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STAT3 activation in circulating myeloid-derived cells contributes to retinal microvascular dysfunction in diabetes.

Chen M, Obasanmi G, Armstrong D, Lavery NJ, Kissenpfennig A, Lois N, Xu H.

J Neuroinflammation. 2019 Jul 8;16(1):138. doi: 10.1186/s12974-019-1533-1.


Development of transplant immunosuppressive agents - considerations in the use of animal models.

Costello R, Kissenpfennig A, Martins PN, McDaid J.

Expert Opin Drug Discov. 2018 Nov;13(11):1041-1053. doi: 10.1080/17460441.2018.1535589. Epub 2018 Oct 17. Review.


Microneedle arrays for vaccine delivery: the possibilities, challenges and use of nanoparticles as a combinatorial approach for enhanced vaccine immunogenicity.

Rodgers AM, Cordeiro AS, Kissenpfennig A, Donnelly RF.

Expert Opin Drug Deliv. 2018 Sep;15(9):851-867. doi: 10.1080/17425247.2018.1505860. Epub 2018 Aug 1. Review.


Design and characterisation of a dissolving microneedle patch for intradermal vaccination with heat-inactivated bacteria: A proof of concept study.

Rodgers AM, McCrudden MTC, Vincente-Perez EM, Dubois AV, Ingram RJ, Larrañeta E, Kissenpfennig A, Donnelly RF.

Int J Pharm. 2018 Oct 5;549(1-2):87-95. doi: 10.1016/j.ijpharm.2018.07.049. Epub 2018 Jul 23.


Cytokine Signaling Protein 3 Deficiency in Myeloid Cells Promotes Retinal Degeneration and Angiogenesis through Arginase-1 Up-Regulation in Experimental Autoimmune Uveoretinitis.

Chen M, Zhao J, Ali IHA, Marry S, Augustine J, Bhuckory M, Lynch A, Kissenpfennig A, Xu H.

Am J Pathol. 2018 Apr;188(4):1007-1020. doi: 10.1016/j.ajpath.2017.12.021. Epub 2018 Feb 13.


Mesenchymal Stromal Cells Modulate Macrophages in Clinically Relevant Lung Injury Models by Extracellular Vesicle Mitochondrial Transfer.

Morrison TJ, Jackson MV, Cunningham EK, Kissenpfennig A, McAuley DF, O'Kane CM, Krasnodembskaya AD.

Am J Respir Crit Care Med. 2017 Nov 15;196(10):1275-1286. doi: 10.1164/rccm.201701-0170OC.


Repeat application of microneedles does not alter skin appearance or barrier function and causes no measurable disturbance of serum biomarkers of infection, inflammation or immunity in mice in vivo.

Vicente-Perez EM, Larrañeta E, McCrudden MTC, Kissenpfennig A, Hegarty S, McCarthy HO, Donnelly RF.

Eur J Pharm Biopharm. 2017 Aug;117:400-407. doi: 10.1016/j.ejpb.2017.04.029. Epub 2017 May 3.


In vivo studies investigating biodistribution of nanoparticle-encapsulated rhodamine B delivered via dissolving microneedles.

Kennedy J, Larrañeta E, McCrudden MTC, McCrudden CM, Brady AJ, Fallows SJ, McCarthy HO, Kissenpfennig A, Donnelly RF.

J Control Release. 2017 Nov 10;265:57-65. doi: 10.1016/j.jconrel.2017.04.022. Epub 2017 Apr 17.


Regulatory T cells promote myelin regeneration in the central nervous system.

Dombrowski Y, O'Hagan T, Dittmer M, Penalva R, Mayoral SR, Bankhead P, Fleville S, Eleftheriadis G, Zhao C, Naughton M, Hassan R, Moffat J, Falconer J, Boyd A, Hamilton P, Allen IV, Kissenpfennig A, Moynagh PN, Evergren E, Perbal B, Williams AC, Ingram RJ, Chan JR, Franklin RJM, Fitzgerald DC.

Nat Neurosci. 2017 May;20(5):674-680. doi: 10.1038/nn.4528. Epub 2017 Mar 13.


Aspirin reduces lipopolysaccharide-induced pulmonary inflammation in human models of ARDS.

Hamid U, Krasnodembskaya A, Fitzgerald M, Shyamsundar M, Kissenpfennig A, Scott C, Lefrancais E, Looney MR, Verghis R, Scott J, Simpson AJ, McNamee J, McAuley DF, O'Kane CM.

Thorax. 2017 Nov;72(11):971-980. doi: 10.1136/thoraxjnl-2016-208571. Epub 2017 Jan 12.


DNA vaccination for cervical cancer; a novel technology platform of RALA mediated gene delivery via polymeric microneedles.

Ali AA, McCrudden CM, McCaffrey J, McBride JW, Cole G, Dunne NJ, Robson T, Kissenpfennig A, Donnelly RF, McCarthy HO.

Nanomedicine. 2017 Apr;13(3):921-932. doi: 10.1016/j.nano.2016.11.019. Epub 2016 Dec 12.


Reduced epithelial suppressor of cytokine signalling 1 in severe eosinophilic asthma.

Doran E, Choy DF, Shikotra A, Butler CA, O'Rourke DM, Johnston JA, Kissenpfennig A, Bradding P, Arron JR, Heaney LG.

Eur Respir J. 2016 Sep;48(3):715-25. doi: 10.1183/13993003.00400-2015. Epub 2016 Jun 23.


Correction: Elucidation of the RamA Regulon in Klebsiella pneumoniae Reveals a Role in LPS Regulation.

De Majumdar S, Yu J, Fookes M, McAteer SP, Llobet E, Spence SF, Monaghan A, Kissenpfennig A, Ingram RJ, Bengoechea J, Gally DL, Fanning S, Elborn JS, Schneiders T.

PLoS Pathog. 2016 May 11;12(5):e1005649. doi: 10.1371/journal.ppat.1005649. eCollection 2016 May.


Mitochondrial Transfer via Tunneling Nanotubes is an Important Mechanism by Which Mesenchymal Stem Cells Enhance Macrophage Phagocytosis in the In Vitro and In Vivo Models of ARDS.

Jackson MV, Morrison TJ, Doherty DF, McAuley DF, Matthay MA, Kissenpfennig A, O'Kane CM, Krasnodembskaya AD.

Stem Cells. 2016 Aug;34(8):2210-23. doi: 10.1002/stem.2372. Epub 2016 Apr 29.


STAT3 Activation in Circulating Monocytes Contributes to Neovascular Age-Related Macular Degeneration.

Chen M, Lechner J, Zhao J, Toth L, Hogg R, Silvestri G, Kissenpfennig A, Chakravarthy U, Xu H.

Curr Mol Med. 2016;16(4):412-23.


Innate Lymphoid Cells Are the Predominant Source of IL-17A during the Early Pathogenesis of Acute Respiratory Distress Syndrome.

Muir R, Osbourn M, Dubois AV, Doran E, Small DM, Monahan A, O'Kane CM, McAllister K, Fitzgerald DC, Kissenpfennig A, McAuley DF, Ingram RJ.

Am J Respir Crit Care Med. 2016 Feb 15;193(4):407-16. doi: 10.1164/rccm.201410-1782OC.


Targeting Siglecs with a sialic acid-decorated nanoparticle abrogates inflammation.

Spence S, Greene MK, Fay F, Hams E, Saunders SP, Hamid U, Fitzgerald M, Beck J, Bains BK, Smyth P, Themistou E, Small DM, Schmid D, O'Kane CM, Fitzgerald DC, Abdelghany SM, Johnston JA, Fallon PG, Burrows JF, McAuley DF, Kissenpfennig A, Scott CJ.

Sci Transl Med. 2015 Sep 2;7(303):303ra140. doi: 10.1126/scitranslmed.aab3459.


The utility of animal models in developing immunosuppressive agents.

McDaid J, Scott CJ, Kissenpfennig A, Chen H, Martins PN.

Eur J Pharmacol. 2015 Jul 15;759:295-302. doi: 10.1016/j.ejphar.2015.03.025. Epub 2015 Mar 24. Review.


FKBPL is a critical antiangiogenic regulator of developmental and pathological angiogenesis.

Yakkundi A, Bennett R, Hernández-Negrete I, Delalande JM, Hanna M, Lyubomska O, Arthur K, Short A, McKeen H, Nelson L, McCrudden CM, McNally R, McClements L, McCarthy HO, Burns AJ, Bicknell R, Kissenpfennig A, Robson T.

Arterioscler Thromb Vasc Biol. 2015 Apr;35(4):845-54. doi: 10.1161/ATVBAHA.114.304539. Epub 2015 Mar 12.


Elucidation of the RamA regulon in Klebsiella pneumoniae reveals a role in LPS regulation.

De Majumdar S, Yu J, Fookes M, McAteer SP, Llobet E, Finn S, Spence S, Monahan A, Monaghan A, Kissenpfennig A, Ingram RJ, Bengoechea J, Gally DL, Fanning S, Elborn JS, Schneiders T.

PLoS Pathog. 2015 Jan 29;11(1):e1004627. doi: 10.1371/journal.ppat.1004627. eCollection 2015 Jan. Erratum in: PLoS Pathog. 2015 Mar;11(3):e1004766. Monaghan, Avril [corrected to Monahan, Avril]. PLoS Pathog. 2016 May;12(5):e1005649.


Antimicrobial efficacy of tobramycin polymeric nanoparticles for Pseudomonas aeruginosa infections in cystic fibrosis: formulation, characterisation and functionalisation with dornase alfa (DNase).

Deacon J, Abdelghany SM, Quinn DJ, Schmid D, Megaw J, Donnelly RF, Jones DS, Kissenpfennig A, Elborn JS, Gilmore BF, Taggart CC, Scott CJ.

J Control Release. 2015 Jan 28;198:55-61. doi: 10.1016/j.jconrel.2014.11.022. Epub 2014 Dec 4.


Nanoencapsulation of ABT-737 and camptothecin enhances their clinical potential through synergistic antitumor effects and reduction of systemic toxicity.

Schmid D, Jarvis GE, Fay F, Small DM, Greene MK, Majkut J, Spence S, McLaughlin KM, McCloskey KD, Johnston PG, Kissenpfennig A, Longley DB, Scott CJ.

Cell Death Dis. 2014 Oct 9;5:e1454. doi: 10.1038/cddis.2014.413.


Dissolving microneedle delivery of nanoparticle-encapsulated antigen elicits efficient cross-priming and Th1 immune responses by murine Langerhans cells.

Zaric M, Lyubomska O, Poux C, Hanna ML, McCrudden MT, Malissen B, Ingram RJ, Power UF, Scott CJ, Donnelly RF, Kissenpfennig A.

J Invest Dermatol. 2015 Feb;135(2):425-434. doi: 10.1038/jid.2014.415. Epub 2014 Sep 22.


Langerhans cells promote early germinal center formation in response to Leishmania-derived cutaneous antigens.

Zimara N, Florian C, Schmid M, Malissen B, Kissenpfennig A, Männel DN, Edinger M, Hutchinson JA, Hoffmann P, Ritter U.

Eur J Immunol. 2014 Oct;44(10):2955-67. doi: 10.1002/eji.201344263.


SMAD inhibition attenuates epithelial to mesenchymal transition by primary keratinocytes in vitro.

O'Kane D, Jackson MV, Kissenpfennig A, Spence S, Damkat-Thomas L, Tolland JP, Smyth AE, Denton CP, Stuart Elborn J, McAuley DF, O'Kane CM.

Exp Dermatol. 2014 Jul;23(7):497-503. doi: 10.1111/exd.12452.


Aging impairs peritoneal but not bone marrow-derived macrophage phagocytosis.

Linehan E, Dombrowski Y, Snoddy R, Fallon PG, Kissenpfennig A, Fitzgerald DC.

Aging Cell. 2014 Aug;13(4):699-708. doi: 10.1111/acel.12223. Epub 2014 May 12.


Laser-engineered dissolving microneedle arrays for protein delivery: potential for enhanced intradermal vaccination.

McCrudden MT, Torrisi BM, Al-Zahrani S, McCrudden CM, Zaric M, Scott CJ, Kissenpfennig A, McCarthy HO, Donnelly RF.

J Pharm Pharmacol. 2015 Mar;67(3):409-25. doi: 10.1111/jphp.12248. Epub 2014 Mar 27.


Btk regulates macrophage polarization in response to lipopolysaccharide.

Ní Gabhann J, Hams E, Smith S, Wynne C, Byrne JC, Brennan K, Spence S, Kissenpfennig A, Johnston JA, Fallon PG, Jefferies CA.

PLoS One. 2014 Jan 21;9(1):e85834. doi: 10.1371/journal.pone.0085834. eCollection 2014.


Targeting treatment-resistant breast cancer stem cells with FKBPL and its peptide derivative, AD-01, via the CD44 pathway.

McClements L, Yakkundi A, Papaspyropoulos A, Harrison H, Ablett MP, Jithesh PV, McKeen HD, Bennett R, Donley C, Kissenpfennig A, McIntosh S, McCarthy HO, O'Neill E, Clarke RB, Robson T.

Clin Cancer Res. 2013 Jul 15;19(14):3881-93. doi: 10.1158/1078-0432.CCR-13-0595. Epub 2013 Jun 5.


Cathepsin S from both tumor and tumor-associated cells promote cancer growth and neovascularization.

Small DM, Burden RE, Jaworski J, Hegarty SM, Spence S, Burrows JF, McFarlane C, Kissenpfennig A, McCarthy HO, Johnston JA, Walker B, Scott CJ.

Int J Cancer. 2013 Nov;133(9):2102-12. doi: 10.1002/ijc.28238. Epub 2013 May 29.


Regulation of Foxp3+ inducible regulatory T cell stability by SOCS2.

Knosp CA, Schiering C, Spence S, Carroll HP, Nel HJ, Osbourn M, Jackson R, Lyubomska O, Malissen B, Ingram R, Fitzgerald DC, Powrie F, Fallon PG, Johnston JA, Kissenpfennig A.

J Immunol. 2013 Apr 1;190(7):3235-45. doi: 10.4049/jimmunol.1201396. Epub 2013 Mar 1.


Skin dendritic cell targeting via microneedle arrays laden with antigen-encapsulated poly-D,L-lactide-co-glycolide nanoparticles induces efficient antitumor and antiviral immune responses.

Zaric M, Lyubomska O, Touzelet O, Poux C, Al-Zahrani S, Fay F, Wallace L, Terhorst D, Malissen B, Henri S, Power UF, Scott CJ, Donnelly RF, Kissenpfennig A.

ACS Nano. 2013 Mar 26;7(3):2042-55. doi: 10.1021/nn304235j. Epub 2013 Feb 15.


Suppressors of cytokine signaling 2 and 3 diametrically control macrophage polarization.

Spence S, Fitzsimons A, Boyd CR, Kessler J, Fitzgerald D, Elliott J, Gabhann JN, Smith S, Sica A, Hams E, Saunders SP, Jefferies CA, Fallon PG, McAuley DF, Kissenpfennig A, Johnston JA.

Immunity. 2013 Jan 24;38(1):66-78. doi: 10.1016/j.immuni.2012.09.013. Epub 2012 Nov 21. Erratum in: Immunity. 2013 Jul 25;39(1):196-7. Retraction in: Immunity. 2014 Jun 19;40(6):1002.


Langerhans cells protect from allergic contact dermatitis in mice by tolerizing CD8(+) T cells and activating Foxp3(+) regulatory T cells.

Gomez de Agüero M, Vocanson M, Hacini-Rachinel F, Taillardet M, Sparwasser T, Kissenpfennig A, Malissen B, Kaiserlian D, Dubois B.

J Clin Invest. 2012 May;122(5):1700-11. doi: 10.1172/JCI59725. Epub 2012 Apr 23.


Microneedle-mediated vaccine delivery: harnessing cutaneous immunobiology to improve efficacy.

Al-Zahrani S, Zaric M, McCrudden C, Scott C, Kissenpfennig A, Donnelly RF.

Expert Opin Drug Deliv. 2012 May;9(5):541-50. doi: 10.1517/17425247.2012.676038. Epub 2012 Apr 5. Review.


Determining the role of mononuclear phagocytes in prion neuroinvasion from the skin.

Wathne GJ, Kissenpfennig A, Malissen B, Zurzolo C, Mabbott NA.

J Leukoc Biol. 2012 May;91(5):817-28. doi: 10.1189/jlb.1211633. Epub 2012 Feb 28.


Skin langerin+ dendritic cells transport intradermally injected anti-DEC-205 antibodies but are not essential for subsequent cytotoxic CD8+ T cell responses.

Flacher V, Tripp CH, Haid B, Kissenpfennig A, Malissen B, Stoitzner P, Idoyaga J, Romani N.

J Immunol. 2012 Mar 1;188(5):2146-55. doi: 10.4049/jimmunol.1004120. Epub 2012 Jan 30.


Defects in acute responses to TLR4 in Btk-deficient mice result in impaired dendritic cell-induced IFN-γ production by natural killer cells.

Ní Gabhann J, Spence S, Wynne C, Smith S, Byrne JC, Coffey B, Stacey K, Kissenpfennig A, Johnston J, Jefferies CA.

Clin Immunol. 2012 Mar;142(3):373-82. doi: 10.1016/j.clim.2011.12.009. Epub 2011 Dec 28.


Antibody targeting of Cathepsin S induces antibody-dependent cellular cytotoxicity.

Kwok HF, Buick RJ, Kuehn D, Gormley JA, Doherty D, Jaquin TJ, McClurg A, Ward C, Byrne T, Jaworski J, Leung KL, Snoddy P, McAnally C, Burden RE, Gray B, Lowry J, Sermadiras I, Gruszka N, Courtenay-Luck N, Kissenpfennig A, Scott CJ, Johnston JA, Olwill SA.

Mol Cancer. 2011 Dec 14;10:147. doi: 10.1186/1476-4598-10-147.


Pax7-expressing satellite cells are indispensable for adult skeletal muscle regeneration.

Sambasivan R, Yao R, Kissenpfennig A, Van Wittenberghe L, Paldi A, Gayraud-Morel B, Guenou H, Malissen B, Tajbakhsh S, Galy A.

Development. 2011 Sep;138(17):3647-56. doi: 10.1242/dev.067587. Erratum in: Development. 2011 Oct;138(19):4333.


SOCS2 regulates T helper type 2 differentiation and the generation of type 2 allergic responses.

Knosp CA, Carroll HP, Elliott J, Saunders SP, Nel HJ, Amu S, Pratt JC, Spence S, Doran E, Cooke N, Jackson R, Swift J, Fitzgerald DC, Heaney LG, Fallon PG, Kissenpfennig A, Johnston JA.

J Exp Med. 2011 Jul 4;208(7):1523-31. doi: 10.1084/jem.20101167. Epub 2011 Jun 6.


Integrated T-cell receptor and costimulatory signals determine TGF-β-dependent differentiation and maintenance of Foxp3+ regulatory T cells.

Gabryšová L, Christensen JR, Wu X, Kissenpfennig A, Malissen B, O'Garra A.

Eur J Immunol. 2011 May;41(5):1242-8. doi: 10.1002/eji.201041073. Epub 2011 Apr 11.


Cell-to-cell interactions and signals involved in the reconstitution of peripheral CD8 T(CM) and T(EM) cell pools.

Zaragoza B, Evaristo C, Kissenpfennig A, Libri V, Malissen B, Rocha B, Freitas AA, Almeida AR.

PLoS One. 2011 Mar 14;6(3):e17423. doi: 10.1371/journal.pone.0017423.


Langerin+ dermal dendritic cells are critical for CD8+ T cell activation and IgH γ-1 class switching in response to gene gun vaccines.

Stoecklinger A, Eticha TD, Mesdaghi M, Kissenpfennig A, Malissen B, Thalhamer J, Hammerl P.

J Immunol. 2011 Feb 1;186(3):1377-83. doi: 10.4049/jimmunol.1002557. Epub 2010 Dec 27.


The role of direct presentation by donor dendritic cells in rejection of minor histocompatibility antigen-mismatched skin and hematopoietic cell grafts.

Fernandes E, Goold HD, Kissenpfennig A, Malissen B, Dyson J, Bennett CL.

Transplantation. 2011 Jan 27;91(2):154-60. doi: 10.1097/TP.0b013e318201ac27.


Vasodilator-stimulated phosphoprotein regulates inside-out signaling of beta2 integrins in neutrophils.

Deevi RK, Koney-Dash M, Kissenpfennig A, Johnston JA, Schuh K, Walter U, Dib K.

J Immunol. 2010 Jun 15;184(12):6575-84. doi: 10.4049/jimmunol.0903910. Epub 2010 May 10.


Langerhans cells prime IL-17-producing T cells and dampen genital cytotoxic responses following mucosal immunization.

Hervouet C, Luci C, Rol N, Rousseau D, Kissenpfennig A, Malissen B, Czerkinsky C, Anjuère F.

J Immunol. 2010 May 1;184(9):4842-51. doi: 10.4049/jimmunol.0901695. Epub 2010 Mar 29.


Foxp3+ T cells induce perforin-dependent dendritic cell death in tumor-draining lymph nodes.

Boissonnas A, Scholer-Dahirel A, Simon-Blancal V, Pace L, Valet F, Kissenpfennig A, Sparwasser T, Malissen B, Fetler L, Amigorena S.

Immunity. 2010 Feb 26;32(2):266-78. doi: 10.1016/j.immuni.2009.11.015. Epub 2010 Feb 4.


CD207+ CD103+ dermal dendritic cells cross-present keratinocyte-derived antigens irrespective of the presence of Langerhans cells.

Henri S, Poulin LF, Tamoutounour S, Ardouin L, Guilliams M, de Bovis B, Devilard E, Viret C, Azukizawa H, Kissenpfennig A, Malissen B.

J Exp Med. 2010 Jan 18;207(1):189-206. doi: 10.1084/jem.20091964. Epub 2009 Dec 28. Erratum in: J Exp Med. 2010 Feb 15;207(2):447.


Langerhans cell (LC) proliferation mediates neonatal development, homeostasis, and inflammation-associated expansion of the epidermal LC network.

Chorro L, Sarde A, Li M, Woollard KJ, Chambon P, Malissen B, Kissenpfennig A, Barbaroux JB, Groves R, Geissmann F.

J Exp Med. 2009 Dec 21;206(13):3089-100. doi: 10.1084/jem.20091586. Epub 2009 Dec 7.

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