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Items: 40

1.

A novel cytochrome P450 mono-oxygenase from Streptomyces platensis resembles activities of human drug metabolizing P450s.

Worsch A, Eggimann FK, Girhard M, von Bühler CJ, Tieves F, Czaja R, Vogel A, Grumaz C, Sohn K, Lütz S, Kittelmann M, Urlacher VB.

Biotechnol Bioeng. 2018 Sep;115(9):2156-2166. doi: 10.1002/bit.26781. Epub 2018 Jul 11.

PMID:
29943426
2.

Protein Storage Vacuoles Originate from Remodeled Preexisting Vacuoles in Arabidopsis thaliana.

Feeney M, Kittelmann M, Menassa R, Hawes C, Frigerio L.

Plant Physiol. 2018 May;177(1):241-254. doi: 10.1104/pp.18.00010. Epub 2018 Mar 19.

3.

The odd one out: Arabidopsis reticulon 20 does not bend ER membranes but has a role in lipid regulation.

Kriechbaumer V, Maneta-Peyret L, Fouillen L, Botchway SW, Upson J, Hughes L, Richardson J, Kittelmann M, Moreau P, Hawes C.

Sci Rep. 2018 Feb 2;8(1):2310. doi: 10.1038/s41598-018-20840-0.

4.

3D Electron Microscopy of the ER.

Kittelmann M.

Methods Mol Biol. 2018;1691:15-21. doi: 10.1007/978-1-4939-7389-7_2.

PMID:
29043666
5.

Draft Genome Sequences of Three Actinobacteria Strains Presenting New Candidate Organisms with High Potentials for Specific P450 Cytochromes.

Grumaz C, Vainshtein Y, Kirstahler P, Luetz S, Kittelmann M, Schroer K, Eggimann FK, Czaja R, Vogel A, Hilberath T, Worsch A, Girhard M, Urlacher VB, Sandberg M, Sohn K.

Genome Announc. 2017 Jul 13;5(28). pii: e00532-17. doi: 10.1128/genomeA.00532-17.

6.

Serial block face scanning electron microscopy and the reconstruction of plant cell membrane systems.

Kittelmann M, Hawes C, Hughes L.

J Microsc. 2016 Aug;263(2):200-11. doi: 10.1111/jmi.12424. Epub 2016 May 20. Review.

PMID:
27197647
7.

Human xanthine oxidase recombinant in E. coli: A whole cell catalyst for preparative drug metabolite synthesis.

Ferreira Antunes M, Eggimann FK, Kittelmann M, Lütz S, Hanlon SP, Wirz B, Bachler T, Winkler M.

J Biotechnol. 2016 Oct 10;235:3-10. doi: 10.1016/j.jbiotec.2016.03.045. Epub 2016 Mar 25. Review.

PMID:
27021957
8.

Identification of Three Novel Ring Expansion Metabolites of KAE609, a New Spiroindolone Agent for the Treatment of Malaria, in Rats, Dogs, and Humans.

Huskey SE, Zhu CQ, Lin MM, Forseth RR, Gu H, Simon O, Eggimann FK, Kittelmann M, Luneau A, Vargas A, Li H, Wang L, Einolf HJ, Zhang J, Favara S, He H, Mangold JB.

Drug Metab Dispos. 2016 May;44(5):653-64. doi: 10.1124/dmd.115.069112. Epub 2016 Feb 26.

9.

Actin-dependent vacuolar occupancy of the cell determines auxin-induced growth repression.

Scheuring D, Löfke C, Krüger F, Kittelmann M, Eisa A, Hughes L, Smith RS, Hawes C, Schumacher K, Kleine-Vehn J.

Proc Natl Acad Sci U S A. 2016 Jan 12;113(2):452-7. doi: 10.1073/pnas.1517445113. Epub 2015 Dec 29.

10.

Diverse Roles of Axonemal Dyneins in Drosophila Auditory Neuron Function and Mechanical Amplification in Hearing.

Karak S, Jacobs JS, Kittelmann M, Spalthoff C, Katana R, Sivan-Loukianova E, Schon MA, Kernan MJ, Eberl DF, Göpfert MC.

Sci Rep. 2015 Nov 26;5:17085. doi: 10.1038/srep17085.

11.

Ankyrin Repeats Convey Force to Gate the NOMPC Mechanotransduction Channel.

Zhang W, Cheng LE, Kittelmann M, Li J, Petkovic M, Cheng T, Jin P, Guo Z, Göpfert MC, Jan LY, Jan YN.

Cell. 2015 Sep 10;162(6):1391-403. doi: 10.1016/j.cell.2015.08.024.

12.

Human FMO2-based microbial whole-cell catalysts for drug metabolite synthesis.

Geier M, Bachler T, Hanlon SP, Eggimann FK, Kittelmann M, Weber H, Lütz S, Wirz B, Winkler M.

Microb Cell Fact. 2015 Jun 12;14:82. doi: 10.1186/s12934-015-0262-0.

13.

Novel cell types, neurosecretory cells, and body plan of the early-diverging metazoan Trichoplax adhaerens.

Smith CL, Varoqueaux F, Kittelmann M, Azzam RN, Cooper B, Winters CA, Eitel M, Fasshauer D, Reese TS.

Curr Biol. 2014 Jul 21;24(14):1565-1572. doi: 10.1016/j.cub.2014.05.046. Epub 2014 Jun 19.

14.

Decisive influence of substitution positions in molecular self-assembly.

Neff JL, Kittelmann M, Bechstein R, Kühnle A.

Phys Chem Chem Phys. 2014 Aug 7;16(29):15437-43. doi: 10.1039/c4cp02077d. Epub 2014 Jun 20.

PMID:
24947801
15.

Syk inhibitors with high potency in presence of blood.

Thoma G, Blanz J, Bühlmayer P, Drückes P, Kittelmann M, Smith AB, van Eis M, Vangrevelinghe E, Zerwes HG, Che JJ, He X, Jin Y, Lee CC, Michellys PY, Uno T, Liu H.

Bioorg Med Chem Lett. 2014 May 15;24(10):2278-82. doi: 10.1016/j.bmcl.2014.03.075. Epub 2014 Apr 3.

PMID:
24726806
16.

Substrate templating guides the photoinduced reaction of C60 on calcite.

Lindner R, Rahe P, Kittelmann M, Gourdon A, Bechstein R, Kühnle A.

Angew Chem Int Ed Engl. 2014 Jul 21;53(30):7952-5. doi: 10.1002/anie.201309128. Epub 2014 Apr 1.

PMID:
24692299
17.

A novel CaM kinase II pathway controls the location of neuropeptide release from Caenorhabditis elegans motor neurons.

Hoover CM, Edwards SL, Yu SC, Kittelmann M, Richmond JE, Eimer S, Yorks RM, Miller KG.

Genetics. 2014 Mar;196(3):745-65. doi: 10.1534/genetics.113.158568.

18.

Liprin-α/SYD-2 determines the size of dense projections in presynaptic active zones in C. elegans.

Kittelmann M, Hegermann J, Goncharov A, Taru H, Ellisman MH, Richmond JE, Jin Y, Eimer S.

J Cell Biol. 2013 Dec 9;203(5):849-63. doi: 10.1083/jcb.201302022.

19.

Tuning molecular self-assembly on bulk insulator surfaces by anchoring of the organic building blocks.

Rahe P, Kittelmann M, Neff JL, Nimmrich M, Reichling M, Maass P, Kühnle A.

Adv Mater. 2013 Aug 7;25(29):3948-56. doi: 10.1002/adma.201300604. Epub 2013 Jun 12. Review.

PMID:
23907708
20.

In vivo synaptic recovery following optogenetic hyperstimulation.

Kittelmann M, Liewald JF, Hegermann J, Schultheis C, Brauner M, Steuer Costa W, Wabnig S, Eimer S, Gottschalk A.

Proc Natl Acad Sci U S A. 2013 Aug 6;110(32):E3007-16. doi: 10.1073/pnas.1305679110. Epub 2013 Jul 22.

21.

Metabolism and disposition of the metabotropic glutamate receptor 5 antagonist (mGluR5) mavoglurant (AFQ056) in healthy subjects.

Walles M, Wolf T, Jin Y, Ritzau M, Leuthold LA, Krauser J, Gschwind HP, Carcache D, Kittelmann M, Ocwieja M, Ufer M, Woessner R, Chakraborty A, Swart P.

Drug Metab Dispos. 2013 Sep;41(9):1626-41. doi: 10.1124/dmd.112.050716. Epub 2013 Jun 17.

22.

Sequential and site-specific on-surface synthesis on a bulk insulator.

Kittelmann M, Nimmrich M, Lindner R, Gourdon A, Kühnle A.

ACS Nano. 2013 Jun 25;7(6):5614-20. doi: 10.1021/nn402018w. Epub 2013 May 23.

PMID:
23682961
23.

Controlling molecular self-assembly on an insulating surface by rationally designing an efficient anchor functionality that maintains structural flexibility.

Hauke CM, Bechstein R, Kittelmann M, Storz C, Kilbinger AF, Rahe P, Kühnle A.

ACS Nano. 2013 Jun 25;7(6):5491-8. doi: 10.1021/nn401589u. Epub 2013 May 15.

PMID:
23659365
24.

Loss of ALS-associated TDP-43 in zebrafish causes muscle degeneration, vascular dysfunction, and reduced motor neuron axon outgrowth.

Schmid B, Hruscha A, Hogl S, Banzhaf-Strathmann J, Strecker K, van der Zee J, Teucke M, Eimer S, Hegermann J, Kittelmann M, Kremmer E, Cruts M, Solchenberger B, Hasenkamp L, van Bebber F, Van Broeckhoven C, Edbauer D, Lichtenthaler SF, Haass C.

Proc Natl Acad Sci U S A. 2013 Mar 26;110(13):4986-91. doi: 10.1073/pnas.1218311110. Epub 2013 Mar 1.

25.

Molecular self-assembly on an insulating surface: interplay between substrate templating and intermolecular interactions.

Kittelmann M, Rahe P, Kühnle A.

J Phys Condens Matter. 2012 Sep 5;24(35):354007. doi: 10.1088/0953-8984/24/35/354007. Epub 2012 Aug 16.

PMID:
22899097
26.

Direct visualization of molecule deprotonation on an insulating surface.

Kittelmann M, Rahe P, Gourdon A, Kühnle A.

ACS Nano. 2012 Aug 28;6(8):7406-11. doi: 10.1021/nn3025942. Epub 2012 Aug 3.

PMID:
22838491
27.

Expression of recombinant human flavin monooxygenase and moclobemide-N-oxide synthesis on multi-mg scale.

Hanlon SP, Camattari A, Abad S, Glieder A, Kittelmann M, Lütz S, Wirz B, Winkler M.

Chem Commun (Camb). 2012 Jun 18;48(48):6001-3. doi: 10.1039/c2cc17878h. Epub 2012 May 10.

PMID:
22576266
28.

From dewetting to wetting molecular layers: C60 on CaCO3(10 ̅14) as a case study.

Rahe P, Lindner R, Kittelmann M, Nimmrich M, Kühnle A.

Phys Chem Chem Phys. 2012 May 14;14(18):6544-8. doi: 10.1039/c2cp40172j. Epub 2012 Mar 28.

PMID:
22456713
29.

Phosphorylation-regulated axonal dependent transport of syntaxin 1 is mediated by a Kinesin-1 adapter.

Chua JJ, Butkevich E, Worseck JM, Kittelmann M, Grønborg M, Behrmann E, Stelzl U, Pavlos NJ, Lalowski MM, Eimer S, Wanker EE, Klopfenstein DR, Jahn R.

Proc Natl Acad Sci U S A. 2012 Apr 10;109(15):5862-7. doi: 10.1073/pnas.1113819109. Epub 2012 Mar 26.

30.

Biocatalytic synthesis and structure elucidation of cyclized metabolites of the deacetylase inhibitor panobinostat (LBH589).

Fredenhagen A, Kittelmann M, Oberer L, Kuhn A, Kühnöl J, Délémonté T, Aichholz R, Wang P, Atadja P, Shultz MD.

Drug Metab Dispos. 2012 May;40(5):1041-50. doi: 10.1124/dmd.111.043620. Epub 2012 Feb 16.

31.

On-surface covalent linking of organic building blocks on a bulk insulator.

Kittelmann M, Rahe P, Nimmrich M, Hauke CM, Gourdon A, Kühnle A.

ACS Nano. 2011 Oct 25;5(10):8420-5. doi: 10.1021/nn2033192. Epub 2011 Sep 13.

PMID:
21899361
32.

Swiss Industrial Biocatalysis Consortium (SIBC).

Wirz B, Kittelmann M, Meyer HP, Wohlgemuth R.

Chimia (Aarau). 2010;64(11):780-1.

PMID:
21197839
33.

Recombinant human cytochrome P450 monooxygenases for drug metabolite synthesis.

Schroer K, Kittelmann M, Lütz S.

Biotechnol Bioeng. 2010 Aug 1;106(5):699-706. doi: 10.1002/bit.22775. Review.

PMID:
20506361
34.

Insertional mutagenesis screening identifies the zinc finger homeodomain 2 (zfh2) gene as a novel factor required for embryonic leg development in Tribolium castaneum.

Kittelmann M, Schinko JB, Winkler M, Bucher G, Wimmer EA, Prpic NM.

Dev Genes Evol. 2009 Aug;219(8):399-407. doi: 10.1007/s00427-009-0303-y. Epub 2009 Sep 17.

35.

3'-Demethoxy-3'-hydroxystaurosporine-O-methyltransferase from Streptomyces longisporoflavus catalyzing the last step in the biosynthesis of staurosporine.

Weidner S, Kittelmann M, Goeke K, Ghisalba O, Zähner H.

J Antibiot (Tokyo). 1998 Jul;51(7):679-82. No abstract available.

36.

Isolation and characterization of highly (R)-specific N-acetyl-1-phenylethylamine amidohydrolase, a new enzyme from Arthrobacter aurescens AcR5b.

Graf M, Brunella A, Kittelmann M, Laumen K, Ghisalba O.

Appl Microbiol Biotechnol. 1997 Jun;47(6):650-7.

PMID:
9237388
37.

Reaction engineering aspects of activated sugar production. CMP-Neu5Ac as an example.

Kragl U, Klein T, Vasic-Racki D, Kittelmann M, Ghisalba O, Wandrey C.

Ann N Y Acad Sci. 1996 Oct 12;799:577-83. No abstract available.

PMID:
8958114
38.

CMP-N-acetyl neuraminic-acid synthetase from Escherichia coli: fermentative production and application for the preparative synthesis of CMP-neuraminic acid.

Kittelmann M, Klein T, Kragl U, Wandrey C, Ghisalba O.

Appl Microbiol Biotechnol. 1995 Dec;44(1-2):59-67.

PMID:
8579837
39.

Preparative enzymatic synthesis of activated neuraminic acid by using a microbial enzyme.

Kittelmann M, Klein T, Kragl U, Wandrey C, Ghisalba O.

Ann N Y Acad Sci. 1992 Nov 30;672:444-50.

PMID:
1476385
40.

Protecting groups for the enzymatic peptide synthesis.

Flörsheimer A, Schwarz A, Steinke D, Kittelmann M, Herrmann G, Kula MR, Wandrey C.

Ann N Y Acad Sci. 1990;613:633-7. No abstract available.

PMID:
2076009

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