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Items: 1 to 50 of 115

1.

Unlocking the Secrets of Mitochondria in the Cardiovascular System: Path to a Cure in Heart Failure—A Report from the 2018 National Heart, Lung, and Blood Institute Workshop

Tian R, Colucci WS, Arany Z, Bachschmid MM, Ballinger SW, Boudina S, Bruce JE, Busija DW, Dikalov S, Dorn GW II, Galis ZS, Gottlieb RA, Kelly DP, Kitsis RN, Kohr MJ, Levy D, Lewandowski ED, McClung JM, Mochly-Rosen D, O'Brien KD, O'Rourke B, Park JY, Ping P, Sack MN, Sheu SS, Shi Y, Shiva S, Wallace DC, Weiss RG, Vernon HJ, Wong R, Schwartz Longacre L.

Circulation. 2019 Oct 1;140(14):1205-1216.

PMID:
31769940
2.

Fundamental Mechanisms of Regulated Cell Death and Implications for Heart Disease.

Del Re DP, Amgalan D, Linkermann A, Liu Q, Kitsis RN.

Physiol Rev. 2019 Oct 1;99(4):1765-1817. doi: 10.1152/physrev.00022.2018. Review.

PMID:
31364924
3.

A mouse model for the most common form of heart failure.

Amgalan D, Kitsis RN.

Nature. 2019 Apr;568(7752):324-325. doi: 10.1038/d41586-019-00983-4. No abstract available.

PMID:
30980035
4.

Small-molecule allosteric inhibitors of BAX.

Garner TP, Amgalan D, Reyna DE, Li S, Kitsis RN, Gavathiotis E.

Nat Chem Biol. 2019 Apr;15(4):322-330. doi: 10.1038/s41589-018-0223-0. Epub 2019 Feb 4.

5.

Heart Disease and Cancer: Are the Two Killers Colluding?

Kitsis RN, Riquelme JA, Lavandero S.

Circulation. 2018 Aug 14;138(7):692-695. doi: 10.1161/CIRCULATIONAHA.118.033907. No abstract available.

6.

SNAP23 regulates BAX-dependent adipocyte programmed cell death independently of canonical macroautophagy.

Feng D, Amgalan D, Singh R, Wei J, Wen J, Wei TP, McGraw TE, Kitsis RN, Pessin JE.

J Clin Invest. 2018 Aug 31;128(9):3941-3956. doi: 10.1172/JCI99217. Epub 2018 Aug 13.

7.

RCAN1-Calcineurin Axis and the Set-Point for Myocardial Damage During Ischemia-Reperfusion.

Corbalan JJ, Kitsis RN.

Circ Res. 2018 Mar 16;122(6):796-798. doi: 10.1161/CIRCRESAHA.118.312787. No abstract available.

8.

MFN2 agonists reverse mitochondrial defects in preclinical models of Charcot-Marie-Tooth disease type 2A.

Rocha AG, Franco A, Krezel AM, Rumsey JM, Alberti JM, Knight WC, Biris N, Zacharioudakis E, Janetka JW, Baloh RH, Kitsis RN, Mochly-Rosen D, Townsend RR, Gavathiotis E, Dorn GW 2nd.

Science. 2018 Apr 20;360(6386):336-341. doi: 10.1126/science.aao1785.

9.

PDCD5 says no to NO.

Riascos-Bernal DF, Sibinga NES, Kitsis RN.

Proc Natl Acad Sci U S A. 2018 May 1;115(18):4535-4537. doi: 10.1073/pnas.1804491115. Epub 2018 Apr 16. No abstract available.

10.

Ryanodine Receptor Calcium Leak in Circulating B-Lymphocytes as a Biomarker in Heart Failure.

Kushnir A, Santulli G, Reiken SR, Coromilas E, Godfrey SJ, Brunjes DL, Colombo PC, Yuzefpolskaya M, Sokol SI, Kitsis RN, Marks AR.

Circulation. 2018 Sep 11;138(11):1144-1154. doi: 10.1161/CIRCULATIONAHA.117.032703.

11.

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Annicchiarico-Petruzzelli M, Antonov AV, Arama E, Baehrecke EH, Barlev NA, Bazan NG, Bernassola F, Bertrand MJM, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Boya P, Brenner C, Campanella M, Candi E, Carmona-Gutierrez D, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Cohen GM, Conrad M, Cubillos-Ruiz JR, Czabotar PE, D'Angiolella V, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin KM, DeBerardinis RJ, Deshmukh M, Di Daniele N, Di Virgilio F, Dixit VM, Dixon SJ, Duckett CS, Dynlacht BD, El-Deiry WS, Elrod JW, Fimia GM, Fulda S, García-Sáez AJ, Garg AD, Garrido C, Gavathiotis E, Golstein P, Gottlieb E, Green DR, Greene LA, Gronemeyer H, Gross A, Hajnoczky G, Hardwick JM, Harris IS, Hengartner MO, Hetz C, Ichijo H, Jäättelä M, Joseph B, Jost PJ, Juin PP, Kaiser WJ, Karin M, Kaufmann T, Kepp O, Kimchi A, Kitsis RN, Klionsky DJ, Knight RA, Kumar S, Lee SW, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Lowe SW, Luedde T, Lugli E, MacFarlane M, Madeo F, Malewicz M, Malorni W, Manic G, Marine JC, Martin SJ, Martinou JC, Medema JP, Mehlen P, Meier P, Melino S, Miao EA, Molkentin JD, Moll UM, Muñoz-Pinedo C, Nagata S, Nuñez G, Oberst A, Oren M, Overholtzer M, Pagano M, Panaretakis T, Pasparakis M, Penninger JM, Pereira DM, Pervaiz S, Peter ME, Piacentini M, Pinton P, Prehn JHM, Puthalakath H, Rabinovich GA, Rehm M, Rizzuto R, Rodrigues CMP, Rubinsztein DC, Rudel T, Ryan KM, Sayan E, Scorrano L, Shao F, Shi Y, Silke J, Simon HU, Sistigu A, Stockwell BR, Strasser A, Szabadkai G, Tait SWG, Tang D, Tavernarakis N, Thorburn A, Tsujimoto Y, Turk B, Vanden Berghe T, Vandenabeele P, Vander Heiden MG, Villunger A, Virgin HW, Vousden KH, Vucic D, Wagner EF, Walczak H, Wallach D, Wang Y, Wells JA, Wood W, Yuan J, Zakeri Z, Zhivotovsky B, Zitvogel L, Melino G, Kroemer G.

Cell Death Differ. 2018 Mar;25(3):486-541. doi: 10.1038/s41418-017-0012-4. Epub 2018 Jan 23. Review.

12.

An Akt3 Splice Variant Lacking the Serine 472 Phosphorylation Site Promotes Apoptosis and Suppresses Mammary Tumorigenesis.

Suyama K, Yao J, Liang H, Benard O, Loudig OD, Amgalan D, McKimpson WM, Phillips GR, Segall J, Wang Y, Fineberg S, Norton L, Kitsis RN, Hazan RB.

Cancer Res. 2018 Jan 1;78(1):103-114. doi: 10.1158/0008-5472.CAN-15-1462. Epub 2017 Oct 16.

13.

Troponin release following brief myocardial ischemia: apoptosis versus necrosis.

Amgalan D, Pekson R, Kitsis RN.

JACC Basic Transl Sci. 2017 Apr;2(2):118-121. doi: 10.1016/j.jacbts.2017.03.008. Epub 2017 Apr 24. No abstract available.

14.

Uncontrolled angiogenic precursor expansion causes coronary artery anomalies in mice lacking Pofut1.

Wang Y, Wu B, Lu P, Zhang D, Wu B, Varshney S, Del Monte-Nieto G, Zhuang Z, Charafeddine R, Kramer AH, Sibinga NE, Frangogiannis NG, Kitsis RN, Adams RH, Alitalo K, Sharp DJ, Harvey RP, Stanley P, Zhou B.

Nat Commun. 2017 Sep 18;8(1):578. doi: 10.1038/s41467-017-00654-w.

15.

Death Receptor Signaling in the Heart: Cell Survival, Apoptosis, and Necroptosis.

Amgalan D, Chen Y, Kitsis RN.

Circulation. 2017 Aug 22;136(8):743-746. doi: 10.1161/CIRCULATIONAHA.117.029566. No abstract available.

16.

Overcoming the Roadblocks to Cardiac Cell Therapy Using Tissue Engineering.

Yanamandala M, Zhu W, Garry DJ, Kamp TJ, Hare JM, Jun HW, Yoon YS, Bursac N, Prabhu SD, Dorn GW 2nd, Bolli R, Kitsis RN, Zhang J.

J Am Coll Cardiol. 2017 Aug 8;70(6):766-775. doi: 10.1016/j.jacc.2017.06.012. Review.

17.

ARC is essential for maintaining pancreatic islet structure and β-cell viability during type 2 diabetes.

McKimpson WM, Zheng M, Chua SC, Pessin JE, Kitsis RN.

Sci Rep. 2017 Aug 1;7(1):7019. doi: 10.1038/s41598-017-07107-w.

18.

Apoptosis Repressor With Caspase Recruitment Domain Ameliorates Amyloid-Induced β-Cell Apoptosis and JNK Pathway Activation.

Templin AT, Samarasekera T, Meier DT, Hogan MF, Mellati M, Crow MT, Kitsis RN, Zraika S, Hull RL, Kahn SE.

Diabetes. 2017 Oct;66(10):2636-2645. doi: 10.2337/db16-1352. Epub 2017 Jul 20.

19.

Grounding Cardio-Oncology in Basic and Clinical Science.

Moslehi J, Amgalan D, Kitsis RN.

Circulation. 2017 Jul 4;136(1):3-5. doi: 10.1161/CIRCULATIONAHA.117.025393. No abstract available.

20.

Beyond Mitophagy: The Diversity and Complexity of Parkin Function.

Shires SE, Kitsis RN, Gustafsson ÅB.

Circ Res. 2017 Apr 14;120(8):1234-1236. doi: 10.1161/CIRCRESAHA.116.310179. Review. No abstract available.

21.

A New Role for the ER Unfolded Protein Response Mediator ATF6: Induction of a Generalized Antioxidant Program.

McKimpson WM, Kitsis RN.

Circ Res. 2017 Mar 3;120(5):759-761. doi: 10.1161/CIRCRESAHA.117.310577. No abstract available.

22.

A myeloid tumor suppressor role for NOL3.

Stanley RF, Piszczatowski RT, Bartholdy B, Mitchell K, McKimpson WM, Narayanagari S, Walter D, Todorova TI, Hirsch C, Makishima H, Will B, McMahon C, Gritsman K, Maciejewski JP, Kitsis RN, Steidl U.

J Exp Med. 2017 Mar 6;214(3):753-771. doi: 10.1084/jem.20162089. Epub 2017 Feb 23.

23.

A Rab5 endosomal pathway mediates Parkin-dependent mitochondrial clearance.

Hammerling BC, Najor RH, Cortez MQ, Shires SE, Leon LJ, Gonzalez ER, Boassa D, Phan S, Thor A, Jimenez RE, Li H, Kitsis RN, Dorn GW II, Sadoshima J, Ellisman MH, Gustafsson ÅB.

Nat Commun. 2017 Jan 30;8:14050. doi: 10.1038/ncomms14050.

24.

Osteocalcin Signaling in Myofibers Is Necessary and Sufficient for Optimum Adaptation to Exercise.

Mera P, Laue K, Ferron M, Confavreux C, Wei J, Galán-Díez M, Lacampagne A, Mitchell SJ, Mattison JA, Chen Y, Bacchetta J, Szulc P, Kitsis RN, de Cabo R, Friedman RA, Torsitano C, McGraw TE, Puchowicz M, Kurland I, Karsenty G.

Cell Metab. 2017 Jan 10;25(1):218. doi: 10.1016/j.cmet.2016.12.003. No abstract available.

25.

Correcting mitochondrial fusion by manipulating mitofusin conformations.

Franco A, Kitsis RN, Fleischer JA, Gavathiotis E, Kornfeld OS, Gong G, Biris N, Benz A, Qvit N, Donnelly SK, Chen Y, Mennerick S, Hodgson L, Mochly-Rosen D, Dorn GW II.

Nature. 2016 Dec 1;540(7631):74-79. doi: 10.1038/nature20156. Epub 2016 Oct 24.

26.

Does Autophagy Mediate Cardiac Myocyte Death During Stress?

Nah J, Fernández ÁF, Kitsis RN, Levine B, Sadoshima J.

Circ Res. 2016 Sep 30;119(8):893-5. doi: 10.1161/CIRCRESAHA.116.309765. Review. No abstract available.

27.

Osteocalcin Signaling in Myofibers Is Necessary and Sufficient for Optimum Adaptation to Exercise.

Mera P, Laue K, Ferron M, Confavreux C, Wei J, Galán-Díez M, Lacampagne A, Mitchell SJ, Mattison JA, Chen Y, Bacchetta J, Szulc P, Kitsis RN, de Cabo R, Friedman RA, Torsitano C, McGraw TE, Puchowicz M, Kurland I, Karsenty G.

Cell Metab. 2016 Jun 14;23(6):1078-1092. doi: 10.1016/j.cmet.2016.05.004. Erratum in: Cell Metab. 2017 Jan 10;25(1):218.

28.

Mitochondrial Function, Biology, and Role in Disease: A Scientific Statement From the American Heart Association.

Murphy E, Ardehali H, Balaban RS, DiLisa F, Dorn GW 2nd, Kitsis RN, Otsu K, Ping P, Rizzuto R, Sack MN, Wallace D, Youle RJ; American Heart Association Council on Basic Cardiovascular Sciences, Council on Clinical Cardiology, and Council on Functional Genomics and Translational Biology.

Circ Res. 2016 Jun 10;118(12):1960-91. doi: 10.1161/RES.0000000000000104. Epub 2016 Apr 28. Review.

29.

Evaluating mitochondrial autophagy in the mouse heart.

Shirakabe A, Fritzky L, Saito T, Zhai P, Miyamoto S, Gustafsson ÅB, Kitsis RN, Sadoshima J.

J Mol Cell Cardiol. 2016 Mar;92:134-9. doi: 10.1016/j.yjmcc.2016.02.007. Epub 2016 Feb 9.

PMID:
26868976
30.

The Cell Death Inhibitor ARC Is Induced in a Tissue-Specific Manner by Deletion of the Tumor Suppressor Gene Men1, but Not Required for Tumor Development and Growth.

McKimpson WM, Yuan Z, Zheng M, Crabtree JS, Libutti SK, Kitsis RN.

PLoS One. 2015 Dec 28;10(12):e0145792. doi: 10.1371/journal.pone.0145792. eCollection 2015.

31.

Catch me if you can: targeting the mitochondrial permeability transition pore in myocardial infarction.

Linkermann A, Konstantinidis K, Kitsis RN.

Cell Death Differ. 2016 Jan;23(1):1-2. doi: 10.1038/cdd.2015.151. Epub 2015 Nov 20. No abstract available.

32.

MacroH2A1 and ATM Play Opposing Roles in Paracrine Senescence and the Senescence-Associated Secretory Phenotype.

Chen H, Ruiz PD, McKimpson WM, Novikov L, Kitsis RN, Gamble MJ.

Mol Cell. 2015 Sep 3;59(5):719-31. doi: 10.1016/j.molcel.2015.07.011. Epub 2015 Aug 20.

33.

Interdependence of Parkin-Mediated Mitophagy and Mitochondrial Fission in Adult Mouse Hearts.

Song M, Gong G, Burelle Y, Gustafsson ÅB, Kitsis RN, Matkovich SJ, Dorn GW 2nd.

Circ Res. 2015 Jul 31;117(4):346-51. doi: 10.1161/CIRCRESAHA.117.306859. Epub 2015 Jun 2.

34.

Recent progress in research on molecular mechanisms of autophagy in the heart.

Maejima Y, Chen Y, Isobe M, Gustafsson ÅB, Kitsis RN, Sadoshima J.

Am J Physiol Heart Circ Physiol. 2015 Feb 15;308(4):H259-68. doi: 10.1152/ajpheart.00711.2014. Epub 2014 Nov 14. Review.

35.

The mitochondrial dynamism-mitophagy-cell death interactome: multiple roles performed by members of a mitochondrial molecular ensemble.

Dorn GW 2nd, Kitsis RN.

Circ Res. 2015 Jan 2;116(1):167-82. doi: 10.1161/CIRCRESAHA.116.303554. Epub 2014 Oct 16. Review.

36.

A novel role for the apoptosis inhibitor ARC in suppressing TNFα-induced regulated necrosis.

Kung G, Dai P, Deng L, Kitsis RN.

Cell Death Differ. 2014 Apr;21(4):634-44. doi: 10.1038/cdd.2013.195. Epub 2014 Jan 17.

37.

Cardioprotective inhibitors of reperfusion injury.

Kane A, Peddibhotla S, Maloney P, Mehta A, Hood B, Suyama E, Nguyen K, Vasile S, Leavitt L, Cheltsov A, Salaiwal S, Stonich D, Mangravita-Novo A, Vicchiarelli M, Smith LH, Diwan J, Chung TDY, Pinkerton AB, Hershberger P, Malany S, Kitsis RN.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2012 Dec 10 [updated 2013 Mar 22].

38.

Apoptosis repressor with a CARD domain (ARC) restrains Bax-mediated pathogenesis in dystrophic skeletal muscle.

Davis J, Kwong JQ, Kitsis RN, Molkentin JD.

PLoS One. 2013 Dec 2;8(12):e82053. doi: 10.1371/journal.pone.0082053. eCollection 2013.

39.

A microRNA links prolactin to peripartum cardiomyopathy.

Yang Y, Rodriguez JE, Kitsis RN.

J Clin Invest. 2013 May;123(5):1925-7. doi: 10.1172/JCI69286. Epub 2013 Apr 24.

40.

Cardiomyocyte life-death decisions in response to chronic β-adrenergic signaling.

Whelan RS, Konstantinidis K, Xiao RP, Kitsis RN.

Circ Res. 2013 Feb 1;112(3):408-10. doi: 10.1161/CIRCRESAHA.113.300805. No abstract available. Erratum in: Circ Res. 2013 Jun 7;112(12):e181.

41.

Novel mechanisms for caspase inhibition protecting cardiac function with chronic pressure overload.

Park M, Vatner SF, Yan L, Gao S, Yoon S, Lee GJ, Xie LH, Kitsis RN, Vatner DE.

Basic Res Cardiol. 2013 Jan;108(1):324. doi: 10.1007/s00395-012-0324-y. Epub 2013 Jan 1.

42.

Mitofusin 2 joins the sarcoplasmic reticulum and mitochondria at the hip to sustain cardiac energetics.

Konstantinidis K, Lederer WJ, Rizzuto R, Kitsis RN.

Circ Res. 2012 Sep 14;111(7):821-3. doi: 10.1161/CIRCRESAHA.112.277269. No abstract available.

43.

The apoptosis inhibitor ARC alleviates the ER stress response to promote β-cell survival.

McKimpson WM, Weinberger J, Czerski L, Zheng M, Crow MT, Pessin JE, Chua SC Jr, Kitsis RN.

Diabetes. 2013 Jan;62(1):183-93. doi: 10.2337/db12-0504. Epub 2012 Aug 29.

44.

Tbx6 is a determinant of cardiac and neural cell fate decisions in multipotent P19CL6 cells.

Gavrilov S, Nührenberg TG, Ashton AW, Peng CF, Moore JC, Konstantinidis K, Mummery CL, Kitsis RN.

Differentiation. 2012 Sep;84(2):176-84. doi: 10.1016/j.diff.2012.04.007. Epub 2012 Jun 19.

45.

Mechanisms of cell death in heart disease.

Konstantinidis K, Whelan RS, Kitsis RN.

Arterioscler Thromb Vasc Biol. 2012 Jul;32(7):1552-62. doi: 10.1161/ATVBAHA.111.224915. Epub 2012 May 17. Review.

46.

Cardiovascular biology: Escaped DNA inflames the heart.

Konstantinidis K, Kitsis RN.

Nature. 2012 May 9;485(7397):179-80. doi: 10.1038/485179a. No abstract available.

PMID:
22575953
47.

Bax regulates primary necrosis through mitochondrial dynamics.

Whelan RS, Konstantinidis K, Wei AC, Chen Y, Reyna DE, Jha S, Yang Y, Calvert JW, Lindsten T, Thompson CB, Crow MT, Gavathiotis E, Dorn GW 2nd, O'Rourke B, Kitsis RN.

Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6566-71. doi: 10.1073/pnas.1201608109. Epub 2012 Apr 9.

48.

A critical role for the protein apoptosis repressor with caspase recruitment domain in hypoxia-induced pulmonary hypertension.

Zaiman AL, Damico R, Thoms-Chesley A, Files DC, Kesari P, Johnston L, Swaim M, Mozammel S, Myers AC, Halushka M, El-Haddad H, Shimoda LA, Peng CF, Hassoun PM, Champion HC, Kitsis RN, Crow MT.

Circulation. 2011 Dec 6;124(23):2533-42. doi: 10.1161/CIRCULATIONAHA.111.034512. Epub 2011 Nov 14.

49.

Apoptosis inhibitor ARC promotes breast tumorigenesis, metastasis, and chemoresistance.

Medina-Ramirez CM, Goswami S, Smirnova T, Bamira D, Benson B, Ferrick N, Segall J, Pollard JW, Kitsis RN.

Cancer Res. 2011 Dec 15;71(24):7705-15. doi: 10.1158/0008-5472.CAN-11-2192. Epub 2011 Oct 28.

50.

High-fat diet-induced adipocyte cell death occurs through a cyclophilin D intrinsic signaling pathway independent of adipose tissue inflammation.

Feng D, Tang Y, Kwon H, Zong H, Hawkins M, Kitsis RN, Pessin JE.

Diabetes. 2011 Aug;60(8):2134-43. doi: 10.2337/db10-1411. Epub 2011 Jul 6.

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