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Items: 1 to 50 of 68

1.
2.

Loss of ALBINO3b Insertase Results in Truncated Light-Harvesting Antenna in Diatoms.

Nymark M, Volpe C, Hafskjold MCG, Kirst H, Serif M, Vadstein O, Bones AM, Melis A, Winge P.

Plant Physiol. 2019 Nov;181(3):1257-1276. doi: 10.1104/pp.19.00868. Epub 2019 Aug 29.

3.

Heterohexamers Formed by CcmK3 and CcmK4 Increase the Complexity of Beta Carboxysome Shells.

Sommer M, Sutter M, Gupta S, Kirst H, Turmo A, Lechno-Yossef S, Burton RL, Saechao C, Sloan NB, Cheng X, Chan LG, Petzold CJ, Fuentes-Cabrera M, Ralston CY, Kerfeld CA.

Plant Physiol. 2019 Jan;179(1):156-167. doi: 10.1104/pp.18.01190. Epub 2018 Nov 2.

4.

Downregulation of the CpSRP43 gene expression confers a truncated light-harvesting antenna (TLA) and enhances biomass and leaf-to-stem ratio in Nicotiana tabacum canopies.

Kirst H, Shen Y, Vamvaka E, Betterle N, Xu D, Warek U, Strickland JA, Melis A.

Planta. 2018 Jul;248(1):139-154. doi: 10.1007/s00425-018-2889-7. Epub 2018 Apr 6.

PMID:
29623472
5.

Deletion of the chloroplast LTD protein impedes LHCI import and PSI-LHCI assembly in Chlamydomonas reinhardtii.

Jeong J, Baek K, Yu J, Kirst H, Betterle N, Shin W, Bae S, Melis A, Jin E.

J Exp Bot. 2018 Feb 23;69(5):1147-1158. doi: 10.1093/jxb/erx457.

6.

Engineering Isoprene Synthase Expression and Activity in Cyanobacteria.

Chaves JE, Rueda-Romero P, Kirst H, Melis A.

ACS Synth Biol. 2017 Dec 15;6(12):2281-2292. doi: 10.1021/acssynbio.7b00214. Epub 2017 Aug 31.

PMID:
28858481
7.

Photosynthetic antenna engineering to improve crop yields.

Kirst H, Gabilly ST, Niyogi KK, Lemaux PG, Melis A.

Planta. 2017 May;245(5):1009-1020. doi: 10.1007/s00425-017-2659-y. Epub 2017 Feb 10.

PMID:
28188423
8.

Loss of CpSRP54 function leads to a truncated light-harvesting antenna size in Chlamydomonas reinhardtii.

Jeong J, Baek K, Kirst H, Melis A, Jin E.

Biochim Biophys Acta Bioenerg. 2017 Jan;1858(1):45-55. doi: 10.1016/j.bbabio.2016.10.007. Epub 2016 Oct 17.

9.

Role of isopentenyl-diphosphate isomerase in heterologous cyanobacterial (Synechocystis) isoprene production.

Chaves JE, Romero PR, Kirst H, Melis A.

Photosynth Res. 2016 Dec;130(1-3):517-527. Epub 2016 Jul 13.

PMID:
27412351
10.

Circumventing resistance to anti-infective agents.

Kirst HA.

Expert Opin Pharmacother. 2015 Feb;16(2):149-50. doi: 10.1517/14656566.2015.1002669. Epub 2015 Jan 5. No abstract available.

PMID:
25556824
11.

Maximizing photosynthetic efficiency and culture productivity in cyanobacteria upon minimizing the phycobilisome light-harvesting antenna size.

Kirst H, Formighieri C, Melis A.

Biochim Biophys Acta. 2014 Oct;1837(10):1653-64. doi: 10.1016/j.bbabio.2014.07.009. Epub 2014 Jul 18.

12.

13th International Conference on the Chemistry of Antibiotics and Other Bioactive Compounds (ICCA-13).

Kirst HA.

J Antibiot (Tokyo). 2014 Mar;67(3):269-72. doi: 10.1038/ja.2013.131. Epub 2013 Dec 4. No abstract available.

PMID:
24301186
13.

The chloroplast signal recognition particle (CpSRP) pathway as a tool to minimize chlorophyll antenna size and maximize photosynthetic productivity.

Kirst H, Melis A.

Biotechnol Adv. 2014 Jan-Feb;32(1):66-72. doi: 10.1016/j.biotechadv.2013.08.018. Epub 2013 Sep 4. Review.

PMID:
24013010
14.

Prologue to the special issue on synthesis.

Kirst HA, Takahashi Y.

J Antibiot (Tokyo). 2013 Mar;66(3):105. doi: 10.1038/ja.2013.6. No abstract available.

PMID:
23532018
15.

Developing new antibacterials through natural product research.

Kirst HA.

Expert Opin Drug Discov. 2013 May;8(5):479-93. doi: 10.1517/17460441.2013.779666. Epub 2013 Mar 12. Review.

PMID:
23480029
16.

Modulation of the light-harvesting chlorophyll antenna size in Chlamydomonas reinhardtii by TLA1 gene over-expression and RNA interference.

Mitra M, Kirst H, Dewez D, Melis A.

Philos Trans R Soc Lond B Biol Sci. 2012 Dec 19;367(1608):3430-43. doi: 10.1098/rstb.2012.0229.

17.

Truncated photosystem chlorophyll antenna size in the green microalga Chlamydomonas reinhardtii upon deletion of the TLA3-CpSRP43 gene.

Kirst H, Garcia-Cerdan JG, Zurbriggen A, Ruehle T, Melis A.

Plant Physiol. 2012 Dec;160(4):2251-60. doi: 10.1104/pp.112.206672. Epub 2012 Oct 5.

18.

12th International Conference on the Chemistry of Antibiotics and other Bioactive Compounds (ICCA-12).

Kirst HA.

J Antibiot (Tokyo). 2012 Mar;65(3):173-174. doi: 10.1038/ja.2011.119. Epub 2011 Dec 14. No abstract available.

PMID:
22167158
19.

Recent derivatives from smaller classes of fermentation-derived antibacterials.

Kirst HA.

Expert Opin Ther Pat. 2012 Jan;22(1):15-35. doi: 10.1517/13543776.2012.642370. Epub 2011 Dec 3. Review.

PMID:
22136593
20.

Assembly of the light-harvesting chlorophyll antenna in the green alga Chlamydomonas reinhardtii requires expression of the TLA2-CpFTSY gene.

Kirst H, García-Cerdán JG, Zurbriggen A, Melis A.

Plant Physiol. 2012 Feb;158(2):930-45. doi: 10.1104/pp.111.189910. Epub 2011 Nov 23.

21.

Antibiotics versus resistant bacteria: a continual challenge.

Kirst HA.

Expert Opin Ther Pat. 2010 Oct;20(10):1271-2. doi: 10.1517/13543776.2010.513908. No abstract available.

PMID:
20839928
22.

New macrolide, lincosaminide and streptogramin B antibiotics.

Kirst HA.

Expert Opin Ther Pat. 2010 Oct;20(10):1343-57. doi: 10.1517/13543776.2010.505921. Review.

PMID:
20645886
23.

The spinosyn family of insecticides: realizing the potential of natural products research.

Kirst HA.

J Antibiot (Tokyo). 2010 Mar;63(3):101-11. doi: 10.1038/ja.2010.5. Epub 2010 Feb 12.

PMID:
20150928
24.

Synthesis and evaluation of a series of 1,4-diarylbutadienes for anticoccidial activity.

Gage JL, Kirst HA, O'Neil D, David BA, Smith CK 2nd, Naylor SA.

Bioorg Med Chem. 2003 Sep 1;11(18):4083-91.

PMID:
12927870
25.

Genetic engineering of aminodeoxyhexose biosynthesis in Streptomyces fradiae.

Butler AR, Bate N, Kiehl DE, Kirst HA, Cundliffe E.

Nat Biotechnol. 2002 Jul;20(7):713-6.

PMID:
12089557
26.

Synthesis and in vitro antimicrobial activity of 3-keto 16-membered macrolides derived from tylosin.

Creemer LC, Toth JE, Kirst HA.

J Antibiot (Tokyo). 2002 Apr;55(4):427-36.

27.

Evaluation and development of spinosyns to control ectoparasites on cattle and sheep.

Kirst HA, Creemer LC, Naylor SA, Pugh PT, Snyder DE, Winkle JR, Lowe LB, Rothwell JT, Sparks TC, Worden TV.

Curr Top Med Chem. 2002 Jul;2(7):675-99. Review.

PMID:
12052185
28.
29.

The stereochemical outcome of electrophilic addition reactions on the 5,6-double bond in the spinosyns.

De Amicis CV, Graupner PR, Erickson JA, Paschal JW, Kirst HA, Creemer LC, Fanwick PE.

J Org Chem. 2001 Dec 14;66(25):8431-5.

PMID:
11735521
30.
31.

The antibacterial and NMDA receptor activating properties of aminoglycosides are dissociable.

Harvey SC, Li X, Skolnick P, Kirst HA.

Eur J Pharmacol. 2000 Jan 3;387(1):1-7.

PMID:
10633153
32.

Conversion of spinosyn A and spinosyn D to their respective 9- and 17-pseudoaglycones and their aglycones.

Creemer LC, Kirst HA, Paschal JW.

J Antibiot (Tokyo). 1998 Aug;51(8):795-800.

33.

Historical yearly usage of vancomycin.

Kirst HA, Thompson DG, Nicas TI.

Antimicrob Agents Chemother. 1998 May;42(5):1303-4. No abstract available.

34.

Macrolide antibiotics in food-animal health.

Kirst HA.

Expert Opin Investig Drugs. 1997 Feb;6(2):103-18.

PMID:
15989594
35.

Synthesis and in vitro evaluation of new wortmannin esters: potent inhibitors of phosphatidylinositol 3-kinase.

Creemer LC, Kirst HA, Vlahos CJ, Schultz RM.

J Med Chem. 1996 Dec 6;39(25):5021-4.

PMID:
8960564
36.

Structure of the spiroketal-macrolide ossamycin.

Kirst HA, Mynderse JS, Martin JW, Baker PJ, Paschal JW, Rios Steiner JL, Lobkovsky E, Clardy J.

J Antibiot (Tokyo). 1996 Feb;49(2):162-7.

37.

Structure of the new spiroketal-macrolide A82548A.

Kirst HA, Larsen SH, Paschal JW, Occolowitz JL, Creemer LC, Steiner JL, Lobkovsky E, Clardy J.

J Antibiot (Tokyo). 1995 Sep;48(9):990-6.

38.

Synthesis, antimicrobial activity and in vivo fluorine NMR of a hexafluorinated derivative of tilmicosin.

Creemer LC, Kirst HA, Shryock TR, Campbell JB, Webb AG.

J Antibiot (Tokyo). 1995 Jul;48(7):671-5.

39.

Antimicrobial characterization and interrelationships of dirithromycin and epidirithromycin.

Kirst HA, Creemer LC, Paschal JW, Preston DA, Alborn WE Jr, Counter FT, Amos JG, Clemens RL, Sullivan KA, Greene JM.

Antimicrob Agents Chemother. 1995 Jul;39(7):1436-41.

40.

Effects of LY267108, an erythromycin analogue derivative, on lower esophageal sphincter function in the cat.

Greenwood B, Dieckman D, Kirst HA, Gidda JS.

Gastroenterology. 1994 Mar;106(3):624-8.

PMID:
8119532
41.

Semi-synthetic derivatives of 16-membered macrolide antibiotics.

Kirst HA.

Prog Med Chem. 1994;31:265-95. Review.

PMID:
8029476
42.

Semi-synthetic derivatives of erythromycin.

Kirst HA.

Prog Med Chem. 1993;30:57-88. Review.

PMID:
8303037
43.

New macrolides: expanded horizons for an old class of antibiotics.

Kirst HA.

J Antimicrob Chemother. 1991 Dec;28(6):787-90. Review. No abstract available.

PMID:
1667781
44.

Synthesis and antimicrobial evaluation of dirithromycin (AS-E 136; LY237216), a new macrolide antibiotic derived from erythromycin.

Counter FT, Ensminger PW, Preston DA, Wu CY, Greene JM, Felty-Duckworth AM, Paschal JW, Kirst HA.

Antimicrob Agents Chemother. 1991 Jun;35(6):1116-26.

45.

Comparative activity of macrolides against Toxoplasma gondii demonstrating utility of an in vitro microassay.

Chamberland S, Kirst HA, Current WL.

Antimicrob Agents Chemother. 1991 May;35(5):903-9.

46.

Synthesis and structure-activity relationships of new 9-N-alkyl derivatives of 9(S)-erythromycylamine.

Kirst HA, Wind JA, Leeds JP, Willard KE, Debono M, Bonjouklian R, Greene JM, Sullivan KA, Paschal JW, Deeter JB, et al.

J Med Chem. 1990 Nov;33(11):3086-94.

PMID:
2231610
47.

Branched-chain fatty acids produced by mutants of Streptomyces fradiae, putative precursors of the lactone ring of tylosin.

Huber ML, Paschal JW, Leeds JP, Kirst HA, Wind JA, Miller FD, Turner JR.

Antimicrob Agents Chemother. 1990 Aug;34(8):1535-41.

48.

Structure-activity studies of 20-deoxo-20-amino derivatives of tylosin-related macrolides.

Kirst HA, Willard KE, Debono M, Toth JE, Truedell BA, Leeds JP, Ott JL, Felty-Duckworth AM, Counter FT, Ose EE, et al.

J Antibiot (Tokyo). 1989 Nov;42(11):1673-83.

49.

New directions for macrolide antibiotics: pharmacokinetics and clinical efficacy.

Kirst HA, Sides GD.

Antimicrob Agents Chemother. 1989 Sep;33(9):1419-22. Review.

50.

New directions for macrolide antibiotics: structural modifications and in vitro activity.

Kirst HA, Sides GD.

Antimicrob Agents Chemother. 1989 Sep;33(9):1413-8. Review. No abstract available.

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