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Quantum dot conjugated nanobodies for multiplex imaging of protein dynamics at synapses.

Modi S, Higgs NF, Sheehan D, Griffin LD, Kittler JT.

Nanoscale. 2018 May 31;10(21):10241-10249. doi: 10.1039/c7nr09130c.


Mitochondria at the neuronal presynapse in health and disease.

Devine MJ, Kittler JT.

Nat Rev Neurosci. 2018 Jan 19;19(2):63-80. doi: 10.1038/nrn.2017.170. Review.


Miro proteins coordinate microtubule- and actin-dependent mitochondrial transport and distribution.

López-Doménech G, Covill-Cooke C, Ivankovic D, Halff EF, Sheehan DF, Norkett R, Birsa N, Kittler JT.

EMBO J. 2018 Feb 1;37(3):321-336. doi: 10.15252/embj.201696380. Epub 2018 Jan 8.


An Essential Role for the Tetraspanin LHFPL4 in the Cell-Type-Specific Targeting and Clustering of Synaptic GABAA Receptors.

Davenport EC, Pendolino V, Kontou G, McGee TP, Sheehan DF, López-Doménech G, Farrant M, Kittler JT.

Cell Rep. 2017 Oct 3;21(1):70-83. doi: 10.1016/j.celrep.2017.09.025.


Ubiquitination at the mitochondria in neuronal health and disease.

Covill-Cooke C, Howden JH, Birsa N, Kittler JT.

Neurochem Int. 2018 Jul;117:55-64. doi: 10.1016/j.neuint.2017.07.003. Epub 2017 Jul 12. Review.


Myostatin-like proteins regulate synaptic function and neuronal morphology.

Augustin H, McGourty K, Steinert JR, Cochemé HM, Adcott J, Cabecinha M, Vincent A, Halff EF, Kittler JT, Boucrot E, Partridge L.

Development. 2017 Jul 1;144(13):2445-2455. doi: 10.1242/dev.152975. Epub 2017 May 22.


Mitochondrial roles of the psychiatric disease risk factor DISC1.

Norkett R, Modi S, Kittler JT.

Schizophr Res. 2017 Sep;187:47-54. doi: 10.1016/j.schres.2016.12.025. Epub 2017 Jan 10. Review.


Miro1-dependent mitochondrial positioning drives the rescaling of presynaptic Ca2+ signals during homeostatic plasticity.

Vaccaro V, Devine MJ, Higgs NF, Kittler JT.

EMBO Rep. 2017 Feb;18(2):231-240. doi: 10.15252/embr.201642710. Epub 2016 Dec 30.


Loss of Dendritic Complexity Precedes Neurodegeneration in a Mouse Model with Disrupted Mitochondrial Distribution in Mature Dendrites.

López-Doménech G, Higgs NF, Vaccaro V, Roš H, Arancibia-Cárcamo IL, MacAskill AF, Kittler JT.

Cell Rep. 2016 Oct 4;17(2):317-327. doi: 10.1016/j.celrep.2016.09.004.


Neuronal activity mediated regulation of glutamate transporter GLT-1 surface diffusion in rat astrocytes in dissociated and slice cultures.

Al Awabdh S, Gupta-Agarwal S, Sheehan DF, Muir J, Norkett R, Twelvetrees AE, Griffin LD, Kittler JT.

Glia. 2016 Jul;64(7):1252-64. doi: 10.1002/glia.22997.


DISC1 is a coordinator of intracellular trafficking to shape neuronal development and connectivity.

Devine MJ, Norkett R, Kittler JT.

J Physiol. 2016 Oct 1;594(19):5459-69. doi: 10.1113/JP272187. Epub 2016 Jun 12. Review.


Miro sculpts mitochondrial dynamics in neuronal health and disease.

Devine MJ, Birsa N, Kittler JT.

Neurobiol Dis. 2016 Jun;90:27-34. doi: 10.1016/j.nbd.2015.12.008. Epub 2015 Dec 19. Review.


Miro1 Regulates Activity-Driven Positioning of Mitochondria within Astrocytic Processes Apposed to Synapses to Regulate Intracellular Calcium Signaling.

Stephen TL, Higgs NF, Sheehan DF, Al Awabdh S, López-Doménech G, Arancibia-Carcamo IL, Kittler JT.

J Neurosci. 2015 Dec 2;35(48):15996-6011. doi: 10.1523/JNEUROSCI.2068-15.2015.


DISC1-dependent Regulation of Mitochondrial Dynamics Controls the Morphogenesis of Complex Neuronal Dendrites.

Norkett R, Modi S, Birsa N, Atkin TA, Ivankovic D, Pathania M, Trossbach SV, Korth C, Hirst WD, Kittler JT.

J Biol Chem. 2016 Jan 8;291(2):613-29. doi: 10.1074/jbc.M115.699447. Epub 2015 Nov 9.


GIT1 and βPIX are essential for GABA(A) receptor synaptic stability and inhibitory neurotransmission.

Smith KR, Davenport EC, Wei J, Li X, Pathania M, Vaccaro V, Yan Z, Kittler JT.

Cell Rep. 2014 Oct 9;9(1):298-310. doi: 10.1016/j.celrep.2014.08.061. Epub 2014 Oct 2.


Activation of calcineurin underlies altered trafficking of α2 subunit containing GABAA receptors during prolonged epileptiform activity.

Eckel R, Szulc B, Walker MC, Kittler JT.

Neuropharmacology. 2015 Jan;88:82-90. doi: 10.1016/j.neuropharm.2014.09.014. Epub 2014 Sep 22.


Mitochondrial dynamics in astrocytes.

Stephen TL, Gupta-Agarwal S, Kittler JT.

Biochem Soc Trans. 2014 Oct;42(5):1302-10. doi: 10.1042/BST20140195. Review.


Plasticity of GABAA receptor diffusion dynamics at the axon initial segment.

Muir J, Kittler JT.

Front Cell Neurosci. 2014 Jun 10;8:151. doi: 10.3389/fncel.2014.00151. eCollection 2014.


Preface. Trafficking of organelles and proteins in the nervous system.

Couve A, Kittler JT.

Semin Cell Dev Biol. 2014 Mar;27:1-2. doi: 10.1016/j.semcdb.2014.03.024. Epub 2014 Mar 28. No abstract available.


Lysine 27 ubiquitination of the mitochondrial transport protein Miro is dependent on serine 65 of the Parkin ubiquitin ligase.

Birsa N, Norkett R, Wauer T, Mevissen TE, Wu HC, Foltynie T, Bhatia K, Hirst WD, Komander D, Plun-Favreau H, Kittler JT.

J Biol Chem. 2014 May 23;289(21):14569-82. doi: 10.1074/jbc.M114.563031. Epub 2014 Mar 26.


The autism and schizophrenia associated gene CYFIP1 is critical for the maintenance of dendritic complexity and the stabilization of mature spines.

Pathania M, Davenport EC, Muir J, Sheehan DF, López-Doménech G, Kittler JT.

Transl Psychiatry. 2014 Mar 25;4:e374. doi: 10.1038/tp.2014.16. Erratum in: Transl Psychiatry. 2014;4:e423.


Mitochondrial trafficking in neurons and the role of the Miro family of GTPase proteins.

Birsa N, Norkett R, Higgs N, Lopez-Domenech G, Kittler JT.

Biochem Soc Trans. 2013 Dec;41(6):1525-31. doi: 10.1042/BST20130234. Review.


Shank3 deficiency induces NMDA receptor hypofunction via an actin-dependent mechanism.

Duffney LJ, Wei J, Cheng J, Liu W, Smith KR, Kittler JT, Yan Z.

J Neurosci. 2013 Oct 2;33(40):15767-78. doi: 10.1523/JNEUROSCI.1175-13.2013.


Stabilization of GABA(A) receptors at endocytic zones is mediated by an AP2 binding motif within the GABA(A) receptor β3 subunit.

Smith KR, Muir J, Rao Y, Browarski M, Gruenig MC, Sheehan DF, Haucke V, Kittler JT.

J Neurosci. 2012 Feb 15;32(7):2485-98. doi: 10.1523/JNEUROSCI.1622-11.2011.


Disrupted in Schizophrenia 1 forms pathological aggresomes that disrupt its function in intracellular transport.

Atkin TA, Brandon NJ, Kittler JT.

Hum Mol Genet. 2012 May 1;21(9):2017-28. doi: 10.1093/hmg/dds018. Epub 2012 Jan 30.


Impaired alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor trafficking and function by mutant huntingtin.

Mandal M, Wei J, Zhong P, Cheng J, Duffney LJ, Liu W, Yuen EY, Twelvetrees AE, Li S, Li XJ, Kittler JT, Yan Z.

J Biol Chem. 2011 Sep 30;286(39):33719-28. doi: 10.1074/jbc.M111.236521. Epub 2011 Aug 5.


Studying the Localization, Surface Stability and Endocytosis of Neurotransmitter Receptors by Antibody Labeling and Biotinylation Approaches.

Arancibia-Cárcamo IL, Fairfax BP, Moss SJ, Kittler JT.

In: Kittler JT, Moss SJ, editors. The Dynamic Synapse: Molecular Methods in Ionotropic Receptor Biology. Boca Raton (FL): CRC Press/Taylor & Francis; 2006. Chapter 6.


Genomic and Post-Genomic Tools for Studying Synapse Biology.

Kittler JT, Oliver PL.

In: Kittler JT, Moss SJ, editors. The Dynamic Synapse: Molecular Methods in Ionotropic Receptor Biology. Boca Raton (FL): CRC Press/Taylor & Francis; 2006. Chapter 15.


Transfecting and Transducing Neurons with Synthetic Nucleic Acids and Biologically Active Macromolecules.

Kittler JT, Hanley JG, Isaac JTR.

In: Kittler JT, Moss SJ, editors. The Dynamic Synapse: Molecular Methods in Ionotropic Receptor Biology. Boca Raton (FL): CRC Press/Taylor & Francis; 2006. Chapter 11.


Disrupted in Schizophrenia-1 regulates intracellular trafficking of mitochondria in neurons.

Atkin TA, MacAskill AF, Brandon NJ, Kittler JT.

Mol Psychiatry. 2011 Feb;16(2):122-4, 121. doi: 10.1038/mp.2010.110. Epub 2010 Nov 16. No abstract available.


Mitochondrial trafficking and the provision of energy and calcium buffering at excitatory synapses.

MacAskill AF, Atkin TA, Kittler JT.

Eur J Neurosci. 2010 Jul;32(2):231-40. doi: 10.1111/j.1460-9568.2010.07345.x. Review.


NMDA receptors regulate GABAA receptor lateral mobility and clustering at inhibitory synapses through serine 327 on the γ2 subunit.

Muir J, Arancibia-Carcamo IL, MacAskill AF, Smith KR, Griffin LD, Kittler JT.

Proc Natl Acad Sci U S A. 2010 Sep 21;107(38):16679-84. doi: 10.1073/pnas.1000589107. Epub 2010 Sep 7.


The receptor subunits generating NMDA receptor mediated currents in oligodendrocytes.

Burzomato V, Frugier G, Pérez-Otaño I, Kittler JT, Attwell D.

J Physiol. 2010 Sep 15;588(Pt 18):3403-14. doi: 10.1113/jphysiol.2010.195503. Epub 2010 Jul 26.


The cell biology of synaptic inhibition in health and disease.

Smith KR, Kittler JT.

Curr Opin Neurobiol. 2010 Oct;20(5):550-6. doi: 10.1016/j.conb.2010.06.001. Epub 2010 Jul 23. Review.


Identification and characterisation of a Maf1/Macoco protein complex that interacts with GABAA receptors in neurons.

Smith KR, Oliver PL, Lumb MJ, Arancibia-Carcamo IL, Revilla-Sanchez R, Brandon NJ, Moss SJ, Kittler JT.

Mol Cell Neurosci. 2010 Aug;44(4):330-41. doi: 10.1016/j.mcn.2010.04.004. Epub 2010 Apr 22.


Delivery of GABAARs to synapses is mediated by HAP1-KIF5 and disrupted by mutant huntingtin.

Twelvetrees AE, Yuen EY, Arancibia-Carcamo IL, MacAskill AF, Rostaing P, Lumb MJ, Humbert S, Triller A, Saudou F, Yan Z, Kittler JT.

Neuron. 2010 Jan 14;65(1):53-65. doi: 10.1016/j.neuron.2009.12.007.


Control of mitochondrial transport and localization in neurons.

MacAskill AF, Kittler JT.

Trends Cell Biol. 2010 Feb;20(2):102-12. doi: 10.1016/j.tcb.2009.11.002. Epub 2009 Dec 16. Review.


Ubiquitin-dependent lysosomal targeting of GABA(A) receptors regulates neuronal inhibition.

Arancibia-Cárcamo IL, Yuen EY, Muir J, Lumb MJ, Michels G, Saliba RS, Smart TG, Yan Z, Kittler JT, Moss SJ.

Proc Natl Acad Sci U S A. 2009 Oct 13;106(41):17552-7. doi: 10.1073/pnas.0905502106. Epub 2009 Oct 6.


Regulation of GABA(A) receptor membrane trafficking and synaptic localization.

Arancibia-Cárcamo IL, Kittler JT.

Pharmacol Ther. 2009 Jul;123(1):17-31. doi: 10.1016/j.pharmthera.2009.03.012. Epub 2009 Apr 15.


Miro1 is a calcium sensor for glutamate receptor-dependent localization of mitochondria at synapses.

Macaskill AF, Rinholm JE, Twelvetrees AE, Arancibia-Carcamo IL, Muir J, Fransson A, Aspenstrom P, Attwell D, Kittler JT.

Neuron. 2009 Feb 26;61(4):541-55. doi: 10.1016/j.neuron.2009.01.030.


GTPase dependent recruitment of Grif-1 by Miro1 regulates mitochondrial trafficking in hippocampal neurons.

MacAskill AF, Brickley K, Stephenson FA, Kittler JT.

Mol Cell Neurosci. 2009 Mar;40(3):301-12. doi: 10.1016/j.mcn.2008.10.016. Epub 2008 Dec 3.


Regulation of inhibitory synaptic transmission by a conserved atypical interaction of GABA(A) receptor beta- and gamma-subunits with the clathrin AP2 adaptor.

Smith KR, McAinsh K, Chen G, Arancibia-Carcamo IL, Haucke V, Yan Z, Moss SJ, Kittler JT.

Neuropharmacology. 2008 Oct;55(5):844-50. doi: 10.1016/j.neuropharm.2008.06.072. Epub 2008 Jul 10.


Regulation of synaptic inhibition by phospho-dependent binding of the AP2 complex to a YECL motif in the GABAA receptor gamma2 subunit.

Kittler JT, Chen G, Kukhtina V, Vahedi-Faridi A, Gu Z, Tretter V, Smith KR, McAinsh K, Arancibia-Carcamo IL, Saenger W, Haucke V, Yan Z, Moss SJ.

Proc Natl Acad Sci U S A. 2008 Mar 4;105(9):3616-21. doi: 10.1073/pnas.0707920105. Epub 2008 Feb 27.


Molecular determinants for the interaction between AMPA receptors and the clathrin adaptor complex AP-2.

Kastning K, Kukhtina V, Kittler JT, Chen G, Pechstein A, Enders S, Lee SH, Sheng M, Yan Z, Haucke V.

Proc Natl Acad Sci U S A. 2007 Feb 20;104(8):2991-6. Epub 2007 Feb 8.


Phospholipase C-related inactive protein is implicated in the constitutive internalization of GABAA receptors mediated by clathrin and AP2 adaptor complex.

Kanematsu T, Fujii M, Mizokami A, Kittler JT, Nabekura J, Moss SJ, Hirata M.

J Neurochem. 2007 May;101(4):898-905. Epub 2007 Jan 24.


Modulation of GABA(A) receptor phosphorylation and membrane trafficking by phospholipase C-related inactive protein/protein phosphatase 1 and 2A signaling complex underlying brain-derived neurotrophic factor-dependent regulation of GABAergic inhibition.

Kanematsu T, Yasunaga A, Mizoguchi Y, Kuratani A, Kittler JT, Jovanovic JN, Takenaka K, Nakayama KI, Fukami K, Takenawa T, Moss SJ, Nabekura J, Hirata M.

J Biol Chem. 2006 Aug 4;281(31):22180-9. Epub 2006 Jun 5.


Censoring the editor in transient forebrain ischemia.

Kittler JT.

Neuron. 2006 Mar 2;49(5):646-8.


Gephyrin regulates the cell surface dynamics of synaptic GABAA receptors.

Jacob TC, Bogdanov YD, Magnus C, Saliba RS, Kittler JT, Haydon PG, Moss SJ.

J Neurosci. 2005 Nov 9;25(45):10469-78.


Phospho-dependent binding of the clathrin AP2 adaptor complex to GABAA receptors regulates the efficacy of inhibitory synaptic transmission.

Kittler JT, Chen G, Honing S, Bogdanov Y, McAinsh K, Arancibia-Carcamo IL, Jovanovic JN, Pangalos MN, Haucke V, Yan Z, Moss SJ.

Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14871-6. Epub 2005 Sep 28.

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