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Items: 50


Inhibition of the histone demethylase, KDM5B, directly induces re-expression of tumor suppressor protein HEXIM1 in cancer cells.

Montano MM, Yeh IJ, Chen Y, Hernandez C, Kiselar JG, de la Fuente M, Lawes AM, Nieman MT, Kiser PD, Jacobberger J, Exner AA, Lawes MC.

Breast Cancer Res. 2019 Dec 5;21(1):138. doi: 10.1186/s13058-019-1228-7.


Photic generation of 11-cis-retinal in bovine retinal pigment epithelium.

Zhang J, Choi EH, Tworak A, Salom D, Leinonen H, Sander CL, Hoang TV, Handa JT, Blackshaw S, Palczewska G, Kiser PD, Palczewski K.

J Biol Chem. 2019 Nov 6. pii: jbc.RA119.011169. doi: 10.1074/jbc.RA119.011169. [Epub ahead of print]


Evidence for distinct rate-limiting steps in the cleavage of alkenes by carotenoid cleavage dioxygenases.

Khadka N, Farquhar ER, Hill HE, Shi W, von Lintig J, Kiser PD.

J Biol Chem. 2019 Jul 5;294(27):10596-10606. doi: 10.1074/jbc.RA119.007535. Epub 2019 May 28.


Abnormal Cannabidiol Modulates Vitamin A Metabolism by Acting as a Competitive Inhibitor of CRBP1.

Silvaroli JA, Widjaja-Adhi MAK, Trischman T, Chelstowska S, Horwitz S, Banerjee S, Kiser PD, Blaner WS, Golczak M.

ACS Chem Biol. 2019 Mar 15;14(3):434-448. doi: 10.1021/acschembio.8b01070. Epub 2019 Feb 18.


Conditional deletion of Des1 in the mouse retina does not impair the visual cycle in cones.

Kiser PD, Kolesnikov AV, Kiser JZ, Dong Z, Chaurasia B, Wang L, Summers SA, Hoang T, Blackshaw S, Peachey NS, Kefalov VJ, Palczewski K.

FASEB J. 2019 Apr;33(4):5782-5792. doi: 10.1096/fj.201802493R. Epub 2019 Jan 15.


Structural biology of 11-cis-retinaldehyde production in the classical visual cycle.

Daruwalla A, Choi EH, Palczewski K, Kiser PD.

Biochem J. 2018 Oct 22;475(20):3171-3188. doi: 10.1042/BCJ20180193. Review.


Preparation and characterization of metal-substituted carotenoid cleavage oxygenases.

Sui X, Farquhar ER, Hill HE, von Lintig J, Shi W, Kiser PD.

J Biol Inorg Chem. 2018 Aug;23(6):887-901. doi: 10.1007/s00775-018-1586-0. Epub 2018 Jun 26.


The Biochemical Basis of Vitamin A Production from the Asymmetric Carotenoid β-Cryptoxanthin.

Kelly ME, Ramkumar S, Sun W, Colon Ortiz C, Kiser PD, Golczak M, von Lintig J.

ACS Chem Biol. 2018 Aug 17;13(8):2121-2129. doi: 10.1021/acschembio.8b00290. Epub 2018 Jun 15.


Targeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor.

Gulati S, Jin H, Masuho I, Orban T, Cai Y, Pardon E, Martemyanov KA, Kiser PD, Stewart PL, Ford CP, Steyaert J, Palczewski K.

Nat Commun. 2018 May 18;9(1):1996. doi: 10.1038/s41467-018-04432-0.


Insights into the pathogenesis of dominant retinitis pigmentosa associated with a D477G mutation in RPE65.

Choi EH, Suh S, Sander CL, Hernandez CJO, Bulman ER, Khadka N, Dong Z, Shi W, Palczewski K, Kiser PD.

Hum Mol Genet. 2018 Jul 1;27(13):2225-2243. doi: 10.1093/hmg/ddy128.


Retinoid isomerase inhibitors impair but do not block mammalian cone photoreceptor function.

Kiser PD, Zhang J, Sharma A, Angueyra JM, Kolesnikov AV, Badiee M, Tochtrop GP, Kinoshita J, Peachey NS, Li W, Kefalov VJ, Palczewski K.

J Gen Physiol. 2018 Apr 2;150(4):571-590. doi: 10.1085/jgp.201711815. Epub 2018 Mar 2.


A Combination of G Protein-Coupled Receptor Modulators Protects Photoreceptors from Degeneration.

Orban T, Leinonen H, Getter T, Dong Z, Sun W, Gao S, Veenstra A, Heidari-Torkabadi H, Kern TS, Kiser PD, Palczewski K.

J Pharmacol Exp Ther. 2018 Feb;364(2):207-220. doi: 10.1124/jpet.117.245167. Epub 2017 Nov 21.


Enzyme That Makes You Cry-Crystal Structure of Lachrymatory Factor Synthase from Allium cepa.

Silvaroli JA, Pleshinger MJ, Banerjee S, Kiser PD, Golczak M.

ACS Chem Biol. 2017 Sep 15;12(9):2296-2304. doi: 10.1021/acschembio.7b00336. Epub 2017 Jul 26.


Reappraisal of dioxygen binding in NOV1 crystal structures.

Kiser PD.

Proc Natl Acad Sci U S A. 2017 Jul 25;114(30):E6027-E6028. doi: 10.1073/pnas.1706550114. Epub 2017 Jul 5. No abstract available.


Structure and Spectroscopy of Alkene-Cleaving Dioxygenases Containing an Atypically Coordinated Non-Heme Iron Center.

Sui X, Weitz AC, Farquhar ER, Badiee M, Banerjee S, von Lintig J, Tochtrop GP, Palczewski K, Hendrich MP, Kiser PD.

Biochemistry. 2017 Jun 6;56(22):2836-2852. doi: 10.1021/acs.biochem.7b00251. Epub 2017 May 19.


Rational Tuning of Visual Cycle Modulator Pharmacodynamics.

Kiser PD, Zhang J, Badiee M, Kinoshita J, Peachey NS, Tochtrop GP, Palczewski K.

J Pharmacol Exp Ther. 2017 Jul;362(1):131-145. doi: 10.1124/jpet.117.240721. Epub 2017 May 5.


Photocyclic behavior of rhodopsin induced by an atypical isomerization mechanism.

Gulati S, Jastrzebska B, Banerjee S, Placeres ÁL, Miszta P, Gao S, Gunderson K, Tochtrop GP, Filipek S, Katayama K, Kiser PD, Mogi M, Stewart PL, Palczewski K.

Proc Natl Acad Sci U S A. 2017 Mar 28;114(13):E2608-E2615. doi: 10.1073/pnas.1617446114. Epub 2017 Mar 13.


Retinoids and Retinal Diseases.

Kiser PD, Palczewski K.

Annu Rev Vis Sci. 2016 Oct;2:197-234. Epub 2016 Jul 18. Review.


Eyes on systems pharmacology.

Chen Y, Kern TS, Kiser PD, Palczewski K.

Pharmacol Res. 2016 Dec;114:39-41. doi: 10.1016/j.phrs.2016.09.026. Epub 2016 Oct 5. No abstract available.


Synergistically acting agonists and antagonists of G protein-coupled receptors prevent photoreceptor cell degeneration.

Chen Y, Palczewska G, Masuho I, Gao S, Jin H, Dong Z, Gieser L, Brooks MJ, Kiser PD, Kern TS, Martemyanov KA, Swaroop A, Palczewski K.

Sci Signal. 2016 Jul 26;9(438):ra74. doi: 10.1126/scisignal.aag0245.


Key Residues for Catalytic Function and Metal Coordination in a Carotenoid Cleavage Dioxygenase.

Sui X, Zhang J, Golczak M, Palczewski K, Kiser PD.

J Biol Chem. 2016 Sep 9;291(37):19401-12. doi: 10.1074/jbc.M116.744912. Epub 2016 Jul 24.


Involvement of Endoplasmic Reticulum Stress in TULP1 Induced Retinal Degeneration.

Lobo GP, Au A, Kiser PD, Hagstrom SA.

PLoS One. 2016 Mar 17;11(3):e0151806. doi: 10.1371/journal.pone.0151806. eCollection 2016.


Ligand Binding Induces Conformational Changes in Human Cellular Retinol-binding Protein 1 (CRBP1) Revealed by Atomic Resolution Crystal Structures.

Silvaroli JA, Arne JM, Chelstowska S, Kiser PD, Banerjee S, Golczak M.

J Biol Chem. 2016 Apr 15;291(16):8528-40. doi: 10.1074/jbc.M116.714535. Epub 2016 Feb 21.


The Biochemical Basis of Vitamin A3 Production in Arthropod Vision.

Babino D, Golczak M, Kiser PD, Wyss A, Palczewski K, von Lintig J.

ACS Chem Biol. 2016 Apr 15;11(4):1049-57. doi: 10.1021/acschembio.5b00967. Epub 2016 Feb 2.


Utilization of Dioxygen by Carotenoid Cleavage Oxygenases.

Sui X, Golczak M, Zhang J, Kleinberg KA, von Lintig J, Palczewski K, Kiser PD.

J Biol Chem. 2015 Dec 18;290(51):30212-23. doi: 10.1074/jbc.M115.696799. Epub 2015 Oct 23.


Characterization of the Role of β-Carotene 9,10-Dioxygenase in Macular Pigment Metabolism.

Babino D, Palczewski G, Widjaja-Adhi MA, Kiser PD, Golczak M, von Lintig J.

J Biol Chem. 2015 Oct 9;290(41):24844-57. doi: 10.1074/jbc.M115.668822. Epub 2015 Aug 25.


Molecular pharmacodynamics of emixustat in protection against retinal degeneration.

Zhang J, Kiser PD, Badiee M, Palczewska G, Dong Z, Golczak M, Tochtrop GP, Palczewski K.

J Clin Invest. 2015 Jul 1;125(7):2781-94. doi: 10.1172/JCI80950. Epub 2015 Jun 15.


Catalytic mechanism of a retinoid isomerase essential for vertebrate vision.

Kiser PD, Zhang J, Badiee M, Li Q, Shi W, Sui X, Golczak M, Tochtrop GP, Palczewski K.

Nat Chem Biol. 2015 Jun;11(6):409-15. doi: 10.1038/nchembio.1799. Epub 2015 Apr 20.


LRAT-specific domain facilitates vitamin A metabolism by domain swapping in HRASLS3.

Golczak M, Sears AE, Kiser PD, Palczewski K.

Nat Chem Biol. 2015 Jan;11(1):26-32. doi: 10.1038/nchembio.1687. Epub 2014 Nov 10.


Identification and characterization of novel inhibitors of Mammalian aspartyl aminopeptidase.

Chen Y, Tang H, Seibel W, Papoian R, Oh K, Li X, Zhang J, Golczak M, Palczewski K, Kiser PD.

Mol Pharmacol. 2014 Aug;86(2):231-42. doi: 10.1124/mol.114.093070. Epub 2014 Jun 9.


Analysis of carotenoid isomerase activity in a prototypical carotenoid cleavage enzyme, apocarotenoid oxygenase (ACO).

Sui X, Kiser PD, Che T, Carey PR, Golczak M, Shi W, von Lintig J, Palczewski K.

J Biol Chem. 2014 May 2;289(18):12286-99. doi: 10.1074/jbc.M114.552836. Epub 2014 Mar 19.


Chemistry of the retinoid (visual) cycle.

Kiser PD, Golczak M, Palczewski K.

Chem Rev. 2014 Jan 8;114(1):194-232. doi: 10.1021/cr400107q. Epub 2013 Jul 11. Review. No abstract available.


Structural basis of carotenoid cleavage: from bacteria to mammals.

Sui X, Kiser PD, Lintig Jv, Palczewski K.

Arch Biochem Biophys. 2013 Nov 15;539(2):203-13. doi: 10.1016/ Epub 2013 Jul 1. Review.


Biochemistry. As good as chocolate.

Palczewski K, Kiser PD.

Science. 2013 May 3;340(6132):562-3. doi: 10.1126/science.1238521. No abstract available.


Structure of RPE65 isomerase in a lipidic matrix reveals roles for phospholipids and iron in catalysis.

Kiser PD, Farquhar ER, Shi W, Sui X, Chance MR, Palczewski K.

Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):E2747-56. doi: 10.1073/pnas.1212025109. Epub 2012 Sep 24.


Structural basis for the acyltransferase activity of lecithin:retinol acyltransferase-like proteins.

Golczak M, Kiser PD, Sears AE, Lodowski DT, Blaner WS, Palczewski K.

J Biol Chem. 2012 Jul 6;287(28):23790-807. doi: 10.1074/jbc.M112.361550. Epub 2012 May 17.


Insights into substrate specificity and metal activation of mammalian tetrahedral aspartyl aminopeptidase.

Chen Y, Farquhar ER, Chance MR, Palczewski K, Kiser PD.

J Biol Chem. 2012 Apr 13;287(16):13356-70. doi: 10.1074/jbc.M112.347518. Epub 2012 Feb 22.


Key enzymes of the retinoid (visual) cycle in vertebrate retina.

Kiser PD, Golczak M, Maeda A, Palczewski K.

Biochim Biophys Acta. 2012 Jan;1821(1):137-51. doi: 10.1016/j.bbalip.2011.03.005. Epub 2011 Apr 5. Review.


Membrane-binding and enzymatic properties of RPE65.

Kiser PD, Palczewski K.

Prog Retin Eye Res. 2010 Sep;29(5):428-42. doi: 10.1016/j.preteyeres.2010.03.002. Epub 2010 Mar 19. Review.


The biochemical and structural basis for trans-to-cis isomerization of retinoids in the chemistry of vision.

von Lintig J, Kiser PD, Golczak M, Palczewski K.

Trends Biochem Sci. 2010 Jul;35(7):400-10. doi: 10.1016/j.tibs.2010.01.005. Epub 2010 Feb 24. Review.


Importance of membrane structural integrity for RPE65 retinoid isomerization activity.

Golczak M, Kiser PD, Lodowski DT, Maeda A, Palczewski K.

J Biol Chem. 2010 Mar 26;285(13):9667-82. doi: 10.1074/jbc.M109.063941. Epub 2010 Jan 25.


A functional kinase homology domain is essential for the activity of photoreceptor guanylate cyclase 1.

Bereta G, Wang B, Kiser PD, Baehr W, Jang GF, Palczewski K.

J Biol Chem. 2010 Jan 15;285(3):1899-908. doi: 10.1074/jbc.M109.061713. Epub 2009 Nov 9.


Use of thallium to identify monovalent cation binding sites in GroEL.

Kiser PD, Lorimer GH, Palczewski K.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Oct 1;65(Pt 10):967-71. doi: 10.1107/S1744309109032928. Epub 2009 Sep 18.


Crystal structure of native RPE65, the retinoid isomerase of the visual cycle.

Kiser PD, Golczak M, Lodowski DT, Chance MR, Palczewski K.

Proc Natl Acad Sci U S A. 2009 Oct 13;106(41):17325-30. doi: 10.1073/pnas.0906600106. Epub 2009 Oct 5.


Impact of retinal disease-associated RPE65 mutations on retinoid isomerization.

Bereta G, Kiser PD, Golczak M, Sun W, Heon E, Saperstein DA, Palczewski K.

Biochemistry. 2008 Sep 16;47(37):9856-65. doi: 10.1021/bi800905v. Epub 2008 Aug 23.


Metabolic basis of visual cycle inhibition by retinoid and nonretinoid compounds in the vertebrate retina.

Golczak M, Maeda A, Bereta G, Maeda T, Kiser PD, Hunzelmann S, von Lintig J, Blaner WS, Palczewski K.

J Biol Chem. 2008 Apr 11;283(15):9543-54. doi: 10.1074/jbc.M708982200. Epub 2008 Jan 14.


Stereospecificity of retinol saturase: absolute configuration, synthesis, and biological evaluation of dihydroretinoids.

Moise AR, Domínguez M, Alvarez S, Alvarez R, Schupp M, Cristancho AG, Kiser PD, de Lera AR, Lazar MA, Palczewski K.

J Am Chem Soc. 2008 Jan 30;130(4):1154-5. doi: 10.1021/ja710487q. Epub 2008 Jan 8. No abstract available.


Purification, crystallization and structure determination of native GroEL from Escherichia coli lacking bound potassium ions.

Kiser PD, Lodowski DT, Palczewski K.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Jun 1;63(Pt 6):457-61. Epub 2007 May 5.


A comprehensive structure-function map of the intracellular surface of the human C5a receptor. I. Identification of critical residues.

Matsumoto ML, Narzinski K, Kiser PD, Nikiforovich GV, Baranski TJ.

J Biol Chem. 2007 Feb 2;282(5):3105-21. Epub 2006 Nov 29.


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