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Molecular chaperone HSP70 prevents formation of inclusion bodies of the 25-kDa C-terminal fragment of TDP-43 by preventing aggregate accumulation.

Kitamura A, Iwasaki N, Kinjo M.

Cell Stress Chaperones. 2018 Aug 11. doi: 10.1007/s12192-018-0930-1. [Epub ahead of print]


The cytoplasmic region of the amyloid β-protein precursor (APP) is necessary and sufficient for the enhanced fast velocity of APP transport by kinesin-1.

Tsukamoto M, Chiba K, Sobu Y, Shiraki Y, Okumura Y, Hata S, Kitamura A, Nakaya T, Uchida S, Kinjo M, Taru H, Suzuki T.

FEBS Lett. 2018 Jul 28. doi: 10.1002/1873-3468.13204. [Epub ahead of print]


The role of virtual-assisted lung mapping in the resection of ground glass nodules.

Sato M, Kuwata T, Kitamura A, Misawa K, Imashimizu K, Yamanashi K, Ikeda M, Koike T, Kobayashi M, Kosaka S, Fukai R, Isowa N, Nagayama K, Aoyama A, Date H, Nakajima J.

J Thorac Dis. 2018 May;10(5):2638-2647. doi: 10.21037/jtd.2018.05.13.


Are the Kihon Checklist and the Kaigo-Yobo Checklist Compatible With the Frailty Index?

Kojima G, Taniguchi Y, Kitamura A, Shinkai S.

J Am Med Dir Assoc. 2018 Jul 3. pii: S1525-8610(18)30284-6. doi: 10.1016/j.jamda.2018.05.012. [Epub ahead of print]


A Community-Wide Intervention Trial for Preventing and Reducing Frailty Among Older Adults Living in Metropolitan Areas: Design and Baseline Survey for a Study Integrating Participatory Action Research With a Cluster Trial.

Seino S, Kitamura A, Tomine Y, Tanaka I, Nishi M, Nonaka K, Nofuji Y, Narita M, Taniguchi Y, Yokoyama Y, Amano H, Ikeuchi T, Fujiwara Y, Shinkai S.

J Epidemiol. 2018 Jun 30. doi: 10.2188/jea.JE20170109. [Epub ahead of print]


Dietary Intake of Energy and Nutrients from Breakfast and Risk of Stroke in The Japanese Population: The Circulatory Risk in Communities Study (CIRCS).

Okada C, Imano H, Yamagishi K, Cui R, Umesawa M, Maruyama K, Muraki I, Hayama-Terada M, Shimizu Y, Sankai T, Okada T, Kiyama M, Kitamura A, Iso H; CIRCS Investigators.

J Atheroscler Thromb. 2018 Jun 13. doi: 10.5551/jat.44438. [Epub ahead of print]


Analysis of the substrate recognition state of TDP-43 to single-stranded DNA using fluorescence correlation spectroscopy.

Kitamura A, Shibasaki A, Takeda K, Suno R, Kinjo M.

Biochem Biophys Rep. 2018 Apr 12;14:58-63. doi: 10.1016/j.bbrep.2018.03.009. eCollection 2018 Jul.


Ingested d-Aspartate Facilitates the Functional Connectivity and Modifies Dendritic Spine Morphology in Rat Hippocampus.

Kitamura A, Hojo Y, Ikeda M, Karakawa S, Kuwahara T, Kim J, Soma M, Kawato S, Tsurugizawa T.

Cereb Cortex. 2018 May 30. doi: 10.1093/cercor/bhy120. [Epub ahead of print]


Individual- and community-level neighbor relationships and physical activity among older Japanese adults living in a metropolitan area: a cross-sectional multilevel analysis.

Seino S, Kitamura A, Nishi M, Tomine Y, Tanaka I, Taniguchi Y, Yokoyama Y, Amano H, Narita M, Ikeuchi T, Fujiwara Y, Shinkai S.

Int J Behav Nutr Phys Act. 2018 May 25;15(1):46. doi: 10.1186/s12966-018-0679-z.


Cardiovascular disease mortality in relation to physical activity during adolescence and adulthood in Japan: Does school-based sport club participation matter?

Gero K, Iso H, Kitamura A, Yamagishi K, Yatsuya H, Tamakoshi A.

Prev Med. 2018 Aug;113:102-108. doi: 10.1016/j.ypmed.2018.05.012. Epub 2018 May 16.


Determination of cytoplasmic optineurin foci sizes using image correlation spectroscopy.

Kitamura A, Shimizu H, Kinjo M.

J Biochem. 2018 Apr 19. doi: 10.1093/jb/mvy044. [Epub ahead of print]


A murine model of atopic dermatitis can be generated by painting the dorsal skin with hapten twice 14 days apart.

Kitamura A, Takata R, Aizawa S, Watanabe H, Wada T.

Sci Rep. 2018 Apr 16;8(1):5988. doi: 10.1038/s41598-018-24363-6.


Digital Clubbing Is Associated with Higher Serum KL-6 Levels and Lower Pulmonary Function in Patients with Interstitial Lung Disease.

Shiraishi K, Jinta T, Nishimura N, Nakaoka H, Tsugitomi R, Okafuji K, Kitamura A, Tomishima Y, Deshpande GA, Tamura T.

Can Respir J. 2018 Jan 23;2018:3640967. doi: 10.1155/2018/3640967. eCollection 2018.


Trajectories of arterial stiffness and all-cause mortality among community-dwelling older Japanese.

Taniguchi Y, Kitamura A, Shinozaki T, Seino S, Yokoyama Y, Narita M, Amano H, Matsuyama Y, Fujiwara Y, Shinkai S.

Geriatr Gerontol Int. 2018 Apr 2. doi: 10.1111/ggi.13323. [Epub ahead of print]


Association of Trajectories of Higher-Level Functional Capacity with Mortality and Medical and Long-Term Care Costs Among Community-Dwelling Older Japanese.

Taniguchi Y, Kitamura A, Nofuji Y, Ishizaki T, Seino S, Yokoyama Y, Shinozaki T, Murayama H, Mitsutake S, Amano H, Nishi M, Matsuyama Y, Fujiwara Y, Shinkai S.

J Gerontol A Biol Sci Med Sci. 2018 Mar 26. doi: 10.1093/gerona/gly024. [Epub ahead of print]


Preoperative weight loss program involving a 20-day very low-calorie diet for obesity before laparoscopic gastrectomy for gastric cancer.

Inoue K, Yoshiuchi S, Yoshida M, Nakamura N, Nakajima S, Kitamura A, Mouri K, Michiura T, Mukaide H, Ozaki T, Miki H, Yanagimoto H, Satoi S, Kaibori M, Hamada M, Kimura Y, Kon M.

Asian J Endosc Surg. 2018 Mar 25. doi: 10.1111/ases.12479. [Epub ahead of print]


State-of-the-Art Fluorescence Fluctuation-Based Spectroscopic Techniques for the Study of Protein Aggregation.

Kitamura A, Kinjo M.

Int J Mol Sci. 2018 Mar 23;19(4). pii: E964. doi: 10.3390/ijms19040964. Review.


Serum creatinine levels and risk of incident type 2 diabetes mellitus or dysglycemia in middle-aged Japanese men: a retrospective cohort study.

Takeuchi M, Imano H, Muraki I, Shimizu Y, Hayama-Terada M, Kitamura A, Okada T, Kiyama M, Iso H.

Vet Rec. 2018 Feb 26. pii: e000492. doi: 10.1136/bmjdrc-2017-000492. [Epub ahead of print]


Determination of diffusion coefficients in live cells using fluorescence recovery after photobleaching with wide-field fluorescence microscopy.

Kitamura A, Kinjo M.

Biophys Physicobiol. 2018 Jan 19;15:1-7. doi: 10.2142/biophysico.15.0_1. eCollection 2018.


Nonfasting Glucose and Incident Stroke and Its Types - The Circulatory Risk in Communities Study (CIRCS).

Imano H, Iso H, Kitamura A, Yamagishi K, Hayama-Terada M, Muraki I, Okada T, Umesawa M, Ohira T, Sankai T, Cui R, Tanigawa T, Kiyama M; CIRCS Investigators.

Circ J. 2018 May 25;82(6):1598-1604. doi: 10.1253/circj.CJ-17-0950. Epub 2018 Feb 14.


Detection of substrate binding of a collagen-specific molecular chaperone HSP47 in solution using fluorescence correlation spectroscopy.

Kitamura A, Ishida Y, Kubota H, Pack CG, Homma T, Ito S, Araki K, Kinjo M, Nagata K.

Biochem Biophys Res Commun. 2018 Feb 26;497(1):279-284. doi: 10.1016/j.bbrc.2018.02.069. Epub 2018 Feb 10.


Malignant mesothelioma with squamous differentiation.

Tanaka H, Akiyama Y, Kitamura A, Matsumoto N, Tomita M, Kataoka H.

Histopathology. 2018 Jun;72(7):1216-1220. doi: 10.1111/his.13482. Epub 2018 Mar 30.


Associations of Tobacco Smoking with Impaired Endothelial Function: The Circulatory Risk in Communities Study (CIRCS).

Cui M, Cui R, Liu K, Dong JY, Imano H, Hayama-Terada M, Muraki I, Kiyama M, Okada T, Kitamura A, Umesawa M, Yamagishi K, Ohira T, Iso H; CIRCS investigators.

J Atheroscler Thromb. 2018 Feb 8. doi: 10.5551/jat.42150. [Epub ahead of print]


Physicochemical Properties of the Mammalian Molecular Chaperone HSP60.

Ishida R, Okamoto T, Motojima F, Kubota H, Takahashi H, Tanabe M, Oka T, Kitamura A, Kinjo M, Yoshida M, Otaka M, Grave E, Itoh H.

Int J Mol Sci. 2018 Feb 6;19(2). pii: E489. doi: 10.3390/ijms19020489.


Early radiographic risk factors for rigid relapse in idiopathic clubfoot treated with the Ponseti method.

Mishima K, Kitoh H, Matsushita M, Sugiura H, Hasegawa S, Kitamura A, Nishida Y, Ishiguro N.

Foot Ankle Surg. 2017 Jun 17. pii: S1268-7731(17)30126-1. doi: 10.1016/j.fas.2017.06.003. [Epub ahead of print]


Applicability of Kd for modelling dissolved 137Cs concentrations in Fukushima river water: Case study of the upstream Ota River.

Sakuma K, Tsuji H, Hayashi S, Funaki H, Malins A, Yoshimura K, Kurikami H, Kitamura A, Iijima K, Hosomi M.

J Environ Radioact. 2018 Apr;184-185:53-62. doi: 10.1016/j.jenvrad.2018.01.001. Epub 2018 Jan 30.


Desquamative interstitial pneumonia complicated by diffuse alveolar haemorrhage.

Matsuo A, Matsumoto N, Kitamura A, Tsubouchi H, Yanagi S, Nakazato M.

Respirol Case Rep. 2017 Dec 22;6(2):e00291. doi: 10.1002/rcr2.291. eCollection 2018 Feb.


Effects of Low-Dose Dairy Protein Plus Micronutrient Supplementation during Resistance Exercise on Muscle Mass and Physical Performance in Older Adults: A Randomized, Controlled Trial.

Seino S, Sumi K, Narita M, Yokoyama Y, Ashida K, Kitamura A, Shinkai S.

J Nutr Health Aging. 2018;22(1):59-67. doi: 10.1007/s12603-017-0904-5.


Rationale and Descriptive Analysis of Specific Health Guidance: the Nationwide Lifestyle Intervention Program Targeting Metabolic Syndrome in Japan.

Tsushita K, S Hosler A, Miura K, Ito Y, Fukuda T, Kitamura A, Tatara K.

J Atheroscler Thromb. 2018 Apr 1;25(4):308-322. doi: 10.5551/jat.42010. Epub 2017 Dec 12.


Roles of children and their parents in the reduction of radiation risk after the 2011 Fukushima Daiichi Nuclear Power Plant accident.

Fujimura MS, Komasa Y, Kimura S, Shibanuma A, Kitamura A, Jimba M.

PLoS One. 2017 Dec 13;12(12):e0188906. doi: 10.1371/journal.pone.0188906. eCollection 2017.


Genome-wide scan identifies candidate loci related to remifentanil requirements during laparoscopic-assisted colectomy.

Nishizawa D, Mieda T, Tsujita M, Nakagawa H, Yamaguchi S, Kasai S, Hasegawa J, Fukuda KI, Kitamura A, Hayashida M, Ikeda K.

Pharmacogenomics. 2018 Jan;19(2):113-127. doi: 10.2217/pgs-2017-0109. Epub 2017 Dec 6.


Evaluation of sediment and 137Cs redistribution in the Oginosawa River catchment near the Fukushima Dai-ichi Nuclear Power Plant using integrated watershed modeling.

Sakuma K, Malins A, Funaki H, Kurikami H, Niizato T, Nakanishi T, Mori K, Tada K, Kobayashi T, Kitamura A, Hosomi M.

J Environ Radioact. 2018 Feb;182:44-51. doi: 10.1016/j.jenvrad.2017.11.021. Epub 2017 Nov 28.


Structural basis for the assembly of the Ragulator-Rag GTPase complex.

Yonehara R, Nada S, Nakai T, Nakai M, Kitamura A, Ogawa A, Nakatsumi H, Nakayama KI, Li S, Standley DM, Yamashita E, Nakagawa A, Okada M.

Nat Commun. 2017 Nov 20;8(1):1625. doi: 10.1038/s41467-017-01762-3.


U6 snRNA expression prevents toxicity in TDP-43-knockdown cells.

Yahara M, Kitamura A, Kinjo M.

PLoS One. 2017 Nov 10;12(11):e0187813. doi: 10.1371/journal.pone.0187813. eCollection 2017.


[Impact of frailty and metabolic syndrome on the incidence of loss of independence in community-dwelling older Japanese: the Kusatsu-town study].

Kitamura A, Shinkai S, Taniguchi Y, Amano H, Seino S, Yokoyama Y, Nishi M, Fujiwara Y.

Nihon Koshu Eisei Zasshi. 2017;64(10):593-606. doi: 10.11236/jph.64.10_593. Japanese.


8-Nitro-cGMP Attenuates the Interaction between SNARE Complex and Complexin through S-Guanylation of SNAP-25.

Kishimoto Y, Kunieda K, Kitamura A, Kakihana Y, Akaike T, Ihara H.

ACS Chem Neurosci. 2018 Feb 21;9(2):217-223. doi: 10.1021/acschemneuro.7b00363. Epub 2017 Nov 10.


Chronic cerebral hypoperfusion: a key mechanism leading to vascular cognitive impairment and dementia. Closing the translational gap between rodent models and human vascular cognitive impairment and dementia.

Duncombe J, Kitamura A, Hase Y, Ihara M, Kalaria RN, Horsburgh K.

Clin Sci (Lond). 2017 Sep 28;131(19):2451-2468. doi: 10.1042/CS20160727. Print 2017 Oct 1. Review.


Millennial-scale northern Hemisphere Atlantic-Pacific climate teleconnections in the earliest Middle Pleistocene.

Hyodo M, Bradák B, Okada M, Katoh S, Kitaba I, Dettman DL, Hayashi H, Kumazawa K, Hirose K, Kazaoka O, Shikoku K, Kitamura A.

Sci Rep. 2017 Aug 30;7(1):10036. doi: 10.1038/s41598-017-10552-2.


Exposure to Electrophiles Impairs Reactive Persulfide-Dependent Redox Signaling in Neuronal Cells.

Ihara H, Kasamatsu S, Kitamura A, Nishimura A, Tsutsuki H, Ida T, Ishizaki K, Toyama T, Yoshida E, Abdul Hamid H, Jung M, Matsunaga T, Fujii S, Sawa T, Nishida M, Kumagai Y, Akaike T.

Chem Res Toxicol. 2017 Sep 18;30(9):1673-1684. doi: 10.1021/acs.chemrestox.7b00120. Epub 2017 Sep 7.


Genome-wide microRNA expression profiling in placentae from frozen-thawed blastocyst transfer.

Hiura H, Hattori H, Kobayashi N, Okae H, Chiba H, Miyauchi N, Kitamura A, Kikuchi H, Yoshida H, Arima T.

Clin Epigenetics. 2017 Aug 3;9:79. doi: 10.1186/s13148-017-0379-6. eCollection 2017.


Notch Balances Th17 and Induced Regulatory T Cell Functions in Dendritic Cells by Regulating Aldh1a2 Expression.

Zaman TS, Arimochi H, Maruyama S, Ishifune C, Tsukumo SI, Kitamura A, Yasutomo K.

J Immunol. 2017 Sep 15;199(6):1989-1997. doi: 10.4049/jimmunol.1700645. Epub 2017 Aug 4.


Minocycline reduces microgliosis and improves subcortical white matter function in a model of cerebral vascular disease.

Manso Y, Holland PR, Kitamura A, Szymkowiak S, Duncombe J, Hennessy E, Searcy JL, Marangoni M, Randall AD, Brown JT, McColl BW, Horsburgh K.

Glia. 2018 Jan;66(1):34-46. doi: 10.1002/glia.23190. Epub 2017 Jul 19.


Association between markers of arterial stiffness and atrial fibrillation in the Circulatory Risk in Communities Study (CIRCS).

Cui R, Yamagishi K, Muraki I, Hayama-Terada M, Umesawa M, Imano H, Li Y, Eshak ES, Ohira T, Kiyama M, Okada T, Kitamura A, Tanigawa T, Iso H; CIRCS investigators.

Atherosclerosis. 2017 Aug;263:244-248. doi: 10.1016/j.atherosclerosis.2017.06.918. Epub 2017 Jun 22.


Long-term cilostazol treatment reduces gliovascular damage and memory impairment in a mouse model of chronic cerebral hypoperfusion.

Kitamura A, Manso Y, Duncombe J, Searcy J, Koudelka J, Binnie M, Webster S, Lennen R, Jansen M, Marshall I, Ihara M, Kalaria RN, Horsburgh K.

Sci Rep. 2017 Jun 27;7(1):4299. doi: 10.1038/s41598-017-04082-0.


Small Cell Lung Cancer in a 20-year-old Non-Smoking Man with Systemic Sclerosis.

Saito G, Jinta T, Nakaoka H, Kitamura A, Yamaguchi K, Nishimura N.

Intern Med. 2017;56(12):1549-1552. doi: 10.2169/internalmedicine.56.7985. Epub 2017 Jun 15.


Factors affecting masticatory function of community-dwelling older people: Investigation of the differences in the relevant factors for subjective and objective assessment.

Takagi D, Watanabe Y, Edahiro A, Ohara Y, Murakami M, Murakami K, Hironaka S, Taniguchi Y, Kitamura A, Shinkai S, Hirano H.

Gerodontology. 2017 Sep;34(3):357-364. doi: 10.1111/ger.12274. Epub 2017 May 29.


Different aggregation states of a nuclear localization signal-tagged 25-kDa C-terminal fragment of TAR RNA/DNA-binding protein 43 kDa.

Kitamura A, Yuno S, Muto H, Kinjo M.

Genes Cells. 2017 Jun;22(6):521-534. doi: 10.1111/gtc.12495. Epub 2017 May 12.


CORRIGENDUM: Diabetes Trend and Impact on Risk of Cardiovascular Disease in Middle-Aged Japanese People.

Hayama-Terada M, Muraki I, Imano H, Kiyama M, Okada T, Yamagishi K, Cui R, Ohira T, Umesawa M, Sankai T, Sato S, Kitamura A, Iso H; CIRCS Investigators.

Circ J. 2017;81(5):766. doi: 10.1253/circj.CJ-66-0142. No abstract available.


Effects of a multifactorial intervention comprising resistance exercise, nutritional and psychosocial programs on frailty and functional health in community-dwelling older adults: A randomized, controlled, cross-over trial.

Seino S, Nishi M, Murayama H, Narita M, Yokoyama Y, Nofuji Y, Taniguchi Y, Amano H, Kitamura A, Shinkai S.

Geriatr Gerontol Int. 2017 Nov;17(11):2034-2045. doi: 10.1111/ggi.13016. Epub 2017 Apr 10.


Impact of Hypertension and Subclinical Organ Damage on the Incidence of Cardiovascular Disease Among Japanese Residents at the Population and Individual Levels - The Circulatory Risk in Communities Study (CIRCS).

Kitamura A, Yamagishi K, Imano H, Kiyama M, Cui R, Ohira T, Umesawa M, Muraki I, Sankai T, Saito I, Iso H; CIRCS Investigators.

Circ J. 2017 Jun 23;81(7):1022-1028. doi: 10.1253/circj.CJ-16-1129. Epub 2017 Mar 29.

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