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Items: 17


Griffithsin carrageenan fast dissolving inserts prevent SHIV HSV-2 and HPV infections in vivo.

Derby N, Lal M, Aravantinou M, Kizima L, Barnable P, Rodriguez A, Lai M, Wesenberg A, Ugaonkar S, Levendosky K, Mizenina O, Kleinbeck K, Lifson JD, Peet MM, Lloyd Z, Benson M, Heneine W, O'Keefe BR, Robbiani M, Martinelli E, Grasperge B, Blanchard J, Gettie A, Teleshova N, Fernández-Romero JA, Zydowsky TM.

Nat Commun. 2018 Sep 24;9(1):3881. doi: 10.1038/s41467-018-06349-0.


Development of a Vaginal Fast-Dissolving Insert Combining Griffithsin and Carrageenan for Potential Use Against Sexually Transmitted Infections.

Lal M, Lai M, Ugaonkar S, Wesenberg A, Kizima L, Rodriguez A, Levendosky K, Mizenina O, Fernández-Romero J, Zydowsky T.

J Pharm Sci. 2018 Oct;107(10):2601-2610. doi: 10.1016/j.xphs.2018.06.002. Epub 2018 Jun 11.


An intravaginal ring that releases three antiviral agents and a contraceptive blocks SHIV-RT infection, reduces HSV-2 shedding, and suppresses hormonal cycling in rhesus macaques.

Derby N, Aravantinou M, Kenney J, Ugaonkar SR, Wesenberg A, Wilk J, Kizima L, Rodriguez A, Zhang S, Mizenina O, Levendosky K, Cooney ML, Seidor S, Gettie A, Grasperge B, Blanchard J, Piatak M Jr, Lifson JD, Fernández-Romero J, Zydowsky TM, Robbiani M.

Drug Deliv Transl Res. 2017 Dec;7(6):840-858. doi: 10.1007/s13346-017-0389-0.


A Novel Microbicide/Contraceptive Intravaginal Ring Protects Macaque Genital Mucosa against SHIV-RT Infection Ex Vivo.

Villegas G, Calenda G, Ugaonkar S, Zhang S, Kizima L, Mizenina O, Gettie A, Blanchard J, Cooney ML, Robbiani M, Fernández-Romero JA, Zydowsky TM, Teleshova N.

PLoS One. 2016 Jul 18;11(7):e0159332. doi: 10.1371/journal.pone.0159332. eCollection 2016.


Multipurpose Prevention Approaches with Antiretroviral-Based Formulations.

Jean-Pierre N, Barnable P, Kizima L, Rodríguez A, Seidor S, Cooney ML, Clark MR, Doncel GF, Robbiani M, Zydowsky TM, Teleshova N, Fernández-Romero JA.

Antimicrob Agents Chemother. 2015 Nov 23;60(2):1141-4. doi: 10.1128/AAC.02468-15. Print 2016 Feb.


Griffithsin and Carrageenan Combination To Target Herpes Simplex Virus 2 and Human Papillomavirus.

Levendosky K, Mizenina O, Martinelli E, Jean-Pierre N, Kizima L, Rodriguez A, Kleinbeck K, Bonnaire T, Robbiani M, Zydowsky TM, O'Keefe BR, Fernández-Romero JA.

Antimicrob Agents Chemother. 2015 Dec;59(12):7290-8. doi: 10.1128/AAC.01816-15. Epub 2015 Sep 14.


A novel intravaginal ring to prevent HIV-1, HSV-2, HPV, and unintended pregnancy.

Ugaonkar SR, Wesenberg A, Wilk J, Seidor S, Mizenina O, Kizima L, Rodriguez A, Zhang S, Levendosky K, Kenney J, Aravantinou M, Derby N, Grasperge B, Gettie A, Blanchard J, Kumar N, Roberts K, Robbiani M, Fernández-Romero JA, Zydowsky TM.

J Control Release. 2015 Sep 10;213:57-68. doi: 10.1016/j.jconrel.2015.06.018. Epub 2015 Jun 17.


A MIV-150/zinc acetate gel inhibits SHIV-RT infection in macaque vaginal explants.

Barnable P, Calenda G, Ouattara L, Gettie A, Blanchard J, Jean-Pierre N, Kizima L, Rodríguez A, Abraham C, Menon R, Seidor S, Cooney ML, Roberts KD, Sperling R, Piatak M Jr, Lifson JD, Fernandez-Romero JA, Zydowsky TM, Robbiani M, Teleshova N.

PLoS One. 2014 Sep 26;9(9):e108109. doi: 10.1371/journal.pone.0108109. eCollection 2014.


In vitro and in vivo evaluation of two carrageenan-based formulations to prevent HPV acquisition.

Rodríguez A, Kleinbeck K, Mizenina O, Kizima L, Levendosky K, Jean-Pierre N, Villegas G, Ford BE, Cooney ML, Teleshova N, Robbiani M, Herold BC, Zydowsky T, Fernández Romero JA.

Antiviral Res. 2014 Aug;108:88-93. doi: 10.1016/j.antiviral.2014.05.018. Epub 2014 Jun 5.


A potent combination microbicide that targets SHIV-RT, HSV-2 and HPV.

Kizima L, Rodríguez A, Kenney J, Derby N, Mizenina O, Menon R, Seidor S, Zhang S, Levendosky K, Jean-Pierre N, Pugach P, Villegas G, Ford BE, Gettie A, Blanchard J, Piatak M Jr, Lifson JD, Paglini G, Teleshova N, Zydowsky TM, Robbiani M, Fernández-Romero JA.

PLoS One. 2014 Apr 16;9(4):e94547. doi: 10.1371/journal.pone.0094547. eCollection 2014.


MIV-150-containing intravaginal rings protect macaque vaginal explants against SHIV-RT infection.

Ouattara LA, Barnable P, Mawson P, Seidor S, Zydowsky TM, Kizima L, Rodriguez A, Fernández-Romero JA, Cooney ML, Roberts KD, Gettie A, Blanchard J, Robbiani M, Teleshova N.

Antimicrob Agents Chemother. 2014 May;58(5):2841-8. doi: 10.1128/AAC.01529-13. Epub 2014 Mar 10.


Exposure to MIV-150 from a high-dose intravaginal ring results in limited emergence of drug resistance mutations in SHIV-RT infected rhesus macaques.

Hsu M, Keele BF, Aravantinou M, Krawczyk N, Seidor S, Abraham CJ, Zhang S, Rodriguez A, Kizima L, Derby N, Jean-Pierre N, Mizenina O, Gettie A, Grasperge B, Blanchard J, Piatak MJ Jr, Lifson JD, Fernández-Romero JA, Zydowsky TM, Robbiani M.

PLoS One. 2014 Feb 27;9(2):e89300. doi: 10.1371/journal.pone.0089300. eCollection 2014.


A modified zinc acetate gel, a potential nonantiretroviral microbicide, is safe and effective against simian-human immunodeficiency virus and herpes simplex virus 2 infection in vivo.

Kenney J, Rodríguez A, Kizima L, Seidor S, Menon R, Jean-Pierre N, Pugach P, Levendosky K, Derby N, Gettie A, Blanchard J, Piatak M Jr, Lifson JD, Paglini G, Zydowsky TM, Robbiani M, Fernández Romero JA.

Antimicrob Agents Chemother. 2013 Aug;57(8):4001-9. doi: 10.1128/AAC.00796-13. Epub 2013 Jun 10.


An intravaginal ring that releases the NNRTI MIV-150 reduces SHIV transmission in macaques.

Singer R, Mawson P, Derby N, Rodriguez A, Kizima L, Menon R, Goldman D, Kenney J, Aravantinou M, Seidor S, Gettie A, Blanchard J, Piatak M Jr, Lifson JD, Fernández-Romero JA, Robbiani M, Zydowsky TM.

Sci Transl Med. 2012 Sep 5;4(150):150ra123. doi: 10.1126/scitranslmed.3003936.


Zinc acetate/carrageenan gels exhibit potent activity in vivo against high-dose herpes simplex virus 2 vaginal and rectal challenge.

Fernández-Romero JA, Abraham CJ, Rodriguez A, Kizima L, Jean-Pierre N, Menon R, Begay O, Seidor S, Ford BE, Gil PI, Peters J, Katz D, Robbiani M, Zydowsky TM.

Antimicrob Agents Chemother. 2012 Jan;56(1):358-68. doi: 10.1128/AAC.05461-11. Epub 2011 Nov 7.


The nonnucleoside reverse transcriptase inhibitor MIV-150 in carrageenan gel prevents rectal transmission of simian/human immunodeficiency virus infection in macaques.

Singer R, Derby N, Rodriguez A, Kizima L, Kenney J, Aravantinou M, Chudolij A, Gettie A, Blanchard J, Lifson JD, Piatak M Jr, Fernández-Romero JA, Zydowsky TM, Robbiani M.

J Virol. 2011 Jun;85(11):5504-12. doi: 10.1128/JVI.02422-10. Epub 2011 Mar 16.


An antiretroviral/zinc combination gel provides 24 hours of complete protection against vaginal SHIV infection in macaques.

Kenney J, Aravantinou M, Singer R, Hsu M, Rodriguez A, Kizima L, Abraham CJ, Menon R, Seidor S, Chudolij A, Gettie A, Blanchard J, Lifson JD, Piatak M Jr, Fernández-Romero JA, Zydowsky TM, Robbiani M.

PLoS One. 2011 Jan 5;6(1):e15835. doi: 10.1371/journal.pone.0015835.

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