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Items: 23


Mechanistic investigations of the liver toxicity of the free fatty acid receptor 1 agonist fasiglifam (TAK875) and its primary metabolites.

Ackerson T, Amberg A, Atzrodt J, Arabeyre C, Defossa E, Dorau M, Dudda A, Dwyer J, Holla W, Kissner T, Kohlmann M, Kürzel U, Pánczél J, Rajanna S, Riedel J, Schmidt F, Wäse K, Weitz D, Derdau V.

J Biochem Mol Toxicol. 2019 Aug;33(8):e22345. doi: 10.1002/jbt.22345. Epub 2019 May 8.


Author Correction: Discovery of small molecule inhibitors of MyD88-dependent signaling pathways using a computational screen.

Olson MA, Lee MS, Kissner TL, Alam S, Waugh DS, Saikh KU.

Sci Rep. 2018 Nov 19;8(1):17074. doi: 10.1038/s41598-018-35538-6.


Rational design of peptide derivatives for inhibition of MyD88-mediated toll-like receptor signaling in human peripheral blood mononuclear cells and epithelial cells exposed to Francisella tularensis.

Ryan DA, Degardin M, Alam S, Kissner TL, Hale M, Cameron MD, Rebek M, Ajami D, Saikh KU, Rebek J Jr.

Chem Biol Drug Des. 2017 Dec;90(6):1190-1205. doi: 10.1111/cbdd.13039. Epub 2017 Jul 17.


Vehicle Systems and Excipients Used in Minipig Drug Development Studies.

Weaver ML, Grossi AB, Schützsack J, Parish J, Løgsted J, Bøgh IB, Cameron D, Harvey W, Festag M, Downes N, Venturella S, Schlichtiger J, Mhedhbi S, Ross V, Kissner T, Stark C, Milano S, Heining P, Sanchez-Felix M.

Toxicol Pathol. 2016 Apr;44(3):367-72. doi: 10.1177/0192623315613088. Epub 2015 Dec 16. Review.


Discovery of small molecule inhibitors of MyD88-dependent signaling pathways using a computational screen.

Olson MA, Lee MS, Kissner TL, Alam S, Waugh DS, Saikh KU.

Sci Rep. 2015 Sep 18;5:14246. doi: 10.1038/srep14246. Erratum in: Sci Rep. 2018 Nov 19;8(1):17074.


Structure-Based Design and Synthesis of a Small Molecule that Exhibits Anti-inflammatory Activity by Inhibition of MyD88-mediated Signaling to Bacterial Toxin Exposure.

Alam S, Javor S, Degardin M, Ajami D, Rebek M, Kissner TL, Waag DM, Rebek J Jr, Saikh KU.

Chem Biol Drug Des. 2015 Aug;86(2):200-9. doi: 10.1111/cbdd.12477. Epub 2014 Dec 8.


Therapeutic inhibition of pro-inflammatory signaling and toxicity to staphylococcal enterotoxin B by a synthetic dimeric BB-loop mimetic of MyD88.

Kissner TL, Ruthel G, Alam S, Mann E, Ajami D, Rebek M, Larkin E, Fernandez S, Ulrich RG, Ping S, Waugh DS, Rebek J Jr, Saikh KU.

PLoS One. 2012;7(7):e40773. doi: 10.1371/journal.pone.0040773. Epub 2012 Jul 27.


A small molecule that mimics the BB-loop in the Toll interleukin-1 (IL-1) receptor domain of MyD88 attenuates staphylococcal enterotoxin B-induced pro-inflammatory cytokine production and toxicity in mice.

Kissner TL, Moisan L, Mann E, Alam S, Ruthel G, Ulrich RG, Rebek M, Rebek J Jr, Saikh KU.

J Biol Chem. 2011 Sep 9;286(36):31385-96. doi: 10.1074/jbc.M110.204982. Epub 2011 Jun 21.


Activation of MyD88 signaling upon staphylococcal enterotoxin binding to MHC class II molecules.

Kissner TL, Ruthel G, Alam S, Ulrich RG, Fernandez S, Saikh KU.

PLoS One. 2011 Jan 20;6(1):e15985. doi: 10.1371/journal.pone.0015985.


MyD88-dependent pro-inflammatory cytokine response contributes to lethal toxicity of staphylococcal enterotoxin B in mice.

Kissner TL, Ruthel G, Cisney ED, Ulrich RG, Fernandez S, Saikh KU.

Innate Immun. 2011 Oct;17(5):451-62. doi: 10.1177/1753425910374092. Epub 2010 Aug 10.


Staphylococcal enterotoxin A induction of pro-inflammatory cytokines and lethality in mice is primarily dependent on MyD88.

Kissner TL, Cisney ED, Ulrich RG, Fernandez S, Saikh KU.

Immunology. 2010 Aug;130(4):516-26. doi: 10.1111/j.1365-2567.2010.03249.x. Epub 2010 May 3.


Interleukin-15 increases vaccine efficacy through a mechanism linked to dendritic cell maturation and enhanced antibody titers.

Saikh KU, Kissner TL, Nystrom S, Ruthel G, Ulrich RG.

Clin Vaccine Immunol. 2008 Jan;15(1):131-7. Epub 2007 Nov 28.


Synthetic Toll-like receptor 4 agonist enhances vaccine efficacy in an experimental model of toxic shock syndrome.

Morefield GL, Hawkins LD, Ishizaka ST, Kissner TL, Ulrich RG.

Clin Vaccine Immunol. 2007 Nov;14(11):1499-504. Epub 2007 Aug 22.


Human cytolytic T cell recognition of Yersinia pestis virulence proteins that target innate immune responses.

Saikh KU, Kissner TL, Dyas B, Tropea JE, Waugh DS, Ulrich RG.

J Infect Dis. 2006 Dec 15;194(12):1753-60. Epub 2006 Nov 2.


Human monocytes infected with Yersinia pestis express cell surface TLR9 and differentiate into dendritic cells.

Saikh KU, Kissner TL, Sultana A, Ruthel G, Ulrich RG.

J Immunol. 2004 Dec 15;173(12):7426-34.


CD56+-T-cell responses to bacterial superantigens and immune recognition of attenuated vaccines.

Saikh KU, Dyas B, Kissner T, Ulrich RG.

Clin Diagn Lab Immunol. 2003 Nov;10(6):1065-73.


Magnetic Resonance Female Breast Imaging (MRFBI) - Evaluation of the Changes in Signal Intensity over Time Pre- and Post-administration of 0.2 mmol/kg Gd-DTPA.

Schedel H, Oellinger H, Kohlschein P, Siewert C, Hadijuana J, Blohmer JU, Kissner T, Felix R.

Zentralbl Gynakol. 2002 Feb;124(2):104-10.


IL-15-induced conversion of monocytes to mature dendritic cells.

Saikh KU, Khan AS, Kissner T, Ulrich RG.

Clin Exp Immunol. 2001 Dec;126(3):447-55.


HLA and HIV-1: heterozygote advantage and B*35-Cw*04 disadvantage.

Carrington M, Nelson GW, Martin MP, Kissner T, Vlahov D, Goedert JJ, Kaslow R, Buchbinder S, Hoots K, O'Brien SJ.

Science. 1999 Mar 12;283(5408):1748-52.


Human leukocyte antigen class I/II alleles and development of human papillomavirus-related cervical neoplasia: results from a case-control study conducted in the United States.

Hildesheim A, Schiffman M, Scott DR, Marti D, Kissner T, Sherman ME, Glass AG, Manos MM, Lorincz AT, Kurman RJ, Buckland J, Rush BB, Carrington M.

Cancer Epidemiol Biomarkers Prev. 1998 Nov;7(11):1035-41.


Novel alleles of the chemokine-receptor gene CCR5.

Carrington M, Kissner T, Gerrard B, Ivanov S, O'Brien SJ, Dean M.

Am J Hum Genet. 1997 Dec;61(6):1261-7.

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