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Items: 35


Cardiomyocyte damage control in heart failure and the role of the sarcolemma.

Kitmitto A, Baudoin F, Cartwright EJ.

J Muscle Res Cell Motil. 2019 Sep 13. doi: 10.1007/s10974-019-09539-5. [Epub ahead of print]


Quantitative proteomics and single-nucleus transcriptomics of the sinus node elucidates the foundation of cardiac pacemaking.

Linscheid N, Logantha SJRJ, Poulsen PC, Zhang S, Schrölkamp M, Egerod KL, Thompson JJ, Kitmitto A, Galli G, Humphries MJ, Zhang H, Pers TH, Olsen JV, Boyett M, Lundby A.

Nat Commun. 2019 Jun 28;10(1):2889. doi: 10.1038/s41467-019-10709-9.


Three-dimensional electron microscopy techniques for unravelling mitochondrial dysfunction in heart failure and identification of new pharmacological targets.

Daghistani HM, Rajab BS, Kitmitto A.

Br J Pharmacol. 2018 Sep 18. doi: 10.1111/bph.14499. [Epub ahead of print] Review.


Calmodulin regulates Cav3 T-type channels at their gating brake.

Chemin J, Taiakina V, Monteil A, Piazza M, Guan W, Stephens RF, Kitmitto A, Pang ZP, Dolphin AC, Perez-Reyes E, Dieckmann T, Guillemette JG, Spafford JD.

J Biol Chem. 2017 Dec 8;292(49):20010-20031. doi: 10.1074/jbc.M117.807925. Epub 2017 Sep 25.


A computational model of spatio-temporal cardiac intracellular calcium handling with realistic structure and spatial flux distribution from sarcoplasmic reticulum and t-tubule reconstructions.

Colman MA, Pinali C, Trafford AW, Zhang H, Kitmitto A.

PLoS Comput Biol. 2017 Aug 31;13(8):e1005714. doi: 10.1371/journal.pcbi.1005714. eCollection 2017 Aug.


Targeting miR-423-5p Reverses Exercise Training-Induced HCN4 Channel Remodeling and Sinus Bradycardia.

D'Souza A, Pearman CM, Wang Y, Nakao S, Logantha SJRJ, Cox C, Bennett H, Zhang Y, Johnsen AB, Linscheid N, Poulsen PC, Elliott J, Coulson J, McPhee J, Robertson A, da Costa Martins PA, Kitmitto A, Wisløff U, Cartwright EJ, Monfredi O, Lundby A, Dobrzynski H, Oceandy D, Morris GM, Boyett MR.

Circ Res. 2017 Oct 13;121(9):1058-1068. doi: 10.1161/CIRCRESAHA.117.311607. Epub 2017 Aug 17.


Post-Myocardial Infarction T-tubules Form Enlarged Branched Structures With Dysregulation of Junctophilin-2 and Bridging Integrator 1 (BIN-1).

Pinali C, Malik N, Davenport JB, Allan LJ, Murfitt L, Iqbal MM, Boyett MR, Wright EJ, Walker R, Zhang Y, Dobryznski H, Holt CM, Kitmitto A.

J Am Heart Assoc. 2017 May 4;6(5). pii: e004834. doi: 10.1161/JAHA.116.004834.


Targeting caveolin-3 for the treatment of diabetic cardiomyopathy.

Murfitt L, Whiteley G, Iqbal MM, Kitmitto A.

Pharmacol Ther. 2015 Jul;151:50-71. doi: 10.1016/j.pharmthera.2015.03.002. Epub 2015 Mar 14. Review.


Three-dimensional structure of the intercalated disc reveals plicate domain and gap junction remodeling in heart failure.

Pinali C, Bennett HJ, Davenport JB, Caldwell JL, Starborg T, Trafford AW, Kitmitto A.

Biophys J. 2015 Feb 3;108(3):498-507. doi: 10.1016/j.bpj.2014.12.001.


Dependence of cardiac transverse tubules on the BAR domain protein amphiphysin II (BIN-1).

Caldwell JL, Smith CE, Taylor RF, Kitmitto A, Eisner DA, Dibb KM, Trafford AW.

Circ Res. 2014 Dec 5;115(12):986-96. doi: 10.1161/CIRCRESAHA.116.303448. Epub 2014 Oct 20.


Serial block face scanning electron microscopy for the study of cardiac muscle ultrastructure at nanoscale resolutions.

Pinali C, Kitmitto A.

J Mol Cell Cardiol. 2014 Nov;76:1-11. doi: 10.1016/j.yjmcc.2014.08.010. Epub 2014 Aug 20. Review.


Three-dimensional reconstruction of cardiac sarcoplasmic reticulum reveals a continuous network linking transverse-tubules: this organization is perturbed in heart failure.

Pinali C, Bennett H, Davenport JB, Trafford AW, Kitmitto A.

Circ Res. 2013 Nov 8;113(11):1219-30. doi: 10.1161/CIRCRESAHA.113.301348. Epub 2013 Sep 17.


Human junctophilin-2 undergoes a structural rearrangement upon binding PtdIns(3,4,5)P3 and the S101R mutation identified in hypertrophic cardiomyopathy obviates this response.

Bennett HJ, Davenport JB, Collins RF, Trafford AW, Pinali C, Kitmitto A.

Biochem J. 2013 Dec 1;456(2):205-17. doi: 10.1042/BJ20130591.


Characterization of the molecular architecture of human caveolin-3 and interaction with the skeletal muscle ryanodine receptor.

Whiteley G, Collins RF, Kitmitto A.

J Biol Chem. 2012 Nov 23;287(48):40302-16. doi: 10.1074/jbc.M112.377085. Epub 2012 Oct 15.


Labelling of the 3D structure of the cardiac L-type voltage-gated calcium channel.

Walsh CP, Davies A, Nieto-Rostro M, Dolphin AC, Kitmitto A.

Channels (Austin). 2009 Nov;3(6):387-92.


Three-dimensional structure of CaV3.1: comparison with the cardiac L-type voltage-gated calcium channel monomer architecture.

Walsh CP, Davies A, Butcher AJ, Dolphin AC, Kitmitto A.

J Biol Chem. 2009 Aug 14;284(33):22310-21. doi: 10.1074/jbc.M109.017152. Epub 2009 Jun 11.


Ca(2+)-calmodulin can activate and inactivate cardiac ryanodine receptors.

Sigalas C, Bent S, Kitmitto A, O'Neill S, Sitsapesan R.

Br J Pharmacol. 2009 Mar;156(5):794-806. doi: 10.1111/j.1476-5381.2008.00092.x. Epub 2009 Feb 3.


Small-angle X-ray scattering and NMR studies of the conformation of the PDZ region of SAP97 and its interactions with Kir2.1.

Goult BT, Rapley JD, Dart C, Kitmitto A, Grossmann JG, Leyland ML, Lian LY.

Biochemistry. 2007 Dec 11;46(49):14117-28. Epub 2007 Nov 16.


Solid-state NMR and functional measurements indicate that the conserved tyrosine residues of sarcolipin are involved directly in the inhibition of SERCA1.

Hughes E, Clayton JC, Kitmitto A, Esmann M, Middleton DA.

J Biol Chem. 2007 Sep 7;282(36):26603-13. Epub 2007 Jul 6.


Apo calmodulin binding to the L-type voltage-gated calcium channel Cav1.2 IQ peptide.

Lian LY, Myatt D, Kitmitto A.

Biochem Biophys Res Commun. 2007 Feb 16;353(3):565-70. Epub 2006 Dec 19.


Applications of electron cryo-microscopy to cardiovascular research.

Kitmitto A.

Methods Mol Med. 2006;129:315-27.


Three-dimensional structure determination of a protein supercomplex that oxidizes methane to formaldehyde in Methylococcus capsulatus (Bath).

Myronova N, Kitmitto A, Collins RF, Miyaji A, Dalton H.

Biochemistry. 2006 Oct 3;45(39):11905-14.


Studies of the aggregation of an amyloidogenic alpha-synuclein peptide fragment.

Madine J, Doig AJ, Kitmitto A, Middleton DA.

Biochem Soc Trans. 2005 Nov;33(Pt 5):1113-5.


Characterization and structural analysis of an active particulate methane monooxygenase trimer from Methylococcus capsulatus (Bath).

Kitmitto A, Myronova N, Basu P, Dalton H.

Biochemistry. 2005 Aug 23;44(33):10954-65.


Structure of the Neisseria meningitidis outer membrane PilQ secretin complex at 12 A resolution.

Collins RF, Frye SA, Kitmitto A, Ford RC, Tønjum T, Derrick JP.

J Biol Chem. 2004 Sep 17;279(38):39750-6. Epub 2004 Jul 14.


L-type voltage-gated calcium channels: understanding function through structure.

Wang MC, Dolphin A, Kitmitto A.

FEBS Lett. 2004 Apr 30;564(3):245-50. Review.


The three-dimensional structure of the cardiac L-type voltage-gated calcium channel: comparison with the skeletal muscle form reveals a common architectural motif.

Wang MC, Collins RF, Ford RC, Berrow NS, Dolphin AC, Kitmitto A.

J Biol Chem. 2004 Feb 20;279(8):7159-68. Epub 2003 Nov 22.


Three-dimensional structure of the Neisseria meningitidis secretin PilQ determined from negative-stain transmission electron microscopy.

Collins RF, Ford RC, Kitmitto A, Olsen RO, Tønjum T, Derrick JP.

J Bacteriol. 2003 Apr;185(8):2611-7.


3D structure of the skeletal muscle dihydropyridine receptor.

Wang MC, Velarde G, Ford RC, Berrow NS, Dolphin AC, Kitmitto A.

J Mol Biol. 2002 Oct 11;323(1):85-98. Erratum in: J Mol Biol. 2003 Mar 14;327(1):299.


The location of plastocyanin in vascular plant photosystem I.

Ruffle SV, Mustafa AO, Kitmitto A, Holzenburg A, Ford RC.

J Biol Chem. 2002 Jul 12;277(28):25692-6. Epub 2002 Apr 25.


The location of the mobile electron carrier ferredoxin in vascular plant photosystem I.

Ruffle SV, Mustafa AO, Kitmitto A, Holzenburg A, Ford RC.

J Biol Chem. 2000 Nov 17;275(46):36250-5.


A fragment of recombinant GABA(A) receptor alpha1 subunit forming rosette-like homo-oligomers.

Xue H, Zheng H, Li HM, Kitmitto A, Zhu H, Lee P, Holzenburg A.

J Mol Biol. 2000 Feb 25;296(3):739-42.


Three-dimensional structure of higher plant photosystem I determined by electron crystallography.

Kitmitto A, Mustafa AO, Holzenburg A, Ford RC.

J Biol Chem. 1998 Nov 6;273(45):29592-9.


Two-dimensional crystals of photosystem I in higher plant grana margins.

Kitmitto A, Holzenburg A, Ford RC.

J Biol Chem. 1997 Aug 1;272(31):19497-501. Erratum in: J Biol Chem 1997 Oct 24;272(43):27492.


Arthrobacter D-xylose isomerase: partial proteolysis with thermolysin.

Siddiqui KS, Rangarajan M, Hartley BS, Kitmitto A, Panico M, Blench IP, Morris HR.

Biochem J. 1993 Jan 1;289 ( Pt 1):201-8.

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