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Items: 1 to 50 of 125

1.

Proteomic and N-Terminomic TAILS Analyses of Human Alveolar Bone Proteins: Improved Protein Extraction Methodology and LysargiNase Digestion Strategies Increase Proteome Coverage and Missing Protein Identification.

Bell PA, Solis N, Kizhakkedathu JN, Matthew I, Overall CM.

J Proteome Res. 2019 Oct 25. doi: 10.1021/acs.jproteome.9b00445. [Epub ahead of print]

PMID:
31601107
2.

An enzymatic pathway in the human gut microbiome that converts A to universal O type blood.

Rahfeld P, Sim L, Moon H, Constantinescu I, Morgan-Lang C, Hallam SJ, Kizhakkedathu JN, Withers SG.

Nat Microbiol. 2019 Sep;4(9):1475-1485. doi: 10.1038/s41564-019-0469-7. Epub 2019 Jun 10.

PMID:
31182795
3.

Design of Safe Nanotherapeutics for the Excretion of Excess Systemic Toxic Iron.

Abbina S, Abbasi U, Gill A, Wong K, Kalathottukaren MT, Kizhakkedathu JN.

ACS Cent Sci. 2019 May 22;5(5):917-926. doi: 10.1021/acscentsci.9b00284. Epub 2019 Apr 11.

4.

Transcriptome analysis of signaling pathways of human peritoneal mesothelial cells in response to different osmotic agents in a peritoneal dialysis solution.

Liu B, Feng S, Dairi G, Guan Q, Chafeeva I, Wang H, Liggins R, da Roza G, Kizhakkedathu JN, Du C.

BMC Nephrol. 2019 May 21;20(1):181. doi: 10.1186/s12882-019-1376-0.

5.

Aurein-Derived Antimicrobial Peptides Formulated with Pegylated Phospholipid Micelles to Target Methicillin-Resistant Staphylococcus aureus Skin Infections.

Kumar P, Pletzer D, Haney EF, Rahanjam N, Cheng JTJ, Yue M, Aljehani W, Hancock REW, Kizhakkedathu JN, Straus SK.

ACS Infect Dis. 2019 Mar 8;5(3):443-453. doi: 10.1021/acsinfecdis.8b00319. Epub 2019 Jan 2.

PMID:
30565465
6.

The proteome microenvironment determines the protective effect of preconditioning in cisplatin-induced acute kidney injury.

Späth MR, Bartram MP, Palacio-Escat N, Hoyer KJR, Debes C, Demir F, Schroeter CB, Mandel AM, Grundmann F, Ciarimboli G, Beyer A, Kizhakkedathu JN, Brodesser S, Göbel H, Becker JU, Benzing T, Schermer B, Höhne M, Burst V, Saez-Rodriguez J, Huesgen PF, Müller RU, Rinschen MM.

Kidney Int. 2019 Feb;95(2):333-349. doi: 10.1016/j.kint.2018.08.037. Epub 2018 Dec 3.

PMID:
30522767
7.

Polymer-Nanoparticle Interaction as a Design Principle in the Development of a Durable Ultrathin Universal Binary Antibiofilm Coating with Long-Term Activity.

Mei Y, Yu K, Lo JCY, Takeuchi LE, Hadjesfandiari N, Yazdani-Ahmadabadi H, Brooks DE, Lange D, Kizhakkedathu JN.

ACS Nano. 2018 Dec 26;12(12):11881-11891. doi: 10.1021/acsnano.8b05512. Epub 2018 Oct 29.

PMID:
30354054
8.

Comparison of reversal activity and mechanism of action of UHRA, andexanet, and PER977 on heparin and oral FXa inhibitors.

Kalathottukaren MT, Creagh AL, Abbina S, Lu G, Karbarz MJ, Pandey A, Conley PB, Kizhakkedathu JN, Haynes C.

Blood Adv. 2018 Aug 28;2(16):2104-2114. doi: 10.1182/bloodadvances.2016003616.

9.

Molecular Dynamics Simulations on Nucleic Acid Binding Polymers Designed To Arrest Thrombosis.

Meneksedag-Erol D, Kizhakkedathu JN, Tang T, Uludağ H.

ACS Appl Mater Interfaces. 2018 Aug 29;10(34):28399-28411. doi: 10.1021/acsami.8b09914. Epub 2018 Aug 20.

PMID:
30085650
10.

Oncotically Driven Control over Glycocalyx Dimension for Cell Surface Engineering and Protein Binding in the Longitudinal Direction.

Siren EMJ, Chapanian R, Constantinescu I, Brooks DE, Kizhakkedathu JN.

Sci Rep. 2018 May 15;8(1):7581. doi: 10.1038/s41598-018-25870-2.

11.

Peritoneal and Systemic Responses of Obese Type II Diabetic Rats to Chronic Exposure to a Hyperbranched Polyglycerol-Based Dialysis Solution.

La Han B, Guan Q, Chafeeva I, Mendelson AA, da Roza G, Liggins R, Kizhakkedathu JN, Du C.

Basic Clin Pharmacol Toxicol. 2018 Oct;123(4):494-503. doi: 10.1111/bcpt.13038. Epub 2018 Jun 21.

12.

Influence of dynamic flow conditions on adsorbed plasma protein corona and surface-induced thrombus generation on antifouling brushes.

Yu K, Andruschak P, Yeh HH, Grecov D, Kizhakkedathu JN.

Biomaterials. 2018 Jun;166:79-95. doi: 10.1016/j.biomaterials.2018.03.009. Epub 2018 Mar 8.

PMID:
29549767
13.

Design of Polyphosphate Inhibitors: A Molecular Dynamics Investigation on Polyethylene Glycol-Linked Cationic Binding Groups.

Mafi A, Abbina S, Kalathottukaren MT, Morrissey JH, Haynes C, Kizhakkedathu JN, Pfaendtner J, Chou KC.

Biomacromolecules. 2018 Apr 9;19(4):1358-1367. doi: 10.1021/acs.biomac.8b00327. Epub 2018 Mar 23.

14.

Antimicrobial Peptides: Diversity, Mechanism of Action and Strategies to Improve the Activity and Biocompatibility In Vivo.

Kumar P, Kizhakkedathu JN, Straus SK.

Biomolecules. 2018 Jan 19;8(1). pii: E4. doi: 10.3390/biom8010004. Review.

15.

Antimicrobial Peptide-Polymer Conjugates with High Activity: Influence of Polymer Molecular Weight and Peptide Sequence on Antimicrobial Activity, Proteolysis, and Biocompatibility.

Kumar P, Takayesu A, Abbasi U, Kalathottukaren MT, Abbina S, Kizhakkedathu JN, Straus SK.

ACS Appl Mater Interfaces. 2017 Nov 1;9(43):37575-37586. doi: 10.1021/acsami.7b09471. Epub 2017 Oct 19.

PMID:
29019386
16.

Development of Antifouling and Bactericidal Coatings for Platelet Storage Bags Using Dopamine Chemistry.

Hadjesfandiari N, Weinhart M, Kizhakkedathu JN, Haag R, Brooks DE.

Adv Healthc Mater. 2018 Mar;7(5). doi: 10.1002/adhm.201700839. Epub 2017 Sep 29.

PMID:
28961393
17.

Comparative Degradomics of Porcine and Human Wound Exudates Unravels Biomarker Candidates for Assessment of Wound Healing Progression in Trauma Patients.

Sabino F, Egli FE, Savickas S, Holstein J, Kaspar D, Rollmann M, Kizhakkedathu JN, Pohlemann T, Smola H, Auf dem Keller U.

J Invest Dermatol. 2018 Feb;138(2):413-422. doi: 10.1016/j.jid.2017.08.032. Epub 2017 Sep 9.

18.

A Polymer Therapeutic Having Universal Heparin Reversal Activity: Molecular Design and Functional Mechanism.

Kalathottukaren MT, Abbina S, Yu K, Shenoi RA, Creagh AL, Haynes C, Kizhakkedathu JN.

Biomacromolecules. 2017 Oct 9;18(10):3343-3358. doi: 10.1021/acs.biomac.7b00994. Epub 2017 Sep 19.

PMID:
28880550
19.

Approaches to prevent bleeding associated with anticoagulants: current status and recent developments.

Kalathottukaren MT, Haynes CA, Kizhakkedathu JN.

Drug Deliv Transl Res. 2018 Aug;8(4):928-944. doi: 10.1007/s13346-017-0413-4. Review.

PMID:
28741113
20.

N-Degradomic Analysis Reveals a Proteolytic Network Processing the Podocyte Cytoskeleton.

Rinschen MM, Hoppe AK, Grahammer F, Kann M, Völker LA, Schurek EM, Binz J, Höhne M, Demir F, Malisic M, Huber TB, Kurschat C, Kizhakkedathu JN, Schermer B, Huesgen PF, Benzing T.

J Am Soc Nephrol. 2017 Oct;28(10):2867-2878. doi: 10.1681/ASN.2016101119. Epub 2017 Jul 19.

21.

Chronic periodontitis is associated with platelet factor 4 (PF4) secretion: A pilot study.

Brousseau-Nault M, Kizhakkedathu JN, Kim H.

J Clin Periodontol. 2017 Nov;44(11):1101-1111. doi: 10.1111/jcpe.12771. Epub 2017 Sep 15.

PMID:
28681377
22.

Nontransformed and Cancer Cells Can Utilize Different Endocytic Pathways To Internalize Dendritic Nanoparticle Variants: Implications on Nanocarrier Design.

Wong NKY, Shenoi RA, Abbina S, Chafeeva I, Kizhakkedathu JN, Khan MK.

Biomacromolecules. 2017 Aug 14;18(8):2427-2438. doi: 10.1021/acs.biomac.7b00590. Epub 2017 Jul 17.

PMID:
28655275
23.

Hemocompatibility of Degrading Polymeric Biomaterials: Degradable Polar Hydrophobic Ionic Polyurethane versus Poly(lactic-co-glycolic) Acid.

Brockman KS, Lai BFL, Kizhakkedathu JN, Santerre JP.

Biomacromolecules. 2017 Aug 14;18(8):2296-2305. doi: 10.1021/acs.biomac.7b00456. Epub 2017 Jun 30.

PMID:
28621927
24.

Cold preservation with hyperbranched polyglycerol-based solution improves kidney functional recovery with less injury at reperfusion in rats.

Li S, Liu B, Guan Q, Chafeeva I, Brooks DE, Nguan CY, Kizhakkedathu JN, Du C.

Am J Transl Res. 2017 Feb 15;9(2):429-441. eCollection 2017.

25.

Profiling of Protein N-Termini and Their Modifications in Complex Samples.

Demir F, Niedermaier S, Kizhakkedathu JN, Huesgen PF.

Methods Mol Biol. 2017;1574:35-50. doi: 10.1007/978-1-4939-6850-3_4.

PMID:
28315242
26.

Alteration of blood clotting and lung damage by protamine are avoided using the heparin and polyphosphate inhibitor UHRA.

Kalathottukaren MT, Abraham L, Kapopara PR, Lai BF, Shenoi RA, Rosell FI, Conway EM, Pryzdial EL, Morrissey JH, Haynes CA, Kizhakkedathu JN.

Blood. 2017 Mar 9;129(10):1368-1379. doi: 10.1182/blood-2016-10-747915. Epub 2016 Dec 29.

27.

Hyperbranched polyglycerol is superior to glucose for long-term preservation of peritoneal membrane in a rat model of chronic peritoneal dialysis.

Du C, Mendelson AA, Guan Q, Dairi G, Chafeeva I, da Roza G, Kizhakkedathu JN.

J Transl Med. 2016 Dec 13;14(1):338.

28.

A planar model of the vessel wall from cellularized-collagen scaffolds: focus on cell-matrix interactions in mono-, bi- and tri-culture models.

Loy C, Meghezi S, Lévesque L, Pezzoli D, Kumra H, Reinhardt D, Kizhakkedathu JN, Mantovani D.

Biomater Sci. 2016 Dec 20;5(1):153-162. doi: 10.1039/c6bm00643d.

PMID:
27918018
29.

Anti-adhesive antimicrobial peptide coating prevents catheter associated infection in a mouse urinary infection model.

Yu K, Lo JC, Yan M, Yang X, Brooks DE, Hancock RE, Lange D, Kizhakkedathu JN.

Biomaterials. 2017 Feb;116:69-81. doi: 10.1016/j.biomaterials.2016.11.047. Epub 2016 Nov 24.

PMID:
27914268
30.

Hemocompatibility studies on a degradable polar hydrophobic ionic polyurethane (D-PHI).

Brockman KS, Kizhakkedathu JN, Santerre JP.

Acta Biomater. 2017 Jan 15;48:368-377. doi: 10.1016/j.actbio.2016.11.005. Epub 2016 Nov 3.

PMID:
27818307
31.

In Vivo Biological Evaluation of High Molecular Weight Multifunctional Acid-Degradable Polymeric Drug Carriers with Structurally Different Ketals.

Shenoi RA, Abbina S, Kizhakkedathu JN.

Biomacromolecules. 2016 Nov 14;17(11):3683-3693. Epub 2016 Oct 27.

PMID:
27750017
32.

Iron Binding and Iron Removal Efficiency of Desferrioxamine Based Polymeric Iron Chelators: Influence of Molecular Size and Chelator Density.

Hamilton JL, Ul-Haq MI, Creagh AL, Haynes CA, Kizhakkedathu JN.

Macromol Biosci. 2017 Mar;17(3). doi: 10.1002/mabi.201600244. Epub 2016 Sep 28.

PMID:
27683190
33.

Advantages of replacing hydroxyethyl starch in University of Wisconsin solution with hyperbranched polyglycerol for cold kidney perfusion.

Li S, Constantinescu I, Guan Q, Kalathottukaren MT, Brooks DE, Nguan CY, Kizhakkedathu JN, Du C.

J Surg Res. 2016 Sep;205(1):59-69. doi: 10.1016/j.jss.2016.06.015. Epub 2016 Jun 15.

PMID:
27621000
34.

Choline phosphate functionalized cellulose membrane: A potential hemostatic dressing based on a unique bioadhesion mechanism.

Yang X, Li N, Constantinesco I, Yu K, Kizhakkedathu JN, Brooks DE.

Acta Biomater. 2016 Aug;40:212-225. doi: 10.1016/j.actbio.2016.06.030. Epub 2016 Jun 23.

PMID:
27345136
35.

In vivo efficacy, toxicity and biodistribution of ultra-long circulating desferrioxamine based polymeric iron chelator.

Hamilton JL, Imran Ul-Haq M, Abbina S, Kalathottukaren MT, Lai BF, Hatef A, Unniappan S, Kizhakkedathu JN.

Biomaterials. 2016 Sep;102:58-71. doi: 10.1016/j.biomaterials.2016.06.019. Epub 2016 Jun 10.

PMID:
27322959
36.

Effect of Extreme Wettability on Platelet Adhesion on Metallic Implants: From Superhydrophilicity to Superhydrophobicity.

Moradi S, Hadjesfandiari N, Toosi SF, Kizhakkedathu JN, Hatzikiriakos SG.

ACS Appl Mater Interfaces. 2016 Jul 13;8(27):17631-41. doi: 10.1021/acsami.6b03644. Epub 2016 Jul 1.

PMID:
27322889
37.

Design Considerations for Developing Hyperbranched Polyglycerol Nanoparticles as Systemic Drug Carriers.

Wong NK, Misri R, Shenoi RA, Chafeeva I, Kizhakkedathu JN, Khan MK.

J Biomed Nanotechnol. 2016 May;12(5):1089-100.

PMID:
27305828
38.

Skin Barrier Defects Caused by Keratinocyte-Specific Deletion of ADAM17 or EGFR Are Based on Highly Similar Proteome and Degradome Alterations.

Tholen S, Wolf C, Mayer B, Knopf JD, Löffek S, Qian Y, Kizhakkedathu JN, Biniossek ML, Franzke CW, Schilling O.

J Proteome Res. 2016 May 6;15(5):1402-17. doi: 10.1021/acs.jproteome.5b00691. Epub 2016 Apr 21.

PMID:
27089454
39.

Formalin-Fixed, Paraffin-Embedded Tissues (FFPE) as a Robust Source for the Profiling of Native and Protease-Generated Protein Amino Termini.

Lai ZW, Weisser J, Nilse L, Costa F, Keller E, Tholen M, Kizhakkedathu JN, Biniossek M, Bronsert P, Schilling O.

Mol Cell Proteomics. 2016 Jun;15(6):2203-13. doi: 10.1074/mcp.O115.056515. Epub 2016 Apr 17.

40.

Toward Infection-Resistant Surfaces: Achieving High Antimicrobial Peptide Potency by Modulating the Functionality of Polymer Brush and Peptide.

Yu K, Lo JC, Mei Y, Haney EF, Siren E, Kalathottukaren MT, Hancock RE, Lange D, Kizhakkedathu JN.

ACS Appl Mater Interfaces. 2015 Dec 30;7(51):28591-605. doi: 10.1021/acsami.5b10074. Epub 2015 Dec 21.

PMID:
26641308
41.

The mechanism and modulation of complement activation on polymer grafted cells.

Leung VL, Kizhakkedathu JN.

Acta Biomater. 2016 Feb;31:252-263. doi: 10.1016/j.actbio.2015.11.022. Epub 2015 Nov 29.

PMID:
26593783
42.

Modulation of Multivalent Protein Binding on Surfaces by Glycopolymer Brush Chemistry.

Yu K, Creagh AL, Haynes CA, Kizhakkedathu JN.

Methods Mol Biol. 2016;1367:183-93. doi: 10.1007/978-1-4939-3130-9_15.

PMID:
26537474
43.

Matrix Metalloproteinase 10 Degradomics in Keratinocytes and Epidermal Tissue Identifies Bioactive Substrates With Pleiotropic Functions.

Schlage P, Kockmann T, Sabino F, Kizhakkedathu JN, Auf dem Keller U.

Mol Cell Proteomics. 2015 Dec;14(12):3234-46. doi: 10.1074/mcp.M115.053520. Epub 2015 Oct 16.

44.

Fibroblast activation protein-α, a stromal cell surface protease, shapes key features of cancer associated fibroblasts through proteome and degradome alterations.

Koczorowska MM, Tholen S, Bucher F, Lutz L, Kizhakkedathu JN, De Wever O, Wellner UF, Biniossek ML, Stahl A, Lassmann S, Schilling O.

Mol Oncol. 2016 Jan;10(1):40-58. doi: 10.1016/j.molonc.2015.08.001. Epub 2015 Aug 11.

45.

Interaction of blood components with cathelicidins and their modified versions.

Yu K, Lai BF, Gani J, Mikut R, Hilpert K, Kizhakkedathu JN.

Biomaterials. 2015 Nov;69:201-11. doi: 10.1016/j.biomaterials.2015.08.003. Epub 2015 Aug 6.

PMID:
26295533
46.

Blood Components Interactions to Ionic and Nonionic Glyconanogels.

Narain R, Wang Y, Ahmed M, Lai BF, Kizhakkedathu JN.

Biomacromolecules. 2015 Sep 14;16(9):2990-7. doi: 10.1021/acs.biomac.5b00890. Epub 2015 Aug 21.

PMID:
26280734
47.

Polymeric nanocarriers for the treatment of systemic iron overload.

Hamilton JL, Kizhakkedathu JN.

Mol Cell Ther. 2015 Mar 24;3:3. doi: 10.1186/s40591-015-0039-1. eCollection 2015.

48.

Chain Length and Grafting Density Dependent Enhancement in the Hydrolysis of Ester-Linked Polymer Brushes.

Melzak KA, Yu K, Bo D, Kizhakkedathu JN, Toca-Herrera JL.

Langmuir. 2015 Jun 16;31(23):6463-70. doi: 10.1021/acs.langmuir.5b01424. Epub 2015 Jun 3.

PMID:
26010390
49.

Investigation of hydrophobically derivatized hyperbranched polyglycerol with PEGylated shell as a nanocarrier for systemic delivery of chemotherapeutics.

Misri R, Wong NK, Shenoi RA, Lum CM, Chafeeva I, Toth K, Rustum Y, Kizhakkedathu JN, Khan MK.

Nanomedicine. 2015 Oct;11(7):1785-95. doi: 10.1016/j.nano.2015.04.016. Epub 2015 May 14.

PMID:
25981338
50.

Monitoring matrix metalloproteinase activity at the epidermal-dermal interface by SILAC-iTRAQ-TAILS.

Schlage P, Kockmann T, Kizhakkedathu JN, auf dem Keller U.

Proteomics. 2015 Jul;15(14):2491-502. doi: 10.1002/pmic.201400627. Epub 2015 May 15.

PMID:
25871442

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