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A randomized controlled trial to reduce sedentary time in rheumatoid arthritis: protocol and rationale of the Take a STAND for Health study.

Pinto AJ, Peçanha T, Meireles K, Benatti FB, Bonfiglioli K, de Sá Pinto AL, Lima FR, Pereira RMR, Irigoyen MCC, Turner JE, Kirwan JP, Owen N, Dunstan DW, Roschel H, Gualano B.

Trials. 2020 Feb 12;21(1):171. doi: 10.1186/s13063-020-4104-y.


Exercise Training Rapidly Increases Hepatic Insulin Extraction in NAFLD.

Hari A, Fealy CE, Axelrod CL, Haus JM, Flask CA, McCullough AJ, Kirwan JP.

Med Sci Sports Exerc. 2020 Feb 5. doi: 10.1249/MSS.0000000000002273. [Epub ahead of print]


UCC118 supplementation reduces exercise-induced gastrointestinal permeability and remodels the gut microbiome in healthy humans.

Axelrod CL, Brennan CJ, Cresci G, Paul D, Hull M, Fealy CE, Kirwan JP.

Physiol Rep. 2019 Nov;7(22):e14276. doi: 10.14814/phy2.14276.


Obesity-linked suppression of membrane-bound O-acyltransferase 7 (MBOAT7) drives non-alcoholic fatty liver disease.

Helsley RN, Varadharajan V, Brown AL, Gromovsky AD, Schugar RC, Ramachandiran I, Fung K, Kabbany MN, Banerjee R, Neumann CK, Finney C, Pathak P, Orabi D, Osborn LJ, Massey W, Zhang R, Kadam A, Sansbury BE, Pan C, Sacks J, Lee RG, Crooke RM, Graham MJ, Lemieux ME, Gogonea V, Kirwan JP, Allende DS, Civelek M, Fox PL, Rudel LL, Lusis AJ, Spite M, Brown JM.

Elife. 2019 Oct 17;8. pii: e49882. doi: 10.7554/eLife.49882.


Sleep, quality of life, and depression in endometrial cancer survivors with obesity seeking weight loss.

Nock NL, Dimitropoulos A, Zanotti KM, Waggoner S, Nagel C, Golubic M, Michener CM, Kirwan JP, Alberts J.

Support Care Cancer. 2019 Sep 2. doi: 10.1007/s00520-019-05051-1. [Epub ahead of print]


Non-invasive assessment of hepatic lipid subspecies matched with non-alcoholic fatty liver disease phenotype.

Erickson ML, Haus JM, Malin SK, Flask CA, McCullough AJ, Kirwan JP.

Nutr Metab Cardiovasc Dis. 2019 Nov;29(11):1197-1204. doi: 10.1016/j.numecd.2019.06.012. Epub 2019 Jun 21.


Exercise Mitigates Bone Loss in Women With Severe Obesity After Roux-en-Y Gastric Bypass: A Randomized Controlled Trial.

Murai IH, Roschel H, Dantas WS, Gil S, Merege-Filho C, de Cleva R, de Sá-Pinto AL, Lima F, Santo MA, Benatti FB, Kirwan JP, Pereira RM, Gualano B.

J Clin Endocrinol Metab. 2019 Oct 1;104(10):4639-4650. doi: 10.1210/jc.2019-00074.


Cardiovascular Biomarkers After Metabolic Surgery Versus Medical Therapy for Diabetes.

Bhatt DL, Aminian A, Kashyap SR, Kirwan JP, Wolski K, Brethauer SA, Hazen SL, Nissen SE, Schauer PR.

J Am Coll Cardiol. 2019 Jul 16;74(2):261-263. doi: 10.1016/j.jacc.2019.04.058. No abstract available.


Skeletal muscle Nur77 and NOR1 insulin responsiveness is blunted in obesity and type 2 diabetes but improved after exercise training.

Mey JT, Solomon TPJ, Kirwan JP, Haus JM.

Physiol Rep. 2019 Mar;7(6):e14042. doi: 10.14814/phy2.14042.


Exercise training promotes a GDF15-associated reduction in fat mass in older adults with obesity.

Zhang H, Fealy CE, Kirwan JP.

Am J Physiol Endocrinol Metab. 2019 May 1;316(5):E829-E836. doi: 10.1152/ajpendo.00439.2018. Epub 2019 Mar 12.


Gastric Bypass Surgery Improves the Skeletal Muscle Ceramide/S1P Ratio and Upregulates the AMPK/ SIRT1/ PGC-1α Pathway in Zucker Diabetic Fatty Rats.

Huang H, Aminian A, Hassan M, Dan O, Axelrod CL, Schauer PR, Brethauer SA, Kirwan JP.

Obes Surg. 2019 Jul;29(7):2158-2165. doi: 10.1007/s11695-019-03800-z.


A Whole-Grain Diet Increases Glucose-Stimulated Insulin Secretion Independent of Gut Hormones in Adults at Risk for Type 2 Diabetes.

Malin SK, Kullman EL, Scelsi AR, Godin JP, Ross AB, Kirwan JP.

Mol Nutr Food Res. 2019 Apr;63(7):e1800967. doi: 10.1002/mnfr.201800967. Epub 2019 Mar 20.


Medical marijuana-an obesity problem or opportunity?

Greenway FL, Kirwan JP.

Int J Obes (Lond). 2019 Apr;43(4):761-762. doi: 10.1038/s41366-019-0334-z. Epub 2019 Feb 12. No abstract available.


The historical context and scientific legacy of John O. Holloszy.

Hagberg JM, Coyle EF, Baldwin KM, Cartee GD, Fontana L, Joyner MJ, Kirwan JP, Seals DR, Weiss EP.

J Appl Physiol (1985). 2019 Aug 1;127(2):277-305. doi: 10.1152/japplphysiol.00669.2018. Epub 2019 Feb 7.


Effects of Lifestyle Intervention on Plasma Trimethylamine N-Oxide in Obese Adults.

Erickson ML, Malin SK, Wang Z, Brown JM, Hazen SL, Kirwan JP.

Nutrients. 2019 Jan 16;11(1). pii: E179. doi: 10.3390/nu11010179.


Exercise-induced improvements in glucose effectiveness are blunted by a high glycemic diet in adults with prediabetes.

Hari A, Fealy C, Solomon TPJ, Haus JM, Kelly KR, Barkoukis H, Kirwan JP.

Acta Diabetol. 2019 Feb;56(2):211-217. doi: 10.1007/s00592-018-1272-2. Epub 2019 Jan 5.


Exercise training remodels human skeletal muscle mitochondrial fission and fusion machinery towards a pro-elongation phenotype.

Axelrod CL, Fealy CE, Mulya A, Kirwan JP.

Acta Physiol (Oxf). 2019 Apr;225(4):e13216. doi: 10.1111/apha.13216. Epub 2018 Dec 1.


Reversal of Improved Endothelial Function After Bariatric Surgery Is Mitigated by Exercise Training.

Dantas WS, Gil S, Murai IH, Costa-Hong V, Peçanha T, Merege-Filho CAA, de Sá-Pinto AL, de Cleva R, Santo MA, Pereira RMR, Kirwan JP, Roschel H, Gualano B.

J Am Coll Cardiol. 2018 Oct 30;72(18):2278-2279. doi: 10.1016/j.jacc.2018.07.094. No abstract available.


Mitochondrial dynamics in skeletal muscle insulin resistance and type 2 diabetes.

Fealy CE, Mulya A, Axelrod CL, Kirwan JP.

Transl Res. 2018 Dec;202:69-82. doi: 10.1016/j.trsl.2018.07.011. Epub 2018 Jul 31. Review.


Mechanisms Responsible for Metabolic Improvements of Bariatric Surgeries.

Kirwan JP, Münzberg H, Berthoud HR.

Diabetes. 2018 Jun;67(6):1043-1044. doi: 10.2337/dbi18-0011. No abstract available.


Weight loss interventions for adults with overweight/obesity and chronic musculoskeletal pain: a mixed methods systematic review.

Cooper L, Ryan CG, Ells LJ, Hamilton S, Atkinson G, Cooper K, Johnson MI, Kirwan JP, Martin D.

Obes Rev. 2018 Jul;19(7):989-1007. doi: 10.1111/obr.12686. Epub 2018 May 20.


Functional high-intensity exercise training ameliorates insulin resistance and cardiometabolic risk factors in type 2 diabetes.

Fealy CE, Nieuwoudt S, Foucher JA, Scelsi AR, Malin SK, Pagadala M, Cruz LA, Li M, Rocco M, Burguera B, Kirwan JP.

Exp Physiol. 2018 Jul;103(7):985-994. doi: 10.1113/EP086844.


2-Octylcyanoacrylate for the prevention of anastomotic leak.

Costales AB, Patil D, Mulya A, Kirwan JP, Michener CM.

J Surg Res. 2018 Jun;226:166-172. doi: 10.1016/j.jss.2018.01.026. Epub 2018 Feb 22.


Effect of Roux-en-Y gastric bypass on liver mitochondrial dynamics in a rat model of obesity.

Sacks J, Mulya A, Fealy CE, Huang H, Mosinski JD, Pagadala MR, Shimizu H, Batayyah E, Schauer PR, Brethauer SA, Kirwan JP.

Physiol Rep. 2018 Feb;6(4). doi: 10.14814/phy2.13600.


A whole-grain diet reduces peripheral insulin resistance and improves glucose kinetics in obese adults: A randomized-controlled trial.

Malin SK, Kullman EL, Scelsi AR, Haus JM, Filion J, Pagadala MR, Godin JP, Kochhar S, Ross AB, Kirwan JP.

Metabolism. 2018 May;82:111-117. doi: 10.1016/j.metabol.2017.12.011. Epub 2018 Jan 3.


A conserved KLF-autophagy pathway modulates nematode lifespan and mammalian age-associated vascular dysfunction.

Hsieh PN, Zhou G, Yuan Y, Zhang R, Prosdocimo DA, Sangwung P, Borton AH, Boriushkin E, Hamik A, Fujioka H, Fealy CE, Kirwan JP, Peters M, Lu Y, Liao X, Ramírez-Bergeron D, Feng Z, Jain MK.

Nat Commun. 2017 Oct 13;8(1):914. doi: 10.1038/s41467-017-00899-5.


Reversal of fibrosis in patients with nonalcoholic steatohepatosis after gastric bypass surgery.

Parker BM, Wu J, You J, Barnes DS, Yerian L, Kirwan JP, Schauer PR, Sessler DI.

BMC Obes. 2017 Sep 12;4:32. doi: 10.1186/s40608-017-0168-y. eCollection 2017.


In vitro contraction protects against palmitate-induced insulin resistance in C2C12 myotubes.

Nieuwoudt S, Mulya A, Fealy CE, Martelli E, Dasarathy S, Naga Prasad SV, Kirwan JP.

Am J Physiol Cell Physiol. 2017 Nov 1;313(5):C575-C583. doi: 10.1152/ajpcell.00123.2017. Epub 2017 Aug 23.


Circulating soluble RAGE isoforms are attenuated in obese, impaired-glucose-tolerant individuals and are associated with the development of type 2 diabetes.

Miranda ER, Somal VS, Mey JT, Blackburn BK, Wang E, Farabi S, Karstoft K, Fealy CE, Kashyap S, Kirwan JP, Quinn L, Solomon TPJ, Haus JM.

Am J Physiol Endocrinol Metab. 2017 Dec 1;313(6):E631-E640. doi: 10.1152/ajpendo.00146.2017. Epub 2017 Aug 15.


The essential role of exercise in the management of type 2 diabetes.

Kirwan JP, Sacks J, Nieuwoudt S.

Cleve Clin J Med. 2017 Jul;84(7 Suppl 1):S15-S21. doi: 10.3949/ccjm.84.s1.03. Review.


Functional high-intensity training improves pancreatic β-cell function in adults with type 2 diabetes.

Nieuwoudt S, Fealy CE, Foucher JA, Scelsi AR, Malin SK, Pagadala M, Rocco M, Burguera B, Kirwan JP.

Am J Physiol Endocrinol Metab. 2017 Sep 1;313(3):E314-E320. doi: 10.1152/ajpendo.00407.2016. Epub 2017 May 16.


Exercise training-induced improvement in skeletal muscle PGC-1α-mediated fat metabolism is independent of dietary glycemic index.

Mulya A, Haus JM, Solomon TP, Kelly KR, Malin SK, Rocco M, Barkoukis H, Kirwan JP.

Obesity (Silver Spring). 2017 Apr;25(4):721-729. doi: 10.1002/oby.21799.


Bariatric Surgery versus Intensive Medical Therapy for Diabetes - 5-Year Outcomes.

Schauer PR, Bhatt DL, Kirwan JP, Wolski K, Aminian A, Brethauer SA, Navaneethan SD, Singh RP, Pothier CE, Nissen SE, Kashyap SR; STAMPEDE Investigators.

N Engl J Med. 2017 Feb 16;376(7):641-651. doi: 10.1056/NEJMoa1600869.


Abnormal Glucose Metabolism and High-Energy Expenditure in Idiopathic Pulmonary Arterial Hypertension.

Heresi GA, Malin SK, Barnes JW, Tian L, Kirwan JP, Dweik RA.

Ann Am Thorac Soc. 2017 Feb;14(2):190-199. doi: 10.1513/AnnalsATS.201608-605OC.


A Whole-Grain Diet Reduces Cardiovascular Risk Factors in Overweight and Obese Adults: A Randomized Controlled Trial.

Kirwan JP, Malin SK, Scelsi AR, Kullman EL, Navaneethan SD, Pagadala MR, Haus JM, Filion J, Godin JP, Kochhar S, Ross AB.

J Nutr. 2016 Nov;146(11):2244-2251. Epub 2016 Oct 19.


Hyperinsulinemia augments endothelin-1 protein expression and impairs vasodilation of human skeletal muscle arterioles.

Mahmoud AM, Szczurek MR, Blackburn BK, Mey JT, Chen Z, Robinson AT, Bian JT, Unterman TG, Minshall RD, Brown MD, Kirwan JP, Phillips SA, Haus JM.

Physiol Rep. 2016 Aug;4(16). pii: e12895. Epub 2016 Aug 22.


Heterogeneity in glucose response curves during an oral glucose tolerance test and associated cardiometabolic risk.

Hulman A, Simmons RK, Vistisen D, Tabák AG, Dekker JM, Alssema M, Rutters F, Koopman AD, Solomon TP, Kirwan JP, Hansen T, Jonsson A, Gjesing AP, Eiberg H, Astrup A, Pedersen O, Sørensen TI, Witte DR, Færch K.

Endocrine. 2017 Feb;55(2):427-434. doi: 10.1007/s12020-016-1126-z. Epub 2016 Oct 3.


Effect of Roux-en-Y Gastric Bypass on the NLRP3 Inflammasome in Pancreatic Islets from Zucker Diabetic Fatty Rats.

Mocanu AO, Mulya A, Huang H, Dan O, Schauer PR, Dinischiotu A, Brethauer SA, Kirwan JP.

Obes Surg. 2016 Dec;26(12):3076-3081.


Weight-loss interventions for overweight/obese adults with chronic musculoskeletal pain: a mixed methods systematic review protocol.

Cooper L, Ryan C, Ells LJ, Hamilton S, Atkinson G, Cooper K, Johnson MI, Kirwan JP, Martin D.

JBI Database System Rev Implement Rep. 2016 May;14(5):57-67. doi: 10.11124/JBISRIR-2016-002725.


Brown and Beige Adipose Tissue: Therapy for Obesity and Its Comorbidities?

Mulya A, Kirwan JP.

Endocrinol Metab Clin North Am. 2016 Sep;45(3):605-21. doi: 10.1016/j.ecl.2016.04.010. Review.


Bariatric Surgery in Obese Patients With Type 1 Diabetes.

Kirwan JP, Aminian A, Kashyap SR, Burguera B, Brethauer SA, Schauer PR.

Diabetes Care. 2016 Jun;39(6):941-8. doi: 10.2337/dc15-2732. Review.


The effect of pregnancy before and/or after bariatric surgery on weight loss.

Froylich D, Corcelles R, Daigle CR, Kirwan JP, Brethauer SA, Schauer PR.

Surg Obes Relat Dis. 2016 Mar-Apr;12(3):596-599. doi: 10.1016/j.soard.2015.09.005. Epub 2015 Sep 24.


Longer-Term Physiological and Metabolic Effects of Gastric Bypass Surgery.

Mosinski JD, Kirwan JP.

Curr Diab Rep. 2016 Jun;16(6):50. doi: 10.1007/s11892-016-0747-1. Review.


Short-term aerobic exercise training improves gut peptide regulation in nonalcoholic fatty liver disease.

Kullman EL, Kelly KR, Haus JM, Fealy CE, Scelsi AR, Pagadala MR, Flask CA, McCullough AJ, Kirwan JP.

J Appl Physiol (1985). 2016 May 15;120(10):1159-64. doi: 10.1152/japplphysiol.00693.2015. Epub 2016 Mar 31.


Body mass index and causes of death in chronic kidney disease.

Navaneethan SD, Schold JD, Arrigain S, Kirwan JP, Nally JV Jr.

Kidney Int. 2016 Mar;89(3):675-82. doi: 10.1016/j.kint.2015.12.002. Epub 2016 Jan 12.


A high-throughput method for liquid chromatography-tandem mass spectrometry determination of plasma alkylresorcinols, biomarkers of whole grain wheat and rye intake.

Ross AB, Svelander C, Savolainen OI, Lind MV, Kirwan JP, Breton I, Godin JP, Sandberg AS.

Anal Biochem. 2016 Apr 15;499:1-7. doi: 10.1016/j.ab.2015.12.023. Epub 2016 Jan 28.


Gastric bypass surgery is protective from high-fat diet-induced non-alcoholic fatty liver disease and hepatic endoplasmic reticulum stress.

Mosinski JD, Pagadala MR, Mulya A, Huang H, Dan O, Shimizu H, Batayyah E, Pai RK, Schauer PR, Brethauer SA, Kirwan JP.

Acta Physiol (Oxf). 2016 Jun;217(2):141-51. doi: 10.1111/apha.12640. Epub 2015 Dec 29.


A Community-Based Exercise and Support Group Program Improves Quality of Life in African-American Breast Cancer Survivors: A Quantitative and Qualitative Analysis.

Nock NL, Owusu C, Flocke S, Krejci SA, Kullman EL, Austin K, Bennett B, Cerne S, Harmon C, Moore H, Vargo M, Hergenroeder P, Malone H, Rocco M, Tracy R, Lazarus HM, Kirwan JP, Heyman E, Berger NA.

Int J Sports Exerc Med. 2015;1(3). pii: 020. Epub 2015 Sep 5.


A Trial of Lifestyle Modification on Cardiopulmonary, Inflammatory, and Metabolic Effects among Obese with Chronic Kidney Disease.

Navaneethan SD, Fealy CE, Scelsi AC, Arrigain S, Malin SK, Kirwan JP.

Am J Nephrol. 2015;42(4):274-81. doi: 10.1159/000441155. Epub 2015 Oct 24.


Effect of Roux-en-Y Gastric Bypass on the NLRP3 Inflammasome in Adipose Tissue from Obese Rats.

Mocanu AO, Mulya A, Huang H, Dan O, Shimizu H, Batayyah E, Brethauer SA, Dinischiotu A, Kirwan JP.

PLoS One. 2015 Oct 5;10(10):e0139764. doi: 10.1371/journal.pone.0139764. eCollection 2015.

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