine scan.

Vinther TN, Ribel U, Pedersen TA, Kjeldsen TB, Jensen KJ, Hubálek F.

Chembiochem. 2011 Nov 4;12(16):2448-55. doi: 10.1002/cbic.201100464. Epub 2011 Sep 8.

PMID:
21905194
27.

Receptor-isoform-selective insulin analogues give tissue-preferential effects.

Vienberg SG, Bouman SD, Sørensen H, Stidsen CE, Kjeldsen T, Glendorf T, Sørensen AR, Olsen GS, Andersen B, Nishimura E.

Biochem J. 2011 Dec 15;440(3):301-8. doi: 10.1042/BJ20110880.

PMID:
21851336
28.

Engineering of insulin receptor isoform-selective insulin analogues.

Glendorf T, Stidsen CE, Norrman M, Nishimura E, Sørensen AR, Kjeldsen T.

PLoS One. 2011;6(5):e20288. doi: 10.1371/journal.pone.0020288. Epub 2011 May 20.

29.

Structural basis of the aberrant receptor binding properties of hagfish and lamprey insulins.

Sajid W, Holst PA, Kiselyov VV, Andersen AS, Conlon JM, Kristensen C, Kjeldsen T, Whittaker J, Chan SJ, De Meyts P.

Biochemistry. 2009 Dec 1;48(47):11283-95. doi: 10.1021/bi901269j.

30.

Importance of the solvent-exposed residues of the insulin B chain alpha-helix for receptor binding.

Glendorf T, Sørensen AR, Nishimura E, Pettersson I, Kjeldsen T.

Biochemistry. 2008 Apr 22;47(16):4743-51. doi: 10.1021/bi800054z. Epub 2008 Apr 1.

PMID:
18376848
31.

Multiphoton electron angular distributions from laser-aligned CS2 molecules.

Kumarappan V, Holmegaard L, Martiny C, Madsen CB, Kjeldsen TK, Viftrup SS, Madsen LB, Stapelfeldt H.

Phys Rev Lett. 2008 Mar 7;100(9):093006. Epub 2008 Mar 7.

PMID:
18352707
32.

Vibrational excitation of diatomic molecular ions in strong field ionization of diatomic molecules.

Kjeldsen TK, Madsen LB.

Phys Rev Lett. 2005 Aug 12;95(7):073004. Epub 2005 Aug 12.

PMID:
16196779
33.

Relationship between self-association of insulin and its secretion efficiency in yeast.

Kjeldsen T, Pettersson AF.

Protein Expr Purif. 2003 Feb;27(2):331-7.

PMID:
12597894
34.

Inducible nitric oxide synthase is responsible for nitric oxide release from murine pituicytes.

Kjeldsen TH, Rivier C, Lee S, Hansen EW, Christensen JD, Moesby L.

J Neuroendocrinol. 2003 Mar;15(3):250-5.

PMID:
12588513
35.

Baclofen influences lipopolysaccharide-mediated interleukin-6 release from murine pituicytes.

Kjeldsen TH, Hansen EW, Christensen JD, Moesby L.

Eur J Pharmacol. 2002 Sep 13;451(2):209-15.

PMID:
12231393
36.

Engineering-enhanced protein secretory expression in yeast with application to insulin.

Kjeldsen T, Ludvigsen S, Diers I, Balschmidt P, Sorensen AR, Kaarsholm NC.

J Biol Chem. 2002 May 24;277(21):18245-8. Epub 2002 Mar 28.

37.

Dopa decarboxylase genotypes may influence age at onset of schizophrenia.

Børglum AD, Hampson M, Kjeldsen TE, Muir W, Murray V, Ewald H, Mors O, Blackwood D, Kruse TA.

Mol Psychiatry. 2001 Nov;6(6):712-7.

38.

Expression of insulin in yeast: the importance of molecular adaptation for secretion and conversion.

Kjeldsen T, Balschmidt P, Diers I, Hach M, Kaarsholm NC, Ludvigsen S.

Biotechnol Genet Eng Rev. 2001;18:89-121. Review. No abstract available.

PMID:
11530700
39.
40.

Yeast secretory expression of insulin precursors.

Kjeldsen T.

Appl Microbiol Biotechnol. 2000 Sep;54(3):277-86. Review.

PMID:
11030562
41.
42.

Two novel variants in the DOPA decarboxylase gene: association with bipolar affective disorder.

Børglum AD, Bruun TG, Kjeldsen TE, Ewald H, Mors O, Kirov G, Russ C, Freeman B, Collier DA, Kruse TA.

Mol Psychiatry. 1999 Nov;4(6):545-51.

43.

Secretory expression and characterization of insulin in Pichia pastoris.

Kjeldsen T, Pettersson AF, Hach M.

Biotechnol Appl Biochem. 1999 Feb;29 ( Pt 1):79-86.

PMID:
9889087
44.

Prepro-leaders lacking N-linked glycosylation for secretory expression in the yeast Saccharomyces cerevisiae.

Kjeldsen T, Hach M, Balschmidt P, Havelund S, Pettersson AF, Markussen J.

Protein Expr Purif. 1998 Dec;14(3):309-16.

PMID:
9882564
45.

Secretory expression of human albumin domains in Saccharomyces cerevisiae and their binding of myristic acid and an acylated insulin analogue.

Kjeldsen T, Pettersson AF, Drube L, Kurtzhals P, Jonassen I, Havelund S, Hansen PH, Markussen J.

Protein Expr Purif. 1998 Jul;13(2):163-9.

PMID:
9675058
46.

alpha-Factor pro-peptide N-linked oligosaccharides facilitate secretion of the insulin precursor in Saccharomyces cerevisiae.

Kjeldsen T, Andersen AS, Hach M, Diers I, Nikolajsen J, Markussen J.

Biotechnol Appl Biochem. 1998 Apr;27(2):109-15.

PMID:
9569605
47.

Alanine scanning mutagenesis of insulin.

Kristensen C, Kjeldsen T, Wiberg FC, Schäffer L, Hach M, Havelund S, Bass J, Steiner DF, Andersen AS.

J Biol Chem. 1997 May 16;272(20):12978-83.

48.

Synthetic leaders with potential BiP binding mediate high-yield secretion of correctly folded insulin precursors from Saccharomyces cerevisiae.

Kjeldsen T, Pettersson AF, Hach M, Diers I, Havelund S, Hansen PH, Andersen AS.

Protein Expr Purif. 1997 Apr;9(3):331-6.

PMID:
9126604
49.

A removable spacer peptide in an alpha-factor-leader/insulin precursor fusion protein improves processing and concomitant yield of the insulin precursor in Saccharomyces cerevisiae.

Kjeldsen T, Brandt J, Andersen AS, Egel-Mitani M, Hach M, Pettersson AF, Vad K.

Gene. 1996 Apr 17;170(1):107-12. Erratum in: Gene 1996 Dec 12;183(1-2):265.

PMID:
8621069
50.

Localization of specific amino acids contributing to insulin specificity of the insulin receptor.

Andersen AS, Wiberg FC, Kjeldsen T.

Ann N Y Acad Sci. 1995 Sep 7;766:466-8. No abstract available.

PMID:
7486693

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