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Items: 20

1.

Host conditioning with IL-1β improves the antitumor function of adoptively transferred T cells.

Lee PH, Yamamoto TN, Gurusamy D, Sukumar M, Yu Z, Hu-Li J, Kawabe T, Gangaplara A, Kishton RJ, Henning AN, Vodnala SK, Germain RN, Paul WE, Restifo NP.

J Exp Med. 2019 Aug 12. pii: jem.20181218. doi: 10.1084/jem.20181218. [Epub ahead of print]

PMID:
31405895
2.

T cell stemness and dysfunction in tumors are triggered by a common mechanism.

Vodnala SK, Eil R, Kishton RJ, Sukumar M, Yamamoto TN, Ha NH, Lee PH, Shin M, Patel SJ, Yu Z, Palmer DC, Kruhlak MJ, Liu X, Locasale JW, Huang J, Roychoudhuri R, Finkel T, Klebanoff CA, Restifo NP.

Science. 2019 Mar 29;363(6434). pii: eaau0135. doi: 10.1126/science.aau0135.

PMID:
30923193
3.

Ribosomal Proteins Regulate MHC Class I Peptide Generation for Immunosurveillance.

Wei J, Kishton RJ, Angel M, Conn CS, Dalla-Venezia N, Marcel V, Vincent A, Catez F, Ferré S, Ayadi L, Marchand V, Dersh D, Gibbs JS, Ivanov IP, Fridlyand N, Couté Y, Diaz JJ, Qian SB, Staudt LM, Restifo NP, Yewdell JW.

Mol Cell. 2019 Mar 21;73(6):1162-1173.e5. doi: 10.1016/j.molcel.2018.12.020. Epub 2019 Jan 31.

PMID:
30712990
4.

T cells genetically engineered to overcome death signaling enhance adoptive cancer immunotherapy.

Yamamoto TN, Lee PH, Vodnala SK, Gurusamy D, Kishton RJ, Yu Z, Eidizadeh A, Eil R, Fioravanti J, Gattinoni L, Kochenderfer JN, Fry TJ, Aksoy BA, Hammerbacher JE, Cruz AC, Siegel RM, Restifo NP, Klebanoff CA.

J Clin Invest. 2019 Feb 25;129(4):1551-1565. doi: 10.1172/JCI121491. eCollection 2019 Feb 25.

5.

Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism.

Johnson MO, Wolf MM, Madden MZ, Andrejeva G, Sugiura A, Contreras DC, Maseda D, Liberti MV, Paz K, Kishton RJ, Johnson ME, de Cubas AA, Wu P, Li G, Zhang Y, Newcomb DC, Wells AD, Restifo NP, Rathmell WK, Locasale JW, Davila ML, Blazar BR, Rathmell JC.

Cell. 2018 Dec 13;175(7):1780-1795.e19. doi: 10.1016/j.cell.2018.10.001. Epub 2018 Nov 1.

PMID:
30392958
6.

Identification of essential genes for cancer immunotherapy.

Patel SJ, Sanjana NE, Kishton RJ, Eidizadeh A, Vodnala SK, Cam M, Gartner JJ, Jia L, Steinberg SM, Yamamoto TN, Merchant AS, Mehta GU, Chichura A, Shalem O, Tran E, Eil R, Sukumar M, Guijarro EP, Day CP, Robbins P, Feldman S, Merlino G, Zhang F, Restifo NP.

Nature. 2017 Aug 31;548(7669):537-542. doi: 10.1038/nature23477. Epub 2017 Aug 7.

7.

Metabolic Regulation of T Cell Longevity and Function in Tumor Immunotherapy.

Kishton RJ, Sukumar M, Restifo NP.

Cell Metab. 2017 Jul 5;26(1):94-109. doi: 10.1016/j.cmet.2017.06.016. Review.

8.

Metabolic reprograming of anti-tumor immunity.

Sukumar M, Kishton RJ, Restifo NP.

Curr Opin Immunol. 2017 Jun;46:14-22. doi: 10.1016/j.coi.2017.03.011. Epub 2017 Apr 13. Review.

9.

CDK4/6 Therapeutic Intervention and Viable Alternative to Taxanes in CRPC.

Stice JP, Wardell SE, Norris JD, Yllanes AP, Alley HM, Haney VO, White HS, Safi R, Winter PS, Cocce KJ, Kishton RJ, Lawrence SA, Strum JC, McDonnell DP.

Mol Cancer Res. 2017 Jun;15(6):660-669. doi: 10.1158/1541-7786.MCR-17-0028. Epub 2017 Feb 16.

10.

Arginine Arms T Cells to Thrive and Survive.

Kishton RJ, Sukumar M, Restifo NP.

Cell Metab. 2016 Nov 8;24(5):647-648. doi: 10.1016/j.cmet.2016.10.019.

11.

Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression.

Gerriets VA, Kishton RJ, Johnson MO, Cohen S, Siska PJ, Nichols AG, Warmoes MO, de Cubas AA, MacIver NJ, Locasale JW, Turka LA, Wells AD, Rathmell JC.

Nat Immunol. 2016 Dec;17(12):1459-1466. doi: 10.1038/ni.3577. Epub 2016 Oct 3.

12.

mTORC1 and mTORC2 Kinase Signaling and Glucose Metabolism Drive Follicular Helper T Cell Differentiation.

Zeng H, Cohen S, Guy C, Shrestha S, Neale G, Brown SA, Cloer C, Kishton RJ, Gao X, Youngblood B, Do M, Li MO, Locasale JW, Rathmell JC, Chi H.

Immunity. 2016 Sep 20;45(3):540-554. doi: 10.1016/j.immuni.2016.08.017. Epub 2016 Sep 13.

13.

Suppression of Glut1 and Glucose Metabolism by Decreased Akt/mTORC1 Signaling Drives T Cell Impairment in B Cell Leukemia.

Siska PJ, van der Windt GJ, Kishton RJ, Cohen S, Eisner W, MacIver NJ, Kater AP, Weinberg JB, Rathmell JC.

J Immunol. 2016 Sep 15;197(6):2532-40. doi: 10.4049/jimmunol.1502464. Epub 2016 Aug 10.

14.

A guide to immunometabolism for immunologists.

O'Neill LA, Kishton RJ, Rathmell J.

Nat Rev Immunol. 2016 Sep;16(9):553-65. doi: 10.1038/nri.2016.70. Epub 2016 Jul 11. Review.

15.

Leptin directly promotes T-cell glycolytic metabolism to drive effector T-cell differentiation in a mouse model of autoimmunity.

Gerriets VA, Danzaki K, Kishton RJ, Eisner W, Nichols AG, Saucillo DC, Shinohara ML, MacIver NJ.

Eur J Immunol. 2016 Aug;46(8):1970-83. doi: 10.1002/eji.201545861. Epub 2016 Jun 13.

16.

AMPK Is Essential to Balance Glycolysis and Mitochondrial Metabolism to Control T-ALL Cell Stress and Survival.

Kishton RJ, Barnes CE, Nichols AG, Cohen S, Gerriets VA, Siska PJ, Macintyre AN, Goraksha-Hicks P, de Cubas AA, Liu T, Warmoes MO, Abel ED, Yeoh AE, Gershon TR, Rathmell WK, Richards KL, Locasale JW, Rathmell JC.

Cell Metab. 2016 Apr 12;23(4):649-62. doi: 10.1016/j.cmet.2016.03.008.

17.

Novel therapeutic targets of tumor metabolism.

Kishton RJ, Rathmell JC.

Cancer J. 2015 Mar-Apr;21(2):62-9. doi: 10.1097/PPO.0000000000000099. Review.

18.

Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation.

Gerriets VA, Kishton RJ, Nichols AG, Macintyre AN, Inoue M, Ilkayeva O, Winter PS, Liu X, Priyadharshini B, Slawinska ME, Haeberli L, Huck C, Turka LA, Wood KC, Hale LP, Smith PA, Schneider MA, MacIver NJ, Locasale JW, Newgard CB, Shinohara ML, Rathmell JC.

J Clin Invest. 2015 Jan;125(1):194-207. doi: 10.1172/JCI76012. Epub 2014 Dec 1.

19.

Glucose transporter 1-mediated glucose uptake is limiting for B-cell acute lymphoblastic leukemia anabolic metabolism and resistance to apoptosis.

Liu T, Kishton RJ, Macintyre AN, Gerriets VA, Xiang H, Liu X, Abel ED, Rizzieri D, Locasale JW, Rathmell JC.

Cell Death Dis. 2014 Oct 16;5:e1470. doi: 10.1038/cddis.2014.431. Erratum in: Cell Death Dis. 2014;5:e1516.

20.

DNA site-specific N3-adenine methylation targeted to estrogen receptor-positive cells.

Kishton RJ, Miller SE, Perry H, Lynch T, Patel M, Gore VK, Akkaraju GR, Varadarajan S.

Bioorg Med Chem. 2011 Sep 1;19(17):5093-102. doi: 10.1016/j.bmc.2011.07.026. Epub 2011 Jul 22.

PMID:
21839641

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