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Items: 1 to 50 of 534

1.

[MUCOSAL MULTI-ECOSYSTEM FOR THE PREVENTION AND TREATMENT OF MUCOSAL DISORDERS].

Tokuhara D, Kiyono H.

Arerugi. 2019;68(6):675-680. doi: 10.15036/arerugi.68.675. Japanese. No abstract available.

PMID:
31308333
2.

Intrinsic Control of Surface Immune and Epithelial Homeostasis by Tissue-Resident Gut Stromal Cells.

Kurashima Y, Tokuhara D, Kamioka M, Inagaki Y, Kiyono H.

Front Immunol. 2019 Jun 19;10:1281. doi: 10.3389/fimmu.2019.01281. eCollection 2019. Review.

3.

Fucosyltransferase 2 induces lung epithelial fucosylation and exacerbates house dust mite-induced airway inflammation.

Saku A, Hirose K, Ito T, Iwata A, Sato T, Kaji H, Tamachi T, Suto A, Goto Y, Domino SE, Narimatsu H, Kiyono H, Nakajima H.

J Allergy Clin Immunol. 2019 May 21. pii: S0091-6749(19)30628-1. doi: 10.1016/j.jaci.2019.05.010. [Epub ahead of print]

PMID:
31125592
4.

Fatty acid metabolism in the host and commensal bacteria for the control of intestinal immune responses and diseases.

Hosomi K, Kiyono H, Kunisawa J.

Gut Microbes. 2019 May 23:1-9. doi: 10.1080/19490976.2019.1612662. [Epub ahead of print]

PMID:
31120334
5.

Distinct Roles for Peyer's Patch B Cells for Induction of Antigen-specific IgA Antibody Responses in Mice Administered Oral Recombinant Salmonella.

Hashizume-Takizawa T, Shibata N, Kurashima Y, Kiyono H, Kurita-Ochiai T, Fujihashi K.

Int Immunol. 2019 Mar 14. pii: dxz029. doi: 10.1093/intimm/dxz029. [Epub ahead of print]

PMID:
30868152
6.

Dietary coconut oil ameliorates skin contact hypersensitivity through mead acid production in mice.

Tiwari P, Nagatake T, Hirata SI, Sawane K, Saika A, Shibata Y, Morimoto S, Honda T, Adachi J, Abe Y, Isoyama J, Tomonaga T, Kiyono H, Kabashima K, Kunisawa J.

Allergy. 2019 Mar 6. doi: 10.1111/all.13762. [Epub ahead of print]

PMID:
30843234
7.

New trends in mucosal immunology and allergy.

Kiyono H, Izuhara K.

Allergol Int. 2019 Jan;68(1):1-3. doi: 10.1016/j.alit.2018.12.002. No abstract available.

8.

Human Norovirus Propagation in Human Induced Pluripotent Stem Cell-Derived Intestinal Epithelial Cells.

Sato S, Hisaie K, Kurokawa S, Suzuki A, Sakon N, Uchida Y, Yuki Y, Kiyono H.

Cell Mol Gastroenterol Hepatol. 2019;7(3):686-688.e5. doi: 10.1016/j.jcmgh.2018.11.001. Epub 2018 Dec 10. No abstract available.

9.

A comprehensive understanding of the gut mucosal immune system in allergic inflammation.

Tokuhara D, Kurashima Y, Kamioka M, Nakayama T, Ernst P, Kiyono H.

Allergol Int. 2019 Jan;68(1):17-25. doi: 10.1016/j.alit.2018.09.004. Epub 2018 Oct 23. Review.

10.

Polymeric Caffeic Acid Is a Safer Mucosal Adjuvant That Augments Antigen-Specific Mucosal and Systemic Immune Responses in Mice.

Tada R, Yamanaka D, Ogasawara M, Saito M, Ohno N, Kiyono H, Kunisawa J, Aramaki Y.

Mol Pharm. 2018 Sep 4;15(9):4226-4234. doi: 10.1021/acs.molpharmaceut.8b00648. Epub 2018 Aug 24.

PMID:
30107747
11.

ATP as a Pathophysiologic Mediator of Bacteria-Host Crosstalk in the Gastrointestinal Tract.

Inami A, Kiyono H, Kurashima Y.

Int J Mol Sci. 2018 Aug 12;19(8). pii: E2371. doi: 10.3390/ijms19082371. Review.

12.
13.

Nasal vaccination with pneumococcal surface protein A in combination with cationic liposomes consisting of DOTAP and DC-chol confers antigen-mediated protective immunity against Streptococcus pneumoniae infections in mice.

Tada R, Suzuki H, Takahashi S, Negishi Y, Kiyono H, Kunisawa J, Aramaki Y.

Int Immunopharmacol. 2018 Aug;61:385-393. doi: 10.1016/j.intimp.2018.06.027. Epub 2018 Jun 23.

PMID:
29945026
14.

Cationic pullulan nanogel as a safe and effective nasal vaccine delivery system for respiratory infectious diseases.

Nakahashi-Ouchida R, Yuki Y, Kiyono H.

Hum Vaccin Immunother. 2018;14(9):2189-2193. doi: 10.1080/21645515.2018.1461298. Epub 2018 Jul 19. Review.

15.

Generation of tumor antigen-specific murine CD8+ T cells with enhanced anti-tumor activity via highly efficient CRISPR/Cas9 genome editing.

Ouchi Y, Patil A, Tamura Y, Nishimasu H, Negishi A, Paul SK, Takemura N, Satoh T, Kimura Y, Kurachi M, Nureki O, Nakai K, Kiyono H, Uematsu S.

Int Immunol. 2018 Apr 3;30(4):141-154. doi: 10.1093/intimm/dxy006.

PMID:
29617862
16.

Eosinophil depletion suppresses radiation-induced small intestinal fibrosis.

Takemura N, Kurashima Y, Mori Y, Okada K, Ogino T, Osawa H, Matsuno H, Aayam L, Kaneto S, Park EJ, Sato S, Matsunaga K, Tamura Y, Ouchi Y, Kumagai Y, Kobayashi D, Suzuki Y, Yoshioka Y, Nishimura J, Mori M, Ishii KJ, Rothenberg ME, Kiyono H, Akira S, Uematsu S.

Sci Transl Med. 2018 Feb 21;10(429). pii: eaan0333. doi: 10.1126/scitranslmed.aan0333.

PMID:
29467297
17.

Characterization of morphological conversion of Helicobacter pylori under anaerobic conditions.

Hirukawa S, Sagara H, Kaneto S, Kondo T, Kiga K, Sanada T, Kiyono H, Mimuro H.

Microbiol Immunol. 2018 Apr;62(4):221-228. doi: 10.1111/1348-0421.12582.

PMID:
29446491
18.

Impaired airway mucociliary function reduces antigen-specific IgA immune response to immunization with a claudin-4-targeting nasal vaccine in mice.

Suzuki H, Nagatake T, Nasu A, Lan H, Ikegami K, Setou M, Hamazaki Y, Kiyono H, Yagi K, Kondoh M, Kunisawa J.

Sci Rep. 2018 Feb 13;8(1):2904. doi: 10.1038/s41598-018-21120-7.

19.

Lymphoid tissue-resident Alcaligenes LPS induces IgA production without excessive inflammatory responses via weak TLR4 agonist activity.

Shibata N, Kunisawa J, Hosomi K, Fujimoto Y, Mizote K, Kitayama N, Shimoyama A, Mimuro H, Sato S, Kishishita N, Ishii KJ, Fukase K, Kiyono H.

Mucosal Immunol. 2018 May;11(3):693-702. doi: 10.1038/mi.2017.103. Epub 2018 Feb 7.

PMID:
29411777
20.

Development of immune and microbial environments is independently regulated in the mammary gland.

Niimi K, Usami K, Fujita Y, Abe M, Furukawa M, Suyama Y, Sakai Y, Kamioka M, Shibata N, Park EJ, Sato S, Kiyono H, Yoneyama H, Kitazawa H, Watanabe K, Nochi T, Aso H.

Mucosal Immunol. 2018 May;11(3):643-653. doi: 10.1038/mi.2017.90. Epub 2017 Dec 20.

PMID:
29346344
21.

Mucosal Mesenchymal Cells: Secondary Barrier and Peripheral Educator for the Gut Immune System.

Kurashima Y, Yamamoto D, Nelson S, Uematsu S, Ernst PB, Nakayama T, Kiyono H.

Front Immunol. 2017 Dec 13;8:1787. doi: 10.3389/fimmu.2017.01787. eCollection 2017. Review.

22.

The 17,18-epoxyeicosatetraenoic acid-G protein-coupled receptor 40 axis ameliorates contact hypersensitivity by inhibiting neutrophil mobility in mice and cynomolgus macaques.

Nagatake T, Shiogama Y, Inoue A, Kikuta J, Honda T, Tiwari P, Kishi T, Yanagisawa A, Isobe Y, Matsumoto N, Shimojou M, Morimoto S, Suzuki H, Hirata SI, Steneberg P, Edlund H, Aoki J, Arita M, Kiyono H, Yasutomi Y, Ishii M, Kabashima K, Kunisawa J.

J Allergy Clin Immunol. 2018 Aug;142(2):470-484.e12. doi: 10.1016/j.jaci.2017.09.053. Epub 2017 Dec 27.

23.

A Refined Culture System for Human Induced Pluripotent Stem Cell-Derived Intestinal Epithelial Organoids.

Takahashi Y, Sato S, Kurashima Y, Yamamoto T, Kurokawa S, Yuki Y, Takemura N, Uematsu S, Lai CY, Otsu M, Matsuno H, Osawa H, Mizushima T, Nishimura J, Hayashi M, Yamaguchi T, Kiyono H.

Stem Cell Reports. 2018 Jan 9;10(1):314-328. doi: 10.1016/j.stemcr.2017.11.004. Epub 2017 Dec 7.

24.

Dietary and Microbial Metabolites in the Regulation of Host Immunity.

Shibata N, Kunisawa J, Kiyono H.

Front Microbiol. 2017 Nov 7;8:2171. doi: 10.3389/fmicb.2017.02171. eCollection 2017. Review.

25.

Nanogel-based nasal vaccines for infectious and lifestyle-related diseases.

Azegami T, Yuki Y, Nakahashi R, Itoh H, Kiyono H.

Mol Immunol. 2018 Jun;98:19-24. doi: 10.1016/j.molimm.2017.10.022. Epub 2017 Oct 31. Review.

PMID:
29096936
26.

Development of a nanogel-based nasal vaccine as a novel antigen delivery system.

Nakahashi-Ouchida R, Yuki Y, Kiyono H.

Expert Rev Vaccines. 2017 Dec;16(12):1231-1240. doi: 10.1080/14760584.2017.1395702. Epub 2017 Oct 27. Review.

PMID:
29053938
27.

Herpes simplex virus-1 evasion of CD8+ T cell accumulation contributes to viral encephalitis.

Koyanagi N, Imai T, Shindo K, Sato A, Fujii W, Ichinohe T, Takemura N, Kakuta S, Uematsu S, Kiyono H, Maruzuru Y, Arii J, Kato A, Kawaguchi Y.

J Clin Invest. 2017 Oct 2;127(10):3784-3795. doi: 10.1172/JCI92931. Epub 2017 Sep 11.

28.

Intranasal vaccination against angiotensin II type 1 receptor and pneumococcal surface protein A attenuates hypertension and pneumococcal infection in rodents.

Azegami T, Yuki Y, Hayashi K, Hishikawa A, Sawada SI, Ishige K, Akiyoshi K, Kiyono H, Itoh H.

J Hypertens. 2018 Feb;36(2):387-394. doi: 10.1097/HJH.0000000000001519.

PMID:
28832363
29.

IL-22 induces Reg3γ and inhibits allergic inflammation in house dust mite-induced asthma models.

Ito T, Hirose K, Saku A, Kono K, Takatori H, Tamachi T, Goto Y, Renauld JC, Kiyono H, Nakajima H.

J Exp Med. 2017 Oct 2;214(10):3037-3050. doi: 10.1084/jem.20162108. Epub 2017 Aug 15.

30.

Reciprocal Inflammatory Signaling Between Intestinal Epithelial Cells and Adipocytes in the Absence of Immune Cells.

Takahashi Y, Sato S, Kurashima Y, Lai CY, Otsu M, Hayashi M, Yamaguchi T, Kiyono H.

EBioMedicine. 2017 Sep;23:34-45. doi: 10.1016/j.ebiom.2017.07.027. Epub 2017 Aug 2.

31.

Seed Metabolome Analysis of a Transgenic Rice Line Expressing Cholera Toxin B-subunit.

Ogawa T, Kashima K, Yuki Y, Mejima M, Kurokawa S, Kuroda M, Okazawa A, Kiyono H, Ohta D.

Sci Rep. 2017 Jul 12;7(1):5196. doi: 10.1038/s41598-017-04701-w.

32.

Microbiota-derived butyrate suppresses group 3 innate lymphoid cells in terminal ileal Peyer's patches.

Kim SH, Cho BH, Kiyono H, Jang YS.

Sci Rep. 2017 Jun 21;7(1):3980. doi: 10.1038/s41598-017-02729-6.

33.

Mast Cells Are Crucial for Induction of Group 2 Innate Lymphoid Cells and Clearance of Helminth Infections.

Shimokawa C, Kanaya T, Hachisuka M, Ishiwata K, Hisaeda H, Kurashima Y, Kiyono H, Yoshimoto T, Kaisho T, Ohno H.

Immunity. 2017 May 16;46(5):863-874.e4. doi: 10.1016/j.immuni.2017.04.017.

34.

IL-22BP dictates characteristics of Peyer's patch follicle-associated epithelium for antigen uptake.

Jinnohara T, Kanaya T, Hase K, Sakakibara S, Kato T, Tachibana N, Sasaki T, Hashimoto Y, Sato T, Watarai H, Kunisawa J, Shibata N, Williams IR, Kiyono H, Ohno H.

J Exp Med. 2017 Jun 5;214(6):1607-1618. doi: 10.1084/jem.20160770. Epub 2017 May 16.

35.

MicroRNA-mediated dynamic control of mucosal immunity.

Park EJ, Shimaoka M, Kiyono H.

Int Immunol. 2017 Apr 1;29(4):157-163. doi: 10.1093/intimm/dxx019. Review.

PMID:
28383678
36.

Critical role of intestinal interleukin-4 modulating regulatory T cells for desensitization, tolerance, and inflammation of food allergy.

Nakajima-Adachi H, Shibahara K, Fujimura Y, Takeyama J, Hiraide E, Kikuchi A, Murakami H, Hosono A, Nochi T, Wakatsuki Y, Shimojo N, Kaminogawa S, Sato R, Kiyono H, Hachimura S.

PLoS One. 2017 Feb 24;12(2):e0172795. doi: 10.1371/journal.pone.0172795. eCollection 2017.

37.

E-NPP3 controls plasmacytoid dendritic cell numbers in the small intestine.

Furuta Y, Tsai SH, Kinoshita M, Fujimoto K, Okumura R, Umemoto E, Kurashima Y, Kiyono H, Kayama H, Takeda K.

PLoS One. 2017 Feb 22;12(2):e0172509. doi: 10.1371/journal.pone.0172509. eCollection 2017.

38.

Allograft inflammatory factor 1 is a regulator of transcytosis in M cells.

Kishikawa S, Sato S, Kaneto S, Uchino S, Kohsaka S, Nakamura S, Kiyono H.

Nat Commun. 2017 Feb 22;8:14509. doi: 10.1038/ncomms14509.

39.

The spleen is the site where mast cells are induced in the development of food allergy.

Toyoshima S, Wakamatsu E, Ishida Y, Obata Y, Kurashima Y, Kiyono H, Abe R.

Int Immunol. 2017 Jan 1;29(1):31-45. doi: 10.1093/intimm/dxx005.

PMID:
28177443
40.

Attachment of class B CpG ODN onto DOTAP/DC-chol liposome in nasal vaccine formulations augments antigen-specific immune responses in mice.

Tada R, Muto S, Iwata T, Hidaka A, Kiyono H, Kunisawa J, Aramaki Y.

BMC Res Notes. 2017 Jan 26;10(1):68. doi: 10.1186/s13104-017-2380-8.

41.

Mucosal Ecological Network of Epithelium and Immune Cells for Gut Homeostasis and Tissue Healing.

Kurashima Y, Kiyono H.

Annu Rev Immunol. 2017 Apr 26;35:119-147. doi: 10.1146/annurev-immunol-051116-052424. Epub 2017 Jan 11. Review.

PMID:
28125357
42.

Nanogel-based nasal ghrelin vaccine prevents obesity.

Azegami T, Yuki Y, Sawada S, Mejima M, Ishige K, Akiyoshi K, Itoh H, Kiyono H.

Mucosal Immunol. 2017 Sep;10(5):1351-1360. doi: 10.1038/mi.2016.137. Epub 2017 Jan 25.

PMID:
28120848
43.

Critical role of TSLP-responsive mucosal dendritic cells in the induction of nasal antigen-specific IgA response.

Joo S, Fukuyama Y, Park EJ, Yuki Y, Kurashima Y, Ouchida R, Ziegler SF, Kiyono H.

Mucosal Immunol. 2017 Jul;10(4):901-911. doi: 10.1038/mi.2016.103. Epub 2016 Dec 7.

PMID:
27924821
44.

Epithelial extracellular ATP: an initiator of immunity to parasitic infections.

Nelson S, Kiyono H, Kurashima Y.

Immunol Cell Biol. 2017 Feb;95(2):117-118. doi: 10.1038/icb.2016.106. Epub 2016 Nov 22. No abstract available.

PMID:
27874014
45.

Epithelial glycosylation in gut homeostasis and inflammation.

Goto Y, Uematsu S, Kiyono H.

Nat Immunol. 2016 Oct 19;17(11):1244-1251. doi: 10.1038/ni.3587. Review.

PMID:
27760104
46.

[MAST CELL MEDIATED HOMEOSTATIC AND BARRIER SYSTEM].

Kogure Y, Kurashima Y, Kiyono H.

Arerugi. 2016 Mar;65(2):104-12. doi: 10.15036/arerugi.65.104. Review. Japanese. No abstract available.

PMID:
27086955
47.

Lymphoid-Tissue-Resident Commensal Bacteria Promote Members of the IL-10 Cytokine Family to Establish Mutualism.

Fung TC, Bessman NJ, Hepworth MR, Kumar N, Shibata N, Kobuley D, Wang K, Ziegler CGK, Goc J, Shima T, Umesaki Y, Sartor RB, Sullivan KV, Lawley TD, Kunisawa J, Kiyono H, Sonnenberg GF.

Immunity. 2016 Mar 15;44(3):634-646. doi: 10.1016/j.immuni.2016.02.019.

48.

MicroRNA-orchestrated pathophysiologic control in gut homeostasis and inflammation.

Lee J, Park EJ, Kiyono H.

BMB Rep. 2016 May;49(5):263-9. Review.

49.

Sphingolipids and Epoxidized Lipid Metabolites in the Control of Gut Immunosurveillance and Allergy.

Kunisawa J, Kiyono H.

Front Nutr. 2016 Jan 27;3:3. doi: 10.3389/fnut.2016.00003. eCollection 2016. Review.

50.

Differential analyses of major allergen proteins in wild-type rice and rice producing a fragment of anti-rotavirus antibody.

Yuki Y, Kurokawa S, Kozuka-Hata H, Tokuhara D, Mejima M, Kuroda M, Oyama M, Nishimaki-Mogami T, Teshima R, Kiyono H.

Regul Toxicol Pharmacol. 2016 Apr;76:128-36. doi: 10.1016/j.yrtph.2016.01.023. Epub 2016 Feb 3.

PMID:
26851506

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