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Items: 39

1.

Impact of traumatic brain injury on amyotrophic lateral sclerosis: from bedside to bench.

Franz CK, Joshi D, Daley EL, Grant RA, Dalamagkas K, Leung A, Finan JD, Kiskinis E.

J Neurophysiol. 2019 Sep 1;122(3):1174-1185. doi: 10.1152/jn.00572.2018. Epub 2019 May 22.

PMID:
31116639
2.

Quantitative proteomics identifies proteins that resist translational repression and become dysregulated in ALS-FUS.

Baron DM, Matheny T, Lin YC, Leszyk JD, Kenna K, Gall KV, Santos DP, Tischbein M, Funes S, Hayward LJ, Kiskinis E, Landers JE, Parker R, Shaffer SA, Bosco DA.

Hum Mol Genet. 2019 Jul 1;28(13):2143-2160. doi: 10.1093/hmg/ddz048.

PMID:
30806671
3.

Peptide-siRNA Supramolecular Particles for Neural Cell Transfection.

Hernandez-Garcia A, Álvarez Z, Simkin D, Madhan A, Pariset E, Tantakitti F, de J Vargas-Dorantes O, Lee SS, Kiskinis E, Stupp SI.

Adv Sci (Weinh). 2018 Dec 5;6(3):1801458. doi: 10.1002/advs.201801458. eCollection 2019 Feb 6.

4.

Comparative genomic analysis of embryonic, lineage-converted and stem cell-derived motor neurons.

Ichida JK, Staats KA, Davis-Dusenbery BN, Clement K, Galloway KE, Babos KN, Shi Y, Son EY, Kiskinis E, Atwater N, Gu H, Gnirke A, Meissner A, Eggan K.

Development. 2018 Nov 21;145(22). pii: dev168617. doi: 10.1242/dev.168617.

5.

Modeling Pediatric Epilepsy Through iPSC-Based Technologies.

Simkin D, Kiskinis E.

Epilepsy Curr. 2018 Jul-Aug;18(4):240-245. doi: 10.5698/1535-7597.18.4.240.

6.

Supramolecular Nanostructure Activates TrkB Receptor Signaling of Neuronal Cells by Mimicking Brain-Derived Neurotrophic Factor.

Edelbrock AN, Àlvarez Z, Simkin D, Fyrner T, Chin SM, Sato K, Kiskinis E, Stupp SI.

Nano Lett. 2018 Oct 10;18(10):6237-6247. doi: 10.1021/acs.nanolett.8b02317. Epub 2018 Sep 13.

PMID:
30211565
7.

Botulinum Toxin Conditioning Enhances Motor Axon Regeneration in Mouse and Human Preclinical Models.

Franz CK, Puritz A, Jordan LA, Chow J, Ortega JA, Kiskinis E, Heckman CJ.

Neurorehabil Neural Repair. 2018 Aug;32(8):735-745. doi: 10.1177/1545968318790020. Epub 2018 Jul 25.

PMID:
30043670
8.

All-Optical Electrophysiology for High-Throughput Functional Characterization of a Human iPSC-Derived Motor Neuron Model of ALS.

Kiskinis E, Kralj JM, Zou P, Weinstein EN, Zhang H, Tsioras K, Wiskow O, Ortega JA, Eggan K, Cohen AE.

Stem Cell Reports. 2018 Jun 5;10(6):1991-2004. doi: 10.1016/j.stemcr.2018.04.020. Epub 2018 May 17.

9.

Progress in Understanding and Treating SCN2A-Mediated Disorders.

Sanders SJ, Campbell AJ, Cottrell JR, Moller RS, Wagner FF, Auldridge AL, Bernier RA, Catterall WA, Chung WK, Empfield JR, George AL Jr, Hipp JF, Khwaja O, Kiskinis E, Lal D, Malhotra D, Millichap JJ, Otis TS, Petrou S, Pitt G, Schust LF, Taylor CM, Tjernagel J, Spiro JE, Bender KJ.

Trends Neurosci. 2018 Jul;41(7):442-456. doi: 10.1016/j.tins.2018.03.011. Epub 2018 Apr 23. Review.

10.

Author Correction: Global delay in nascent strand DNA methylation.

Charlton J, Downing TL, Smith ZD, Gu H, Clement K, Pop R, Akopian V, Klages S, Santos DP, Tsankov AM, Timmermann B, Ziller MJ, Kiskinis E, Gnirke A, Meissner A.

Nat Struct Mol Biol. 2018 Apr;25(4):355. doi: 10.1038/s41594-018-0055-3.

PMID:
29581568
11.

Direct evidence of impaired neuronal Na/K-ATPase pump function in alternating hemiplegia of childhood.

Simmons CQ, Thompson CH, Cawthon BE, Westlake G, Swoboda KJ, Kiskinis E, Ess KC, George AL Jr.

Neurobiol Dis. 2018 Jul;115:29-38. doi: 10.1016/j.nbd.2018.03.009. Epub 2018 Mar 19.

PMID:
29567111
12.

Dissecting the Functional Consequences of De Novo DNA Methylation Dynamics in Human Motor Neuron Differentiation and Physiology.

Ziller MJ, Ortega JA, Quinlan KA, Santos DP, Gu H, Martin EJ, Galonska C, Pop R, Maidl S, Di Pardo A, Huang M, Meltzer HY, Gnirke A, Heckman CJ, Meissner A, Kiskinis E.

Cell Stem Cell. 2018 Apr 5;22(4):559-574.e9. doi: 10.1016/j.stem.2018.02.012. Epub 2018 Mar 15.

13.

Global delay in nascent strand DNA methylation.

Charlton J, Downing TL, Smith ZD, Gu H, Clement K, Pop R, Akopian V, Klages S, Santos DP, Tsankov AM, Timmermann B, Ziller MJ, Kiskinis E, Gnirke A, Meissner A.

Nat Struct Mol Biol. 2018 Apr;25(4):327-332. doi: 10.1038/s41594-018-0046-4. Epub 2018 Mar 12. Erratum in: Nat Struct Mol Biol. 2018 Mar 26;:.

14.

Genomic variants in the FTO gene are associated with sporadic amyotrophic lateral sclerosis in Greek patients.

Mitropoulos K, Merkouri Papadima E, Xiromerisiou G, Balasopoulou A, Charalampidou K, Galani V, Zafeiri KV, Dardiotis E, Ralli S, Deretzi G, John A, Kydonopoulou K, Papadopoulou E, di Pardo A, Akcimen F, Loizedda A, Dobričić V, Novaković I, Kostić VS, Mizzi C, Peters BA, Basak N, Orrù S, Kiskinis E, Cooper DN, Gerou S, Drmanac R, Bartsakoulia M, Tsermpini EE, Hadjigeorgiou GM, Ali BR, Katsila T, Patrinos GP.

Hum Genomics. 2017 Dec 8;11(1):30. doi: 10.1186/s40246-017-0126-2.

15.

Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson's disease.

Burbulla LF, Song P, Mazzulli JR, Zampese E, Wong YC, Jeon S, Santos DP, Blanz J, Obermaier CD, Strojny C, Savas JN, Kiskinis E, Zhuang X, Krüger R, Surmeier DJ, Krainc D.

Science. 2017 Sep 22;357(6357):1255-1261. doi: 10.1126/science.aam9080. Epub 2017 Sep 7.

16.

Generation of Spinal Motor Neurons from Human Pluripotent Stem Cells.

Santos DP, Kiskinis E.

Methods Mol Biol. 2017;1538:53-66.

PMID:
27943183
17.

Comprehensive Protocols for CRISPR/Cas9-based Gene Editing in Human Pluripotent Stem Cells.

Santos DP, Kiskinis E, Eggan K, Merkle FT.

Curr Protoc Stem Cell Biol. 2016 Aug 17;38:5B.6.1-5B.6.60. doi: 10.1002/cpsc.15.

18.

Probing disorders of the nervous system using reprogramming approaches.

Ichida JK, Kiskinis E.

EMBO J. 2015 Jun 3;34(11):1456-77. doi: 10.15252/embj.201591267. Epub 2015 Apr 29. Review.

19.

Focus on induced pluripotency and cellular reprogramming.

Schwarz-Romond T, Kiskinis E, Eggan K.

EMBO J. 2015 Jun 3;34(11):1435. doi: 10.15252/embj.201591615. Epub 2015 Apr 27. No abstract available.

20.

Genetic validation of a therapeutic target in a mouse model of ALS.

de Boer AS, Koszka K, Kiskinis E, Suzuki N, Davis-Dusenbery BN, Eggan K.

Sci Transl Med. 2014 Aug 6;6(248):248ra104. doi: 10.1126/scitranslmed.3009351.

21.

Pathways disrupted in human ALS motor neurons identified through genetic correction of mutant SOD1.

Kiskinis E, Sandoe J, Williams LA, Boulting GL, Moccia R, Wainger BJ, Han S, Peng T, Thams S, Mikkilineni S, Mellin C, Merkle FT, Davis-Dusenbery BN, Ziller M, Oakley D, Ichida J, Di Costanzo S, Atwater N, Maeder ML, Goodwin MJ, Nemesh J, Handsaker RE, Paull D, Noggle S, McCarroll SA, Joung JK, Woolf CJ, Brown RH, Eggan K.

Cell Stem Cell. 2014 Jun 5;14(6):781-95. doi: 10.1016/j.stem.2014.03.004. Epub 2014 Apr 3.

22.

Intrinsic membrane hyperexcitability of amyotrophic lateral sclerosis patient-derived motor neurons.

Wainger BJ, Kiskinis E, Mellin C, Wiskow O, Han SS, Sandoe J, Perez NP, Williams LA, Lee S, Boulting G, Berry JD, Brown RH Jr, Cudkowicz ME, Bean BP, Eggan K, Woolf CJ.

Cell Rep. 2014 Apr 10;7(1):1-11. doi: 10.1016/j.celrep.2014.03.019. Epub 2014 Apr 3.

23.

Axonal transport of TDP-43 mRNA granules is impaired by ALS-causing mutations.

Alami NH, Smith RB, Carrasco MA, Williams LA, Winborn CS, Han SSW, Kiskinis E, Winborn B, Freibaum BD, Kanagaraj A, Clare AJ, Badders NM, Bilican B, Chaum E, Chandran S, Shaw CE, Eggan KC, Maniatis T, Taylor JP.

Neuron. 2014 Feb 5;81(3):536-543. doi: 10.1016/j.neuron.2013.12.018.

24.

RIP140 represses the "brown-in-white" adipocyte program including a futile cycle of triacylglycerol breakdown and synthesis.

Kiskinis E, Chatzeli L, Curry E, Kaforou M, Frontini A, Cinti S, Montana G, Parker MG, Christian M.

Mol Endocrinol. 2014 Mar;28(3):344-56. doi: 10.1210/me.2013-1254. Epub 2014 Jan 30.

25.

Erosion of dosage compensation impacts human iPSC disease modeling.

Mekhoubad S, Bock C, de Boer AS, Kiskinis E, Meissner A, Eggan K.

Cell Stem Cell. 2012 May 4;10(5):595-609. doi: 10.1016/j.stem.2012.02.014.

26.

Somatic coding mutations in human induced pluripotent stem cells.

Gore A, Li Z, Fung HL, Young JE, Agarwal S, Antosiewicz-Bourget J, Canto I, Giorgetti A, Israel MA, Kiskinis E, Lee JH, Loh YH, Manos PD, Montserrat N, Panopoulos AD, Ruiz S, Wilbert ML, Yu J, Kirkness EF, Izpisua Belmonte JC, Rossi DJ, Thomson JA, Eggan K, Daley GQ, Goldstein LS, Zhang K.

Nature. 2011 Mar 3;471(7336):63-7. doi: 10.1038/nature09805.

27.

Reference Maps of human ES and iPS cell variation enable high-throughput characterization of pluripotent cell lines.

Bock C, Kiskinis E, Verstappen G, Gu H, Boulting G, Smith ZD, Ziller M, Croft GF, Amoroso MW, Oakley DH, Gnirke A, Eggan K, Meissner A.

Cell. 2011 Feb 4;144(3):439-52. doi: 10.1016/j.cell.2010.12.032.

28.

A functionally characterized test set of human induced pluripotent stem cells.

Boulting GL, Kiskinis E, Croft GF, Amoroso MW, Oakley DH, Wainger BJ, Williams DJ, Kahler DJ, Yamaki M, Davidow L, Rodolfa CT, Dimos JT, Mikkilineni S, MacDermott AB, Woolf CJ, Henderson CE, Wichterle H, Eggan K.

Nat Biotechnol. 2011 Mar;29(3):279-86. doi: 10.1038/nbt.1783. Epub 2011 Feb 3.

29.

Shushing down the epigenetic landscape towards stem cell differentiation.

Ichida JK, Kiskinis E, Eggan K.

Development. 2010 Aug 1;137(15):2455-60. doi: 10.1242/dev.049130. Epub 2010 Jun 16.

30.

Progress toward the clinical application of patient-specific pluripotent stem cells.

Kiskinis E, Eggan K.

J Clin Invest. 2010 Jan;120(1):51-9. doi: 10.1172/JCI40553. Review.

31.

A functional interaction between RIP140 and PGC-1alpha regulates the expression of the lipid droplet protein CIDEA.

Hallberg M, Morganstein DL, Kiskinis E, Shah K, Kralli A, Dilworth SM, White R, Parker MG, Christian M.

Mol Cell Biol. 2008 Nov;28(22):6785-95. doi: 10.1128/MCB.00504-08. Epub 2008 Sep 15.

32.

RIP140 directs histone and DNA methylation to silence Ucp1 expression in white adipocytes.

Kiskinis E, Hallberg M, Christian M, Olofsson M, Dilworth SM, White R, Parker MG.

EMBO J. 2007 Nov 28;26(23):4831-40. Epub 2007 Nov 1.

33.

The SWI/SNF chromatin remodeling subunit BAF57 is a critical regulator of estrogen receptor function in breast cancer cells.

García-Pedrero JM, Kiskinis E, Parker MG, Belandia B.

J Biol Chem. 2006 Aug 11;281(32):22656-64. Epub 2006 Jun 12.

34.

Identification of BAF57 mutations in human breast cancer cell lines.

Kiskinis E, García-Pedrero JM, Villaronga MA, Parker MG, Belandia B.

Breast Cancer Res Treat. 2006 Jul;98(2):191-8. Epub 2006 Mar 15.

35.

Suppression of oxidative metabolism and mitochondrial biogenesis by the transcriptional corepressor RIP140 in mouse adipocytes.

Powelka AM, Seth A, Virbasius JV, Kiskinis E, Nicoloro SM, Guilherme A, Tang X, Straubhaar J, Cherniack AD, Parker MG, Czech MP.

J Clin Invest. 2006 Jan;116(1):125-36. Epub 2005 Dec 22.

36.

RIP140-targeted repression of gene expression in adipocytes.

Christian M, Kiskinis E, Debevec D, Leonardsson G, White R, Parker MG.

Mol Cell Biol. 2005 Nov;25(21):9383-91.

37.

High throughput Comet assay using 96-well plates.

Kiskinis E, Suter W, Hartmann A.

Mutagenesis. 2002 Jan;17(1):37-43.

PMID:
11752232
38.

Influence of cytotoxicity and compound precipitation on test results in the alkaline comet assay.

Hartmann A, Kiskinis E, Fjällman A, Suter W.

Mutat Res. 2001 Oct 18;497(1-2):199-212.

PMID:
11525923
39.

Use of the alkaline comet assay for industrial genotoxicity screening: comparative investigation with the micronucleus test.

Hartmann A, Elhajouji A, Kiskinis E, Poetter F, Martus H, Fjällman A, Frieauff W, Suter W.

Food Chem Toxicol. 2001 Aug;39(8):843-58.

PMID:
11434992

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