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Items: 1 to 50 of 78

1.

Analgesic effect of ASP3662, a novel 11β-HSD1 inhibitor, in rat models of neuropathic and dysfunctional pain.

Kiso T, Sekizawa T, Uchino H, Tsukamoto M, Kakimoto S.

Br J Pharmacol. 2018 Jul 14. doi: 10.1111/bph.14448. [Epub ahead of print]

PMID:
30006998
2.

Design, synthesis, and biological evaluation of novel biphenyl-4-carboxamide derivatives as orally available TRPV1 antagonists.

Oka H, Yonezawa K, Kamikawa A, Ikegai K, Asai N, Shirakami S, Miyamoto S, Watanabe T, Kiso T, Takemoto Y, Tamura S, Kuramochi T.

Bioorg Med Chem. 2018 Jul 23;26(12):3716-3726. doi: 10.1016/j.bmc.2018.06.001. Epub 2018 Jun 2.

PMID:
29887511
3.

Effects of pregabalin and duloxetine on neurotransmitters in the dorsal horn of the spinal cord in a rat model of fibromyalgia.

Kiso T, Moriyama A, Furutani M, Matsuda R, Funatsu Y.

Eur J Pharmacol. 2018 May 15;827:117-124. doi: 10.1016/j.ejphar.2018.03.011. Epub 2018 Mar 9.

PMID:
29530591
4.

In vitro and in vivo pharmacological characterization of ASP8477: A novel highly selective fatty acid amide hydrolase inhibitor.

Watabiki T, Tsuji N, Kiso T, Ozawa T, Narazaki F, Kakimoto S.

Eur J Pharmacol. 2017 Nov 15;815:42-48. doi: 10.1016/j.ejphar.2017.10.007. Epub 2017 Oct 7.

PMID:
29017758
5.

Analgesic effects of novel lysophosphatidic acid receptor 5 antagonist AS2717638 in rodents.

Murai N, Hiyama H, Kiso T, Sekizawa T, Watabiki T, Oka H, Aoki T.

Neuropharmacology. 2017 Nov;126:97-107. doi: 10.1016/j.neuropharm.2017.08.032. Epub 2017 Aug 30.

PMID:
28859883
6.

Discovery of an 8-methoxytetrahydroisoquinoline derivative as an orally active N-type calcium channel blocker for neuropathic pain without CYP inhibition liability.

Ogiyama T, Yonezawa K, Inoue M, Katayama N, Watanabe T, Yoshimura S, Gotoh T, Kiso T, Koakutsu A, Kakimoto S, Shishikura J.

Bioorg Med Chem. 2015 Aug 1;23(15):4638-48. doi: 10.1016/j.bmc.2015.05.053. Epub 2015 Jun 3.

PMID:
26078010
7.

Discovery of a 1-isopropyltetrahydroisoquinoline derivative as an orally active N-type calcium channel blocker for neuropathic pain.

Ogiyama T, Yonezawa K, Inoue M, Watanabe T, Sugano Y, Gotoh T, Kiso T, Koakutsu A, Kakimoto S, Shishikura J.

Bioorg Med Chem. 2015 Aug 1;23(15):4624-37. doi: 10.1016/j.bmc.2015.05.030. Epub 2015 May 27.

PMID:
26071371
8.

Lactobionic and cellobionic acid production profiles of the resting cells of acetic acid bacteria.

Kiryu T, Kiso T, Nakano H, Murakami H.

Biosci Biotechnol Biochem. 2015;79(10):1712-8. doi: 10.1080/09168451.2015.1038214. Epub 2015 May 12.

PMID:
25965080
9.

Discovery of novel tetrahydroisoquinoline derivatives as orally active N-type calcium channel blockers with high selectivity for hERG potassium channels.

Ogiyama T, Inoue M, Honda S, Yamada H, Watanabe T, Gotoh T, Kiso T, Koakutsu A, Kakimoto S, Shishikura J.

Bioorg Med Chem. 2014 Dec 15;22(24):6899-907. doi: 10.1016/j.bmc.2014.10.020. Epub 2014 Oct 22. Erratum in: Bioorg Med Chem. 2015 Sep 1;23(17):6079.

PMID:
25456079
10.

Preparation of branched cyclomaltoheptaose with 3-O-α-L-fucopyranosyl-α-D-mannopyranose and changes in fucosylation of HCT116 cells treated with the fucose-modified cyclomaltoheptaose.

Kimura M, Masui Y, Shirai Y, Honda C, Moriwaki K, Imai T, Takagi U, Kiryu T, Kiso T, Murakami H, Nakano H, Kitahata S, Miyoshi E, Tanimoto T.

Carbohydr Res. 2013 Jun 7;374:49-58. doi: 10.1016/j.carres.2013.03.022. Epub 2013 Apr 3.

PMID:
23623960
11.

Automated measurement of spontaneous pain-associated limb movement and drug efficacy evaluation in a rat model of neuropathic pain.

Kawasaki-Yatsugi S, Nagakura Y, Ogino S, Sekizawa T, Kiso T, Takahashi M, Ishikawa G, Ito H, Shimizu Y.

Eur J Pain. 2012 Nov;16(10):1426-36. doi: 10.1002/j.1532-2149.2012.00142.x. Epub 2012 Mar 27.

PMID:
22451419
12.

Optimization of lactobionic acid production by Acetobacter orientalis isolated from Caucasian fermented milk, "Caspian Sea yogurt".

Kiryu T, Yamauchi K, Masuyama A, Ooe K, Kimura T, Kiso T, Nakano H, Murakami H.

Biosci Biotechnol Biochem. 2012;76(2):361-3. Epub 2012 Feb 7.

13.

An evaluation tool for FKBP12-dependent and -independent mTOR inhibitors using a combination of FKBP-mTOR fusion protein, DSC and NMR.

Sekiguchi M, Kobashigawa Y, Kawasaki M, Yokochi M, Kiso T, Suzumura K, Mori K, Teramura T, Inagaki F.

Protein Eng Des Sel. 2011 Nov;24(11):811-7. doi: 10.1093/protein/gzr045. Epub 2011 Sep 6.

15.

Enhanced insulin secretion and sensitization in diabetic mice on chronic treatment with a transient receptor potential vanilloid 1 antagonist.

Tanaka H, Shimaya A, Kiso T, Kuramochi T, Shimokawa T, Shibasaki M.

Life Sci. 2011 Mar 14;88(11-12):559-63. doi: 10.1016/j.lfs.2011.01.016. Epub 2011 Jan 26.

PMID:
21277869
16.

Amelioration of neuropathic pain by novel transient receptor potential vanilloid 1 antagonist AS1928370 in rats without hyperthermic effect.

Watabiki T, Kiso T, Kuramochi T, Yonezawa K, Tsuji N, Kohara A, Kakimoto S, Aoki T, Matsuoka N.

J Pharmacol Exp Ther. 2011 Mar;336(3):743-50. doi: 10.1124/jpet.110.175570. Epub 2010 Nov 22.

17.

Spinal mechanism of standard analgesics: evaluation using mouse models of allodynia.

Tsukamoto M, Kiso T, Shimoshige Y, Aoki T, Matsuoka N.

Eur J Pharmacol. 2010 May 25;634(1-3):40-5. doi: 10.1016/j.ejphar.2010.02.025. Epub 2010 Feb 25.

PMID:
20188724
18.

Involvement of Acetobacter orientalis in the production of lactobionic acid in Caucasian yogurt ("Caspian Sea yogurt") in Japan.

Kiryu T, Kiso T, Nakano H, Ooe K, Kimura T, Murakami H.

J Dairy Sci. 2009 Jan;92(1):25-34. doi: 10.3168/jds.2008-1081.

PMID:
19109260
19.

Pharmacological characterization and gene expression profiling of an L5/L6 spinal nerve ligation model for neuropathic pain in mice.

Kiso T, Watabiki T, Tsukamoto M, Okabe M, Kagami M, Nishimura K, Aoki T, Matsuoka N.

Neuroscience. 2008 May 2;153(2):492-500. doi: 10.1016/j.neuroscience.2008.02.031. Epub 2008 Feb 29.

PMID:
18400411
20.

Purification and characterization of a carbohydrate: acceptor oxidoreductase from Paraconiothyrium sp. that produces lactobionic acid efficiently.

Kiryu T, Nakano H, Kiso T, Murakami H.

Biosci Biotechnol Biochem. 2008 Mar;72(3):833-41. Epub 2008 Mar 7.

21.

Development of a two-step chromatography procedure that allows the purification of a high-purity anti-histone H1 monoclonal immunoglobulin M antibody with immunosuppressant activity.

Shimada Y, Goto T, Kawamoto S, Kiso T, Katayama A, Yamanaka Y, Aki T, Chiang KC, Nakano T, Goto S, Chen CL, Ohmori N, Ono K, Sato S.

Biomed Chromatogr. 2008 Jan;22(1):13-9.

PMID:
17604361
22.

Antinociceptive profile of a selective metabotropic glutamate receptor 1 antagonist YM-230888 in chronic pain rodent models.

Kohara A, Nagakura Y, Kiso T, Toya T, Watabiki T, Tamura S, Shitaka Y, Itahana H, Okada M.

Eur J Pharmacol. 2007 Sep 24;571(1):8-16. Epub 2007 Jun 5.

PMID:
17597604
23.

Characterization of dimers of hydroquinone glucosides produced by peroxidase-catalyzed polymerization.

Kiso T, Shizuma M, Watase S, Kiryu T, Murakami H, Nakano H.

Biosci Biotechnol Biochem. 2007 Apr;71(4):1083-5. Epub 2007 Apr 7.

24.

Syntheses of alpha-arbutin-alpha-glycosides and their inhibitory effects on human tyrosinase.

Sugimoto K, Nomura K, Nishimura T, Kiso T, Sugimoto K, Kuriki T.

J Biosci Bioeng. 2005 Mar;99(3):272-6.

PMID:
16233788
25.

Synthesis of glycosyl glycerol by cyclodextrin glucanotransferases.

Nakano H, Kiso T, Okamoto K, Tomita T, Manan MB, Kitahata S.

J Biosci Bioeng. 2003;95(6):583-8.

PMID:
16233461
26.

Hydrolysis of beta-glucosyl ester linkage of p-hydroxybenzoyl beta-D-glucose, a chemically synthesized glucoside, by beta-glucosidases.

Kiso T, Kitahata S, Okamoto K, Miyoshi S, Nakano H.

J Biosci Bioeng. 2000;90(6):614-8.

PMID:
16232920
27.
28.

Comparison of the binding affinity of some newly synthesized phenylethanolamine and phenoxypropanolamine compounds at recombinant human beta- and alpha1-adrenoceptor subtypes.

Ahmed M, Hanaoka Y, Kiso T, Kakita T, Ohtsubo Y, Muramatsu I, Nagatomo T.

J Pharm Pharmacol. 2005 Jan;57(1):75-81.

PMID:
15638996
30.

Molecular characterization of pharmacological properties and selectivity of SWR-0315NA for beta3-adrenoceptors.

Ahmed M, Hanaoka Y, Kiso T, Kakita T, Ohtsubo Y, Nagatomo T.

Biol Pharm Bull. 2004 May;27(5):718-22.

32.

Inhibition of beta-fructofuranosidases and alpha-glucosidases by synthetic thio-fructofuranoside.

Kiso T, Hamayasu K, Fujita K, Hara K, Kitahata S, Nakano H.

Biosci Biotechnol Biochem. 2003 Aug;67(8):1719-24.

33.

Morphologic and histopathologic changes in the bowel after super-selective transcatheter embolization for focal lower gastrointestinal hemorrhage.

Horiguchi J, Naito A, Fukuda H, Nakashige A, Ito K, Kiso T, Mori M.

Acta Radiol. 2003 May;44(3):334-9.

PMID:
12752008
34.

Allodynia and hyperalgesia in adjuvant-induced arthritic rats: time course of progression and efficacy of analgesics.

Nagakura Y, Okada M, Kohara A, Kiso T, Toya T, Iwai A, Wanibuchi F, Yamaguchi T.

J Pharmacol Exp Ther. 2003 Aug;306(2):490-7. Epub 2003 May 1.

35.

New thiazole derivatives as potent and selective 5-hydroxytriptamine 3 (5-HT3) receptor agonists for the treatment of constipation.

Imanishi N, Iwaoka K, Koshio H, Nagashima SY, Kazuta K, Ohta M, Sakamoto S, Ito H, Akuzawa S, Kiso T, Tsukamoto S, Mase T.

Bioorg Med Chem. 2003 Apr 3;11(7):1493-502.

PMID:
12628674
36.
37.

UK-2A, B, C and D, novel antifungal antibiotics from Streptomyces sp. 517-02 VI (2). Structure-activity relationships of UK-2A.

Usuki Y, Goto K, Kiso T, Tani K, Ping X, Fujita K, Iio H, Taniguchi M.

J Antibiot (Tokyo). 2002 Jun;55(6):607-10. No abstract available.

38.

The effect of the selective 5-HT(3) receptor agonist on ferret gut motility.

Nagakura Y, Kiso T, Miyata K, Ito H, Iwaoka K, Yamaguchi T.

Life Sci. 2002 Aug 2;71(11):1313-9.

PMID:
12106596
39.
40.

Psychosocial factors associated with quality of life in Japanese patients with human immunodeficiency virus infection.

Hirabayashi N, Fukunishi I, Kojima K, Kiso T, Yamashita Y, Fukutake K, Hanaoka T, Iimori M.

Psychosomatics. 2002 Jan-Feb;43(1):16-23.

PMID:
11927753
41.

L-2,5-dihydrophenylalanine, an inducer of cathepsin-dependent apoptosis in human promyelocytic leukemia cells (HL-60).

Kiso T, Usuki Y, Ping X, Fujita K, Taniguchi M.

J Antibiot (Tokyo). 2001 Oct;54(10):810-7.

42.

A novel 5-HT3 receptor agonist, YM-31636, increases gastrointestinal motility without increasing abdominal pain.

Kiso T, Ito H, Miyata K, Kamato T, Naitoh Y, Iwaoka K, Yamaguchi T.

Eur J Pharmacol. 2001 Nov 9;431(1):35-41.

PMID:
11716840
43.

Investigation of the effects of YM-31636, a novel 5-HT3 receptor agonist, on defecation in normal and constipated ferrets.

Ito H, Kiso T, Yuki H, Naitoh Y, Miyata K, Iwaoka K, Yamaguchi T.

Eur J Pharmacol. 2001 Jul 20;424(2):151-7.

PMID:
11476761
44.

Neurometer measurement of current stimulus threshold in rats.

Kiso T, Nagakura Y, Toya T, Matsumoto N, Tamura S, Ito H, Okada M, Yamaguchi T.

J Pharmacol Exp Ther. 2001 Apr;297(1):352-6.

45.

Pharmacological profile of YM-31636, a novel 5-HT3 receptor agonist, in vitro.

Ito H, Kiso T, Miyata K, Kamato T, Yuki H, Akuzawa S, Nagakura Y, Yamano M, Suzuki M, Naitoh Y, Sakai H, Iwaoka K, Yamaguchi T.

Eur J Pharmacol. 2000 Dec 8;409(2):195-201.

PMID:
11104834
46.

Hydrolysis of beta-galactosyl ester linkage by beta-galactosidases.

Kiso T, Nakano H, Nakajima H, Terai T, Okamoto K, Kitahata S.

Biosci Biotechnol Biochem. 2000 Aug;64(8):1702-6.

47.

Transfructosylation of thiol group by beta-fructofuranosidases.

Nakano H, Murakami H, Shizuma M, Kiso T, de Araujo TL, Kitahata S.

Biosci Biotechnol Biochem. 2000 Jul;64(7):1472-6.

48.

The role of 5-hydroxytryptamine3 and 5-hydroxytryptamine4 receptors in the regulation of gut motility in the ferret.

Nagakura Y, Kiso T, Ito H, Miyata K, Yamaguchi T.

Life Sci. 2000 May 5;66(24):PL331-8.

PMID:
10864103
49.

Galactosylation of thiol group by beta-galactosidase.

Nakano H, Shizuma M, Kiso T, Kitahata S.

Biosci Biotechnol Biochem. 2000 Apr;64(4):735-40.

50.

Purification and some properties of a beta-glucosidase from Flavobacterium johnsonae.

Okamoto K, Nakano H, Yatake T, Kiso T, Kitahata S.

Biosci Biotechnol Biochem. 2000 Feb;64(2):333-40.

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