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Items: 1 to 50 of 557

1.

Deciphering the mechanism of potent peptidomimetic inhibitors targeting plasmepsins - biochemical and structural insights.

Mishra V, Rathore I, Arekar A, Sthanam LK, Xiao H, Kiso Y, Sen S, Patankar S, Gustchina A, Hidaka K, Wlodawer A, Yada RY, Bhaumik P.

FEBS J. 2018 Jun 26. doi: 10.1111/febs.14598. [Epub ahead of print]

PMID:
29943906
2.

Identification of Highly Potent Human Immunodeficiency Virus Type-1 Protease Inhibitors against Lopinavir and Darunavir Resistant Viruses from Allophenylnorstatine-Based Peptidomimetics with P2 Tetrahydrofuranylglycine.

Hidaka K, Kimura T, Sankaranarayanan R, Wang J, McDaniel KF, Kempf DJ, Kameoka M, Adachi M, Kuroki R, Nguyen JT, Hayashi Y, Kiso Y.

J Med Chem. 2018 Jun 28;61(12):5138-5153. doi: 10.1021/acs.jmedchem.7b01709. Epub 2018 Jun 11.

PMID:
29852069
3.

Telomere length determined by the fluorescence in situ hybridisation distinguishes malignant and benign cells in cytological specimens.

Matsuda Y, Suzuki A, Esaka S, Hamashima Y, Imaizumi M, Kinoshita M, Shirahata H, Kiso Y, Kojima H, Matsukawa M, Fujii Y, Ishikawa N, Aida J, Takubo K, Ishiwata T, Nishimura M, Arai T.

Cytopathology. 2018 Jun;29(3):262-266. doi: 10.1111/cyt.12535. Epub 2018 Mar 26.

PMID:
29578263
4.

Morphological analyses of the retinal photoreceptor cells in the nocturnally adapted owl monkeys.

Kuniyoshi N, Yoshida Y, Itoh Y, Yokota SI, Kuraishi T, Hattori S, Kondo T, Yoshizawa M, Kai C, Kiso Y, Kusakabe KT.

J Vet Med Sci. 2018 Mar 24;80(3):413-420. doi: 10.1292/jvms.17-0418. Epub 2018 Jan 26.

5.

Mediators of the effects of rice intake on health in individuals consuming a traditional Japanese diet centered on rice.

Koga M, Toyomaki A, Miyazaki A, Nakai Y, Yamaguchi A, Kubo C, Suzuki J, Ohkubo I, Shimizu M, Musashi M, Kiso Y, Kusumi I.

PLoS One. 2017 Oct 2;12(10):e0185816. doi: 10.1371/journal.pone.0185816. eCollection 2017.

6.

Efficacy of recombinant measles virus expressing highly pathogenic avian influenza virus (HPAIV) antigen against HPAIV infection in monkeys.

Fujiyuki T, Horie R, Yoneda M, Kuraishi T, Yasui F, Kwon HJ, Munekata K, Ikeda F, Hoshi M, Kiso Y, Omi M, Sato H, Kida H, Hattori S, Kohara M, Kai C.

Sci Rep. 2017 Sep 20;7(1):12017. doi: 10.1038/s41598-017-08326-x.

7.

Editorial.

Moroder L, Kiso Y, Diederichsen U, Teshima T.

J Pept Sci. 2017 Jul;23(7-8):471. doi: 10.1002/psc.3030. No abstract available.

PMID:
28786204
8.

The relationship between a low grain intake dietary pattern and impulsive behaviors in middle-aged Japanese people.

Toyomaki A, Koga M, Okada E, Nakai Y, Miyazaki A, Tamakoshi A, Kiso Y, Kusumi I.

PLoS One. 2017 Jul 13;12(7):e0181057. doi: 10.1371/journal.pone.0181057. eCollection 2017.

9.

Generation of monoclonal antibodies against mitocryptide-2: toward a new strategy to investigate the biological roles of cryptides.

Hattori T, Yamada T, Morikawa H, Marutani T, Tsutsumi K, Nishino K, Shimizu T, Nishi Y, Kiso Y, Mukai H.

J Pept Sci. 2017 Jul;23(7-8):610-617. doi: 10.1002/psc.3000. Epub 2017 Mar 29.

PMID:
28370673
10.

Effects of whole genome duplication on cell size and gene expression in mouse embryonic stem cells.

Imai H, Fujii W, Kusakabe KT, Kiso Y, Kano K.

J Reprod Dev. 2016 Dec 20;62(6):571-576. doi: 10.1262/jrd.2016-037. Epub 2016 Aug 29.

11.

Intracytoplasmic sperm injection into oocytes matured in vitro and early embryonic development in the owl monkey (Aotus lemurinus).

Watanabe H, Matsumoto T, Nishi M, Kusakabe KT, Kuraishi T, Hattori S, Matsumoto H, Fukui E, Kuwahata A, Ochi M, Kiso Y, Kai C, Yoshizawa M.

Reprod Med Biol. 2015 Dec 16;15(3):183-186. doi: 10.1007/s12522-015-0229-1. eCollection 2016 Jul.

12.

Mitochondrial protein-derived cryptides: Are endogenous N-formylated peptides including mitocryptide-2 components of mitochondrial damage-associated molecular patterns?

Marutani T, Hattori T, Tsutsumi K, Koike Y, Harada A, Noguchi K, Kiso Y, Mukai H.

Biopolymers. 2016 Nov 4;106(4):580-7. doi: 10.1002/bip.22788. Review.

PMID:
26600263
13.

New directions for protease inhibitors directed drug discovery.

Hamada Y, Kiso Y.

Biopolymers. 2016 Nov 4;106(4):563-79. doi: 10.1002/bip.22780. Review.

PMID:
26584340
14.

Histocytological specificities of adrenal cortex in the New World Monkeys, Aotus lemurinus and Saimiri boliviensis.

Tachibana T, Kusakabe KT, Osaki S, Kuraishi T, Hattori S, Yoshizawa M, Kai C, Kiso Y.

J Vet Med Sci. 2016 Jan;78(1):161-5. doi: 10.1292/jvms.15-0290. Epub 2015 Aug 28.

15.

Tetraploid Embryonic Stem Cells Maintain Pluripotency and Differentiation Potency into Three Germ Layers.

Imai H, Kano K, Fujii W, Takasawa K, Wakitani S, Hiyama M, Nishino K, Kusakabe KT, Kiso Y.

PLoS One. 2015 Jun 19;10(6):e0130585. doi: 10.1371/journal.pone.0130585. eCollection 2015.

16.

Successful acquisition of a neutralizing monoclonal antibody against a novel neutrophil-activating peptide, mitocryptide-1.

Hattori T, Nakashima K, Marutani T, Kiso Y, Nishi Y, Mukai H.

Biochem Biophys Res Commun. 2015 Jul 17-24;463(1-2):54-9. doi: 10.1016/j.bbrc.2015.05.016. Epub 2015 May 15.

PMID:
25986736
17.

Arachidonic acid diet attenuates brain Aβ deposition in Tg2576 mice.

Hosono T, Nishitsuji K, Nakamura T, Jung CG, Kontani M, Tokuda H, Kawashima H, Kiso Y, Suzuki T, Michikawa M.

Brain Res. 2015 Jul 10;1613:92-9. doi: 10.1016/j.brainres.2015.04.005. Epub 2015 Apr 13.

PMID:
25881896
18.

Novel β-amyloid aggregation inhibitors possessing a turn mimic.

Hamada Y, Miyamoto N, Kiso Y.

Bioorg Med Chem Lett. 2015 Apr 1;25(7):1572-6. doi: 10.1016/j.bmcl.2015.02.016. Epub 2015 Feb 19.

PMID:
25736996
19.

The zymogen of plasmepsin V from Plasmodium falciparum is enzymatically active.

Xiao H, Bryksa BC, Bhaumik P, Gustchina A, Kiso Y, Yao SQ, Wlodawer A, Yada RY.

Mol Biochem Parasitol. 2014 Oct;197(1-2):56-63. doi: 10.1016/j.molbiopara.2014.10.004. Epub 2014 Oct 25.

PMID:
25447707
20.

Nutrient starvation affects expression of LC3 family at the feto-maternal interface during murine placentation.

Hiyama M, Kusakabe KT, Takeshita A, Sugi S, Kuniyoshi N, Imai H, Kano K, Kiso Y.

J Vet Med Sci. 2015 Mar;77(3):305-11. doi: 10.1292/jvms.14-0490. Epub 2014 Nov 25.

21.

Bacteria of the candidate phylum TM7 are prevalent in acidophilic nitrifying sequencing-batch reactors.

Hanada A, Kurogi T, Giang NM, Yamada T, Kamimoto Y, Kiso Y, Hiraishi A.

Microbes Environ. 2014;29(4):353-62. doi: 10.1264/jsme2.ME14052. Epub 2014 Sep 20.

22.

Differential effect of arachidonic acid and docosahexaenoic acid on age-related decreases in hippocampal neurogenesis.

Tokuda H, Kontani M, Kawashima H, Kiso Y, Shibata H, Osumi N.

Neurosci Res. 2014 Nov;88:58-66. doi: 10.1016/j.neures.2014.08.002. Epub 2014 Aug 19.

PMID:
25149915
23.

Non-pretreated O-acyl isopeptide of amyloid β peptide 1-42 is monomeric with a random coil structure but starts to aggregate in a concentration-dependent manner.

Yoshiya T, Maruno T, Uemura T, Kubo S, Kiso Y, Sohma Y, Yoshizawa-Kumagaye K, Kobayashi Y, Nishiuchi Y.

Bioorg Med Chem Lett. 2014 Aug 15;24(16):3861-4. doi: 10.1016/j.bmcl.2014.06.052. Epub 2014 Jun 25.

24.

O-acyl isopeptide method: development of an O-acyl isodipeptide unit for Boc SPPS and its application to the synthesis of Aβ1-42 isopeptide.

Yoshiya T, Uemura T, Maruno T, Kubo S, Kiso Y, Sohma Y, Kobayashi Y, Yoshizawa-Kumagaye K, Nishiuchi Y.

J Pept Sci. 2014 Sep;20(9):669-74. doi: 10.1002/psc.2662. Epub 2014 May 28.

PMID:
24889810
25.

Optimization of plasmepsin inhibitor by focusing on similar structural feature with chloroquine to avoid drug-resistant mechanism of Plasmodium falciparum.

Miura T, Hidaka K, Azai Y, Kashimoto K, Kawasaki Y, Chen SE, de Freitas RF, Freire E, Kiso Y.

Bioorg Med Chem Lett. 2014 Apr 1;24(7):1698-701. doi: 10.1016/j.bmcl.2014.02.051. Epub 2014 Mar 3.

PMID:
24631188
26.

Dynamics and reproductive effects of complement factors in the spontaneous abortion model of CBA/J×DBA/2 mice.

Takeshita A, Kusakabe KT, Hiyama M, Kuniyoshi N, Kondo T, Kano K, Kiso Y, Okada T.

Immunobiology. 2014 May;219(5):385-91. doi: 10.1016/j.imbio.2014.01.001. Epub 2014 Jan 10.

PMID:
24576554
27.

Influence of atopic dermatitis on reproduction and uterine natural killer cells.

Hayashi K, Kusakabe KT, Sugimoto S, Wakitani S, Sugi S, Kuniyoshi N, Hiyama M, Takeshita A, Kano K, Kiso Y.

J Vet Med Sci. 2014 Jun;76(6):913-6. Epub 2014 Feb 27.

28.

Arachidonic acid-enriched triacylglycerol improves cognitive function in elderly with low serum levels of arachidonic acid.

Tokuda H, Kontani M, Kawashima H, Akimoto K, Kusumoto A, Kiso Y, Koga Y, Shibata H.

J Oleo Sci. 2014;63(3):219-27. Epub 2014 Feb 13.

29.

Experimental infection of macaques with a wild water bird-derived highly pathogenic avian influenza virus (H5N1).

Fujiyuki T, Yoneda M, Yasui F, Kuraishi T, Hattori S, Kwon HJ, Munekata K, Kiso Y, Kida H, Kohara M, Kai C.

PLoS One. 2013 Dec 18;8(12):e83551. doi: 10.1371/journal.pone.0083551. eCollection 2013.

30.

Structure-activity relationship study of BACE1 inhibitors possessing a chelidonic or 2,6-pyridinedicarboxylic scaffold at the P(2) position.

Hamada Y, Suzuki K, Nakanishi T, Sarma D, Ohta H, Yamaguchi R, Yamasaki M, Hidaka K, Ishiura S, Kiso Y.

Bioorg Med Chem Lett. 2014 Jan 15;24(2):618-23. doi: 10.1016/j.bmcl.2013.12.007. Epub 2013 Dec 8.

PMID:
24360554
31.

Application of plug-plug technique to ACE experiments for discovery of peptides binding to a larger target protein: a model study of calmodulin-binding fragments selected from a digested mixture of reduced BSA.

Saito K, Nakato M, Mizuguchi T, Wada S, Uchimura H, Kataoka H, Yokoyama S, Hirota H, Kiso Y.

Electrophoresis. 2014 Mar;35(6):846-54. doi: 10.1002/elps.201300339. Epub 2014 Jan 13.

PMID:
24254403
32.

The effect of the sympathetic nervous system on splenic natural killer cell activity in mice administered the Lactobacillus pentosus strain S-PT84.

Izumo T, Maekawa T, Horii Y, Fujisaki Y, Ida M, Furukawa Y, Ono Y, Kiso Y, Kitagawa Y, Shibata H, Nagai K.

Neuroreport. 2013 Dec 4;24(17):988-91. doi: 10.1097/WNR.0000000000000036.

33.

A fluorogenic probe for γ-glutamyl cyclotransferase: application of an enzyme-triggered O-to-N acyl migration-type reaction.

Yoshiya T, Tsuda S, Mochizuki M, Hidaka K, Tsuda Y, Kiso Y, Kageyama S, Ii H, Yoshiki T, Nishiuchi Y.

Chembiochem. 2013 Nov 4;14(16):2110-3. doi: 10.1002/cbic.201300481. Epub 2013 Sep 24.

PMID:
24115556
34.

A new class of aggregation inhibitor of amyloid-β peptide based on an O-acyl isopeptide.

Kawashima H, Sohma Y, Nakanishi T, Kitamura H, Mukai H, Yamashita M, Akaji K, Kiso Y.

Bioorg Med Chem. 2013 Nov 1;21(21):6323-7. doi: 10.1016/j.bmc.2013.08.062. Epub 2013 Sep 7.

PMID:
24076366
35.

Discoidin domain receptor 2 (DDR2) regulates body size and fat metabolism in mice.

Kawai I, Matsumura H, Fujii W, Naito K, Kusakabe K, Kiso Y, Kano K.

Transgenic Res. 2014 Feb;23(1):165-75. doi: 10.1007/s11248-013-9751-2. Epub 2013 Sep 14.

PMID:
24036888
36.

Novel BACE1 inhibitors with a non-acidic heterocycle at the P1' position.

Suzuki K, Hamada Y, Nguyen JT, Kiso Y.

Bioorg Med Chem. 2013 Nov 1;21(21):6665-73. doi: 10.1016/j.bmc.2013.08.016. Epub 2013 Aug 12.

PMID:
23993670
37.

Design, synthesis, and biological evaluation of novel dipeptide-type SARS-CoV 3CL protease inhibitors: structure-activity relationship study.

Thanigaimalai P, Konno S, Yamamoto T, Koiwai Y, Taguchi A, Takayama K, Yakushiji F, Akaji K, Kiso Y, Kawasaki Y, Chen SE, Naser-Tavakolian A, Schön A, Freire E, Hayashi Y.

Eur J Med Chem. 2013 Jul;65:436-47. doi: 10.1016/j.ejmech.2013.05.005. Epub 2013 May 20.

PMID:
23747811
38.

Characteristic patterns of maternal and fetal arterial construction in the rabbit placenta.

Hayashi K, Kusakabe KT, Khan H, Kuniyoshi N, Takeshita A, Hiyama M, Kano K, Kiso Y.

Med Mol Morphol. 2014 Jun;47(2):76-82. doi: 10.1007/s00795-013-0044-x. Epub 2013 Apr 23.

PMID:
23604951
39.

Advances in the identification of β-secretase inhibitors.

Hamada Y, Kiso Y.

Expert Opin Drug Discov. 2013 Jun;8(6):709-31. doi: 10.1517/17460441.2013.784267. Epub 2013 Apr 9. Review.

PMID:
23565721
40.

Synthesis of O-acyl isopeptides.

Sohma Y, Kiso Y.

Chem Rec. 2013 Apr;13(2):218-23. doi: 10.1002/tcr.201200023. Epub 2013 Mar 20.

PMID:
23512813
41.

Effects of heat-killed Lactobacillus pentosus S-PT84 on postprandial hypertriacylglycerolemia in rats.

Zhou Y, Inoue N, Ozawa R, Maekawa T, Izumo T, Kitagawa Y, Kiso Y, Shibata H, Ikeda I.

Biosci Biotechnol Biochem. 2013;77(3):591-4. Epub 2013 Mar 7.

42.

Comparative properties of Aβ1-42, Aβ11-42, and [Pyr¹¹]Aβ11-42 generated from O-acyl isopeptides.

Sohma Y, Yamasaki M, Kawashima H, Taniguchi A, Yamashita M, Akaji K, Mukai H, Kiso Y.

Bioorg Med Chem Lett. 2013 Mar 1;23(5):1326-9. doi: 10.1016/j.bmcl.2012.12.082. Epub 2013 Jan 5.

PMID:
23352512
43.

Evaluation of antioxidative effects of sesamin on the in vivo hepatic reducing abilities by a radiofrequency ESR method.

Tada M, Ono Y, Nakai M, Harada M, Shibata H, Kiso Y, Ogata T.

Anal Sci. 2013;29(1):89-94.

44.

Design and synthesis of new tripeptide-type SARS-CoV 3CL protease inhibitors containing an electrophilic arylketone moiety.

Konno S, Thanigaimalai P, Yamamoto T, Nakada K, Kakiuchi R, Takayama K, Yamazaki Y, Yakushiji F, Akaji K, Kiso Y, Kawasaki Y, Chen SE, Freire E, Hayashi Y.

Bioorg Med Chem. 2013 Jan 15;21(2):412-24. doi: 10.1016/j.bmc.2012.11.017. Epub 2012 Nov 24.

PMID:
23245752
45.

Evaluation of dimerization-inhibitory activities of cyclic peptides containing a β-hairpin loop sequence of the EGF receptor.

Mizuguchi T, Ohara N, Iida M, Ninomiya R, Wada S, Kiso Y, Saito K, Akaji K.

Bioorg Med Chem. 2012 Oct 1;20(19):5730-7. doi: 10.1016/j.bmc.2012.08.013. Epub 2012 Aug 17.

PMID:
22959765
46.

The application of bioisosteres in drug design for novel drug discovery: focusing on acid protease inhibitors.

Hamada Y, Kiso Y.

Expert Opin Drug Discov. 2012 Oct;7(10):903-22. Epub 2012 Aug 8. Review.

PMID:
22873630
47.

Synthesis and structure-activity relationships of benzophenone-bearing diketopiperazine-type anti-microtubule agents.

Yamazaki Y, Sumikura M, Masuda Y, Hayashi Y, Yasui H, Kiso Y, Chinen T, Usui T, Yakushiji F, Potts B, Neuteboom S, Palladino M, Lloyd GK, Hayashi Y.

Bioorg Med Chem. 2012 Jul 15;20(14):4279-89. doi: 10.1016/j.bmc.2012.05.059. Epub 2012 Jun 4.

PMID:
22727370
48.

Novel BACE1 inhibitors possessing a 5-nitroisophthalic scaffold at the P2 position.

Hamada Y, Nakanishi T, Suzuki K, Yamaguchi R, Hamada T, Hidaka K, Ishiura S, Kiso Y.

Bioorg Med Chem Lett. 2012 Jul 15;22(14):4640-4. doi: 10.1016/j.bmcl.2012.05.089. Epub 2012 Jun 1.

PMID:
22726930
49.

Identification of the metabolites of episesamin in rat bile and human liver microsomes.

Tomimori N, Nakai M, Ono Y, Kitagawa Y, Kiso Y, Shibata H.

Biol Pharm Bull. 2012;35(5):709-16.

50.

Isolation and identification of novel neutrophil-activating cryptides hidden in mitochondrial cytochrome C.

Hokari Y, Seki T, Nakano H, Matsuo Y, Fukamizu A, Munekata E, Kiso Y, Mukai H.

Protein Pept Lett. 2012 Jun 1;19(6):680-7.

PMID:
22519541

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