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Items: 1 to 50 of 539

1.

A role for the CCR5-CCL5 interaction in the preferential migration of HSV-2-specific effector cells to the vaginal mucosa upon nasal immunization.

Joo S, Suwanto A, Sato A, Nakahashi-Ouchida R, Mori H, Uchida Y, Sato S, Kurashima Y, Yuki Y, Fujihashi K, Kawaguchi Y, Kiyono H.

Mucosal Immunol. 2019 Sep 24. doi: 10.1038/s41385-019-0203-z. [Epub ahead of print]

PMID:
31551493
2.

[THE MUCOSAL IMMUNE SYSTEM LEADS TO THE DEVELOPMENT OF NOVEL STRATEGY FOR THE PREVENTION AND TREATMENT OF INFLAMMATORY AND ALLERGIC DISEASES].

Yoshihara S, Kiyono H.

Arerugi. 2019;68(8):933-941. doi: 10.15036/arerugi.68.933. Japanese. No abstract available.

3.

Intestinal Permeability and IgA Provoke Immune Vasculitis Linked to Cardiovascular Inflammation.

Noval Rivas M, Wakita D, Franklin MK, Carvalho TT, Abolhesn A, Gomez AC, Fishbein MC, Chen S, Lehman TJ, Sato K, Shibuya A, Fasano A, Kiyono H, Abe M, Tatsumoto N, Yamashita M, Crother TR, Shimada K, Arditi M.

Immunity. 2019 Sep 17;51(3):508-521.e6. doi: 10.1016/j.immuni.2019.05.021. Epub 2019 Aug 27.

PMID:
31471109
4.

Antigen-specific Mucosal Immunity Regulates Development of Intestinal Bacteria-mediated Diseases.

Fujimoto K, Kawaguchi Y, Shimohigoshi M, Gotoh Y, Nakano Y, Usui Y, Hayashi T, Kimura Y, Uematsu M, Yamamoto T, Akeda Y, Rhee JH, Yuki Y, Ishii KJ, Crowe SE, Ernst PB, Kiyono H, Uematsu S.

Gastroenterology. 2019 Aug 21. pii: S0016-5085(19)41241-9. doi: 10.1053/j.gastro.2019.08.021. [Epub ahead of print]

PMID:
31445037
5.

Mast cells play role in wound healing through the ZnT2/GPR39/IL-6 axis.

Nishida K, Hasegawa A, Yamasaki S, Uchida R, Ohashi W, Kurashima Y, Kunisawa J, Kimura S, Iwanaga T, Watarai H, Hase K, Ogura H, Nakayama M, Kashiwakura JI, Okayama Y, Kubo M, Ohara O, Kiyono H, Koseki H, Murakami M, Hirano T.

Sci Rep. 2019 Jul 25;9(1):10842. doi: 10.1038/s41598-019-47132-5.

6.

[MUCOSAL MULTI-ECOSYSTEM FOR THE PREVENTION AND TREATMENT OF MUCOSAL DISORDERS].

Tokuhara D, Kiyono H.

Arerugi. 2019;68(6):675-680. doi: 10.15036/arerugi.68.675. Japanese. No abstract available.

PMID:
31308333
7.

Intrinsic Control of Surface Immune and Epithelial Homeostasis by Tissue-Resident Gut Stromal Cells.

Kurashima Y, Tokuhara D, Kamioka M, Inagaki Y, Kiyono H.

Front Immunol. 2019 Jun 19;10:1281. doi: 10.3389/fimmu.2019.01281. eCollection 2019. Review.

8.

Fucosyltransferase 2 induces lung epithelial fucosylation and exacerbates house dust mite-induced airway inflammation.

Saku A, Hirose K, Ito T, Iwata A, Sato T, Kaji H, Tamachi T, Suto A, Goto Y, Domino SE, Narimatsu H, Kiyono H, Nakajima H.

J Allergy Clin Immunol. 2019 Sep;144(3):698-709.e9. doi: 10.1016/j.jaci.2019.05.010. Epub 2019 May 21.

PMID:
31125592
9.

Fatty acid metabolism in the host and commensal bacteria for the control of intestinal immune responses and diseases.

Hosomi K, Kiyono H, Kunisawa J.

Gut Microbes. 2019 May 23:1-9. doi: 10.1080/19490976.2019.1612662. [Epub ahead of print]

PMID:
31120334
10.

Distinct roles for Peyer's patch B cells for induction of antigen-specific IgA antibody responses in mice administered oral recombinant Salmonella.

Hashizume-Takizawa T, Shibata N, Kurashima Y, Kiyono H, Kurita-Ochiai T, Fujihashi K.

Int Immunol. 2019 Jul 30;31(8):531-541. doi: 10.1093/intimm/dxz029.

PMID:
30868152
11.

Dietary coconut oil ameliorates skin contact hypersensitivity through mead acid production in mice.

Tiwari P, Nagatake T, Hirata SI, Sawane K, Saika A, Shibata Y, Morimoto S, Honda T, Adachi J, Abe Y, Isoyama J, Tomonaga T, Kiyono H, Kabashima K, Kunisawa J.

Allergy. 2019 Aug;74(8):1522-1532. doi: 10.1111/all.13762. Epub 2019 Apr 10.

PMID:
30843234
12.

New trends in mucosal immunology and allergy.

Kiyono H, Izuhara K.

Allergol Int. 2019 Jan;68(1):1-3. doi: 10.1016/j.alit.2018.12.002. No abstract available.

13.

Human Norovirus Propagation in Human Induced Pluripotent Stem Cell-Derived Intestinal Epithelial Cells.

Sato S, Hisaie K, Kurokawa S, Suzuki A, Sakon N, Uchida Y, Yuki Y, Kiyono H.

Cell Mol Gastroenterol Hepatol. 2019;7(3):686-688.e5. doi: 10.1016/j.jcmgh.2018.11.001. Epub 2018 Dec 10. No abstract available.

14.

A comprehensive understanding of the gut mucosal immune system in allergic inflammation.

Tokuhara D, Kurashima Y, Kamioka M, Nakayama T, Ernst P, Kiyono H.

Allergol Int. 2019 Jan;68(1):17-25. doi: 10.1016/j.alit.2018.09.004. Epub 2018 Oct 23. Review.

15.

Polymeric Caffeic Acid Is a Safer Mucosal Adjuvant That Augments Antigen-Specific Mucosal and Systemic Immune Responses in Mice.

Tada R, Yamanaka D, Ogasawara M, Saito M, Ohno N, Kiyono H, Kunisawa J, Aramaki Y.

Mol Pharm. 2018 Sep 4;15(9):4226-4234. doi: 10.1021/acs.molpharmaceut.8b00648. Epub 2018 Aug 24.

PMID:
30107747
16.

ATP as a Pathophysiologic Mediator of Bacteria-Host Crosstalk in the Gastrointestinal Tract.

Inami A, Kiyono H, Kurashima Y.

Int J Mol Sci. 2018 Aug 12;19(8). pii: E2371. doi: 10.3390/ijms19082371. Review.

17.
18.

Nasal vaccination with pneumococcal surface protein A in combination with cationic liposomes consisting of DOTAP and DC-chol confers antigen-mediated protective immunity against Streptococcus pneumoniae infections in mice.

Tada R, Suzuki H, Takahashi S, Negishi Y, Kiyono H, Kunisawa J, Aramaki Y.

Int Immunopharmacol. 2018 Aug;61:385-393. doi: 10.1016/j.intimp.2018.06.027. Epub 2018 Jun 23.

PMID:
29945026
19.

Cationic pullulan nanogel as a safe and effective nasal vaccine delivery system for respiratory infectious diseases.

Nakahashi-Ouchida R, Yuki Y, Kiyono H.

Hum Vaccin Immunother. 2018;14(9):2189-2193. doi: 10.1080/21645515.2018.1461298. Epub 2018 Jul 19. Review.

20.

Generation of tumor antigen-specific murine CD8+ T cells with enhanced anti-tumor activity via highly efficient CRISPR/Cas9 genome editing.

Ouchi Y, Patil A, Tamura Y, Nishimasu H, Negishi A, Paul SK, Takemura N, Satoh T, Kimura Y, Kurachi M, Nureki O, Nakai K, Kiyono H, Uematsu S.

Int Immunol. 2018 Apr 3;30(4):141-154. doi: 10.1093/intimm/dxy006.

PMID:
29617862
21.

Eosinophil depletion suppresses radiation-induced small intestinal fibrosis.

Takemura N, Kurashima Y, Mori Y, Okada K, Ogino T, Osawa H, Matsuno H, Aayam L, Kaneto S, Park EJ, Sato S, Matsunaga K, Tamura Y, Ouchi Y, Kumagai Y, Kobayashi D, Suzuki Y, Yoshioka Y, Nishimura J, Mori M, Ishii KJ, Rothenberg ME, Kiyono H, Akira S, Uematsu S.

Sci Transl Med. 2018 Feb 21;10(429). pii: eaan0333. doi: 10.1126/scitranslmed.aan0333.

PMID:
29467297
22.

Characterization of morphological conversion of Helicobacter pylori under anaerobic conditions.

Hirukawa S, Sagara H, Kaneto S, Kondo T, Kiga K, Sanada T, Kiyono H, Mimuro H.

Microbiol Immunol. 2018 Apr;62(4):221-228. doi: 10.1111/1348-0421.12582.

PMID:
29446491
23.

Impaired airway mucociliary function reduces antigen-specific IgA immune response to immunization with a claudin-4-targeting nasal vaccine in mice.

Suzuki H, Nagatake T, Nasu A, Lan H, Ikegami K, Setou M, Hamazaki Y, Kiyono H, Yagi K, Kondoh M, Kunisawa J.

Sci Rep. 2018 Feb 13;8(1):2904. doi: 10.1038/s41598-018-21120-7.

24.

Lymphoid tissue-resident Alcaligenes LPS induces IgA production without excessive inflammatory responses via weak TLR4 agonist activity.

Shibata N, Kunisawa J, Hosomi K, Fujimoto Y, Mizote K, Kitayama N, Shimoyama A, Mimuro H, Sato S, Kishishita N, Ishii KJ, Fukase K, Kiyono H.

Mucosal Immunol. 2018 May;11(3):693-702. doi: 10.1038/mi.2017.103. Epub 2018 Feb 7.

PMID:
29411777
25.

Development of immune and microbial environments is independently regulated in the mammary gland.

Niimi K, Usami K, Fujita Y, Abe M, Furukawa M, Suyama Y, Sakai Y, Kamioka M, Shibata N, Park EJ, Sato S, Kiyono H, Yoneyama H, Kitazawa H, Watanabe K, Nochi T, Aso H.

Mucosal Immunol. 2018 May;11(3):643-653. doi: 10.1038/mi.2017.90. Epub 2017 Dec 20.

PMID:
29346344
26.

Mucosal Mesenchymal Cells: Secondary Barrier and Peripheral Educator for the Gut Immune System.

Kurashima Y, Yamamoto D, Nelson S, Uematsu S, Ernst PB, Nakayama T, Kiyono H.

Front Immunol. 2017 Dec 13;8:1787. doi: 10.3389/fimmu.2017.01787. eCollection 2017. Review.

27.

The 17,18-epoxyeicosatetraenoic acid-G protein-coupled receptor 40 axis ameliorates contact hypersensitivity by inhibiting neutrophil mobility in mice and cynomolgus macaques.

Nagatake T, Shiogama Y, Inoue A, Kikuta J, Honda T, Tiwari P, Kishi T, Yanagisawa A, Isobe Y, Matsumoto N, Shimojou M, Morimoto S, Suzuki H, Hirata SI, Steneberg P, Edlund H, Aoki J, Arita M, Kiyono H, Yasutomi Y, Ishii M, Kabashima K, Kunisawa J.

J Allergy Clin Immunol. 2018 Aug;142(2):470-484.e12. doi: 10.1016/j.jaci.2017.09.053. Epub 2017 Dec 27.

28.

A Refined Culture System for Human Induced Pluripotent Stem Cell-Derived Intestinal Epithelial Organoids.

Takahashi Y, Sato S, Kurashima Y, Yamamoto T, Kurokawa S, Yuki Y, Takemura N, Uematsu S, Lai CY, Otsu M, Matsuno H, Osawa H, Mizushima T, Nishimura J, Hayashi M, Yamaguchi T, Kiyono H.

Stem Cell Reports. 2018 Jan 9;10(1):314-328. doi: 10.1016/j.stemcr.2017.11.004. Epub 2017 Dec 7.

29.

Dietary and Microbial Metabolites in the Regulation of Host Immunity.

Shibata N, Kunisawa J, Kiyono H.

Front Microbiol. 2017 Nov 7;8:2171. doi: 10.3389/fmicb.2017.02171. eCollection 2017. Review.

30.

Nanogel-based nasal vaccines for infectious and lifestyle-related diseases.

Azegami T, Yuki Y, Nakahashi R, Itoh H, Kiyono H.

Mol Immunol. 2018 Jun;98:19-24. doi: 10.1016/j.molimm.2017.10.022. Epub 2017 Oct 31. Review.

PMID:
29096936
31.

Development of a nanogel-based nasal vaccine as a novel antigen delivery system.

Nakahashi-Ouchida R, Yuki Y, Kiyono H.

Expert Rev Vaccines. 2017 Dec;16(12):1231-1240. doi: 10.1080/14760584.2017.1395702. Epub 2017 Oct 27. Review.

PMID:
29053938
32.

Herpes simplex virus-1 evasion of CD8+ T cell accumulation contributes to viral encephalitis.

Koyanagi N, Imai T, Shindo K, Sato A, Fujii W, Ichinohe T, Takemura N, Kakuta S, Uematsu S, Kiyono H, Maruzuru Y, Arii J, Kato A, Kawaguchi Y.

J Clin Invest. 2017 Oct 2;127(10):3784-3795. doi: 10.1172/JCI92931. Epub 2017 Sep 11.

33.

Intranasal vaccination against angiotensin II type 1 receptor and pneumococcal surface protein A attenuates hypertension and pneumococcal infection in rodents.

Azegami T, Yuki Y, Hayashi K, Hishikawa A, Sawada SI, Ishige K, Akiyoshi K, Kiyono H, Itoh H.

J Hypertens. 2018 Feb;36(2):387-394. doi: 10.1097/HJH.0000000000001519.

PMID:
28832363
34.

IL-22 induces Reg3γ and inhibits allergic inflammation in house dust mite-induced asthma models.

Ito T, Hirose K, Saku A, Kono K, Takatori H, Tamachi T, Goto Y, Renauld JC, Kiyono H, Nakajima H.

J Exp Med. 2017 Oct 2;214(10):3037-3050. doi: 10.1084/jem.20162108. Epub 2017 Aug 15.

35.

Reciprocal Inflammatory Signaling Between Intestinal Epithelial Cells and Adipocytes in the Absence of Immune Cells.

Takahashi Y, Sato S, Kurashima Y, Lai CY, Otsu M, Hayashi M, Yamaguchi T, Kiyono H.

EBioMedicine. 2017 Sep;23:34-45. doi: 10.1016/j.ebiom.2017.07.027. Epub 2017 Aug 2.

36.

Seed Metabolome Analysis of a Transgenic Rice Line Expressing Cholera Toxin B-subunit.

Ogawa T, Kashima K, Yuki Y, Mejima M, Kurokawa S, Kuroda M, Okazawa A, Kiyono H, Ohta D.

Sci Rep. 2017 Jul 12;7(1):5196. doi: 10.1038/s41598-017-04701-w.

37.

Microbiota-derived butyrate suppresses group 3 innate lymphoid cells in terminal ileal Peyer's patches.

Kim SH, Cho BH, Kiyono H, Jang YS.

Sci Rep. 2017 Jun 21;7(1):3980. doi: 10.1038/s41598-017-02729-6.

38.

Mast Cells Are Crucial for Induction of Group 2 Innate Lymphoid Cells and Clearance of Helminth Infections.

Shimokawa C, Kanaya T, Hachisuka M, Ishiwata K, Hisaeda H, Kurashima Y, Kiyono H, Yoshimoto T, Kaisho T, Ohno H.

Immunity. 2017 May 16;46(5):863-874.e4. doi: 10.1016/j.immuni.2017.04.017.

39.

IL-22BP dictates characteristics of Peyer's patch follicle-associated epithelium for antigen uptake.

Jinnohara T, Kanaya T, Hase K, Sakakibara S, Kato T, Tachibana N, Sasaki T, Hashimoto Y, Sato T, Watarai H, Kunisawa J, Shibata N, Williams IR, Kiyono H, Ohno H.

J Exp Med. 2017 Jun 5;214(6):1607-1618. doi: 10.1084/jem.20160770. Epub 2017 May 16.

40.

MicroRNA-mediated dynamic control of mucosal immunity.

Park EJ, Shimaoka M, Kiyono H.

Int Immunol. 2017 Apr 1;29(4):157-163. doi: 10.1093/intimm/dxx019. Review.

PMID:
28383678
41.

Critical role of intestinal interleukin-4 modulating regulatory T cells for desensitization, tolerance, and inflammation of food allergy.

Nakajima-Adachi H, Shibahara K, Fujimura Y, Takeyama J, Hiraide E, Kikuchi A, Murakami H, Hosono A, Nochi T, Wakatsuki Y, Shimojo N, Kaminogawa S, Sato R, Kiyono H, Hachimura S.

PLoS One. 2017 Feb 24;12(2):e0172795. doi: 10.1371/journal.pone.0172795. eCollection 2017.

42.

E-NPP3 controls plasmacytoid dendritic cell numbers in the small intestine.

Furuta Y, Tsai SH, Kinoshita M, Fujimoto K, Okumura R, Umemoto E, Kurashima Y, Kiyono H, Kayama H, Takeda K.

PLoS One. 2017 Feb 22;12(2):e0172509. doi: 10.1371/journal.pone.0172509. eCollection 2017.

43.

Allograft inflammatory factor 1 is a regulator of transcytosis in M cells.

Kishikawa S, Sato S, Kaneto S, Uchino S, Kohsaka S, Nakamura S, Kiyono H.

Nat Commun. 2017 Feb 22;8:14509. doi: 10.1038/ncomms14509.

44.

The spleen is the site where mast cells are induced in the development of food allergy.

Toyoshima S, Wakamatsu E, Ishida Y, Obata Y, Kurashima Y, Kiyono H, Abe R.

Int Immunol. 2017 Jan 1;29(1):31-45. doi: 10.1093/intimm/dxx005.

PMID:
28177443
45.

Attachment of class B CpG ODN onto DOTAP/DC-chol liposome in nasal vaccine formulations augments antigen-specific immune responses in mice.

Tada R, Muto S, Iwata T, Hidaka A, Kiyono H, Kunisawa J, Aramaki Y.

BMC Res Notes. 2017 Jan 26;10(1):68. doi: 10.1186/s13104-017-2380-8.

46.

Mucosal Ecological Network of Epithelium and Immune Cells for Gut Homeostasis and Tissue Healing.

Kurashima Y, Kiyono H.

Annu Rev Immunol. 2017 Apr 26;35:119-147. doi: 10.1146/annurev-immunol-051116-052424. Epub 2017 Jan 11. Review.

PMID:
28125357
47.

Nanogel-based nasal ghrelin vaccine prevents obesity.

Azegami T, Yuki Y, Sawada S, Mejima M, Ishige K, Akiyoshi K, Itoh H, Kiyono H.

Mucosal Immunol. 2017 Sep;10(5):1351-1360. doi: 10.1038/mi.2016.137. Epub 2017 Jan 25.

PMID:
28120848
48.

Critical role of TSLP-responsive mucosal dendritic cells in the induction of nasal antigen-specific IgA response.

Joo S, Fukuyama Y, Park EJ, Yuki Y, Kurashima Y, Ouchida R, Ziegler SF, Kiyono H.

Mucosal Immunol. 2017 Jul;10(4):901-911. doi: 10.1038/mi.2016.103. Epub 2016 Dec 7.

PMID:
27924821
49.

Epithelial extracellular ATP: an initiator of immunity to parasitic infections.

Nelson S, Kiyono H, Kurashima Y.

Immunol Cell Biol. 2017 Feb;95(2):117-118. doi: 10.1038/icb.2016.106. Epub 2016 Nov 22. No abstract available.

PMID:
27874014
50.

Epithelial glycosylation in gut homeostasis and inflammation.

Goto Y, Uematsu S, Kiyono H.

Nat Immunol. 2016 Oct 19;17(11):1244-1251. doi: 10.1038/ni.3587. Review.

PMID:
27760104

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