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Items: 1 to 50 of 88

1.

Design, synthesis, and evaluation of indeno[2,1-c]pyrazolones for use as inhibitors against hypoxia-inducible factor (HIF)-1 transcriptional activity.

Fuse S, Suzuki K, Kuchimaru T, Kadonosono T, Ueda H, Sato S, Kizaka-Kondoh S, Nakamura H.

Bioorg Med Chem. 2019 Nov 9:115207. doi: 10.1016/j.bmc.2019.115207. [Epub ahead of print]

PMID:
31740202
2.

Imaging Hypoxic Stress and the Treatment of Amyotrophic Lateral Sclerosis with Dimethyloxalylglycine in a Mice Model.

Nomura E, Ohta Y, Tadokoro K, Shang J, Feng T, Liu X, Shi X, Matsumoto N, Sasaki R, Tsunoda K, Sato K, Takemoto M, Hishikawa N, Yamashita T, Kuchimaru T, Kizaka-Kondoh S, Abe K.

Neuroscience. 2019 Sep 1;415:31-43. doi: 10.1016/j.neuroscience.2019.06.025. Epub 2019 Jul 22.

PMID:
31344397
3.

Characterization and Biodistribution Analysis of Oxygen-Doped Single-Walled Carbon Nanotubes Used as in Vivo Fluorescence Imaging Probes.

Takeuchi T, Iizumi Y, Yudasaka M, Kizaka-Kondoh S, Okazaki T.

Bioconjug Chem. 2019 May 15;30(5):1323-1330. doi: 10.1021/acs.bioconjchem.9b00088. Epub 2019 Mar 20.

PMID:
30848886
4.

Microfluidic High-Migratory Cell Collector Suppressing Artifacts Caused by Microstructures.

Ishida T, Shimamoto T, Kaminaga M, Kuchimaru T, Kizaka-Kondoh S, Omata T.

Micromachines (Basel). 2019 Feb 11;10(2). pii: E116. doi: 10.3390/mi10020116.

5.

Microfluidic Device for Screening for Target Cell-Specific Binding Molecules by Using Adherent Cells.

Kaminaga M, Ishida T, Kadonosono T, Kizaka-Kondoh S, Omata T.

Micromachines (Basel). 2019 Jan 9;10(1). pii: E41. doi: 10.3390/mi10010041.

6.

A reliable murine model of bone metastasis by injecting cancer cells through caudal arteries.

Kuchimaru T, Kataoka N, Nakagawa K, Isozaki T, Miyabara H, Minegishi M, Kadonosono T, Kizaka-Kondoh S.

Nat Commun. 2018 Jul 30;9(1):2981. doi: 10.1038/s41467-018-05366-3.

7.

Novel lymphoid enhancer-binding factor 1-cytoglobin axis promotes extravasation of osteosarcoma cells into the lungs.

Pongsuchart M, Kuchimaru T, Yonezawa S, Tran DTP, Kha NT, Hoang NTH, Kadonosono T, Kizaka-Kondoh S.

Cancer Sci. 2018 Sep;109(9):2746-2756. doi: 10.1111/cas.13702. Epub 2018 Jul 24.

8.

Blockage of the mevalonate pathway overcomes the apoptotic resistance to MEK inhibitors with suppressing the activation of Akt in cancer cells.

Iizuka-Ohashi M, Watanabe M, Sukeno M, Morita M, Hoang NTH, Kuchimaru T, Kizaka-Kondoh S, Sowa Y, Sakaguchi K, Taguchi T, Sakai T.

Oncotarget. 2018 Apr 13;9(28):19597-19612. doi: 10.18632/oncotarget.24696. eCollection 2018 Apr 13.

9.

Novel adherent CD11b+ Gr-1+ tumor-infiltrating cells initiate an immunosuppressive tumor microenvironment.

Tsubaki T, Kadonosono T, Sakurai S, Shiozawa T, Goto T, Sakai S, Kuchimaru T, Sakamoto T, Watanabe H, Kondoh G, Kizaka-Kondoh S.

Oncotarget. 2018 Jan 29;9(13):11209-11226. doi: 10.18632/oncotarget.24359. eCollection 2018 Feb 16.

10.

Single-cell bioluminescence imaging of deep tissue in freely moving animals.

Iwano S, Sugiyama M, Hama H, Watakabe A, Hasegawa N, Kuchimaru T, Tanaka KZ, Takahashi M, Ishida Y, Hata J, Shimozono S, Namiki K, Fukano T, Kiyama M, Okano H, Kizaka-Kondoh S, McHugh TJ, Yamamori T, Hioki H, Maki S, Miyawaki A.

Science. 2018 Feb 23;359(6378):935-939. doi: 10.1126/science.aaq1067.

PMID:
29472486
11.

Domain architecture of vasohibins required for their chaperone-dependent unconventional extracellular release.

Kadonosono T, Yimchuen W, Tsubaki T, Shiozawa T, Suzuki Y, Kuchimaru T, Sato Y, Kizaka-Kondoh S.

Protein Sci. 2017 Mar;26(3):452-463. doi: 10.1002/pro.3089. Epub 2017 Feb 11.

12.

A novel injectable BRET-based in vivo imaging probe for detecting the activity of hypoxia-inducible factor regulated by the ubiquitin-proteasome system.

Kuchimaru T, Suka T, Hirota K, Kadonosono T, Kizaka-Kondoh S.

Sci Rep. 2016 Oct 4;6:34311. doi: 10.1038/srep34311.

13.

Investigation of the Influence of Glucose Concentration on Cancer Cells by Using a Microfluidic Gradient Generator without the Induction of Large Shear Stress.

Ishida T, Shimamoto T, Ozaki N, Takaki S, Kuchimaru T, Kizaka-Kondoh S, Omata T.

Micromachines (Basel). 2016 Sep 1;7(9). pii: E155. doi: 10.3390/mi7090155.

14.

A luciferin analogue generating near-infrared bioluminescence achieves highly sensitive deep-tissue imaging.

Kuchimaru T, Iwano S, Kiyama M, Mitsumata S, Kadonosono T, Niwa H, Maki S, Kizaka-Kondoh S.

Nat Commun. 2016 Jun 14;7:11856. doi: 10.1038/ncomms11856.

15.

Hypoxia-inducible factor-targeting prodrug TOP3 combined with gemcitabine or TS-1 improves pancreatic cancer survival in an orthotopic model.

Hoang NT, Kadonosono T, Kuchimaru T, Kizaka-Kondoh S.

Cancer Sci. 2016 Aug;107(8):1151-8. doi: 10.1111/cas.12982. Epub 2016 Jul 21.

16.

A metal carbonyl-protein needle composite designed for intracellular CO delivery to modulate NF-κB activity.

Inaba H, Sanghamitra NJ, Fujita K, Sho T, Kuchimaru T, Kitagawa S, Kizaka-Kondoh S, Ueno T.

Mol Biosyst. 2015 Nov;11(11):3111-8. doi: 10.1039/c5mb00327j. Epub 2015 Sep 11.

PMID:
26360102
17.

High resolution imaging of intracellular oxygen concentration by phosphorescence lifetime.

Kurokawa H, Ito H, Inoue M, Tabata K, Sato Y, Yamagata K, Kizaka-Kondoh S, Kadonosono T, Yano S, Inoue M, Kamachi T.

Sci Rep. 2015 Jun 12;5:10657. doi: 10.1038/srep10657.

18.

The effect of triamcinolone acetonide on laser-induced choroidal neovascularization in mice using a hypoxia visualization bio-imaging probe.

Takata S, Masuda T, Nakamura S, Kuchimaru T, Tsuruma K, Shimazawa M, Nagasawa H, Kizaka-Kondoh S, Hara H.

Sci Rep. 2015 Apr 30;5:9898. doi: 10.1038/srep09898.

19.

Cell penetrating peptides improve tumor delivery of cargos through neuropilin-1-dependent extravasation.

Kadonosono T, Yamano A, Goto T, Tsubaki T, Niibori M, Kuchimaru T, Kizaka-Kondoh S.

J Control Release. 2015 Mar 10;201:14-21. doi: 10.1016/j.jconrel.2015.01.011. Epub 2015 Jan 13.

PMID:
25592386
20.

Preparation of a cross-linked porous protein crystal containing Ru carbonyl complexes as a CO-releasing extracellular scaffold.

Tabe H, Fujita K, Abe S, Tsujimoto M, Kuchimaru T, Kizaka-Kondoh S, Takano M, Kitagawa S, Ueno T.

Inorg Chem. 2015 Jan 5;54(1):215-20. doi: 10.1021/ic502159x. Epub 2014 Dec 15.

PMID:
25494847
21.

Intracellular CO release from composite of ferritin and ruthenium carbonyl complexes.

Fujita K, Tanaka Y, Sho T, Ozeki S, Abe S, Hikage T, Kuchimaru T, Kizaka-Kondoh S, Ueno T.

J Am Chem Soc. 2014 Dec 3;136(48):16902-8. doi: 10.1021/ja508938f. Epub 2014 Nov 19.

PMID:
25352251
22.

A fluorescent protein scaffold for presenting structurally constrained peptides provides an effective screening system to identify high affinity target-binding peptides.

Kadonosono T, Yabe E, Furuta T, Yamano A, Tsubaki T, Sekine T, Kuchimaru T, Sakurai M, Kizaka-Kondoh S.

PLoS One. 2014 Aug 1;9(8):e103397. doi: 10.1371/journal.pone.0103397. eCollection 2014.

23.

Bone resorption facilitates osteoblastic bone metastatic colonization by cooperation of insulin-like growth factor and hypoxia.

Kuchimaru T, Hoshino T, Aikawa T, Yasuda H, Kobayashi T, Kadonosono T, Kizaka-Kondoh S.

Cancer Sci. 2014 May;105(5):553-9. doi: 10.1111/cas.12391. Epub 2014 Apr 3.

24.

Development of a novel interferon-α2b gene construct with a repetitive hypoxia-inducible factor binding site and its suppressive effects on human renal cell carcinoma cell lines in vitro.

Fukui N, Kageyama Y, Higashi Y, Kihara K, Kizaka-Kondoh S, Hiraoka M, Shinojima T, Suzuki K, Oya M.

Int J Clin Oncol. 2014;19(3):497-504. doi: 10.1007/s10147-013-0568-z. Epub 2013 Jun 6.

PMID:
23739923
25.

Development of an oxygen-sensitive degradable peptide probe for the imaging of hypoxia-inducible factor-1-active regions in tumors.

Ueda M, Ogawa K, Miyano A, Ono M, Kizaka-Kondoh S, Saji H.

Mol Imaging Biol. 2013 Dec;15(6):713-21. doi: 10.1007/s11307-013-0647-6.

PMID:
23689986
26.

A hypoxia-inducible factor (HIF)-3α splicing variant, HIF-3α4 impairs angiogenesis in hypervascular malignant meningiomas with epigenetically silenced HIF-3α4.

Ando H, Natsume A, Iwami K, Ohka F, Kuchimaru T, Kizaka-Kondoh S, Ito K, Saito K, Sugita S, Hoshino T, Wakabayashi T.

Biochem Biophys Res Commun. 2013 Mar 29;433(1):139-44. doi: 10.1016/j.bbrc.2013.02.044. Epub 2013 Feb 26.

PMID:
23485455
27.

Radiosynthesis and initial evaluation of (18)F labeled nanocarrier composed of poly(L-lactic acid)-block-poly(sarcosine) amphiphilic polydepsipeptide.

Yamamoto F, Yamahara R, Makino A, Kurihara K, Tsukada H, Hara E, Hara I, Kizaka-Kondoh S, Ohkubo Y, Ozeki E, Kimura S.

Nucl Med Biol. 2013 Apr;40(3):387-94. doi: 10.1016/j.nucmedbio.2012.12.008. Epub 2013 Jan 22.

PMID:
23347829
28.

In vivo imaging of brain ischemia using an oxygen-dependent degradative fusion protein probe.

Fujita Y, Kuchimaru T, Kadonosono T, Tanaka S, Hase Y, Tomimoto H, Hiraoka M, Kizaka-Kondoh S, Ihara M, Takahashi R.

PLoS One. 2012;7(10):e48051. doi: 10.1371/journal.pone.0048051. Epub 2012 Oct 19.

29.

The protective role of the transmembrane thioredoxin-related protein TMX in inflammatory liver injury.

Matsuo Y, Irie K, Kiyonari H, Okuyama H, Nakamura H, Son A, Lopez-Ramos DA, Tian H, Oka S, Okawa K, Kizaka-Kondoh S, Masutani H, Yodoi J.

Antioxid Redox Signal. 2013 Apr 10;18(11):1263-72. doi: 10.1089/ars.2011.4430. Epub 2012 Oct 25.

30.

In vivo visualization of heterogeneous intratumoral distribution of hypoxia-inducible factor-1α activity by the fusion of high-resolution SPECT and morphological imaging tests.

Fujii H, Yamaguchi M, Inoue K, Mutou Y, Ueda M, Saji H, Kizaka-Kondoh S, Moriyama N, Umeda IO.

J Biomed Biotechnol. 2012;2012:262741. doi: 10.1155/2012/262741. Epub 2012 Jun 12.

31.

MT1-MMP plays a critical role in hematopoiesis by regulating HIF-mediated chemokine/cytokine gene transcription within niche cells.

Nishida C, Kusubata K, Tashiro Y, Gritli I, Sato A, Ohki-Koizumi M, Morita Y, Nagano M, Sakamoto T, Koshikawa N, Kuchimaru T, Kizaka-Kondoh S, Seiki M, Nakauchi H, Heissig B, Hattori K.

Blood. 2012 Jun 7;119(23):5405-16. doi: 10.1182/blood-2011-11-390849. Epub 2012 Apr 27.

PMID:
22544701
32.

Development of a hypoxia-selective near-infrared fluorescent probe for non-invasive tumor imaging.

Youssif BG, Okuda K, Kadonosono T, Salem OI, Hayallah AA, Hussein MA, Kizaka-Kondoh S, Nagasawa H.

Chem Pharm Bull (Tokyo). 2012;60(3):402-7.

33.

2-Nitroimidazole-tricarbocyanine conjugate as a near-infrared fluorescent probe for in vivo imaging of tumor hypoxia.

Okuda K, Okabe Y, Kadonosono T, Ueno T, Youssif BG, Kizaka-Kondoh S, Nagasawa H.

Bioconjug Chem. 2012 Mar 21;23(3):324-9. doi: 10.1021/bc2004704. Epub 2012 Feb 22.

PMID:
22335430
34.

Detection of the onset of ischemia and carcinogenesis by hypoxia-inducible transcription factor-based in vivo bioluminescence imaging.

Kadonosono T, Kuchimaru T, Yamada S, Takahashi Y, Murakami A, Tani T, Watanabe H, Tanaka T, Hirota K, Inoue M, Tsukamoto T, Toyoda T, Urano K, Machida K, Eto T, Ogura T, Tsutsumi H, Ito M, Hiraoka M, Kondoh G, Kizaka-Kondoh S.

PLoS One. 2011;6(11):e26640. doi: 10.1371/journal.pone.0026640. Epub 2011 Nov 10.

35.

Evaluation of [125I]IPOS as a molecular imaging probe for hypoxia-inducible factor-1-active regions in a tumor: comparison among single-photon emission computed tomography/X-ray computed tomography imaging, autoradiography, and immunohistochemistry.

Ueda M, Kudo T, Mutou Y, Umeda IO, Miyano A, Ogawa K, Ono M, Fujii H, Kizaka-Kondoh S, Hiraoka M, Saji H.

Cancer Sci. 2011 Nov;102(11):2090-6. doi: 10.1111/j.1349-7006.2011.02057.x. Epub 2011 Sep 15.

36.
37.

In vivo imaging of HIF-active tumors by an oxygen-dependent degradation protein probe with an interchangeable labeling system.

Kuchimaru T, Kadonosono T, Tanaka S, Ushiki T, Hiraoka M, Kizaka-Kondoh S.

PLoS One. 2010 Dec 23;5(12):e15736. doi: 10.1371/journal.pone.0015736.

38.

Early protective effect of bone marrow mononuclear cells against ischemic white matter damage through augmentation of cerebral blood flow.

Fujita Y, Ihara M, Ushiki T, Hirai H, Kizaka-Kondoh S, Hiraoka M, Ito H, Takahashi R.

Stroke. 2010 Dec;41(12):2938-43. doi: 10.1161/STROKEAHA.110.596379. Epub 2010 Oct 14.

PMID:
20947840
39.

PET imaging of hypoxia-inducible factor-1-active tumor cells with pretargeted oxygen-dependent degradable streptavidin and a novel 18F-labeled biotin derivative.

Kudo T, Ueda M, Konishi H, Kawashima H, Kuge Y, Mukai T, Miyano A, Tanaka S, Kizaka-Kondoh S, Hiraoka M, Saji H.

Mol Imaging Biol. 2011 Oct;13(5):1003-10. doi: 10.1007/s11307-010-0418-6.

PMID:
20838908
40.

Inactivation of chemokine (C-C motif) receptor 1 (CCR1) suppresses colon cancer liver metastasis by blocking accumulation of immature myeloid cells in a mouse model.

Kitamura T, Fujishita T, Loetscher P, Revesz L, Hashida H, Kizaka-Kondoh S, Aoki M, Taketo MM.

Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):13063-8. doi: 10.1073/pnas.1002372107. Epub 2010 Jun 29.

41.

Noninvasive tracking of donor cell homing by near-infrared fluorescence imaging shortly after bone marrow transplantation.

Ushiki T, Kizaka-Kondoh S, Ashihara E, Tanaka S, Masuko M, Hirai H, Kimura S, Aizawa Y, Maekawa T, Hiraoka M.

PLoS One. 2010 Jun 14;5(6):e11114. doi: 10.1371/journal.pone.0011114.

42.

Rapid detection of hypoxia-inducible factor-1-active tumours: pretargeted imaging with a protein degrading in a mechanism similar to hypoxia-inducible factor-1alpha.

Ueda M, Kudo T, Kuge Y, Mukai T, Tanaka S, Konishi H, Miyano A, Ono M, Kizaka-Kondoh S, Hiraoka M, Saji H.

Eur J Nucl Med Mol Imaging. 2010 Aug;37(8):1566-74. doi: 10.1007/s00259-010-1467-4. Epub 2010 Apr 29.

PMID:
20428865
43.

Functional molecular imaging of ILK-mediated Akt/PKB signaling cascades and the associated role of beta-parvin.

Kimura M, Murakami T, Kizaka-Kondoh S, Itoh M, Yamamoto K, Hojo Y, Takano M, Kario K, Shimada K, Kobayashi E.

J Cell Sci. 2010 Mar 1;123(Pt 5):747-55. doi: 10.1242/jcs.052498.

44.

Persisting mild hypothermia suppresses hypoxia-inducible factor-1alpha protein synthesis and hypoxia-inducible factor-1-mediated gene expression.

Tanaka T, Wakamatsu T, Daijo H, Oda S, Kai S, Adachi T, Kizaka-Kondoh S, Fukuda K, Hirota K.

Am J Physiol Regul Integr Comp Physiol. 2010 Mar;298(3):R661-71. doi: 10.1152/ajpregu.00732.2009. Epub 2009 Dec 30.

45.
46.

Near-infrared fluorescence tumor imaging using nanocarrier composed of poly(L-lactic acid)-block-poly(sarcosine) amphiphilic polydepsipeptide.

Makino A, Kizaka-Kondoh S, Yamahara R, Hara I, Kanzaki T, Ozeki E, Hiraoka M, Kimura S.

Biomaterials. 2009 Oct;30(28):5156-60. doi: 10.1016/j.biomaterials.2009.05.046. Epub 2009 Jun 13.

PMID:
19525007
47.

Imaging and Targeting of the Hypoxia-inducible Factor 1-active Microenvironment.

Kizaka-Kondoh S, Tanaka S, Hiraoka M.

J Toxicol Pathol. 2009 Jun;22(2):93-100. doi: 10.1293/tox.22.93. Epub 2009 Jul 7.

48.

Enhanced percolation and gene expression in tumor hypoxia by PEGylated polyplex micelles.

Han M, Oba M, Nishiyama N, Kano MR, Kizaka-Kondoh S, Kataoka K.

Mol Ther. 2009 Aug;17(8):1404-10. doi: 10.1038/mt.2009.119. Epub 2009 May 26.

49.

Significance of nitroimidazole compounds and hypoxia-inducible factor-1 for imaging tumor hypoxia.

Kizaka-Kondoh S, Konse-Nagasawa H.

Cancer Sci. 2009 Aug;100(8):1366-73. doi: 10.1111/j.1349-7006.2009.01195.x. Epub 2009 May 14. Review.

50.

Imaging of HIF-1-active tumor hypoxia using a protein effectively delivered to and specifically stabilized in HIF-1-active tumor cells.

Kudo T, Ueda M, Kuge Y, Mukai T, Tanaka S, Masutani M, Kiyono Y, Kizaka-Kondoh S, Hiraoka M, Saji H.

J Nucl Med. 2009 Jun;50(6):942-9. doi: 10.2967/jnumed.108.061119. Epub 2009 May 14.

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