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Withholding and withdrawal of life-sustaining treatments for neonate in Japan: Are hospital practices associated with physicians' beliefs, practices, or perceived barriers?

Yotani N, Nabetani M, Feudtner C, Honda J, Kizawa Y, Iijima K.

Early Hum Dev. 2019 Dec 3;141:104931. doi: 10.1016/j.earlhumdev.2019.104931. [Epub ahead of print]


Patients' Self-Assessment of the Symptoms and Impact of Opioid-Induced Constipation: Results From a Prospective Observational Cohort Study of Japanese Patients With Cancer.

Fumita S, Imai H, Harada T, Noriyuki T, Gamoh M, Akashi Y, Sato H, Kizawa Y, Tokoro A.

J Pain Symptom Manage. 2019 Dec 2. pii: S0885-3924(19)30676-1. doi: 10.1016/j.jpainsymman.2019.11.021. [Epub ahead of print]


Decision-making dilemmas of paediatricians: a qualitative study in Japan.

Sasazuki M, Sakai Y, Kira R, Toda N, Ichimiya Y, Akamine S, Torio M, Ishizaki Y, Sanefuji M, Narama M, Itai K, Hara T, Takada H, Kizawa Y, Ohga S.

BMJ Open. 2019 Aug 19;9(8):e026579. doi: 10.1136/bmjopen-2018-026579.


Anti-fungal activity of a novel triazole, PC1244, against emerging azole-resistant Aspergillus fumigatus and other species of Aspergillus.

Colley T, Sharma C, Alanio A, Kimura G, Daly L, Nakaoki T, Nishimoto Y, Bretagne S, Kizawa Y, Strong P, Rapeport G, Ito K, Meis JF, Chowdhary A.

J Antimicrob Chemother. 2019 Oct 1;74(10):2950-2958. doi: 10.1093/jac/dkz302.


2019 Taipei Declaration on Advance Care Planning: A Cultural Adaptation of End-of-Life Care Discussion.

Lin CP, Cheng SY, Mori M, Suh SY, Chan HY, Martina D, Pang WS, Huang HL, Peng JK, Yao CA, Tsai JS, Hu WY, Wang YW, Shih CY, Hsu SH, Wu CY, Chen PJ, Ho HL, Pang GS, Menon S, Ng-Han Lip R, Yuen KK, Kwok AO, Kim SH, Kim JY, Takenouchi S, Kizawa Y, Morita T, Iwata F, Tashiro S, Chiu TY.

J Palliat Med. 2019 Oct;22(10):1175-1177. doi: 10.1089/jpm.2019.0247. Epub 2019 Jul 3. No abstract available.


Antifungal synergy of a topical triazole, PC945, with a systemic triazole against respiratory Aspergillus fumigatus infection.

Colley T, Sehra G, Daly L, Kimura G, Nakaoki T, Nishimoto Y, Kizawa Y, Strong P, Rapeport G, Ito K.

Sci Rep. 2019 Jul 1;9(1):9482. doi: 10.1038/s41598-019-45890-w.


Incidence of opioid-induced constipation in Japanese patients with cancer pain: A prospective observational cohort study.

Tokoro A, Imai H, Fumita S, Harada T, Noriyuki T, Gamoh M, Akashi Y, Sato H, Kizawa Y.

Cancer Med. 2019 Aug;8(10):4883-4891. doi: 10.1002/cam4.2341. Epub 2019 Jun 24.


[The Involvement of Src in Airway Inflammation Induced by Repeated Exposure to Lipopolysaccharide in Mice].

Nishimoto Y, Yasuda H, Masuko K, Usui Y, Ueda K, Kimura G, Ito K, Kizawa Y.

Yakugaku Zasshi. 2019 Sep 1;139(9):1211-1217. doi: 10.1248/yakushi.19-00086. Epub 2019 Jun 13. Japanese.


[TNF-α Decreased Corticosteroid Responsiveness in Mice Models of Airway Inflammation Induced by Double Strand RNA and/or Tobacco Smoke Exposure].

Nishimoto Y, Iwamoto I, Suzuki A, Ueda K, Kimura G, Ito K, Kizawa Y.

Yakugaku Zasshi. 2019 Jun 1;139(6):955-961. doi: 10.1248/yakushi.18-00230. Epub 2019 Apr 2. Japanese.


Attitude of Japanese palliative care specialists towards adjuvant analgesics cancer-related neuropathic pain refractory to opioid therapy: a nationwide cross-sectional survey.

Matsuoka H, Tagami K, Ariyoshi K, Oyamada S, Kizawa Y, Inoue A, Koyama A.

Jpn J Clin Oncol. 2019 May 1;49(5):486-490. doi: 10.1093/jjco/hyz002.


Validation of the Integrated Palliative care Outcome Scale (IPOS) - Japanese Version.

Sakurai H, Miyashita M, Imai K, Miyamoto S, Otani H, Oishi A, Kizawa Y, Matsushima E.

Jpn J Clin Oncol. 2019 Mar 1;49(3):257-262. doi: 10.1093/jjco/hyy203.


Difference in Opinions About Continuous Deep Sedation Among Cancer Patients, Bereaved Families, and Physicians.

Morita T, Kiuchi D, Ikenaga M, Abo H, Maeda S, Aoyama M, Shinjo T, Kizawa Y, Tsuneto S, Miyashita M.

J Pain Symptom Manage. 2019 Mar;57(3):e5-e9. doi: 10.1016/j.jpainsymman.2018.11.025. Epub 2018 Dec 6. No abstract available.


Prevalence and Characteristics of Patients Being at Risk of Deteriorating and Dying in Primary Care.

Hamano J, Oishi A, Kizawa Y.

J Pain Symptom Manage. 2019 Feb;57(2):266-272.e1. doi: 10.1016/j.jpainsymman.2018.11.006. Epub 2018 Nov 15.


Achievement of a good death among young adult patients with cancer: analyses of combined data from three nationwide surveys among bereaved family members.

Mori M, Sasahara T, Morita T, Aoyama M, Kizawa Y, Tsuneto S, Shima Y, Miyashita M.

Support Care Cancer. 2019 Apr;27(4):1519-1527. doi: 10.1007/s00520-018-4539-9. Epub 2018 Nov 16.


Changes in opinions on palliative sedation of palliative care specialists over 16 years and their effects on clinical practice.

Maeda S, Morita T, Ikenaga M, Abo H, Kizawa Y, Tsuneto S.

Support Care Cancer. 2019 Jun;27(6):2211-2219. doi: 10.1007/s00520-018-4497-2. Epub 2018 Oct 12.


Efficacy of immediate-release oxycodone for dyspnoea in cancer patient: cancer dyspnoea relief (CDR) trial.

Yamaguchi T, Matsuda Y, Matsuoka H, Hisanaga T, Osaka I, Watanabe H, Maeda I, Imai K, Tsuneto S, Wagatsuma Y, Kizawa Y.

Jpn J Clin Oncol. 2018 Dec 1;48(12):1070-1075. doi: 10.1093/jjco/hyy139.


Development of a Standard for Hospital-Based Palliative Care Consultation Teams in Japan Using a Modified Delphi Method.

Sakashita A, Kizawa Y, Kato M, Akizuki N, Nakazawa Y, Kaizu M, Yano K, Sato T, Tokoro A.

J Pain Symptom Manage. 2018 Nov;56(5):746-751.e5. doi: 10.1016/j.jpainsymman.2018.08.013. Epub 2018 Aug 24. Review.


Nonbacterial Thrombotic Endocarditis Concomitant with Repeated Systemic Embolization That Received Palliative Care Based on the Antemortem Diagnosis.

Shibata N, Matsumoto K, Kitamura S, Sakashita A, Kizawa Y, Hirata KI.

Intern Med. 2018 Dec 15;57(24):3559-3563. doi: 10.2169/internalmedicine.1381-18. Epub 2018 Aug 10.


Development of an Instrument for Evaluating Nurses' Knowledge and Attitude Toward End-of-Life Care: End-of-Life Nursing Education Consortium-Japan Core Quiz.

Arahata T, Miyashita M, Takenouchi S, Tamura K, Kizawa Y.

J Hosp Palliat Nurs. 2018 Feb;20(1):55-62. doi: 10.1097/NJH.0000000000000393.


Specialist Palliative Care Service for Children With Life-Threatening Conditions: A Nationwide Survey of Availability and Utilization.

Yotani N, Kizawa Y.

J Pain Symptom Manage. 2018 Oct;56(4):582-587. doi: 10.1016/j.jpainsymman.2018.06.005. Epub 2018 Jun 15.


The Japan hospice and palliative evaluation study 4: a cross-sectional questionnaire survey.

Masukawa K, Aoyama M, Morita T, Kizawa Y, Tsuneto S, Shima Y, Miyashita M.

BMC Palliat Care. 2018 Apr 20;17(1):66. doi: 10.1186/s12904-018-0319-z.


Advance care planning for adolescent patients with life-threatening neurological conditions: a survey of Japanese paediatric neurologists.

Yotani N, Kizawa Y, Shintaku H.

BMJ Paediatr Open. 2017 Sep 28;1(1):e000102. doi: 10.1136/bmjpo-2017-000102. eCollection 2017.


Bereaved Family Members' Perceptions of the Distressing Symptoms of Terminal Patients With Cancer.

Okamoto Y, Morita T, Tsuneto S, Aoyama M, Kizawa Y, Shima Y, Miyashita M.

Am J Hosp Palliat Care. 2018 Jul;35(7):972-977. doi: 10.1177/1049909118765409. Epub 2018 Apr 2.


Families' Sense of Abandonment When Patients Are Referred to Hospice.

Odagiri T, Morita T, Aoyama M, Kizawa Y, Tsuneto S, Shima Y, Miyashita M; J‐HOPE Group.

Oncologist. 2018 Sep;23(9):1109-1115. doi: 10.1634/theoncologist.2017-0547. Epub 2018 Mar 22.


N1-Nonyl-1,4-diaminobutane ameliorates brain infarction size in photochemically induced thrombosis model mice.

Masuko T, Takao K, Samejima K, Shirahata A, Igarashi K, Casero RA Jr, Kizawa Y, Sugita Y.

Neurosci Lett. 2018 Apr 13;672:118-122. doi: 10.1016/j.neulet.2018.01.054. Epub 2018 Feb 22.


In Vitro and In Vivo Efficacy of a Novel and Long-Acting Fungicidal Azole, PC1244, on Aspergillus fumigatus Infection.

Colley T, Sehra G, Chowdhary A, Alanio A, Kelly SL, Kizawa Y, Armstrong-James D, Fisher MC, Warrilow AGS, Parker JE, Kelly DE, Kimura G, Nishimoto Y, Sunose M, Onions S, Crepin D, Lagasse F, Crittall M, Shannon J, McConville M, King-Underwood J, Naylor A, Bretagne S, Murray J, Ito K, Strong P, Rapeport G.

Antimicrob Agents Chemother. 2018 Apr 26;62(5). pii: e01941-17. doi: 10.1128/AAC.01941-17. Print 2018 May.


Identified Palliative Care Approach Needs with SPICT in Family Practice: A Preliminary Observational Study.

Hamano J, Oishi A, Kizawa Y.

J Palliat Med. 2018 Jul;21(7):992-998. doi: 10.1089/jpm.2017.0491. Epub 2018 Feb 9.


Factors associated with possible complicated grief and major depressive disorders.

Aoyama M, Sakaguchi Y, Morita T, Ogawa A, Fujisawa D, Kizawa Y, Tsuneto S, Shima Y, Miyashita M.

Psychooncology. 2018 Mar;27(3):915-921. doi: 10.1002/pon.4610. Epub 2018 Jan 9.


Psychological and psychiatric symptoms of terminally ill patients with cancer and their family caregivers in the home-care setting: A nation-wide survey from the perspective of bereaved family members in Japan.

Kobayakawa M, Ogawa A, Konno M, Kurata A, Hamano J, Morita T, Kizawa Y, Tsuneto S, Shima Y, Aoyama M, Miyashita M.

J Psychosom Res. 2017 Dec;103:127-132. doi: 10.1016/j.jpsychores.2017.10.012. Epub 2017 Oct 23.


"What I Did for My Loved One Is More Important than Whether We Talked About Death": A Nationwide Survey of Bereaved Family Members.

Mori M, Yoshida S, Shiozaki M, Morita T, Baba M, Aoyama M, Kizawa Y, Tsuneto S, Shima Y, Miyashita M.

J Palliat Med. 2018 Mar;21(3):335-341. doi: 10.1089/jpm.2017.0267. Epub 2017 Nov 20.


Japanese physicians' experiences of terminally ill patients voluntarily stopping eating and drinking: a national survey.

Shinjo T, Morita T, Kiuchi D, Ikenaga M, Abo H, Maeda S, Tsuneto S, Kizawa Y.

BMJ Support Palliat Care. 2019 Jun;9(2):143-145. doi: 10.1136/bmjspcare-2017-001426. Epub 2017 Nov 8.


RV568, a narrow-spectrum kinase inhibitor with p38 MAPK-α and -γ selectivity, suppresses COPD inflammation.

Charron CE, Russell P, Ito K, Lea S, Kizawa Y, Brindley C, Singh D.

Eur Respir J. 2017 Oct 26;50(4). pii: 1700188. doi: 10.1183/13993003.00188-2017. Print 2017 Oct.


A Nationwide Survey About Palliative Sedation Involving Japanese Palliative Care Specialists: Intentions and Key Factors Used to Determine Sedation as Proportionally Appropriate.

Hamano J, Morita T, Ikenaga M, Abo H, Kizawa Y, Tunetou S.

J Pain Symptom Manage. 2018 Mar;55(3):785-791. doi: 10.1016/j.jpainsymman.2017.10.006. Epub 2017 Oct 19.


Improved knowledge of and difficulties in palliative care among physicians during 2008 and 2015 in Japan: Association with a nationwide palliative care education program.

Nakazawa Y, Yamamoto R, Kato M, Miyashita M, Kizawa Y, Morita T.

Cancer. 2018 Feb 1;124(3):626-635. doi: 10.1002/cncr.31071. Epub 2017 Oct 12.


Which Research Questions Are Important for the Bereaved Families of Palliative Care Cancer Patients? A Nationwide Survey.

Sakashita A, Morita T, Kishino M, Aoyama M, Kizawa Y, Tsuneto S, Shima Y, Miyashita M.

J Pain Symptom Manage. 2018 Feb;55(2):379-386. doi: 10.1016/j.jpainsymman.2017.09.012. Epub 2017 Sep 19.


Changes in Nurses' Knowledge, Difficulties, and Self-reported Practices Toward Palliative Care for Cancer Patients in Japan: An Analysis of Two Nationwide Representative Surveys in 2008 and 2015.

Nakazawa Y, Kato M, Miyashita M, Morita T, Kizawa Y.

J Pain Symptom Manage. 2018 Feb;55(2):402-412. doi: 10.1016/j.jpainsymman.2017.08.034. Epub 2017 Sep 15.


Study protocol for a multi-institutional, randomised, double-blinded, placebo-controlled phase III trial investigating additive efficacy of duloxetine for neuropathic cancer pain refractory to opioids and gabapentinoids: the DIRECT study.

Matsuoka H, Ishiki H, Iwase S, Koyama A, Kawaguchi T, Kizawa Y, Morita T, Matsuda Y, Miyaji T, Ariyoshi K, Yamaguchi T.

BMJ Open. 2017 Aug 28;7(8):e017280. doi: 10.1136/bmjopen-2017-017280.


Unfinished Business in Families of Terminally Ill With Cancer Patients.

Yamashita R, Arao H, Takao A, Masutani E, Morita T, Shima Y, Kizawa Y, Tsuneto S, Aoyama M, Miyashita M.

J Pain Symptom Manage. 2017 Dec;54(6):861-869. doi: 10.1016/j.jpainsymman.2017.04.013. Epub 2017 Aug 12.


Talking About Death With Terminally-Ill Cancer Patients: What Contributes to the Regret of Bereaved Family Members?

Mori M, Yoshida S, Shiozaki M, Baba M, Morita T, Aoyama M, Kizawa Y, Tsuneto S, Shima Y, Miyashita M.

J Pain Symptom Manage. 2017 Dec;54(6):853-860.e1. doi: 10.1016/j.jpainsymman.2017.02.021. Epub 2017 Aug 8.


[Achievement and Future Direction of the PEACE Project - A National Education Project for Palliative Care Education].

Kizawa Y, Yamamoto R.

Gan To Kagaku Ryoho. 2017 Jul;44(7):541-544. Review. Japanese.


Practice and Perceived Importance of Advance Care Planning and Difficulties in Providing Palliative Care in Geriatric Health Service Facilities in Japan: A Nationwide Survey.

Yokoya S, Kizawa Y, Maeno T.

Am J Hosp Palliat Care. 2018 Mar;35(3):464-472. doi: 10.1177/1049909117723859. Epub 2017 Aug 8.


Trust in Physicians, Continuity and Coordination of Care, and Quality of Death in Patients with Advanced Cancer.

Hamano J, Morita T, Fukui S, Kizawa Y, Tunetou S, Shima Y, Kobayakawa M, Aoyama M, Miyashita M.

J Palliat Med. 2017 Nov;20(11):1252-1259. doi: 10.1089/jpm.2017.0049. Epub 2017 Jul 21.


End-of-life experiences of family caregivers of deceased patients with cancer: A nation-wide survey.

Hirooka K, Otani H, Morita T, Miura T, Fukahori H, Aoyama M, Kizawa Y, Shima Y, Tsuneto S, Miyashita M.

Psychooncology. 2018 Jan;27(1):272-278. doi: 10.1002/pon.4504. Epub 2017 Aug 15.


Assessment of indomethacin oral spray for the treatment of oropharyngeal mucositis-induced pain during anticancer therapy.

Momo K, Nagaoka H, Kizawa Y, Bukawa H, Chiba S, Kohda Y, Homma M.

Support Care Cancer. 2017 Oct;25(10):2997-3000. doi: 10.1007/s00520-017-3817-2. Epub 2017 Jul 15.


Meaningful Communication Before Death, but Not Present at the Time of Death Itself, Is Associated With Better Outcomes on Measures of Depression and Complicated Grief Among Bereaved Family Members of Cancer Patients.

Otani H, Yoshida S, Morita T, Aoyama M, Kizawa Y, Shima Y, Tsuneto S, Miyashita M.

J Pain Symptom Manage. 2017 Sep;54(3):273-279. doi: 10.1016/j.jpainsymman.2017.07.010. Epub 2017 Jul 13.


Effects of intranasally dosed posaconazole on fungal load and biomarkers in Aspergillus fumigatus infected immunocompromised mice.

Kimura G, Nakaoki T, Nishimoto Y, Suzuki Y, Rapeport G, Strong P, Ito K, Kizawa Y.

Mycoses. 2017 Nov;60(11):728-735. doi: 10.1111/myc.12653. Epub 2017 Jul 11.


In Vivo Biomarker Analysis of the Effects of Intranasally Dosed PC945, a Novel Antifungal Triazole, on Aspergillus fumigatus Infection in Immunocompromised Mice.

Kimura G, Nakaoki T, Colley T, Rapeport G, Strong P, Ito K, Kizawa Y.

Antimicrob Agents Chemother. 2017 Aug 24;61(9). pii: e00124-17. doi: 10.1128/AAC.00124-17. Print 2017 Sep.


Effects of End-of-Life Discussions on the Mental Health of Bereaved Family Members and Quality of Patient Death and Care.

Yamaguchi T, Maeda I, Hatano Y, Mori M, Shima Y, Tsuneto S, Kizawa Y, Morita T, Yamaguchi T, Aoyama M, Miyashita M.

J Pain Symptom Manage. 2017 Jul;54(1):17-26.e1. doi: 10.1016/j.jpainsymman.2017.03.008. Epub 2017 Apr 24.


Quality of life and cost-utility of surgical treatment for patients with spinal metastases: prospective cohort study.

Miyazaki S, Kakutani K, Sakai Y, Ejima Y, Maeno K, Takada T, Yurube T, Terashima Y, Ito M, Kakiuchi Y, Takeoka Y, Hara H, Kawamoto T, Sakashita A, Okada T, Kiyota N, Kizawa Y, Sasaki R, Akisue T, Minami H, Kuroda R, Nishida K.

Int Orthop. 2017 Jun;41(6):1265-1271. doi: 10.1007/s00264-017-3463-9. Epub 2017 Apr 10.


The relationship between cancer patients' place of death and bereaved caregivers' mental health status.

Hatano Y, Aoyama M, Morita T, Yamaguchi T, Maeda I, Kizawa Y, Tsuneto S, Shima Y, Miyashita M.

Psychooncology. 2017 Nov;26(11):1959-1964. doi: 10.1002/pon.4412. Epub 2017 Mar 27.


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