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Items: 20

1.

In Vitro Activities and Spectrum of the Novel Fluoroquinolone Lascufloxacin (KRP-AM1977).

Kishii R, Yamaguchi Y, Takei M.

Antimicrob Agents Chemother. 2017 May 24;61(6). pii: e00120-17. doi: 10.1128/AAC.00120-17. Print 2017 Jun.

2.

Sulfonamide-based non-alkyne LpxC inhibitors as Gram-negative antibacterial agents.

Kawai T, Kazuhiko I, Takaya N, Yamaguchi Y, Kishii R, Kohno Y, Kurasaki H.

Bioorg Med Chem Lett. 2017 Feb 15;27(4):1045-1049. doi: 10.1016/j.bmcl.2016.12.059. Epub 2016 Dec 24.

PMID:
28082037
3.

LpxC Inhibitors: Design, Synthesis, and Biological Evaluation of Oxazolidinones as Gram-negative Antibacterial Agents.

Kurasaki H, Tsuda K, Shinoyama M, Takaya N, Yamaguchi Y, Kishii R, Iwase K, Ando N, Nomura M, Kohno Y.

ACS Med Chem Lett. 2016 Apr 5;7(6):623-8. doi: 10.1021/acsmedchemlett.6b00057. eCollection 2016 Jun 9.

4.

In Vitro and In Vivo Characterization of the Novel Oxabicyclooctane-Linked Bacterial Topoisomerase Inhibitor AM-8722, a Selective, Potent Inhibitor of Bacterial DNA Gyrase.

Tan CM, Gill CJ, Wu J, Toussaint N, Yin J, Tsuchiya T, Garlisi CG, Kaelin D, Meinke PT, Miesel L, Olsen DB, Lagrutta A, Fukuda H, Kishii R, Takei M, Oohata K, Takeuchi T, Shibue T, Takano H, Nishimura A, Fukuda Y, Singh SB.

Antimicrob Agents Chemother. 2016 Jul 22;60(8):4830-9. doi: 10.1128/AAC.00619-16. Print 2016 Aug.

5.

Structure activity relationship of C-2 ether substituted 1,5-naphthyridine analogs of oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents (Part-5).

Singh SB, Kaelin DE, Meinke PT, Wu J, Miesel L, Tan CM, Olsen DB, Lagrutta A, Fukuda H, Kishii R, Takei M, Takeuchi T, Takano H, Ohata K, Kurasaki H, Nishimura A, Shibata T, Fukuda Y.

Bioorg Med Chem Lett. 2015 Sep 1;25(17):3630-5. doi: 10.1016/j.bmcl.2015.06.061. Epub 2015 Jun 23.

PMID:
26152426
6.

Structure activity relationship of pyridoxazinone substituted RHS analogs of oxabicyclooctane-linked 1,5-naphthyridinyl novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents (Part-6).

Singh SB, Kaelin DE, Wu J, Miesel L, Tan CM, Meinke PT, Olsen DB, Lagrutta A, Wei C, Liao Y, Peng X, Wang X, Fukuda H, Kishii R, Takei M, Yajima M, Shibue T, Shibata T, Ohata K, Nishimura A, Fukuda Y.

Bioorg Med Chem Lett. 2015 Sep 1;25(17):3636-43. doi: 10.1016/j.bmcl.2015.06.057. Epub 2015 Jun 19.

PMID:
26141771
7.

Hydroxy tricyclic 1,5-naphthyridinone oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents-SAR of RHS moiety (Part-3).

Singh SB, Kaelin DE, Wu J, Miesel L, Tan CM, Gill C, Black T, Nargund R, Meinke PT, Olsen DB, Lagrutta A, Wei C, Peng X, Wang X, Fukuda H, Kishii R, Takei M, Takeuchi T, Shibue T, Ohata K, Takano H, Ban S, Nishimura A, Fukuda Y.

Bioorg Med Chem Lett. 2015 Jun 15;25(12):2473-8. doi: 10.1016/j.bmcl.2015.04.063. Epub 2015 Apr 28.

PMID:
25978963
8.

Structure activity relationship of substituted 1,5-naphthyridine analogs of oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents (Part-4).

Singh SB, Kaelin DE, Wu J, Miesel L, Tan CM, Meinke PT, Olsen DB, Lagrutta A, Wei C, Peng X, Wang X, Fukuda H, Kishii R, Takei M, Shibata T, Ohata K, Takano H, Kurasaki H, Takeuchi T, Nishimura A, Fukuda Y.

Bioorg Med Chem Lett. 2015 Jun 1;25(11):2409-15. doi: 10.1016/j.bmcl.2015.04.002. Epub 2015 Apr 7.

PMID:
25911300
9.

Tricyclic 1,5-naphthyridinone oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents-SAR of left-hand-side moiety (Part-2).

Singh SB, Kaelin DE, Wu J, Miesel L, Tan CM, Black T, Nargund R, Meinke PT, Olsen DB, Lagrutta A, Lu J, Patel S, Rickert KW, Smith RF, Soisson S, Sherer E, Joyce LA, Wei C, Peng X, Wang X, Fukuda H, Kishii R, Takei M, Takano H, Shibasaki M, Yajima M, Nishimura A, Shibata T, Fukuda Y.

Bioorg Med Chem Lett. 2015 May 1;25(9):1831-5. doi: 10.1016/j.bmcl.2015.03.044. Epub 2015 Mar 24.

PMID:
25851938
10.

Kibdelomycin is a bactericidal broad-spectrum aerobic antibacterial agent.

Singh SB, Dayananth P, Balibar CJ, Garlisi CG, Lu J, Kishii R, Takei M, Fukuda Y, Ha S, Young K.

Antimicrob Agents Chemother. 2015;59(6):3474-81. doi: 10.1128/AAC.00382-15. Epub 2015 Apr 6.

11.

Structures of kibdelomycin bound to Staphylococcus aureus GyrB and ParE showed a novel U-shaped binding mode.

Lu J, Patel S, Sharma N, Soisson SM, Kishii R, Takei M, Fukuda Y, Lumb KJ, Singh SB.

ACS Chem Biol. 2014 Sep 19;9(9):2023-31. doi: 10.1021/cb5001197. Epub 2014 Jul 3.

PMID:
24992706
12.

Oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad spectrum antibacterial agents.

Singh SB, Kaelin DE, Wu J, Miesel L, Tan CM, Meinke PT, Olsen D, Lagrutta A, Bradley P, Lu J, Patel S, Rickert KW, Smith RF, Soisson S, Wei C, Fukuda H, Kishii R, Takei M, Fukuda Y.

ACS Med Chem Lett. 2014 Mar 12;5(5):609-14. doi: 10.1021/ml500069w. eCollection 2014 May 8.

13.

Contribution of topoisomerase IV mutation to quinolone resistance in Mycoplasma genitalium.

Yamaguchi Y, Takei M, Kishii R, Yasuda M, Deguchi T.

Antimicrob Agents Chemother. 2013 Apr;57(4):1772-6. doi: 10.1128/AAC.01956-12. Epub 2013 Jan 28.

14.

Relationship between the expression of ompF and quinolone resistance in Escherichia coli.

Kishii R, Takei M.

J Infect Chemother. 2009 Dec;15(6):361-6. doi: 10.1007/s10156-009-0716-6.

PMID:
20012725
15.

Structural and functional studies of the HAMP domain of EnvZ, an osmosensing transmembrane histidine kinase in Escherichia coli.

Kishii R, Falzon L, Yoshida T, Kobayashi H, Inouye M.

J Biol Chem. 2007 Sep 7;282(36):26401-8. Epub 2007 Jul 16.

17.

Contribution of the 8-methoxy group to the activity of gatifloxacin against type II topoisomerases of Streptococcus pneumoniae.

Kishii R, Takei M, Fukuda H, Hayashi K, Hosaka M.

Antimicrob Agents Chemother. 2003 Jan;47(1):77-81.

18.

Contribution of the C-8-methoxy group of gatifloxacin to inhibition of type II topoisomerases of Staphylococcus aureus.

Takei M, Fukuda H, Kishii R, Kadowaki Y, Atobe Y, Hosaka M.

Antimicrob Agents Chemother. 2002 Oct;46(10):3337-8. No abstract available.

19.

Target preference of 15 quinolones against Staphylococcus aureus, based on antibacterial activities and target inhibition.

Takei M, Fukuda H, Kishii R, Hosaka M.

Antimicrob Agents Chemother. 2001 Dec;45(12):3544-7.

20.

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