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Items: 44


Reducing INS-IGF1 signaling protects against non-cell autonomous vesicle rupture caused by SNCA spreading.

Sandhof CA, Hoppe SO, Druffel-Augustin S, Gallrein C, Kirstein J, Voisine C, Nussbaum-Krammer C.

Autophagy. 2019 Jul 29:1-22. doi: 10.1080/15548627.2019.1643657. [Epub ahead of print]


Crosstalk Between Chaperone-Mediated Protein Disaggregation and Proteolytic Pathways in Aging and Disease.

Feleciano DR, Juenemann K, Iburg M, Brás IC, Holmberg CI, Kirstein J.

Front Aging Neurosci. 2019 Jan 29;11:9. doi: 10.3389/fnagi.2019.00009. eCollection 2019.


ATM phosphorylation of the actin-binding protein drebrin controls oxidation stress-resistance in mammalian neurons and C. elegans.

Kreis P, Gallrein C, Rojas-Puente E, Mack TGA, Kroon C, Dinkel V, Willmes C, Murk K, Tom-Dieck S, Schuman EM, Kirstein J, Eickholt BJ.

Nat Commun. 2019 Jan 30;10(1):486. doi: 10.1038/s41467-019-08420-w.


Correction to: The Toronto cognitive assessment (TorCA): normative data and validation to detect amnestic mild cognitive impairment.

Freedman M, Leach L, Carmela Tartaglia M, Stokes KA, Goldberg Y, Spring R, Nourhaghighi N, Gee T, Strother SC, Alhaj MO, Borrie M, Darvesh S, Fernandez A, Fischer CE, Fogarty J, Greenberg BD, Gyenes M, Herrmann N, Keren R, Kirstein J, Kumar S, Lam B, Lena S, McAndrews MP, Naglie G, Partridge R, Rajji TK, Reichmann W, Uri Wolf M, Verhoeff NPLG, Waserman JL, Black SE, Tang-Wai DF.

Alzheimers Res Ther. 2018 Dec 7;10(1):120. doi: 10.1186/s13195-018-0446-z.


Function, evolution, and structure of J-domain proteins.

Kampinga HH, Andreasson C, Barducci A, Cheetham ME, Cyr D, Emanuelsson C, Genevaux P, Gestwicki JE, Goloubinoff P, Huerta-Cepas J, Kirstein J, Liberek K, Mayer MP, Nagata K, Nillegoda NB, Pulido P, Ramos C, De Los Rios P, Rospert S, Rosenzweig R, Sahi C, Taipale M, Tomiczek B, Ushioda R, Young JC, Zimmermann R, Zylicz A, Zylicz M, Craig EA, Marszalek J.

Cell Stress Chaperones. 2019 Jan;24(1):7-15. doi: 10.1007/s12192-018-0948-4. Epub 2018 Nov 26.


Immunogenicity of the CYD tetravalent dengue vaccine using an accelerated schedule: randomised phase II study in US adults.

Kirstein J, Douglas W, Thakur M, Boaz M, Papa T, Skipetrova A, Plennevaux E.

BMC Infect Dis. 2018 Sep 21;18(1):475. doi: 10.1186/s12879-018-3389-x.


mHTT Seeding Activity: A Marker of Disease Progression and Neurotoxicity in Models of Huntington's Disease.

Ast A, Buntru A, Schindler F, Hasenkopf R, Schulz A, Brusendorf L, Klockmeier K, Grelle G, McMahon B, Niederlechner H, Jansen I, Diez L, Edel J, Boeddrich A, Franklin SA, Baldo B, Schnoegl S, Kunz S, Purfürst B, Gaertner A, Kampinga HH, Morton AJ, Petersén Å, Kirstein J, Bates GP, Wanker EE.

Mol Cell. 2018 Sep 6;71(5):675-688.e6. doi: 10.1016/j.molcel.2018.07.032.


The Toronto Cognitive Assessment (TorCA): normative data and validation to detect amnestic mild cognitive impairment.

Freedman M, Leach L, Carmela Tartaglia M, Stokes KA, Goldberg Y, Spring R, Nourhaghighi N, Gee T, Strother SC, Alhaj MO, Borrie M, Darvesh S, Fernandez A, Fischer CE, Fogarty J, Greenberg BD, Gyenes M, Herrmann N, Keren R, Kirstein J, Kumar S, Lam B, Lena S, McAndrews MP, Naglie G, Partridge R, Rajji TK, Reichmann W, Uri Wolf M, Verhoeff NPLG, Waserman JL, Black SE, Tang-Wai DF.

Alzheimers Res Ther. 2018 Jul 18;10(1):65. doi: 10.1186/s13195-018-0382-y. Erratum in: Alzheimers Res Ther. 2018 Dec 7;10(1):120.


Efficacy, immunogenicity, and safety evaluation of an MF59-adjuvanted quadrivalent influenza virus vaccine compared with non-adjuvanted influenza vaccine in children: a multicentre, randomised controlled, observer-blinded, phase 3 trial.

Vesikari T, Kirstein J, Devota Go G, Leav B, Ruzycky ME, Isakov L, de Bruijn M, Oberye J, Heijnen E.

Lancet Respir Med. 2018 May;6(5):345-356. doi: 10.1016/S2213-2600(18)30108-5. Epub 2018 Apr 6.


Dynamic recruitment of ubiquitin to mutant huntingtin inclusion bodies.

Juenemann K, Jansen AHP, van Riel L, Merkx R, Mulder MPC, An H, Statsyuk A, Kirstein J, Ovaa H, Reits EA.

Sci Rep. 2018 Jan 23;8(1):1405. doi: 10.1038/s41598-018-19538-0.


Complete suppression of Htt fibrilization and disaggregation of Htt fibrils by a trimeric chaperone complex.

Scior A, Buntru A, Arnsburg K, Ast A, Iburg M, Juenemann K, Pigazzini ML, Mlody B, Puchkov D, Priller J, Wanker EE, Prigione A, Kirstein J.

EMBO J. 2018 Jan 17;37(2):282-299. doi: 10.15252/embj.201797212. Epub 2017 Dec 6.


In vivo properties of the disaggregase function of J-proteins and Hsc70 in Caenorhabditis elegans stress and aging.

Kirstein J, Arnsburg K, Scior A, Szlachcic A, Guilbride DL, Morimoto RI, Bukau B, Nillegoda NB.

Aging Cell. 2017 Dec;16(6):1414-1424. doi: 10.1111/acel.12686. Epub 2017 Oct 10.


Reduced Insulin/IGF-1 Signaling Restores the Dynamic Properties of Key Stress Granule Proteins during Aging.

Lechler MC, Crawford ED, Groh N, Widmaier K, Jung R, Kirstein J, Trinidad JC, Burlingame AL, David DC.

Cell Rep. 2017 Jan 10;18(2):454-467. doi: 10.1016/j.celrep.2016.12.033.


Cellular strategies to cope with protein aggregation.

Scior A, Juenemann K, Kirstein J.

Essays Biochem. 2016 Oct 15;60(2):153-161. Review.


Interplay between redox and protein homeostasis.

Feleciano DR, Arnsburg K, Kirstein J.

Worm. 2016 Mar 30;5(2):e1170273. doi: 10.1080/21624054.2016.1170273. eCollection 2016 Apr-Jun. Review.


Collapse of redox homeostasis during aging and stress.

Feleciano DR, Kirstein J.

Mol Cell Oncol. 2015 Nov 11;3(2):e1091060. doi: 10.1080/23723556.2015.1091060. eCollection 2016 Mar.


Primary melanoma tumor inhibits metastasis through alterations in systemic hemostasis.

Kirstein JM, Hague MN, McGowan PM, Tuck AB, Chambers AF.

J Mol Med (Berl). 2016 Aug;94(8):899-910. doi: 10.1007/s00109-016-1415-2. Epub 2016 Apr 6.


Comparative Assessment of a Single Dose and a 2-dose Vaccination Series of a Quadrivalent Meningococcal CRM-conjugate Vaccine (MenACWY-CRM) in Children 2-10 Years of Age.

Johnston W, Essink B, Kirstein J, Forleo-Neto E, Percell S, Han L, Keshavan P, Smolenov I.

Pediatr Infect Dis J. 2016 Jan;35(1):e19-27. doi: 10.1097/INF.0000000000000931.


Safety and immunogenicity of different doses and schedules of a live attenuated tetravalent dengue vaccine (TDV) in healthy adults: A Phase 1b randomized study.

Rupp R, Luckasen GJ, Kirstein JL, Osorio JE, Santangelo JD, Raanan M, Smith MK, Wallace D, Gordon GS, Stinchcomb DT.

Vaccine. 2015 Nov 17;33(46):6351-9. doi: 10.1016/j.vaccine.2015.09.008. Epub 2015 Sep 15.


Crucial HSP70 co-chaperone complex unlocks metazoan protein disaggregation.

Nillegoda NB, Kirstein J, Szlachcic A, Berynskyy M, Stank A, Stengel F, Arnsburg K, Gao X, Scior A, Aebersold R, Guilbride DL, Wade RC, Morimoto RI, Mayer MP, Bukau B.

Nature. 2015 Aug 13;524(7564):247-51. doi: 10.1038/nature14884. Epub 2015 Aug 5.


Proteotoxic stress and ageing triggers the loss of redox homeostasis across cellular compartments.

Kirstein J, Morito D, Kakihana T, Sugihara M, Minnen A, Hipp MS, Nussbaum-Krammer C, Kasturi P, Hartl FU, Nagata K, Morimoto RI.

EMBO J. 2015 Sep 14;34(18):2334-49. doi: 10.15252/embj.201591711. Epub 2015 Jul 29.


In-depth profiling of the LiaR response of Bacillus subtilis.

Wolf D, Kalamorz F, Wecke T, Juszczak A, Mäder U, Homuth G, Jordan S, Kirstein J, Hoppert M, Voigt B, Hecker M, Mascher T.

J Bacteriol. 2010 Sep;192(18):4680-93. doi: 10.1128/JB.00543-10. Epub 2010 Jul 16.


The antibiotic ADEP reprogrammes ClpP, switching it from a regulated to an uncontrolled protease.

Kirstein J, Hoffmann A, Lilie H, Schmidt R, Rübsamen-Waigmann H, Brötz-Oesterhelt H, Mogk A, Turgay K.

EMBO Mol Med. 2009 Apr;1(1):37-49. doi: 10.1002/emmm.200900002.


Micrometastatic disease and metastatic outgrowth: clinical issues and experimental approaches.

McGowan PM, Kirstein JM, Chambers AF.

Future Oncol. 2009 Sep;5(7):1083-98. doi: 10.2217/fon.09.73. Review.


Adapting the machine: adaptor proteins for Hsp100/Clp and AAA+ proteases.

Kirstein J, Molière N, Dougan DA, Turgay K.

Nat Rev Microbiol. 2009 Aug;7(8):589-99. doi: 10.1038/nrmicro2185. Review.


Effect of anti-fibrinolytic therapy on experimental melanoma metastasis.

Kirstein JM, Graham KC, Mackenzie LT, Johnston DE, Martin LJ, Tuck AB, MacDonald IC, Chambers AF.

Clin Exp Metastasis. 2009;26(2):121-31. doi: 10.1007/s10585-008-9221-z. Epub 2008 Dec 12.


Localization of general and regulatory proteolysis in Bacillus subtilis cells.

Kirstein J, Strahl H, Molière N, Hamoen LW, Turgay K.

Mol Microbiol. 2008 Nov;70(3):682-94. doi: 10.1111/j.1365-2958.2008.06438.x. Epub 2008 Sep 10.


Protein disaggregation by the AAA+ chaperone ClpB involves partial threading of looped polypeptide segments.

Haslberger T, Zdanowicz A, Brand I, Kirstein J, Turgay K, Mogk A, Bukau B.

Nat Struct Mol Biol. 2008 Jun;15(6):641-50. doi: 10.1038/nsmb.1425. Epub 2008 May 18.


Conserved residues in the N-domain of the AAA+ chaperone ClpA regulate substrate recognition and unfolding.

Erbse AH, Wagner JN, Truscott KN, Spall SK, Kirstein J, Zeth K, Turgay K, Mogk A, Bukau B, Dougan DA.

FEBS J. 2008 Apr;275(7):1400-10. doi: 10.1111/j.1742-4658.2008.06304.x. Epub 2008 Feb 14.


Diffusion of oriented single molecules with switchable mobility in networks of long unidimensional nanochannels.

Jung C, Kirstein J, Platschek B, Bein T, Budde M, Frank I, Müllen K, Michaelis J, Bräuchle C.

J Am Chem Soc. 2008 Feb 6;130(5):1638-48. doi: 10.1021/ja075927e. Epub 2008 Jan 15.


Visualizing single-molecule diffusion in mesoporous materials.

Zürner A, Kirstein J, Döblinger M, Bräuchle C, Bein T.

Nature. 2007 Nov 29;450(7170):705-8.


The tyrosine kinase McsB is a regulated adaptor protein for ClpCP.

Kirstein J, Dougan DA, Gerth U, Hecker M, Turgay K.

EMBO J. 2007 Apr 18;26(8):2061-70. Epub 2007 Mar 22.


Exploration of nanostructured channel systems with single-molecule probes.

Kirstein J, Platschek B, Jung C, Brown R, Bein T, Bräuchle C.

Nat Mater. 2007 Apr;6(4):303-10. Epub 2007 Mar 11.


Adaptor protein controlled oligomerization activates the AAA+ protein ClpC.

Kirstein J, Schlothauer T, Dougan DA, Lilie H, Tischendorf G, Mogk A, Bukau B, Turgay K.

EMBO J. 2006 Apr 5;25(7):1481-91. Epub 2006 Mar 9.


A new tyrosine phosphorylation mechanism involved in signal transduction in Bacillus subtilis.

Kirstein J, Turgay K.

J Mol Microbiol Biotechnol. 2005;9(3-4):182-8. Review.


Cyanobacterial ClpC/HSP100 protein displays intrinsic chaperone activity.

Andersson FI, Blakytny R, Kirstein J, Turgay K, Bukau B, Mogk A, Clarke AK.

J Biol Chem. 2006 Mar 3;281(9):5468-75. Epub 2005 Dec 16.


A tyrosine kinase and its activator control the activity of the CtsR heat shock repressor in B. subtilis.

Kirstein J, Zühlke D, Gerth U, Turgay K, Hecker M.

EMBO J. 2005 Oct 5;24(19):3435-45. Epub 2005 Sep 15.


Rebuilding Family Relationship Competencies as a Primary Health Intervention.

Reiss-Brennan B, Oppenheim D, Kirstein JL.

Prim Care Companion J Clin Psychiatry. 2002 Apr;4(2):41-53.


Fine-tuning in regulation of Clp protein content in Bacillus subtilis.

Gerth U, Kirstein J, Mostertz J, Waldminghaus T, Miethke M, Kock H, Hecker M.

J Bacteriol. 2004 Jan;186(1):179-91.


Binding of sigma(A) and sigma(B) to core RNA polymerase after environmental stress in Bacillus subtilis.

Rollenhagen C, Antelmann H, Kirstein J, Delumeau O, Hecker M, Yudkin MD.

J Bacteriol. 2003 Jan;185(1):35-40.


Organ retrieval trends in southern Alberta, Canada.

Werner G, Kirstein J, Shewchuk M, Sutherland F.

Transplant Proc. 1996 Feb;28(1):276-7. No abstract available.


An animal model of reversible cardiac edema.

Mandin H, Alexander F, Kirstein J.

Kidney Int. 1975 Jun;7(6):433-6. No abstract available.


Fetus in fetu and teratoma. A case report and review.

Du Plessis JP, Winship WS, Kirstein JD.

S Afr Med J. 1974 Oct 16;48(50):2119-22. No abstract available.


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