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Items: 1 to 50 of 175

1.

Structural Basis of Substrate Recognition and Covalent Inhibition of Cdu1 from Chlamydia trachomatis.

Ramirez YA, Adler TB, Altmann E, Klemm T, Tiesmeyer C, Sauer F, Kathman SG, Statsyuk AV, Sotriffer C, Kisker C.

ChemMedChem. 2018 Jul 20. doi: 10.1002/cmdc.201800364. [Epub ahead of print]

PMID:
30028574
2.

Repurposing a Library of Human Cathepsin L Ligands: Identification of Macrocyclic Lactams as Potent Rhodesain and Trypanosoma brucei Inhibitors.

Giroud M, Dietzel U, Anselm L, Banner D, Kuglstatter A, Benz J, Blanc JB, Gaufreteau D, Liu H, Lin X, Stich A, Kuhn B, Schuler F, Kaiser M, Brun R, Schirmeister T, Kisker C, Diederich F, Haap W.

J Med Chem. 2018 Apr 26;61(8):3350-3369. doi: 10.1021/acs.jmedchem.7b01869. Epub 2018 Apr 13.

PMID:
29590750
3.

Structural Basis for the Recruitment of Ctf18-RFC to the Replisome.

Grabarczyk DB, Silkenat S, Kisker C.

Structure. 2018 Jan 2;26(1):137-144.e3. doi: 10.1016/j.str.2017.11.004. Epub 2017 Dec 7.

PMID:
29225079
4.

Conserved salt-bridge competition triggered by phosphorylation regulates the protein interactome.

Skinner JJ, Wang S, Lee J, Ong C, Sommese R, Sivaramakrishnan S, Koelmel W, Hirschbeck M, Schindelin H, Kisker C, Lorenz K, Sosnick TR, Rosner MR.

Proc Natl Acad Sci U S A. 2017 Dec 19;114(51):13453-13458. doi: 10.1073/pnas.1711543114. Epub 2017 Dec 5.

5.

The intricate network between the p34 and p44 subunits is central to the activity of the transcription/DNA repair factor TFIIH.

Radu L, Schoenwetter E, Braun C, Marcoux J, Koelmel W, Schmitt DR, Kuper J, Cianférani S, Egly JM, Poterszman A, Kisker C.

Nucleic Acids Res. 2017 Oct 13;45(18):10872-10883. doi: 10.1093/nar/gkx743.

6.

Structural basis for the shielding function of the dynamic trypanosome variant surface glycoprotein coat.

Bartossek T, Jones NG, Schäfer C, Cvitković M, Glogger M, Mott HR, Kuper J, Brennich M, Carrington M, Smith AS, Fenz S, Kisker C, Engstler M.

Nat Microbiol. 2017 Nov;2(11):1523-1532. doi: 10.1038/s41564-017-0013-6. Epub 2017 Sep 11.

PMID:
28894098
7.

Catabolism of the Cholesterol Side Chain in Mycobacterium tuberculosis Is Controlled by a Redox-Sensitive Thiol Switch.

Lu R, Schaefer CM, Nesbitt NM, Kuper J, Kisker C, Sampson NS.

ACS Infect Dis. 2017 Sep 8;3(9):666-675. doi: 10.1021/acsinfecdis.7b00072. Epub 2017 Aug 16.

8.

The structural and functional characterization of human RecQ4 reveals insights into its helicase mechanism.

Kaiser S, Sauer F, Kisker C.

Nat Commun. 2017 Jun 27;8:15907. doi: 10.1038/ncomms15907.

9.

Chlamydia trachomatis-containing vacuole serves as deubiquitination platform to stabilize Mcl-1 and to interfere with host defense.

Fischer A, Harrison KS, Ramirez Y, Auer D, Chowdhury SR, Prusty BK, Sauer F, Dimond Z, Kisker C, Hefty PS, Rudel T.

Elife. 2017 Mar 28;6. pii: e21465. doi: 10.7554/eLife.21465.

10.

Rationalizing the Binding Kinetics for the Inhibition of the Burkholderia pseudomallei FabI1 Enoyl-ACP Reductase.

Neckles C, Eltschkner S, Cummings JE, Hirschbeck M, Daryaee F, Bommineni GR, Zhang Z, Spagnuolo L, Yu W, Davoodi S, Slayden RA, Kisker C, Tonge PJ.

Biochemistry. 2017 Apr 4;56(13):1865-1878. doi: 10.1021/acs.biochem.6b01048. Epub 2017 Mar 21.

11.

Evaluating the Contribution of Transition-State Destabilization to Changes in the Residence Time of Triazole-Based InhA Inhibitors.

Spagnuolo LA, Eltschkner S, Yu W, Daryaee F, Davoodi S, Knudson SE, Allen EK, Merino J, Pschibul A, Moree B, Thivalapill N, Truglio JJ, Salafsky J, Slayden RA, Kisker C, Tonge PJ.

J Am Chem Soc. 2017 Mar 8;139(9):3417-3429. doi: 10.1021/jacs.6b11148. Epub 2017 Feb 22.

12.

OmoMYC blunts promoter invasion by oncogenic MYC to inhibit gene expression characteristic of MYC-dependent tumors.

Jung LA, Gebhardt A, Koelmel W, Ade CP, Walz S, Kuper J, von Eyss B, Letschert S, Redel C, d'Artista L, Biankin A, Zender L, Sauer M, Wolf E, Evan G, Kisker C, Eilers M.

Oncogene. 2017 Apr 6;36(14):1911-1924. doi: 10.1038/onc.2016.354. Epub 2016 Oct 17.

PMID:
27748763
13.

Correlating Drug-Target Kinetics and In vivo Pharmacodynamics: Long Residence Time Inhibitors of the FabI Enoyl-ACP Reductase.

Daryaee F, Chang A, Schiebel J, Lu Y, Zhang Z, Kapilashrami K, Walker SG, Kisker C, Sotriffer CA, Fisher SL, Tonge PJ.

Chem Sci. 2016 Sep 1;7(9):5945-5954. Epub 2016 May 25.

14.

Different promoter affinities account for specificity in MYC-dependent gene regulation.

Lorenzin F, Benary U, Baluapuri A, Walz S, Jung LA, von Eyss B, Kisker C, Wolf J, Eilers M, Wolf E.

Elife. 2016 Jul 27;5. pii: e15161. doi: 10.7554/eLife.15161.

15.

Conservation and Divergence in Nucleotide Excision Repair Lesion Recognition.

Wirth N, Gross J, Roth HM, Buechner CN, Kisker C, Tessmer I.

J Biol Chem. 2016 Sep 2;291(36):18932-46. doi: 10.1074/jbc.M116.739425. Epub 2016 Jul 12.

16.

Role of XPD in cellular functions: To TFIIH and beyond.

Houten BV, Kuper J, Kisker C.

DNA Repair (Amst). 2016 Aug;44:136-142. doi: 10.1016/j.dnarep.2016.05.019. Epub 2016 May 16. Review.

PMID:
27262611
17.

Selectivity of Pyridone- and Diphenyl Ether-Based Inhibitors for the Yersinia pestis FabV Enoyl-ACP Reductase.

Neckles C, Pschibul A, Lai CT, Hirschbeck M, Kuper J, Davoodi S, Zou J, Liu N, Pan P, Shah S, Daryaee F, Bommineni GR, Lai C, Simmerling C, Kisker C, Tonge PJ.

Biochemistry. 2016 May 31;55(21):2992-3006. doi: 10.1021/acs.biochem.5b01301. Epub 2016 May 17.

18.

FANCM interacts with PCNA to promote replication traverse of DNA interstrand crosslinks.

Rohleder F, Huang J, Xue Y, Kuper J, Round A, Seidman M, Wang W, Kisker C.

Nucleic Acids Res. 2016 Apr 20;44(7):3219-32. doi: 10.1093/nar/gkw037. Epub 2016 Jan 28.

19.

Crystallizing the 6S and 8S spliceosomal assembly intermediates: a complex project.

Pelz JP, Schindelin H, van Pee K, Kuper J, Kisker C, Diederichs K, Fischer U, Grimm C.

Acta Crystallogr D Biol Crystallogr. 2015 Oct;71(Pt 10):2040-53. doi: 10.1107/S1399004715014832. Epub 2015 Sep 26.

PMID:
26457428
20.

Structural insights into the recognition of cisplatin and AAF-dG lesion by Rad14 (XPA).

Koch SC, Kuper J, Gasteiger KL, Simon N, Strasser R, Eisen D, Geiger S, Schneider S, Kisker C, Carell T.

Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):8272-7. doi: 10.1073/pnas.1508509112. Epub 2015 Jun 22.

21.

An ordered water channel in Staphylococcus aureus FabI: unraveling the mechanism of substrate recognition and reduction.

Schiebel J, Chang A, Merget B, Bommineni GR, Yu W, Spagnuolo LA, Baxter MV, Tareilus M, Tonge PJ, Kisker C, Sotriffer CA.

Biochemistry. 2015 Mar 17;54(10):1943-55. doi: 10.1021/bi5014358. Epub 2015 Mar 3.

22.

FadA5 a thiolase from Mycobacterium tuberculosis: a steroid-binding pocket reveals the potential for drug development against tuberculosis.

Schaefer CM, Lu R, Nesbitt NM, Schiebel J, Sampson NS, Kisker C.

Structure. 2015 Jan 6;23(1):21-33. doi: 10.1016/j.str.2014.10.010. Epub 2014 Dec 4.

23.

PKA catalytic subunit mutations in adrenocortical Cushing's adenoma impair association with the regulatory subunit.

Calebiro D, Hannawacker A, Lyga S, Bathon K, Zabel U, Ronchi C, Beuschlein F, Reincke M, Lorenz K, Allolio B, Kisker C, Fassnacht M, Lohse MJ.

Nat Commun. 2014 Dec 5;5:5680. doi: 10.1038/ncomms6680.

PMID:
25477193
24.

Impact of age-associated cyclopurine lesions on DNA repair helicases.

Khan I, Suhasini AN, Banerjee T, Sommers JA, Kaplan DL, Kuper J, Kisker C, Brosh RM Jr.

PLoS One. 2014 Nov 19;9(11):e113293. doi: 10.1371/journal.pone.0113293. eCollection 2014.

25.

In TFIIH, XPD helicase is exclusively devoted to DNA repair.

Kuper J, Braun C, Elias A, Michels G, Sauer F, Schmitt DR, Poterszman A, Egly JM, Kisker C.

PLoS Biol. 2014 Sep 30;12(9):e1001954. doi: 10.1371/journal.pbio.1001954. eCollection 2014 Sep.

26.

Novel somatic mutations in the catalytic subunit of the protein kinase A as a cause of adrenal Cushing's syndrome: a European multicentric study.

Di Dalmazi G, Kisker C, Calebiro D, Mannelli M, Canu L, Arnaldi G, Quinkler M, Rayes N, Tabarin A, Laure Jullié M, Mantero F, Rubin B, Waldmann J, Bartsch DK, Pasquali R, Lohse M, Allolio B, Fassnacht M, Beuschlein F, Reincke M.

J Clin Endocrinol Metab. 2014 Oct;99(10):E2093-100. doi: 10.1210/jc.2014-2152. Epub 2014 Jul 24.

PMID:
25057884
27.

The structure of the TFIIH p34 subunit reveals a von Willebrand factor A like fold.

Schmitt DR, Kuper J, Elias A, Kisker C.

PLoS One. 2014 Jul 11;9(7):e102389. doi: 10.1371/journal.pone.0102389. eCollection 2014.

28.

Rational design of broad spectrum antibacterial activity based on a clinically relevant enoyl-acyl carrier protein (ACP) reductase inhibitor.

Schiebel J, Chang A, Shah S, Lu Y, Liu L, Pan P, Hirschbeck MW, Tareilus M, Eltschkner S, Yu W, Cummings JE, Knudson SE, Bommineni GR, Walker SG, Slayden RA, Sotriffer CA, Tonge PJ, Kisker C.

J Biol Chem. 2014 Jun 6;289(23):15987-6005. doi: 10.1074/jbc.M113.532804. Epub 2014 Apr 16.

29.

Transcriptional pausing to scout ahead for DNA damage.

Van Houten B, Kisker C.

Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):3905-6. doi: 10.1073/pnas.1402020111. Epub 2014 Mar 5. No abstract available.

30.

Constitutive activation of PKA catalytic subunit in adrenal Cushing's syndrome.

Beuschlein F, Fassnacht M, Assié G, Calebiro D, Stratakis CA, Osswald A, Ronchi CL, Wieland T, Sbiera S, Faucz FR, Schaak K, Schmittfull A, Schwarzmayr T, Barreau O, Vezzosi D, Rizk-Rabin M, Zabel U, Szarek E, Salpea P, Forlino A, Vetro A, Zuffardi O, Kisker C, Diener S, Meitinger T, Lohse MJ, Reincke M, Bertherat J, Strom TM, Allolio B.

N Engl J Med. 2014 Mar 13;370(11):1019-28. doi: 10.1056/NEJMoa1310359. Epub 2014 Feb 26.

31.

Strand-specific recognition of DNA damages by XPD provides insights into nucleotide excision repair substrate versatility.

Buechner CN, Heil K, Michels G, Carell T, Kisker C, Tessmer I.

J Biol Chem. 2014 Feb 7;289(6):3613-24. doi: 10.1074/jbc.M113.523001. Epub 2013 Dec 14.

32.

Structural basis for the recognition of mycolic acid precursors by KasA, a condensing enzyme and drug target from Mycobacterium tuberculosis.

Schiebel J, Kapilashrami K, Fekete A, Bommineni GR, Schaefer CM, Mueller MJ, Tonge PJ, Kisker C.

J Biol Chem. 2013 Nov 22;288(47):34190-204. doi: 10.1074/jbc.M113.511436. Epub 2013 Oct 9.

33.

Specialization among iron-sulfur cluster helicases to resolve G-quadruplex DNA structures that threaten genomic stability.

Bharti SK, Sommers JA, George F, Kuper J, Hamon F, Shin-ya K, Teulade-Fichou MP, Kisker C, Brosh RM Jr.

J Biol Chem. 2013 Sep 27;288(39):28217-29. doi: 10.1074/jbc.M113.496463. Epub 2013 Aug 9.

34.

Rational optimization of drug-target residence time: insights from inhibitor binding to the Staphylococcus aureus FabI enzyme-product complex.

Chang A, Schiebel J, Yu W, Bommineni GR, Pan P, Baxter MV, Khanna A, Sotriffer CA, Kisker C, Tonge PJ.

Biochemistry. 2013 Jun 18;52(24):4217-28. doi: 10.1021/bi400413c. Epub 2013 Jun 6.

35.

Prokaryotic nucleotide excision repair.

Kisker C, Kuper J, Van Houten B.

Cold Spring Harb Perspect Biol. 2013 Mar 1;5(3):a012591. doi: 10.1101/cshperspect.a012591. Review.

36.

Structural basis of assembly chaperone- mediated snRNP formation.

Grimm C, Chari A, Pelz JP, Kuper J, Kisker C, Diederichs K, Stark H, Schindelin H, Fischer U.

Mol Cell. 2013 Feb 21;49(4):692-703. doi: 10.1016/j.molcel.2012.12.009. Epub 2013 Jan 17.

37.

DNA Helicases in NER, BER, and MMR.

Kuper J, Kisker C.

Adv Exp Med Biol. 2013;767:203-24. doi: 10.1007/978-1-4614-5037-5_10.

PMID:
23161013
38.

Efficacy evaluation of products for treatment of bleeding episodes.

Kisker C, Aledort L, Farin H.

Haemophilia. 2012 Sep;18(5):e367-9. doi: 10.1111/j.1365-2516.2012.02911.x. Epub 2012 Jul 22. No abstract available.

PMID:
22816674
39.

Raf kinase inhibitor protein (RKIP) dimer formation controls its target switch from Raf1 to G protein-coupled receptor kinase (GRK) 2.

Deiss K, Kisker C, Lohse MJ, Lorenz K.

J Biol Chem. 2012 Jul 6;287(28):23407-17. doi: 10.1074/jbc.M112.363812. Epub 2012 May 17.

40.

The Q motif of Fanconi anemia group J protein (FANCJ) DNA helicase regulates its dimerization, DNA binding, and DNA repair function.

Wu Y, Sommers JA, Loiland JA, Kitao H, Kuper J, Kisker C, Brosh RM Jr.

J Biol Chem. 2012 Jun 22;287(26):21699-716. doi: 10.1074/jbc.M112.351338. Epub 2012 May 10.

41.

Staphylococcus aureus FabI: inhibition, substrate recognition, and potential implications for in vivo essentiality.

Schiebel J, Chang A, Lu H, Baxter MV, Tonge PJ, Kisker C.

Structure. 2012 May 9;20(5):802-13. doi: 10.1016/j.str.2012.03.013.

42.

Biophysical and functional analyses suggest that adenovirus E4-ORF3 protein requires higher-order multimerization to function against promyelocytic leukemia protein nuclear bodies.

Patsalo V, Yondola MA, Luan B, Shoshani I, Kisker C, Green DF, Raleigh DP, Hearing P.

J Biol Chem. 2012 Jun 29;287(27):22573-83. doi: 10.1074/jbc.M112.344234. Epub 2012 May 9.

43.

[Old and new anti-mycobacterial drugs. Fatty acid synthesis as a target].

Topf CM, Schiebel J, Kisker C, Holzgrabe U.

Pharm Unserer Zeit. 2012 Jan;41(1):64-70. Review. German. No abstract available.

PMID:
22470920
44.

Damage recognition in nucleotide excision DNA repair.

Kuper J, Kisker C.

Curr Opin Struct Biol. 2012 Feb;22(1):88-93. doi: 10.1016/j.sbi.2011.12.002. Epub 2012 Jan 17. Review.

PMID:
22257761
45.

Structure of the Yersinia pestis FabV enoyl-ACP reductase and its interaction with two 2-pyridone inhibitors.

Hirschbeck MW, Kuper J, Lu H, Liu N, Neckles C, Shah S, Wagner S, Sotriffer CA, Tonge PJ, Kisker C.

Structure. 2012 Jan 11;20(1):89-100. doi: 10.1016/j.str.2011.07.019.

46.

XPB helicase regulates DNA incision by the Thermoplasma acidophilum endonuclease Bax1.

Roth HM, Römer J, Grundler V, Van Houten B, Kisker C, Tessmer I.

DNA Repair (Amst). 2012 Mar 1;11(3):286-93. doi: 10.1016/j.dnarep.2011.12.002. Epub 2012 Jan 9.

PMID:
22237014
47.

Functional and structural studies of the nucleotide excision repair helicase XPD suggest a polarity for DNA translocation.

Kuper J, Wolski SC, Michels G, Kisker C.

EMBO J. 2012 Jan 18;31(2):494-502. doi: 10.1038/emboj.2011.374. Epub 2011 Nov 11.

48.

Molecular dynamics of Mycobacterium tuberculosis KasA: implications for inhibitor and substrate binding and consequences for drug design.

Schaefer B, Kisker C, Sotriffer CA.

J Comput Aided Mol Des. 2011 Nov;25(11):1053-69. doi: 10.1007/s10822-011-9483-4. Epub 2011 Nov 11.

PMID:
22076471
49.

Mechanism of the intramolecular Claisen condensation reaction catalyzed by MenB, a crotonase superfamily member.

Li HJ, Li X, Liu N, Zhang H, Truglio JJ, Mishra S, Kisker C, Garcia-Diaz M, Tonge PJ.

Biochemistry. 2011 Nov 8;50(44):9532-44. doi: 10.1021/bi200877x. Epub 2011 Oct 11.

50.

Elucidation of the protonation states of the catalytic residues in mtKasA: implications for inhibitor design.

Lee W, Luckner SR, Kisker C, Tonge PJ, Engels B.

Biochemistry. 2011 Jun 28;50(25):5743-56. doi: 10.1021/bi200006t. Epub 2011 Jun 7.

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