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Items: 7


MUC2 Mucin and Butyrate Contribute to the Synthesis of the Antimicrobial Peptide Cathelicidin in Response to Entamoeba histolytica- and Dextran Sodium Sulfate-Induced Colitis.

Cobo ER, Kissoon-Singh V, Moreau F, Holani R, Chadee K.

Infect Immun. 2017 Feb 23;85(3). pii: e00905-16. doi: 10.1128/IAI.00905-16. Print 2017 Mar.


Probiotic mixture VSL#3 reduces colonic inflammation and improves intestinal barrier function in Muc2 mucin-deficient mice.

Kumar M, Kissoon-Singh V, Coria AL, Moreau F, Chadee K.

Am J Physiol Gastrointest Liver Physiol. 2017 Jan 1;312(1):G34-G45. doi: 10.1152/ajpgi.00298.2016. Epub 2016 Nov 17.


Colonic MUC2 mucin regulates the expression and antimicrobial activity of β-defensin 2.

Cobo ER, Kissoon-Singh V, Moreau F, Chadee K.

Mucosal Immunol. 2015 Nov;8(6):1360-72. doi: 10.1038/mi.2015.27. Epub 2015 Apr 29.


Entamoeba histolytica exacerbates epithelial tight junction permeability and proinflammatory responses in Muc2(-/-) mice.

Kissoon-Singh V, Moreau F, Trusevych E, Chadee K.

Am J Pathol. 2013 Mar;182(3):852-65. doi: 10.1016/j.ajpath.2012.11.035. Epub 2013 Jan 26.


Entamoeba histolytica cathepsin-like enzymes : interactions with the host gut.

Kissoon-Singh V, Mortimer L, Chadee K.

Adv Exp Med Biol. 2011;712:62-83. doi: 10.1007/978-1-4419-8414-2_5. Review.


Muc2 protects against lethal infectious colitis by disassociating pathogenic and commensal bacteria from the colonic mucosa.

Bergstrom KS, Kissoon-Singh V, Gibson DL, Ma C, Montero M, Sham HP, Ryz N, Huang T, Velcich A, Finlay BB, Chadee K, Vallance BA.

PLoS Pathog. 2010 May 13;6(5):e1000902. doi: 10.1371/journal.ppat.1000902.


Role of intestinal mucins in innate host defense mechanisms against pathogens.

Dharmani P, Srivastava V, Kissoon-Singh V, Chadee K.

J Innate Immun. 2009;1(2):123-35. doi: 10.1159/000163037. Epub 2008 Oct 8. Review.

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