Sort by
Items per page

Send to

Choose Destination

Search results

Items: 36


Inhibition of the histone demethylase, KDM5B, directly induces re-expression of tumor suppressor protein HEXIM1 in cancer cells.

Montano MM, Yeh IJ, Chen Y, Hernandez C, Kiselar JG, de la Fuente M, Lawes AM, Nieman MT, Kiser PD, Jacobberger J, Exner AA, Lawes MC.

Breast Cancer Res. 2019 Dec 5;21(1):138. doi: 10.1186/s13058-019-1228-7.


POT1-TPP1 differentially regulates telomerase via POT1 His266 and as a function of single-stranded telomere DNA length.

Xu M, Kiselar J, Whited TL, Hernandez-Sanchez W, Taylor DJ.

Proc Natl Acad Sci U S A. 2019 Nov 19;116(47):23527-23533. doi: 10.1073/pnas.1905381116. Epub 2019 Nov 4.


A Metastable Contact and Structural Disorder in the Estrogen Receptor Transactivation Domain.

Peng Y, Cao S, Kiselar J, Xiao X, Du Z, Hsieh A, Ko S, Chen Y, Agrawal P, Zheng W, Shi W, Jiang W, Yang L, Chance MR, Surewicz WK, Buck M, Yang S.

Structure. 2019 Feb 5;27(2):229-240.e4. doi: 10.1016/j.str.2018.10.026. Epub 2018 Dec 20.


Structural attributes of mammalian prion infectivity: Insights from studies with synthetic prions.

Li Q, Wang F, Xiao X, Kim C, Bohon J, Kiselar J, Safar JG, Ma J, Surewicz WK.

J Biol Chem. 2018 Nov 30;293(48):18494-18503. doi: 10.1074/jbc.RA118.005622. Epub 2018 Oct 1.


Multidomain architecture of estrogen receptor reveals interfacial cross-talk between its DNA-binding and ligand-binding domains.

Huang W, Peng Y, Kiselar J, Zhao X, Albaqami A, Mendez D, Chen Y, Chakravarthy S, Gupta S, Ralston C, Kao HY, Chance MR, Yang S.

Nat Commun. 2018 Aug 30;9(1):3520. doi: 10.1038/s41467-018-06034-2.


Structural insights into the molecular mechanism of mouse TRPA1 activation and inhibition.

Samanta A, Kiselar J, Pumroy RA, Han S, Moiseenkova-Bell VY.

J Gen Physiol. 2018 May 7;150(5):751-762. doi: 10.1085/jgp.201711876. Epub 2018 Apr 27.


High-Resolution Hydroxyl Radical Protein Footprinting: Biophysics Tool for Drug Discovery.

Kiselar J, Chance MR.

Annu Rev Biophys. 2018 Mar 14. doi: 10.1146/annurev-biophys-070317-033123. [Epub ahead of print]


Small-Molecule Activators of Protein Phosphatase 2A for the Treatment of Castration-Resistant Prostate Cancer.

McClinch K, Avelar RA, Callejas D, Izadmehr S, Wiredja D, Perl A, Sangodkar J, Kastrinsky DB, Schlatzer D, Cooper M, Kiselar J, Stachnik A, Yao S, Hoon D, McQuaid D, Zaware N, Gong Y, Brautigan DL, Plymate SR, Sprenger CCT, Oh WK, Levine AC, Kirschenbaum A, Sfakianos JP, Sears R, DiFeo A, Ioannou Y, Ohlmeyer M, Narla G, Galsky MD.

Cancer Res. 2018 Apr 15;78(8):2065-2080. doi: 10.1158/0008-5472.CAN-17-0123. Epub 2018 Jan 22.


Activation of tumor suppressor protein PP2A inhibits KRAS-driven tumor growth.

Sangodkar J, Perl A, Tohme R, Kiselar J, Kastrinsky DB, Zaware N, Izadmehr S, Mazhar S, Wiredja DD, O'Connor CM, Hoon D, Dhawan NS, Schlatzer D, Yao S, Leonard D, Borczuk AC, Gokulrangan G, Wang L, Svenson E, Farrington CC, Yuan E, Avelar RA, Stachnik A, Smith B, Gidwani V, Giannini HM, McQuaid D, McClinch K, Wang Z, Levine AC, Sears RC, Chen EY, Duan Q, Datt M, Haider S, Ma'ayan A, DiFeo A, Sharma N, Galsky MD, Brautigan DL, Ioannou YA, Xu W, Chance MR, Ohlmeyer M, Narla G.

J Clin Invest. 2017 Jun 1;127(6):2081-2090. doi: 10.1172/JCI89548. Epub 2017 May 15.


Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase.

Stanford SM, Aleshin AE, Zhang V, Ardecky RJ, Hedrick MP, Zou J, Ganji SR, Bliss MR, Yamamoto F, Bobkov AA, Kiselar J, Liu Y, Cadwell GW, Khare S, Yu J, Barquilla A, Chung TDY, Mustelin T, Schenk S, Bankston LA, Liddington RC, Pinkerton AB, Bottini N.

Nat Chem Biol. 2017 Jun;13(6):624-632. doi: 10.1038/nchembio.2344. Epub 2017 Mar 27.


FAD-I, a Fusobacterium nucleatum Cell Wall-Associated Diacylated Lipoprotein That Mediates Human Beta Defensin 2 Induction through Toll-Like Receptor-1/2 (TLR-1/2) and TLR-2/6.

Bhattacharyya S, Ghosh SK, Shokeen B, Eapan B, Lux R, Kiselar J, Nithianantham S, Young A, Pandiyan P, McCormick TS, Weinberg A.

Infect Immun. 2016 Apr 22;84(5):1446-1456. doi: 10.1128/IAI.01311-15. Print 2016 May.


Nerve Growth Factor Regulates Transient Receptor Potential Vanilloid 2 via Extracellular Signal-Regulated Kinase Signaling To Enhance Neurite Outgrowth in Developing Neurons.

Cohen MR, Johnson WM, Pilat JM, Kiselar J, DeFrancesco-Lisowitz A, Zigmond RE, Moiseenkova-Bell VY.

Mol Cell Biol. 2015 Dec;35(24):4238-52. doi: 10.1128/MCB.00549-15. Epub 2015 Sep 28.


Modification of β-Defensin-2 by Dicarbonyls Methylglyoxal and Glyoxal Inhibits Antibacterial and Chemotactic Function In Vitro.

Kiselar JG, Wang X, Dubyak GR, El Sanadi C, Ghosh SK, Lundberg K, Williams WM.

PLoS One. 2015 Aug 5;10(8):e0130533. doi: 10.1371/journal.pone.0130533. eCollection 2015.


Characterizing monoclonal antibody structure by carboxyl group footprinting.

Kaur P, Tomechko SE, Kiselar J, Shi W, Deperalta G, Wecksler AT, Gokulrangan G, Ling V, Chance MR.

MAbs. 2015;7(3):540-52. doi: 10.1080/19420862.2015.1023683.


Quantitative protein topography analysis and high-resolution structure prediction using hydroxyl radical labeling and tandem-ion mass spectrometry (MS).

Kaur P, Kiselar J, Yang S, Chance MR.

Mol Cell Proteomics. 2015 Apr;14(4):1159-68. doi: 10.1074/mcp.O114.044362. Epub 2015 Feb 16.


Characterizing monoclonal antibody structure by carbodiimide/GEE footprinting.

Kaur P, Tomechko S, Kiselar J, Shi W, Deperalta G, Wecksler AT, Gokulrangan G, Ling V, Chance MR.

MAbs. 2014;6(6):1486-99. doi: 10.4161/19420862.2014.975096. Retraction in: MAbs. 2015;7(3):651.


A synchrotron-based hydroxyl radical footprinting analysis of amyloid fibrils and prefibrillar intermediates with residue-specific resolution.

Klinger AL, Kiselar J, Ilchenko S, Komatsu H, Chance MR, Axelsen PH.

Biochemistry. 2014 Dec 16;53(49):7724-34. doi: 10.1021/bi5010409. Epub 2014 Dec 3.


Multiple glycosaminoglycan-binding epitopes of monocyte chemoattractant protein-3/CCL7 enable it to function as a non-oligomerizing chemokine.

Salanga CL, Dyer DP, Kiselar JG, Gupta S, Chance MR, Handel TM.

J Biol Chem. 2014 May 23;289(21):14896-912. doi: 10.1074/jbc.M114.547737. Epub 2014 Apr 11.


Cellular prion protein regulates its own α-cleavage through ADAM8 in skeletal muscle.

Liang J, Wang W, Sorensen D, Medina S, Ilchenko S, Kiselar J, Surewicz WK, Booth SA, Kong Q.

J Biol Chem. 2012 May 11;287(20):16510-20. doi: 10.1074/jbc.M112.360891. Epub 2012 Mar 23.


GSK3 is a regulator of RAR-mediated differentiation.

Gupta K, Gulen F, Sun L, Aguilera R, Chakrabarti A, Kiselar J, Agarwal MK, Wald DN.

Leukemia. 2012 Jun;26(6):1277-85. doi: 10.1038/leu.2012.2. Epub 2012 Jan 6.


Structural analysis of proinsulin hexamer assembly by hydroxyl radical footprinting and computational modeling.

Kiselar JG, Datt M, Chance MR, Weiss MA.

J Biol Chem. 2011 Dec 23;286(51):43710-6. doi: 10.1074/jbc.M111.297853. Epub 2011 Oct 26.


Circulating human CD4 and CD8 T cells do not have large intracellular pools of CCR5.

Pilch-Cooper HA, Sieg SF, Hope TJ, Koons A, Escola JM, Offord R, Veazey RS, Mosier DE, Clagett B, Medvik K, Jadlowsky JK, Chance MR, Kiselar JG, Hoxie JA, Collman RG, Riddick NE, Mercanti V, Hartley O, Lederman MM.

Blood. 2011 Jul 28;118(4):1015-9. doi: 10.1182/blood-2010-05-282509. Epub 2010 Nov 10.


Future directions of structural mass spectrometry using hydroxyl radical footprinting.

Kiselar JG, Chance MR.

J Mass Spectrom. 2010 Dec;45(12):1373-82. doi: 10.1002/jms.1808. Review.


Integrated algorithms for high-throughput examination of covalently labeled biomolecules by structural mass spectrometry.

Kaur P, Kiselar JG, Chance MR.

Anal Chem. 2009 Oct 1;81(19):8141-9. doi: 10.1021/ac9013644.


Ribosomal S6 kinase 2 directly phosphorylates the 5-hydroxytryptamine 2A (5-HT2A) serotonin receptor, thereby modulating 5-HT2A signaling.

Strachan RT, Sheffler DJ, Willard B, Kinter M, Kiselar JG, Roth BL.

J Biol Chem. 2009 Feb 27;284(9):5557-73. doi: 10.1074/jbc.M805705200. Epub 2008 Dec 22.


The Beamline X28C of the Center for Synchrotron Biosciences: a national resource for biomolecular structure and dynamics experiments using synchrotron footprinting.

Gupta S, Sullivan M, Toomey J, Kiselar J, Chance MR.

J Synchrotron Radiat. 2007 May;14(Pt 3):233-43. Epub 2007 Apr 11.


Visualizing Arp2/3 complex activation mediated by binding of ATP and WASp using structural mass spectrometry.

Kiselar JG, Mahaffy R, Pollard TD, Almo SC, Chance MR.

Proc Natl Acad Sci U S A. 2007 Jan 30;104(5):1552-7. Epub 2007 Jan 24.


Secondary reactions and strategies to improve quantitative protein footprinting.

Xu G, Kiselar J, He Q, Chance MR.

Anal Chem. 2005 May 15;77(10):3029-37.


Structural analysis of gelsolin using synchrotron protein footprinting.

Kiselar JG, Janmey PA, Almo SC, Chance MR.

Mol Cell Proteomics. 2003 Oct;2(10):1120-32. Epub 2003 Sep 8.


Visualizing the Ca2+-dependent activation of gelsolin by using synchrotron footprinting.

Kiselar JG, Janmey PA, Almo SC, Chance MR.

Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):3942-7. Epub 2003 Mar 24.


Hydroxyl radical probe of protein surfaces using synchrotron X-ray radiolysis and mass spectrometry.

Kiselar JG, Maleknia SD, Sullivan M, Downard KM, Chance MR.

Int J Radiat Biol. 2002 Feb;78(2):101-14.


Hydroxyl radical probe of the surface of lysozyme by synchrotron radiolysis and mass spectrometry.

Maleknia SD, Kiselar JG, Downard KM.

Rapid Commun Mass Spectrom. 2002;16(1):53-61.


Antigenic surveillance of the influenza virus by mass spectrometry.

Kiselar JG, Downard KM.

Biochemistry. 1999 Oct 26;38(43):14185-91.


Antigenic mapping of bacterial and animal cytochromes P-450.

Kolesanova EF, Kiselar JG, Jung C, Kozin SA, Hui Bon Hoa G, Archakov AI.

Biochimie. 1996;78(8-9):752-62.


Supplemental Content

Loading ...
Support Center