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Items: 50

1.

A reaction mechanism-based prediction of mutagenicity: α-halo carbonyl compounds adduct with DNA by SN2 reaction.

Haranosono Y, Ueoka H, Kito G, Nemoto S, Kurata M, Sakaki H.

J Toxicol Sci. 2018;43(3):203-211. doi: 10.2131/jts.43.203.

2.

Characteristics of corneal phospholipidosis induced by topical ocular application of chloroquine and amiodarone in rabbits.

Yamagiwa Y, Haranosono Y, Nemoto S, Atsumi I, Kurata M, Kito G, Hatakeyama H, Koizumi H, Sakaki H.

J Toxicol Pathol. 2017 Apr;30(2):135-143. doi: 10.1293/tox.2016-0003. Epub 2016 Nov 27.

3.

Sex- and age-dependent gene expression in human liver: An implication for drug-metabolizing enzymes.

Uno Y, Takata R, Kito G, Yamazaki H, Nakagawa K, Nakamura Y, Kamataki T, Katagiri T.

Drug Metab Pharmacokinet. 2017 Feb;32(1):100-107. doi: 10.1016/j.dmpk.2016.10.409. Epub 2016 Oct 27.

PMID:
28153492
4.

The putative promoters of germ cell-specific genes and Nanog are hypomethylated in chicken sperm.

Kito G, Tanaka H, Soh T, Yamauchi N, Hattori MA.

J Reprod Dev. 2014;60(3):224-9. Epub 2014 Mar 16.

5.

FSH induces the development of circadian clockwork in rat granulosa cells via a gap junction protein Cx43-dependent pathway.

Chen H, Zhao L, Chu G, Kito G, Yamauchi N, Shigeyoshi Y, Hashimoto S, Hattori MA.

Am J Physiol Endocrinol Metab. 2013 Mar 15;304(6):E566-75. doi: 10.1152/ajpendo.00432.2012. Epub 2013 Jan 8.

6.
7.

Effect of estradiol on gene expression profile in cynomolgus macaque liver: implications for drug-metabolizing enzymes.

Uno Y, Kito G.

Drug Metab Dispos. 2011 Nov;39(11):2003-7. doi: 10.1124/dmd.111.041004. Epub 2011 Aug 2.

8.

Temporal and spatial differential expression of chicken germline-specific proteins cDAZL, CDH and CVH during gametogenesis.

Kito G, Aramaki S, Tanaka K, Soh T, Yamauchi N, Hattori MA.

J Reprod Dev. 2010 Jun;56(3):341-6. Epub 2010 Mar 24.

9.

Effects of metoprolol on epinephrine-induced takotsubo-like left ventricular dysfunction in non-human primates.

Izumi Y, Okatani H, Shiota M, Nakao T, Ise R, Kito G, Miura K, Iwao H.

Hypertens Res. 2009 May;32(5):339-46. doi: 10.1038/hr.2009.28. Epub 2009 Mar 20.

PMID:
19300450
10.

Sex-related differences in the expression of mfGSTA2, a novel GST identified in cynomolgus monkey (Macaca fascicularis).

Uno Y, Ohuchi T, Uehara S, Kito G, Kamataki T, Nagata R.

Drug Metab Dispos. 2009 Mar;37(3):453-6. doi: 10.1124/dmd.108.023747. Epub 2008 Dec 16.

11.

A null allele impairs function of CYP2C76 gene in cynomolgus monkeys: a possible genetic tool for generation of a better animal model in drug metabolism.

Uno Y, Sakuraba H, Uehara S, Kumano T, Matsuno K, Nakamura C, Kito G, Kamataki T, Nagata R.

Drug Metab Dispos. 2009 Jan;37(1):14-7. doi: 10.1124/dmd.108.023622. Epub 2008 Sep 29.

12.

Ginsenoside Rb1 reduces neurodegeneration in the peri-infarct area of a thromboembolic stroke model in non-human primates.

Yoshikawa T, Akiyoshi Y, Susumu T, Tokado H, Fukuzaki K, Nagata R, Samukawa K, Iwao H, Kito G.

J Pharmacol Sci. 2008 May;107(1):32-40. Epub 2008 Apr 29.

13.

Characterization of cynomolgus monkey cytochrome P450 (CYP) cDNAs: is CYP2C76 the only monkey-specific CYP gene responsible for species differences in drug metabolism?

Uno Y, Hosaka S, Matsuno K, Nakamura C, Kito G, Kamataki T, Nagata R.

Arch Biochem Biophys. 2007 Oct 1;466(1):98-105. Epub 2007 Jul 14.

PMID:
17689485
14.
15.

Left ventricular volume and function in cynomolgus monkeys using real-time three-dimensional echocardiography.

Tsusaki H, Yonamine H, Tamai A, Shimomoto M, Kuwano K, Iwao H, Nagata R, Kito G.

J Med Primatol. 2007 Feb;36(1):39-46.

PMID:
17359465
16.

CYP2C76-mediated species difference in drug metabolism: a comparison of pitavastatin metabolism between monkeys and humans.

Uno Y, Kumano T, Kito G, Nagata R, Kamataki T, Fujino H.

Xenobiotica. 2007 Jan;37(1):30-43.

PMID:
17178632
17.

Effects of phosphodiesterase (PDE) inhibitors on human ether-a-go-go related gene (hERG) channel activity.

Yunomae K, Ichisaki S, Matsuo J, Nagayama S, Fukuzaki K, Nagata R, Kito G.

J Appl Toxicol. 2007 Jan-Feb;27(1):78-85.

PMID:
17146843
18.

Evaluation of QT interval using a linear model in individual cynomolgus monkeys.

Koga T, Kuwano K, Kito G, Kanefuji K.

J Pharmacol Toxicol Methods. 2007 May-Jun;55(3):248-53. Epub 2006 Oct 25.

PMID:
17141531
19.

[Extrapolation of stroke model data to humans].

Susumu T, Yoshikawa T, Kito G.

Nihon Yakurigaku Zasshi. 2006 Jun;127(6):481-4. Review. Japanese. No abstract available.

PMID:
16880699
20.

CYP2C76, a novel cytochrome P450 in cynomolgus monkey, is a major CYP2C in liver, metabolizing tolbutamide and testosterone.

Uno Y, Fujino H, Kito G, Kamataki T, Nagata R.

Mol Pharmacol. 2006 Aug;70(2):477-86. Epub 2006 Apr 28.

21.

Effects of intra-arterial urokinase on a non-human primate thromboembolic stroke model.

Susumu T, Yoshikawa T, Akiyoshi Y, Nagata R, Fujiwara M, Kito G.

J Pharmacol Sci. 2006 Apr;100(4):278-84. Epub 2006 Mar 25.

22.

Evaluation of cardiac function in primates using real-time three-dimensional echocardiography as applications to safety assessment.

Tsusaki H, Yonamine H, Tamai A, Shimomoto M, Iwao H, Nagata R, Kito G.

J Pharmacol Toxicol Methods. 2005 Jul-Aug;52(1):182-7.

PMID:
15935708
23.

Post-ischemic cyclooxygenase-2 expression is regulated by the extent of cerebral blood flow reduction in non-human primates.

Yokota C, Kuge Y, Inoue H, Tagaya M, Kito G, Susumu T, Tamaki N, Minematsu K.

Neurosci Lett. 2003 Apr 24;341(1):37-40.

PMID:
12676338
24.

Development of telemetry system in the common marmoset--cardiovascular effects of astemizole and nicardipine.

Horii I, Kito G, Hamada T, Jikuzono T, Kobayashi K, Hashimoto K.

J Toxicol Sci. 2002 May;27(2):123-30.

25.

Serial changes in cerebral blood flow and flow-metabolism uncoupling in primates with acute thromboembolic stroke.

Kuge Y, Yokota C, Tagaya M, Hasegawa Y, Nishimura A, Kito G, Tamaki N, Hashimoto N, Yamaguchi T, Minematsu K.

J Cereb Blood Flow Metab. 2001 Mar;21(3):202-10.

PMID:
11295874
26.

Experimental thromboembolic stroke in cynomolgus monkey.

Kito G, Nishimura A, Susumu T, Nagata R, Kuge Y, Yokota C, Minematsu K.

J Neurosci Methods. 2001 Jan 30;105(1):45-53.

PMID:
11166365
27.

Characterization of the high sensitivity of rabbits to the effects of TCV-116, an angiotensin II receptor antagonist.

Sato K, Chatani F, Ito K, Kito G.

Fundam Appl Toxicol. 1997 Jan;35(1):49-54.

PMID:
9024672
30.

Effects of the non-peptide angiotensin II receptor antagonist TCV-116 on systemic and renal hemodynamics in dogs with renal hypertension.

Ito K, Shiomi M, Kito G.

Hypertens Res. 1995 Mar;18(1):69-75. Erratum in: Hypertens Res 1996 Jun;19(2):139.

31.
32.

[Effect of CV-4151 on the cerebral hypoperfusion and production of thromboxane A2 following complete cerebral ischemia-reperfusion in dogs].

Kito G, Tanabe M, Terashita Z.

Nihon Yakurigaku Zasshi. 1993 Dec;102(6):413-20. Japanese.

PMID:
8282273
33.

Quinones. 4. Novel eicosanoid antagonists: synthesis and pharmacological evaluation.

Shiraishi M, Kato K, Terao S, Ashida Y, Terashita Z, Kito G.

J Med Chem. 1989 Sep;32(9):2214-21.

PMID:
2769691
34.
35.

The antiobesity action of (S)-(+)-1-(4-chlorophenylthiomethyl)-N-methylethylamine fumarate (AO-124).

Ikeda H, Shimakawa K, Kito G, Meguro K, Matsuo T.

Eur J Pharmacol. 1986 Jun 17;125(2):201-10.

PMID:
3743636
36.

Influence of cerebral cortex stimulation upon cough-like spasmodic expiratory response (SER) and cough in the cat.

Kasé Y, Kito G, Miyata T, Takahama K.

Brain Res. 1984 Jul 23;306(1-2):293-8.

PMID:
6466978
37.

Contractile activities of leukotrienes C4 and D4 on vascular strips from rabbits.

Kito G, Okuda H, Ohkawa S, Terao S, Kikuchi K.

Life Sci. 1981 Sep 28;29(13):1325-32. No abstract available.

PMID:
6895239
39.

[Pharmacological studies on expectorants (author's transl)].

Kasé Y, Yakushiji T, Seo H, Sakata M, Kito G.

Nihon Yakurigaku Zasshi. 1977 Jul;73(5):605-24. Japanese.

PMID:
924268
40.

A cough-like respiratory response induced by electrical stimulation of the amygdaloid complex in the cat.

Kito G, Kasé Y, Miyata T.

Arch Int Pharmacodyn Ther. 1977 May;227(1):82-92. No abstract available.

PMID:
332098
41.

On the sites of antitussive action of d-3-methyl-N-methylmorphinan (AT-17).

Kasé Y, Kito G, Miyata T, Takahama K, Uno T.

Arzneimittelforschung. 1976;26(3):361-6.

PMID:
989327
42.

Antitussive activity and other related pharmacological properties of d-3-methyl-N-methylmorphinan (AT-17).

Kasé Y, Kito G, Miyata T, Uno T, Takahama K, Ida H.

Arzneimittelforschung. 1976;26(3):353-60.

PMID:
989326
43.

Pharmacological studies of 1-(o-chlorophenyl)-2-tert.-butylaminoethanol (C-78), a new bonchodilator.

Kubo S, Kasé Y, Miyata T, Kito G, Uesaka I.

Arzneimittelforschung. 1975 Jul;25(7):1028-37.

PMID:
241356
44.

Syntheses and pharmacological activities of 2-heterocyclic substituted 4(3H)-quinazolinone derivatives.

Hisano T, Ichikawa M, Kito G, Nishi T.

Chem Pharm Bull (Tokyo). 1972 Dec;20(12):2575-84. No abstract available.

PMID:
4652820
45.

Synthesis and pharmacological evaluation of some pyridylmethyl substituted ethylenediamines.

Miyano S, Abe A, Kasé Y, Yuizono T, Tachibana K, Miyata T, Kito G.

J Med Chem. 1970 Jul;13(4):704-8. No abstract available.

PMID:
5452434
46.

On the sites of antitsive action of N-(2-picolyl)-N-phenyl-N-(2-piperidinoethyl)amine (TAT-3).

Kasé Y, Wakita Y, Yuizono T, Kito G, Kikuchi K.

Arzneimittelforschung. 1970 Jan;20(1):37-43. No abstract available.

PMID:
5467446
47.

Centrally-induced coughs in the cat.

Kasé Y, Wakita Y, Kito G, Miyata T, Yuizono T, Kataoka M.

Life Sci. 1970 Jan 1;9(1):49-59. No abstract available.

PMID:
5435854
48.

Pharmacology of N-(2-picolyl)-N-phenyl-N-(2-piperidinoethyl)amine (TAT-3), a new antitussive agent.

Kasé Y, Yuizono T, Tachibana K, Miyata T, Kito G, Miyano S.

Arzneimittelforschung. 1969 Dec;19(12):1916-27. No abstract available.

PMID:
4392320
49.

The influence of anesthesia on the evaluation of antitussive effected.

Kasé Y, Yuizono T, Kito G.

Jpn J Pharmacol. 1969 Mar;19(1):115-24. No abstract available.

50.

The influence of anesthesia on the evaluation of antitussive effect.

Kas0e Y, Yuizono T, Kito G.

Jpn J Pharmacol. 1969 Mar;19(1):115-24. No abstract available.

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