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Items: 29

1.

Combating Multidrug-Resistant Pathogens with Host-Directed Nonantibiotic Therapeutics.

Andersson JA, Sha J, Kirtley ML, Reyes E, Fitts EC, Dann SM, Chopra AK.

Antimicrob Agents Chemother. 2017 Dec 21;62(1). pii: e01943-17. doi: 10.1128/AAC.01943-17. Print 2018 Jan.

2.

Identification of New Virulence Factors and Vaccine Candidates for Yersinia pestis.

Andersson JA, Sha J, Erova TE, Fitts EC, Ponnusamy D, Kozlova EV, Kirtley ML, Chopra AK.

Front Cell Infect Microbiol. 2017 Oct 17;7:448. doi: 10.3389/fcimb.2017.00448. eCollection 2017.

3.

A Bivalent Anthrax-Plague Vaccine That Can Protect against Two Tier-1 Bioterror Pathogens, Bacillus anthracis and Yersinia pestis.

Tao P, Mahalingam M, Zhu J, Moayeri M, Kirtley ML, Fitts EC, Andersson JA, Lawrence WS, Leppla SH, Chopra AK, Rao VB.

Front Immunol. 2017 Jun 26;8:687. doi: 10.3389/fimmu.2017.00687. eCollection 2017.

4.

Phospholipase A2-activating protein is associated with a novel form of leukoencephalopathy.

Falik Zaccai TC, Savitzki D, Zivony-Elboum Y, Vilboux T, Fitts EC, Shoval Y, Kalfon L, Samra N, Keren Z, Gross B, Chasnyk N, Straussberg R, Mullikin JC, Teer JK, Geiger D, Kornitzer D, Bitterman-Deutsch O, Samson AO, Wakamiya M, Peterson JW, Kirtley ML, Pinchuk IV, Baze WB, Gahl WA, Kleta R, Anikster Y, Chopra AK.

Brain. 2017 Feb;140(2):370-386. doi: 10.1093/brain/aww295. Epub 2016 Dec 21.

5.

New Insights into Autoinducer-2 Signaling as a Virulence Regulator in a Mouse Model of Pneumonic Plague.

Fitts EC, Andersson JA, Kirtley ML, Sha J, Erova TE, Chauhan S, Motin VL, Chopra AK.

mSphere. 2016 Dec 14;1(6). pii: e00342-16. eCollection 2016 Nov-Dec.

6.

Protective Immunity Elicited by Oral Immunization of Mice with Salmonella enterica Serovar Typhimurium Braun Lipoprotein (Lpp) and Acetyltransferase (MsbB) Mutants.

Erova TE, Kirtley ML, Fitts EC, Ponnusamy D, Baze WB, Andersson JA, Cong Y, Tiner BL, Sha J, Chopra AK.

Front Cell Infect Microbiol. 2016 Nov 10;6:148. eCollection 2016.

7.

Immunisation of two rodent species with new live-attenuated mutants of Yersinia pestis CO92 induces protective long-term humoral- and cell-mediated immunity against pneumonic plague.

Tiner BL, Sha J, Cong Y, Kirtley ML, Andersson JA, Chopra AK.

NPJ Vaccines. 2016 Oct 13;1:16020. doi: 10.1038/npjvaccines.2016.20. eCollection 2016.

8.

A Replication-Defective Human Type 5 Adenovirus-Based Trivalent Vaccine Confers Complete Protection against Plague in Mice and Nonhuman Primates.

Sha J, Kirtley ML, Klages C, Erova TE, Telepnev M, Ponnusamy D, Fitts EC, Baze WB, Sivasubramani SK, Lawrence WS, Patrikeev I, Peel JE, Andersson JA, Kozlova EV, Tiner BL, Peterson JW, McWilliams D, Patel S, Rothe E, Motin VL, Chopra AK.

Clin Vaccine Immunol. 2016 Jul 5;23(7):586-600. doi: 10.1128/CVI.00150-16. Print 2016 Jul.

9.

New Role for FDA-Approved Drugs in Combating Antibiotic-Resistant Bacteria.

Andersson JA, Fitts EC, Kirtley ML, Ponnusamy D, Peniche AG, Dann SM, Motin VL, Chauhan S, Rosenzweig JA, Sha J, Chopra AK.

Antimicrob Agents Chemother. 2016 May 23;60(6):3717-29. doi: 10.1128/AAC.00326-16. Print 2016 Jun.

10.

Cross-talk among flesh-eating Aeromonas hydrophila strains in mixed infection leading to necrotizing fasciitis.

Ponnusamy D, Kozlova EV, Sha J, Erova TE, Azar SR, Fitts EC, Kirtley ML, Tiner BL, Andersson JA, Grim CJ, Isom RP, Hasan NA, Colwell RR, Chopra AK.

Proc Natl Acad Sci U S A. 2016 Jan 19;113(3):722-7. doi: 10.1073/pnas.1523817113. Epub 2016 Jan 5.

11.

High-throughput, signature-tagged mutagenic approach to identify novel virulence factors of Yersinia pestis CO92 in a mouse model of infection.

Ponnusamy D, Fitts EC, Sha J, Erova TE, Kozlova EV, Kirtley ML, Tiner BL, Andersson JA, Chopra AK.

Infect Immun. 2015 May;83(5):2065-81. doi: 10.1128/IAI.02913-14. Epub 2015 Mar 9.

12.

Combinational deletion of three membrane protein-encoding genes highly attenuates yersinia pestis while retaining immunogenicity in a mouse model of pneumonic plague.

Tiner BL, Sha J, Kirtley ML, Erova TE, Popov VL, Baze WB, van Lier CJ, Ponnusamy D, Andersson JA, Motin VL, Chauhan S, Chopra AK.

Infect Immun. 2015 Apr;83(4):1318-38. doi: 10.1128/IAI.02778-14. Epub 2015 Jan 20.

13.

Functional genomic characterization of virulence factors from necrotizing fasciitis-causing strains of Aeromonas hydrophila.

Grim CJ, Kozlova EV, Ponnusamy D, Fitts EC, Sha J, Kirtley ML, van Lier CJ, Tiner BL, Erova TE, Joseph SJ, Read TD, Shak JR, Joseph SW, Singletary E, Felland T, Baze WB, Horneman AJ, Chopra AK.

Appl Environ Microbiol. 2014 Jul;80(14):4162-83. doi: 10.1128/AEM.00486-14. Epub 2014 May 2.

14.

Deletion of Braun lipoprotein and plasminogen-activating protease-encoding genes attenuates Yersinia pestis in mouse models of bubonic and pneumonic plague.

van Lier CJ, Sha J, Kirtley ML, Cao A, Tiner BL, Erova TE, Cong Y, Kozlova EV, Popov VL, Baze WB, Chopra AK.

Infect Immun. 2014 Jun;82(6):2485-503. doi: 10.1128/IAI.01595-13. Epub 2014 Mar 31.

15.

The effects of modeled microgravity on growth kinetics, antibiotic susceptibility, cold growth, and the virulence potential of a Yersinia pestis ymoA-deficient mutant and its isogenic parental strain.

Lawal A, Kirtley ML, van Lier CJ, Erova TE, Kozlova EV, Sha J, Chopra AK, Rosenzweig JA.

Astrobiology. 2013 Sep;13(9):821-32. doi: 10.1089/ast.2013.0968. Epub 2013 Aug 29.

16.

Mutated and bacteriophage T4 nanoparticle arrayed F1-V immunogens from Yersinia pestis as next generation plague vaccines.

Tao P, Mahalingam M, Kirtley ML, van Lier CJ, Sha J, Yeager LA, Chopra AK, Rao VB.

PLoS Pathog. 2013;9(7):e1003495. doi: 10.1371/journal.ppat.1003495. Epub 2013 Jul 11.

17.

Characterization of Aeromonas hydrophila wound pathotypes by comparative genomic and functional analyses of virulence genes.

Grim CJ, Kozlova EV, Sha J, Fitts EC, van Lier CJ, Kirtley ML, Joseph SJ, Read TD, Burd EM, Tall BD, Joseph SW, Horneman AJ, Chopra AK, Shak JR.

MBio. 2013 Apr 23;4(2):e00064-13. doi: 10.1128/mBio.00064-13.

18.

Evaluation of the roles played by Hcp and VgrG type 6 secretion system effectors in Aeromonas hydrophila SSU pathogenesis.

Sha J, Rosenzweig JA, Kozlova EV, Wang S, Erova TE, Kirtley ML, van Lier CJ, Chopra AK.

Microbiology. 2013 Jun;159(Pt 6):1120-35. doi: 10.1099/mic.0.063495-0. Epub 2013 Mar 21.

19.

Deletion of the Braun lipoprotein-encoding gene and altering the function of lipopolysaccharide attenuate the plague bacterium.

Sha J, Kirtley ML, van Lier CJ, Wang S, Erova TE, Kozlova EV, Cao A, Cong Y, Fitts EC, Rosenzweig JA, Chopra AK.

Infect Immun. 2013 Mar;81(3):815-28. doi: 10.1128/IAI.01067-12. Epub 2012 Dec 28.

20.

Evaluation of protective potential of Yersinia pestis outer membrane protein antigens as possible candidates for a new-generation recombinant plague vaccine.

Erova TE, Rosenzweig JA, Sha J, Suarez G, Sierra JC, Kirtley ML, van Lier CJ, Telepnev MV, Motin VL, Chopra AK.

Clin Vaccine Immunol. 2013 Feb;20(2):227-38. doi: 10.1128/CVI.00597-12. Epub 2012 Dec 12.

21.

A non-invasive in vivo imaging system to study dissemination of bioluminescent Yersinia pestis CO92 in a mouse model of pneumonic plague.

Sha J, Rosenzweig JA, Kirtley ML, van Lier CJ, Fitts EC, Kozlova EV, Erova TE, Tiner BL, Chopra AK.

Microb Pathog. 2013 Feb;55:39-50. doi: 10.1016/j.micpath.2012.09.011. Epub 2012 Oct 9.

22.

Cethromycin-mediated protection against the plague pathogen Yersinia pestis in a rat model of infection and comparison with levofloxacin.

Rosenzweig JA, Brackman SM, Kirtley ML, Sha J, Erova TE, Yeager LA, Peterson JW, Xu ZQ, Chopra AK.

Antimicrob Agents Chemother. 2011 Nov;55(11):5034-42. doi: 10.1128/AAC.00632-11. Epub 2011 Aug 22.

23.

Progress on plague vaccine development.

Rosenzweig JA, Jejelowo O, Sha J, Erova TE, Brackman SM, Kirtley ML, van Lier CJ, Chopra AK.

Appl Microbiol Biotechnol. 2011 Jul;91(2):265-86. doi: 10.1007/s00253-011-3380-6. Epub 2011 Jun 14.

PMID:
21670978
24.

Immunomodulatory and protective roles of quorum-sensing signaling molecules N-acyl homoserine lactones during infection of mice with Aeromonas hydrophila.

Khajanchi BK, Kirtley ML, Brackman SM, Chopra AK.

Infect Immun. 2011 Jul;79(7):2646-57. doi: 10.1128/IAI.00096-11. Epub 2011 May 2.

25.

Characterization of an F1 deletion mutant of Yersinia pestis CO92, pathogenic role of F1 antigen in bubonic and pneumonic plague, and evaluation of sensitivity and specificity of F1 antigen capture-based dipsticks.

Sha J, Endsley JJ, Kirtley ML, Foltz SM, Huante MB, Erova TE, Kozlova EV, Popov VL, Yeager LA, Zudina IV, Motin VL, Peterson JW, DeBord KL, Chopra AK.

J Clin Microbiol. 2011 May;49(5):1708-15. doi: 10.1128/JCM.00064-11. Epub 2011 Mar 2.

26.

Pathogenesis of Y. enterocolitica and Y. pseudotuberculosis in Human Yersiniosis.

Galindo CL, Rosenzweig JA, Kirtley ML, Chopra AK.

J Pathog. 2011;2011:182051. doi: 10.4061/2011/182051. Epub 2011 Sep 12.

27.

Protection Afforded by Fluoroquinolones in Animal Models of Respiratory Infections with Bacillus anthracis, Yersinia pestis, and Francisella tularensis.

Peterson JW, Moen ST, Healy D, Pawlik JE, Taormina J, Hardcastle J, Thomas JM, Lawrence WS, Ponce C, Chatuev BM, Gnade BT, Foltz SM, Agar SL, Sha J, Klimpel GR, Kirtley ML, Eaves-Pyles T, Chopra AK.

Open Microbiol J. 2010 Jun 3;4:34-46. doi: 10.2174/1874285801004010034.

28.

Role of Hcp, a type 6 secretion system effector, of Aeromonas hydrophila in modulating activation of host immune cells.

Suarez G, Sierra JC, Kirtley ML, Chopra AK.

Microbiology. 2010 Dec;156(Pt 12):3678-88. doi: 10.1099/mic.0.041277-0. Epub 2010 Aug 26.

29.

Comparative Global Gene Expression Profiles of Wild-Type Yersinia pestis CO92 and Its Braun Lipoprotein Mutant at Flea and Human Body Temperatures.

Galindo CL, Sha J, Moen ST, Agar SL, Kirtley ML, Foltz SM, McIver LJ, Kozlova EV, Garner HR, Chopra AK.

Comp Funct Genomics. 2010:342168. doi: 10.1155/2010/342168. Epub 2010 May 19.

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