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Items: 1 to 50 of 164

1.

Heparan Sulfate-Editing Extracellular Sulfatases Enhance VEGF Bioavailability for Ischemic Heart Repair.

Korf-Klingebiel M, Reboll MR, Grote K, Schleiner H, Wang Y, Wu X, Klede S, Mikhed Y, Bauersachs J, Klintschar M, Rudat C, Kispert A, Niessen HW, Lübke T, Dierks T, Wollert KC.

Circ Res. 2019 Oct 11;125(9):787-801. doi: 10.1161/CIRCRESAHA.119.315023. Epub 2019 Aug 22.

PMID:
31434553
2.

Inactivation of Sox9 in fibroblasts reduces cardiac fibrosis and inflammation.

Scharf GM, Kilian K, Cordero J, Wang Y, Grund A, Hofmann M, Froese N, Wang X, Kispert A, Kist R, Conway SJ, Geffers R, Wollert KC, Dobreva G, Bauersachs J, Heineke J.

JCI Insight. 2019 Jul 16;5. pii: 126721. doi: 10.1172/jci.insight.126721.

3.

Dexamethasone improves therapeutic outcomes in a preclinical bacterial epididymitis mouse model.

Klein B, Pant S, Bhushan S, Kautz J, Rudat C, Kispert A, Pilatz A, Wijayarathna R, Middendorff R, Loveland KL, Hedger MP, Meinhardt A.

Hum Reprod. 2019 Jul 8;34(7):1195-1205. doi: 10.1093/humrep/dez073.

PMID:
31211847
4.

The transcription factor GATA4 promotes myocardial regeneration in neonatal mice.

Malek Mohammadi M, Kattih B, Grund A, Froese N, Korf-Klingebiel M, Gigina A, Schrameck U, Rudat C, Liang Q, Kispert A, Wollert KC, Bauersachs J, Heineke J.

EMBO Mol Med. 2019 Jun;11(6). pii: e10678. doi: 10.15252/emmm.201910678. No abstract available.

5.

Delayed onset of smooth muscle cell differentiation leads to hydroureter formation in mice with conditional loss of the zinc finger transcription factor gene Gata2 in the ureteric mesenchyme.

Weiss AC, Bohnenpoll T, Kurz J, Blank P, Airik R, Lüdtke TH, Kleppa MJ, Deuper L, Kaiser M, Mamo TM, Costa R, von Hahn T, Trowe MO, Kispert A.

J Pathol. 2019 Aug;248(4):452-463. doi: 10.1002/path.5270. Epub 2019 Apr 30.

PMID:
30916783
6.

Mesothelial mobilization in the developing lung and heart differs in timing, quantity, and pathway dependency.

Lüdtke TH, Rudat C, Kurz J, Häfner R, Greulich F, Wojahn I, Aydoğdu N, Mamo TM, Kleppa MJ, Trowe MO, Bohnenpoll T, Taketo MM, Kispert A.

Am J Physiol Lung Cell Mol Physiol. 2019 May 1;316(5):L767-L783. doi: 10.1152/ajplung.00212.2018. Epub 2019 Jan 31.

PMID:
30702346
7.

Hepatocyte-specific suppression of microRNA-221-3p mitigates liver fibrosis.

Tsay HC, Yuan Q, Balakrishnan A, Kaiser M, Möbus S, Kozdrowska E, Farid M, Tegtmeyer PK, Borst K, Vondran FWR, Kalinke U, Kispert A, Manns MP, Ott M, Sharma AD.

J Hepatol. 2019 Apr;70(4):722-734. doi: 10.1016/j.jhep.2018.12.016. Epub 2018 Dec 22.

PMID:
30582979
8.

TBX2 and TBX3 act downstream of canonical WNT signaling in patterning and differentiation of the mouse ureteric mesenchyme.

Aydoğdu N, Rudat C, Trowe MO, Kaiser M, Lüdtke TH, Taketo MM, Christoffels VM, Moon A, Kispert A.

Development. 2018 Nov 26;145(23). pii: dev171827. doi: 10.1242/dev.171827.

9.

Sialic acid is a critical fetal defense against maternal complement attack.

Abeln M, Albers I, Peters-Bernard U, Flächsig-Schulz K, Kats E, Kispert A, Tomlinson S, Gerardy-Schahn R, Münster-Kühnel A, Weinhold B.

J Clin Invest. 2019 Jan 2;129(1):422-436. doi: 10.1172/JCI99945. Epub 2018 Dec 10.

10.

Proteomic analysis identifies transcriptional cofactors and homeobox transcription factors as TBX18 binding proteins.

Rivera-Reyes R, Kleppa MJ, Kispert A.

PLoS One. 2018 Aug 2;13(8):e0200964. doi: 10.1371/journal.pone.0200964. eCollection 2018.

11.

Retinoic acid signaling maintains epithelial and mesenchymal progenitors in the developing mouse ureter.

Bohnenpoll T, Weiss AC, Labuhn M, Lüdtke TH, Trowe MO, Kispert A.

Sci Rep. 2017 Nov 1;7(1):14803. doi: 10.1038/s41598-017-14790-2.

12.

Tbx15 Defines a Glycolytic Subpopulation and White Adipocyte Heterogeneity.

Lee KY, Sharma R, Gase G, Ussar S, Li Y, Welch L, Berryman DE, Kispert A, Bluher M, Kahn CR.

Diabetes. 2017 Nov;66(11):2822-2829. doi: 10.2337/db17-0218. Epub 2017 Aug 28.

13.

A SHH-FOXF1-BMP4 signaling axis regulating growth and differentiation of epithelial and mesenchymal tissues in ureter development.

Bohnenpoll T, Wittern AB, Mamo TM, Weiss AC, Rudat C, Kleppa MJ, Schuster-Gossler K, Wojahn I, Lüdtke TH, Trowe MO, Kispert A.

PLoS Genet. 2017 Aug 10;13(8):e1006951. doi: 10.1371/journal.pgen.1006951. eCollection 2017 Aug.

14.

BMP4 uses several different effector pathways to regulate proliferation and differentiation in the epithelial and mesenchymal tissue compartments of the developing mouse ureter.

Mamo TM, Wittern AB, Kleppa MJ, Bohnenpoll T, Weiss AC, Kispert A.

Hum Mol Genet. 2017 Sep 15;26(18):3553-3563. doi: 10.1093/hmg/ddx242.

PMID:
28655168
15.

A Dominant Mutation in Nuclear Receptor Interacting Protein 1 Causes Urinary Tract Malformations via Dysregulation of Retinoic Acid Signaling.

Vivante A, Mann N, Yonath H, Weiss AC, Getwan M, Kaminski MM, Bohnenpoll T, Teyssier C, Chen J, Shril S, van der Ven AT, Ityel H, Schmidt JM, Widmeier E, Bauer SB, Sanna-Cherchi S, Gharavi AG, Lu W, Magen D, Shukrun R, Lifton RP, Tasic V, Stanescu HC, Cavaillès V, Kleta R, Anikster Y, Dekel B, Kispert A, Lienkamp SS, Hildebrandt F.

J Am Soc Nephrol. 2017 Aug;28(8):2364-2376. doi: 10.1681/ASN.2016060694. Epub 2017 Apr 5.

16.

Mutations in the leukemia inhibitory factor receptor (LIFR) gene and Lifr deficiency cause urinary tract malformations.

Kosfeld A, Brand F, Weiss AC, Kreuzer M, Goerk M, Martens H, Schubert S, Schäfer AK, Riehmer V, Hennies I, Bräsen JH, Pape L, Amann K, Krogvold L, Bjerre A, Daniel C, Kispert A, Haffner D, Weber RG.

Hum Mol Genet. 2017 May 1;26(9):1716-1731. doi: 10.1093/hmg/ddx086.

PMID:
28334964
17.

T-Box Genes in the Kidney and Urinary Tract.

Kispert A.

Curr Top Dev Biol. 2017;122:245-278. doi: 10.1016/bs.ctdb.2016.06.002. Epub 2016 Jul 27. Review.

PMID:
28057266
18.

The transcription factor GATA4 promotes myocardial regeneration in neonatal mice.

Malek Mohammadi M, Kattih B, Grund A, Froese N, Korf-Klingebiel M, Gigina A, Schrameck U, Rudat C, Liang Q, Kispert A, Wollert KC, Bauersachs J, Heineke J.

EMBO Mol Med. 2017 Feb;9(2):265-279. doi: 10.15252/emmm.201606602. Erratum in: EMBO Mol Med. 2019 Jun;11(6):.

19.

Diversification of Cell Lineages in Ureter Development.

Bohnenpoll T, Feraric S, Nattkemper M, Weiss AC, Rudat C, Meuser M, Trowe MO, Kispert A.

J Am Soc Nephrol. 2017 Jun;28(6):1792-1801. doi: 10.1681/ASN.2016080849. Epub 2016 Dec 27.

20.

Tbx2 and Tbx3 Act Downstream of Shh to Maintain Canonical Wnt Signaling during Branching Morphogenesis of the Murine Lung.

Lüdtke TH, Rudat C, Wojahn I, Weiss AC, Kleppa MJ, Kurz J, Farin HF, Moon A, Christoffels VM, Kispert A.

Dev Cell. 2016 Oct 24;39(2):239-253. doi: 10.1016/j.devcel.2016.08.007. Epub 2016 Oct 6.

21.

Establishment of the Visceral Embryonic Midline Is a Dynamic Process that Requires Bilaterally Symmetric BMP Signaling.

Arraf AA, Yelin R, Reshef I, Kispert A, Schultheiss TM.

Dev Cell. 2016 Jun 20;37(6):571-80. doi: 10.1016/j.devcel.2016.05.018.

22.

Lack of Genetic Interaction between Tbx18 and Tbx2/Tbx20 in Mouse Epicardial Development.

Greulich F, Rudat C, Farin HF, Christoffels VM, Kispert A.

PLoS One. 2016 Jun 2;11(6):e0156787. doi: 10.1371/journal.pone.0156787. eCollection 2016.

23.

Misexpression of Tbx18 in cardiac chambers of fetal mice interferes with chamber-specific developmental programs but does not induce a pacemaker-like gene signature.

Greulich F, Trowe MO, Leffler A, Stoetzer C, Farin HF, Kispert A.

J Mol Cell Cardiol. 2016 Aug;97:140-9. doi: 10.1016/j.yjmcc.2016.05.004. Epub 2016 May 11.

PMID:
27180262
24.

Tbx18 Regulates the Differentiation of Periductal Smooth Muscle Stroma and the Maintenance of Epithelial Integrity in the Prostate.

Bolt CC, Negi S, Guimarães-Camboa N, Zhang H, Troy JM, Lu X, Kispert A, Evans SM, Stubbs L.

PLoS One. 2016 Apr 27;11(4):e0154413. doi: 10.1371/journal.pone.0154413. eCollection 2016. Erratum in: PLoS One. 2016;11(6):e0157283.

25.

Tetrodotoxin-sensitive α-subunits of voltage-gated sodium channels are relevant for inhibition of cardiac sodium currents by local anesthetics.

Stoetzer C, Doll T, Stueber T, Herzog C, Echtermeyer F, Greulich F, Rudat C, Kispert A, Wegner F, Leffler A.

Naunyn Schmiedebergs Arch Pharmacol. 2016 Jun;389(6):625-36. doi: 10.1007/s00210-016-1231-9. Epub 2016 Mar 22.

PMID:
27000037
26.

GTPase domain driven dimerization of SEPT7 is dispensable for the critical role of septins in fibroblast cytokinesis.

Abbey M, Hakim C, Anand R, Lafera J, Schambach A, Kispert A, Taft MH, Kaever V, Kotlyarov A, Gaestel M, Menon MB.

Sci Rep. 2016 Jan 28;6:20007. doi: 10.1038/srep20007.

27.

Whole-exome sequencing identifies mutations of TBC1D1 encoding a Rab-GTPase-activating protein in patients with congenital anomalies of the kidneys and urinary tract (CAKUT).

Kosfeld A, Kreuzer M, Daniel C, Brand F, Schäfer AK, Chadt A, Weiss AC, Riehmer V, Jeanpierre C, Klintschar M, Bräsen JH, Amann K, Pape L, Kispert A, Al-Hasani H, Haffner D, Weber RG.

Hum Genet. 2016 Jan;135(1):69-87. doi: 10.1007/s00439-015-1610-1. Epub 2015 Nov 16.

PMID:
26572137
28.

Tbx15 controls skeletal muscle fibre-type determination and muscle metabolism.

Lee KY, Singh MK, Ussar S, Wetzel P, Hirshman MF, Goodyear LJ, Kispert A, Kahn CR.

Nat Commun. 2015 Aug 24;6:8054. doi: 10.1038/ncomms9054.

29.

Mutations in TBX18 Cause Dominant Urinary Tract Malformations via Transcriptional Dysregulation of Ureter Development.

Vivante A, Kleppa MJ, Schulz J, Kohl S, Sharma A, Chen J, Shril S, Hwang DY, Weiss AC, Kaminski MM, Shukrun R, Kemper MJ, Lehnhardt A, Beetz R, Sanna-Cherchi S, Verbitsky M, Gharavi AG, Stuart HM, Feather SA, Goodship JA, Goodship TH, Woolf AS, Westra SJ, Doody DP, Bauer SB, Lee RS, Adam RM, Lu W, Reutter HM, Kehinde EO, Mancini EJ, Lifton RP, Tasic V, Lienkamp SS, Jüppner H, Kispert A, Hildebrandt F.

Am J Hum Genet. 2015 Aug 6;97(2):291-301. doi: 10.1016/j.ajhg.2015.07.001. Epub 2015 Jul 30.

30.

Fgfr2 is required for the expansion of the early adrenocortical primordium.

Häfner R, Bohnenpoll T, Rudat C, Schultheiss TM, Kispert A.

Mol Cell Endocrinol. 2015 Sep 15;413:168-77. doi: 10.1016/j.mce.2015.06.022. Epub 2015 Jun 30.

PMID:
26141512
31.

Eph/ephrin signaling in the kidney and lower urinary tract.

Weiss AC, Kispert A.

Pediatr Nephrol. 2016 Mar;31(3):359-71. doi: 10.1007/s00467-015-3112-8. Epub 2015 Apr 23. Review.

PMID:
25903642
32.

Wnt5a and Wnt11 regulate mammalian anterior-posterior axis elongation.

Andre P, Song H, Kim W, Kispert A, Yang Y.

Development. 2015 Apr 15;142(8):1516-27. doi: 10.1242/dev.119065. Epub 2015 Mar 26.

33.

Repression of Sox9 by Jag1 is continuously required to suppress the default chondrogenic fate of vascular smooth muscle cells.

Briot A, Jaroszewicz A, Warren CM, Lu J, Touma M, Rudat C, Hofmann JJ, Airik R, Weinmaster G, Lyons K, Wang Y, Kispert A, Pellegrini M, Iruela-Arispe ML.

Dev Cell. 2014 Dec 22;31(6):707-21. doi: 10.1016/j.devcel.2014.11.023.

34.

Upk3b is dispensable for development and integrity of urothelium and mesothelium.

Rudat C, Grieskamp T, Röhr C, Airik R, Wrede C, Hegermann J, Herrmann BG, Schuster-Gossler K, Kispert A.

PLoS One. 2014 Nov 12;9(11):e112112. doi: 10.1371/journal.pone.0112112. eCollection 2014.

35.

Nephric duct insertion requires EphA4/EphA7 signaling from the pericloacal mesenchyme.

Weiss AC, Airik R, Bohnenpoll T, Greulich F, Foik A, Trowe MO, Rudat C, Costantini F, Adams RH, Kispert A.

Development. 2014 Sep;141(17):3420-30. doi: 10.1242/dev.113928.

36.

MicroRNA-199a-5p inhibition enhances the liver repopulation ability of human embryonic stem cell-derived hepatic cells.

Möbus S, Yang D, Yuan Q, Lüdtke TH, Balakrishnan A, Sgodda M, Rani B, Kispert A, Araúzo-Bravo MJ, Vogel A, Manns MP, Ott M, Cantz T, Sharma AD.

J Hepatol. 2015 Jan;62(1):101-10. doi: 10.1016/j.jhep.2014.08.016. Epub 2014 Aug 15.

PMID:
25135862
37.

Ureter growth and differentiation.

Bohnenpoll T, Kispert A.

Semin Cell Dev Biol. 2014 Dec;36:21-30. doi: 10.1016/j.semcdb.2014.07.014. Epub 2014 Aug 1. Review.

PMID:
25087982
38.

Expression of fibulin-6 in failing hearts and its role for cardiac fibroblast migration.

Chowdhury A, Herzog C, Hasselbach L, Khouzani HL, Zhang J, Hammerschmidt M, Rudat C, Kispert A, Gaestel M, Menon MB, Tudorache I, Hilfiker-Kleiner D, Mühlfeld C, Schmitto JD, Müller M, Theilmeier G.

Cardiovasc Res. 2014 Sep 1;103(4):509-20. doi: 10.1093/cvr/cvu161. Epub 2014 Jun 20.

PMID:
24951538
39.

A distant downstream enhancer directs essential expression of Tbx18 in urogenital tissues.

Bolt CC, Elso CM, Lu X, Pan F, Kispert A, Stubbs L.

Dev Biol. 2014 Aug 15;392(2):483-93. doi: 10.1016/j.ydbio.2014.05.010. Epub 2014 May 20.

40.

Canonical Wnt signaling regulates the proliferative expansion and differentiation of fibrocytes in the murine inner ear.

Bohnenpoll T, Trowe MO, Wojahn I, Taketo MM, Petry M, Kispert A.

Dev Biol. 2014 Jul 1;391(1):54-65. doi: 10.1016/j.ydbio.2014.03.023. Epub 2014 Apr 12.

41.

Renal-retinal ciliopathy gene Sdccag8 regulates DNA damage response signaling.

Airik R, Slaats GG, Guo Z, Weiss AC, Khan N, Ghosh A, Hurd TW, Bekker-Jensen S, Schrøder JM, Elledge SJ, Andersen JS, Kispert A, Castelli M, Boletta A, Giles RH, Hildebrandt F.

J Am Soc Nephrol. 2014 Nov;25(11):2573-83. doi: 10.1681/ASN.2013050565. Epub 2014 Apr 10.

42.

Wnt11 is required for oriented migration of dermogenic progenitor cells from the dorsomedial lip of the avian dermomyotome.

Morosan-Puopolo G, Balakrishnan-Renuka A, Yusuf F, Chen J, Dai F, Zoidl G, Lüdtke TH, Kispert A, Theiss C, Abdelsabour-Khalaf M, Brand-Saberi B.

PLoS One. 2014 Mar 26;9(3):e92679. doi: 10.1371/journal.pone.0092679. eCollection 2014. Erratum in: PLoS One. 2018 Sep 10;13(9):e0203913.

43.

Wnt6 is expressed in granulomatous lesions of Mycobacterium tuberculosis-infected mice and is involved in macrophage differentiation and proliferation.

Schaale K, Brandenburg J, Kispert A, Leitges M, Ehlers S, Reiling N.

J Immunol. 2013 Nov 15;191(10):5182-95. doi: 10.4049/jimmunol.1201819. Epub 2013 Oct 11.

44.

Epicardial function of canonical Wnt-, Hedgehog-, Fgfr1/2-, and Pdgfra-signalling.

Rudat C, Norden J, Taketo MM, Kispert A.

Cardiovasc Res. 2013 Dec 1;100(3):411-21. doi: 10.1093/cvr/cvt210. Epub 2013 Sep 2.

PMID:
24000064
45.

Phenotypical analysis of atypical PKCs in vivo function display a compensatory system at mouse embryonic day 7.5.

Seidl S, Braun U, Roos N, Li S, Lüdtke TH, Kispert A, Leitges M.

PLoS One. 2013 May 14;8(5):e62756. doi: 10.1371/journal.pone.0062756. Print 2013.

46.

Tbx18 expression demarcates multipotent precursor populations in the developing urogenital system but is exclusively required within the ureteric mesenchymal lineage to suppress a renal stromal fate.

Bohnenpoll T, Bettenhausen E, Weiss AC, Foik AB, Trowe MO, Blank P, Airik R, Kispert A.

Dev Biol. 2013 Aug 1;380(1):25-36. doi: 10.1016/j.ydbio.2013.04.036. Epub 2013 May 15.

47.

Inhibition of Sox2-dependent activation of Shh in the ventral diencephalon by Tbx3 is required for formation of the neurohypophysis.

Trowe MO, Zhao L, Weiss AC, Christoffels V, Epstein DJ, Kispert A.

Development. 2013 Jun;140(11):2299-309. doi: 10.1242/dev.094524.

48.

TSHZ3 and SOX9 regulate the timing of smooth muscle cell differentiation in the ureter by reducing myocardin activity.

Martin E, Caubit X, Airik R, Vola C, Fatmi A, Kispert A, Fasano L.

PLoS One. 2013 May 6;8(5):e63721. doi: 10.1371/journal.pone.0063721. Print 2013.

49.

Tbx2 terminates shh/fgf signaling in the developing mouse limb bud by direct repression of gremlin1.

Farin HF, Lüdtke TH, Schmidt MK, Placzko S, Schuster-Gossler K, Petry M, Christoffels VM, Kispert A.

PLoS Genet. 2013;9(4):e1003467. doi: 10.1371/journal.pgen.1003467. Epub 2013 Apr 25.

50.

Tbx2 controls lung growth by direct repression of the cell cycle inhibitor genes Cdkn1a and Cdkn1b.

Lüdtke TH, Farin HF, Rudat C, Schuster-Gossler K, Petry M, Barnett P, Christoffels VM, Kispert A.

PLoS Genet. 2013;9(1):e1003189. doi: 10.1371/journal.pgen.1003189. Epub 2013 Jan 17.

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