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Hypoxia induces the dormant state in oocytes through expression of Foxo3.

Shimamoto S, Nishimura Y, Nagamatsu G, Hamada N, Kita H, Hikabe O, Hamazaki N, Hayashi K.

Proc Natl Acad Sci U S A. 2019 Jun 18;116(25):12321-12326. doi: 10.1073/pnas.1817223116. Epub 2019 May 30.


BCL6 modulates tissue neutrophil survival and exacerbates pulmonary inflammation following influenza virus infection.

Zhu B, Zhang R, Li C, Jiang L, Xiang M, Ye Z, Kita H, Melnick AM, Dent AL, Sun J.

Proc Natl Acad Sci U S A. 2019 Jun 11;116(24):11888-11893. doi: 10.1073/pnas.1902310116. Epub 2019 May 28.


Therapeutic Antibodies for Nasal Polyposis Treatment: Where Are We Headed?

Agarwal A, Spath D, Sherris DA, Kita H, Ponikau JU.

Clin Rev Allergy Immunol. 2019 May 10. doi: 10.1007/s12016-019-08734-z. [Epub ahead of print] Review.


Pro-GA, a Novel Inhibitor of γ-Glutamylcyclotransferase, Suppresses Human Bladder Cancer Cell Growth.

Hanada E, Kageyama S, Murai R, Kubota S, Ii H, Nakata S, Kita H, Kawauchi A, Chano T.

Anticancer Res. 2019 Apr;39(4):1893-1898. doi: 10.21873/anticanres.13297.


Periphery Design of Macrocyclic Materials for Organic Light-Emitting Devices with a Blue Phosphorescent Emitter.

Yoshii A, Ikemoto K, Izumi T, Taka H, Kita H, Sato S, Isobe H.

Org Lett. 2019 Apr 19;21(8):2759-2762. doi: 10.1021/acs.orglett.9b00717. Epub 2019 Apr 5.


Perspectives on End-of-Life Treatment among Patients with COPD: A Multicenter, Cross-sectional Study in Japan.

Fuseya Y, Muro S, Sato S, Sato A, Tanimura K, Hasegawa K, Uemasu K, Hamakawa Y, Takahashi Y, Nakayama T, Sakai N, Fukui M, Kita H, Mio T, Mishima M, Hirai T.

COPD. 2019 Feb;16(1):75-81. doi: 10.1080/15412555.2019.1573888. Epub 2019 Feb 21.


Eosinophil peroxidase, GATA3, and T-bet as tissue biomarkers in chronic rhinosinusitis.

Lal D, Wright BL, Shim KP, Zarka MA, Lee JJ, Chang YH, Ochkur SI, Divekar R, Doyle AD, Jacobsen EA, Kita H, Rank MA.

J Allergy Clin Immunol. 2019 Jun;143(6):2284-2287.e6. doi: 10.1016/j.jaci.2019.01.038. Epub 2019 Feb 8. No abstract available.


Investigation of the Lewis acidic behaviour of an oxygen-bridged planarized triphenylborane toward amines and the properties of their Lewis acid-base adducts.

Kitamoto Y, Kobayashi F, Suzuki T, Miyata Y, Kita H, Funaki K, Oi S.

Dalton Trans. 2019 Feb 5;48(6):2118-2127. doi: 10.1039/c8dt00128f.


Enzyme-like Regiodivergent Behavior of a Flavopeptide Catalyst in Aerobic Baeyer-Villiger Oxidation.

Yamanomoto K, Kita H, Arakawa Y, Minagawa K, Imada Y.

Chimia (Aarau). 2018 Dec 19;72(12):866-869. doi: 10.2533/chimia.2018.866.


Baseline Gastrointestinal Eosinophilia Is Common in Oral Immunotherapy Subjects With IgE-Mediated Peanut Allergy.

Wright BL, Fernandez-Becker NQ, Kambham N, Purington N, Tupa D, Zhang W, Rank MA, Kita H, Shim KP, Bunning BJ, Doyle AD, Jacobsen EA, Boyd SD, Tsai M, Maecker H, Manohar M, Galli SJ, Nadeau KC, Chinthrajah RS.

Front Immunol. 2018 Nov 22;9:2624. doi: 10.3389/fimmu.2018.02624. eCollection 2018.


Design of peptide-containing N5-unmodified neutral flavins that catalyze aerobic oxygenations.

Arakawa Y, Yamanomoto K, Kita H, Minagawa K, Tanaka M, Haraguchi N, Itsuno S, Imada Y.

Chem Sci. 2017 Aug 1;8(8):5468-5475. doi: 10.1039/c7sc01933e. Epub 2017 May 30.


Innate Immunity Induced by the Major Allergen Alt a 1 From the Fungus Alternaria Is Dependent Upon Toll-Like Receptors 2/4 in Human Lung Epithelial Cells.

Hayes T, Rumore A, Howard B, He X, Luo M, Wuenschmann S, Chapman M, Kale S, Li L, Kita H, Lawrence CB.

Front Immunol. 2018 Jul 30;9:1507. doi: 10.3389/fimmu.2018.01507. eCollection 2018.


Innate and adaptive immune responses to fungi in the airway.

Bartemes KR, Kita H.

J Allergy Clin Immunol. 2018 Aug;142(2):353-363. doi: 10.1016/j.jaci.2018.06.015. Review.


Eosinophilic Inflammation in Peritoneal Fibrosis Patients Undergoing Peritoneal Dialysis.

Kobayashi T, Noguchi T, Saito K, Shirasaki F, Kita H, Nagata M, Okada H, Nakamoto H.

Contrib Nephrol. 2018;196:1-4. doi: 10.1159/000485689. Epub 2018 Jul 24. Review.


Cellular Stress Response to Varicella-Zoster Virus Infection of Human Skin Includes Highly Elevated Interleukin-6 Expression.

Jarosinski KW, Carpenter JE, Buckingham EM, Jackson W, Knudtson K, Moffat JF, Kita H, Grose C.

Open Forum Infect Dis. 2018 May 22;5(6):ofy118. doi: 10.1093/ofid/ofy118. eCollection 2018 Jun.


Single Gas Permeance Performance of High Silica SSZ-13 Zeolite Membranes.

Liang L, Zhu M, Chen L, Zhong C, Yang Y, Wu T, Wang H, Kumakiri I, Chen X, Kita H.

Membranes (Basel). 2018 Jul 13;8(3). pii: E43. doi: 10.3390/membranes8030043.


Difference between the Upper and the Lower Gastrointestinal Bleeding in Patients Taking Nonvitamin K Oral Anticoagulants.

Maruyama K, Yamamoto T, Aoyagi H, Isono A, Abe K, Kodashima S, Kita H, Watari Y, Kozuma K.

Biomed Res Int. 2018 May 15;2018:7123607. doi: 10.1155/2018/7123607. eCollection 2018.


Great Saphenous Vein Flow Pattern as a Simple Ultrasonographic Sign of Early Recanalization of Deep Vein Thrombosis: A Case Series Report.

Okunaga A, Oshima Y, Yasui I, Ikuma S, Higashidani N, Takashima S, Kita H, Hiramoto Y, Kuroda T, Morimoto S, Sasaki S, Takami H, Izumi M.

Ann Vasc Dis. 2018 Mar 25;11(1):130-133. doi: 10.3400/


Preoperative biliary drainage using a fully covered self-expandable metallic stent for pancreatic head cancer: A prospective feasibility study.

Togawa O, Isayama H, Kawakami H, Nakai Y, Mohri D, Hamada T, Kogure H, Kawakubo K, Sakamoto N, Koike K, Kita H.

Saudi J Gastroenterol. 2018 May-Jun;24(3):151-156. doi: 10.4103/sjg.SJG_448_17.


Prominent role of RAB39A-RXRB axis in cancer development and stemness.

Chano T, Kita H, Avnet S, Lemma S, Baldini N.

Oncotarget. 2018 Jan 4;9(11):9852-9866. doi: 10.18632/oncotarget.23955. eCollection 2018 Feb 9.



Tajiri T, Toriyama A, Sokai A, Goto K, Fukata H, Nakamura Y, Kita H.

Arerugi. 2018;67(1):46-52. doi: 10.15036/arerugi.67.46. Japanese.


Significance of early detection of acute kidney function worsening among outpatients having CKD using automatic calculation system for the rate of eGFR decline.

Ito J, Kita H, Fujisawa T.

Clin Exp Nephrol. 2018 Aug;22(4):898-905. doi: 10.1007/s10157-018-1541-y. Epub 2018 Feb 14.


Automated chart review utilizing natural language processing algorithm for asthma predictive index.

Kaur H, Sohn S, Wi CI, Ryu E, Park MA, Bachman K, Kita H, Croghan I, Castro-Rodriguez JA, Voge GA, Liu H, Juhn YJ.

BMC Pulm Med. 2018 Feb 13;18(1):34. doi: 10.1186/s12890-018-0593-9.


Possible Effect of Concomitant Prokinetics and Herbal Medicines against Nausea in Patients Taking Lubiprostone.

Yamamoto T, Osumi S, Yanagisawa D, Yamato H, Aoyagi H, Isono A, Abe K, Kita H.

Biomed Res Int. 2017;2017:3762179. doi: 10.1155/2017/3762179. Epub 2017 Dec 7.


Neonatal hyperoxia promotes asthma-like features through IL-33-dependent ILC2 responses.

Cheon IS, Son YM, Jiang L, Goplen NP, Kaplan MH, Limper AH, Kita H, Paczesny S, Prakash YS, Tepper R, Ahlfeld SK, Sun J.

J Allergy Clin Immunol. 2018 Oct;142(4):1100-1112. doi: 10.1016/j.jaci.2017.11.025. Epub 2017 Dec 15.


Airway exposure initiates peanut allergy by involving the IL-1 pathway and T follicular helper cells in mice.

Dolence JJ, Kobayashi T, Iijima K, Krempski J, Drake LY, Dent AL, Kita H.

J Allergy Clin Immunol. 2018 Oct;142(4):1144-1158.e8. doi: 10.1016/j.jaci.2017.11.020. Epub 2017 Dec 14.


IL-33-Responsive Group 2 Innate Lymphoid Cells Are Regulated by Female Sex Hormones in the Uterus.

Bartemes K, Chen CC, Iijima K, Drake L, Kita H.

J Immunol. 2018 Jan 1;200(1):229-236. doi: 10.4049/jimmunol.1602085. Epub 2017 Nov 13.


Extensive gastric mucosal atrophy is a possible predictor of clinical effectiveness of acotiamide in patients with functional dyspepsia

Miki A, Yamamoto T, Maruyama K, Nakamura N, Aoyagi H, Isono A, Abe K, Kita H.

Int J Clin Pharmacol Ther. 2017 Dec;55(12):901-904. doi: 10.5414/CP203016.


Efficacy of Oxycodone for Dyspnea in End-stage Heart Failure with Renal Insufficiency.

Tanaka M, Maeba H, Senoo T, Iwasaka J, Ohkita A, Kita H, Uchitani K, Hirota Y.

Intern Med. 2018 Jan 1;57(1):53-57. doi: 10.2169/internalmedicine.9216-17. Epub 2017 Oct 16.


Impact of lubiprostone on gastric-emptying profile and the possible effect of concomitant domperidone in healthy adults

Okamura T, Yamamoto T, Kimura S, Miki A, Abe K, Kita H.

Int J Clin Pharmacol Ther. 2017 Nov;55(11):861-865. doi: 10.5414/CP203014.


IL-33: biological properties, functions, and roles in airway disease.

Drake LY, Kita H.

Immunol Rev. 2017 Jul;278(1):173-184. doi: 10.1111/imr.12552. Review.


π-Expanded Dipyrrolonaphthyridinediones with Large Two-Photon Absorption Cross-Section Values.

Sadowski B, Kita H, Grzybowski M, Kamada K, Gryko DT.

J Org Chem. 2017 Jul 21;82(14):7254-7264. doi: 10.1021/acs.joc.7b00831. Epub 2017 Jul 11.


Comparison of Different Disease-Specific Health-Related Quality of Life Measurements in Patients with Long-Term Noninvasive Ventilation.

Oga T, Taniguchi H, Kita H, Tsuboi T, Tomii K, Ando M, Kojima E, Tomioka H, Taguchi Y, Kaji Y, Maekura R, Hiraga T, Sakai N, Kimura T, Mishima M, Windisch W, Chin K.

Can Respir J. 2017;2017:8295079. doi: 10.1155/2017/8295079. Epub 2017 May 15.


Role of mast cells in the induction of dry skin in a mouse model of rheumatoid arthritis.

Goto K, Hiramoto K, Kita H, Ooi K.

Cutan Ocul Toxicol. 2018 Mar;37(1):61-70. doi: 10.1080/15569527.2017.1337784. Epub 2017 Jun 21.


Airway epithelial anion secretion and barrier function following exposure to fungal aeroallergens: role of oxidative stress.

Zaidman NA, O'Grady KE, Patil N, Milavetz F, Maniak PJ, Kita H, O'Grady SM.

Am J Physiol Cell Physiol. 2017 Jul 1;313(1):C68-C79. doi: 10.1152/ajpcell.00043.2017. Epub 2017 Apr 26.


Correlation of Symptoms, Clinical Signs, and Biomarkers of Inflammation in Postsurgical Chronic Rhinosinusitis.

Racette SD, Wijewickrama RC, Jayaprakash V, Sherris DA, Santos C, Kita H, O'Donnell FE Jr, Ponikau JU.

Ann Otol Rhinol Laryngol. 2017 Jun;126(6):455-462. doi: 10.1177/0003489417701939. Epub 2017 Apr 4.


Application of a Natural Language Processing Algorithm to Asthma Ascertainment. An Automated Chart Review.

Wi CI, Sohn S, Rolfes MC, Seabright A, Ryu E, Voge G, Bachman KA, Park MA, Kita H, Croghan IT, Liu H, Juhn YJ.

Am J Respir Crit Care Med. 2017 Aug 15;196(4):430-437. doi: 10.1164/rccm.201610-2006OC.


IL4Rα and ADAM33 as genetic markers in asthma exacerbations and type-2 inflammatory endotype.

Sunadome H, Matsumoto H, Petrova G, Kanemitsu Y, Tohda Y, Horiguchi T, Kita H, Kuwabara K, Tomii K, Otsuka K, Fujimura M, Ohkura N, Tomita K, Yokoyama A, Ohnishi H, Nakano Y, Oguma T, Hozawa S, Nagasaki T, Ito I, Oguma T, Inoue H, Tajiri T, Iwata T, Izuhara Y, Ono J, Ohta S, Hirota T, Tamari M, Yokoyama T, Niimi A, Izuhara K, Mishima M.

Clin Exp Allergy. 2017 Aug;47(8):998-1006. doi: 10.1111/cea.12927. Epub 2017 Apr 21.


Validation of the Japanese Severe Respiratory Insufficiency Questionnaire in hypercapnic patients with noninvasive ventilation.

Oga T, Taniguchi H, Kita H, Tsuboi T, Tomii K, Ando M, Kojima E, Tomioka H, Taguchi Y, Kaji Y, Maekura R, Hiraga T, Sakai N, Kimura T, Mishima M, Windisch W, Chin K.

Respir Investig. 2017 Mar;55(2):166-172. doi: 10.1016/j.resinv.2016.12.003. Epub 2017 Feb 6.


Oxidative stress serves as a key checkpoint for IL-33 release by airway epithelium.

Uchida M, Anderson EL, Squillace DL, Patil N, Maniak PJ, Iijima K, Kita H, O'Grady SM.

Allergy. 2017 Oct;72(10):1521-1531. doi: 10.1111/all.13158. Epub 2017 Mar 31.


Efficient Blue Electroluminescence from a Single-layer Organic Device Composed Solely of Hydrocarbons.

Izumi T, Tian Y, Ikemoto K, Yoshii A, Koretsune T, Arita R, Kita H, Taka H, Sato S, Isobe H.

Chem Asian J. 2017 Apr 4;12(7):730-733. doi: 10.1002/asia.201700198. Epub 2017 Mar 21.


Cellular senescence mediates fibrotic pulmonary disease.

Schafer MJ, White TA, Iijima K, Haak AJ, Ligresti G, Atkinson EJ, Oberg AL, Birch J, Salmonowicz H, Zhu Y, Mazula DL, Brooks RW, Fuhrmann-Stroissnigg H, Pirtskhalava T, Prakash YS, Tchkonia T, Robbins PD, Aubry MC, Passos JF, Kirkland JL, Tschumperlin DJ, Kita H, LeBrasseur NK.

Nat Commun. 2017 Feb 23;8:14532. doi: 10.1038/ncomms14532.


Urinary Leukotriene E4 to Determine Aspirin Intolerance in Asthma: A Systematic Review and Meta-Analysis.

Hagan JB, Laidlaw TM, Divekar R, O'Brien EK, Kita H, Volcheck GW, Hagan CR, Lal D, Teaford HG 3rd, Erwin PJ, Zhang N, Rank MA.

J Allergy Clin Immunol Pract. 2017 Jul - Aug;5(4):990-997.e1. doi: 10.1016/j.jaip.2016.11.004. Epub 2017 Feb 12. Review.


IL-33 dysregulates regulatory T cells and impairs established immunologic tolerance in the lungs.

Chen CC, Kobayashi T, Iijima K, Hsu FC, Kita H.

J Allergy Clin Immunol. 2017 Nov;140(5):1351-1363.e7. doi: 10.1016/j.jaci.2017.01.015. Epub 2017 Feb 11.


Unsupervised network mapping of commercially available immunoassay yields three distinct chronic rhinosinusitis endotypes.

Divekar R, Rank M, Squillace D, Kita H, Lal D.

Int Forum Allergy Rhinol. 2017 Apr;7(4):373-379. doi: 10.1002/alr.21904. Epub 2017 Jan 2.


Staphylococcus aureus enterotoxin sensitization involvement and its association with the CysLTR1 variant in different asthma phenotypes.

Matsumoto H, Kanemitsu Y, Nagasaki T, Tohda Y, Horiguchi T, Kita H, Kuwabara K, Tomii K, Otsuka K, Fujimura M, Ohkura N, Tomita K, Yokoyama A, Ohnishi H, Nakano Y, Oguma T, Hozawa S, Izuhara Y, Ito I, Oguma T, Inoue H, Tajiri T, Iwata T, Ono J, Ohta S, Hirota T, Kawaguchi T, Tamari M, Yokoyama T, Tabara Y, Matsuda F, Izuhara K, Niimi A, Mishima M.

Ann Allergy Asthma Immunol. 2017 Feb;118(2):197-203. doi: 10.1016/j.anai.2016.11.013. Epub 2016 Dec 27.


Endogenous Protease Inhibitors in Airway Epithelial Cells Contribute to Eosinophilic Chronic Rhinosinusitis.

Kouzaki H, Matsumoto K, Kikuoka H, Kato T, Tojima I, Shimizu S, Kita H, Shimizu T.

Am J Respir Crit Care Med. 2017 Mar 15;195(6):737-747. doi: 10.1164/rccm.201603-0529OC.


Gastrointestinal bleeding risk of non-vitamin K oral anticoagulants is similar to warfarin - a Japanese retrospective cohort study

Shirai T, Yamamoto T, Kawasugi K, Kuyama Y, Kita H.

Int J Clin Pharmacol Ther. 2016 Nov;54(11):841-846.


Intralaminar and tectal projections to the subthalamus in the rat.

Kita T, Shigematsu N, Kita H.

Eur J Neurosci. 2016 Dec;44(11):2899-2908. doi: 10.1111/ejn.13413. Epub 2016 Oct 11.


Influence of HLA-DR polymorphism and allergic sensitization on humoral immune responses to intact pneumococcus in a transgenic mouse model.

Sheen YH, Rajagopalan G, Snapper CM, Kita H, Wi CI, Umaretiya PJ, Juhn YJ.

HLA. 2016 Jul;88(1-2):25-34. doi: 10.1111/tan.12851. Epub 2016 Aug 10.

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