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Items: 19


AP-1 Signaling by Fra-1 Directly Regulates HMGA1 Oncogene Transcription in Triple-Negative Breast Cancers.

Tolza C, Bejjani F, Evanno E, Mahfoud S, Moquet-Torcy G, Gostan T, Maqbool MA, Kirsh O, Piechaczyk M, Jariel-Encontre I.

Mol Cancer Res. 2019 Oct;17(10):1999-2014. doi: 10.1158/1541-7786.MCR-19-0036. Epub 2019 Jul 12.


Genetic screens reveal mechanisms for the transcriptional regulation of tissue-specific genes in normal cells and tumors.

Naciri I, Laisné M, Ferry L, Bourmaud M, Gupta N, Di Carlo S, Huna A, Martin N, Peduto L, Bernard D, Kirsh O, Defossez PA.

Nucleic Acids Res. 2019 Apr 23;47(7):3407-3421. doi: 10.1093/nar/gkz080.


Mechanisms of DNA Methyltransferase Recruitment in Mammals.

Laisné M, Gupta N, Kirsh O, Pradhan S, Defossez PA.

Genes (Basel). 2018 Dec 10;9(12). pii: E617. doi: 10.3390/genes9120617. Review.


The nuclear receptor RXRA controls cellular senescence by regulating calcium signaling.

Ma X, Warnier M, Raynard C, Ferrand M, Kirsh O, Defossez PA, Martin N, Bernard D.

Aging Cell. 2018 Dec;17(6):e12831. doi: 10.1111/acel.12831. Epub 2018 Sep 14.


[Unexpected roles for a methyl-binding protein in cancer].

Naciri I, Roussel-Gervais A, Defossez PA, Kirsh O.

Med Sci (Paris). 2017 Aug-Sep;33(8-9):714-716. doi: 10.1051/medsci/20173308009. Epub 2017 Sep 18. French. No abstract available.


Methylation of DNA Ligase 1 by G9a/GLP Recruits UHRF1 to Replicating DNA and Regulates DNA Methylation.

Ferry L, Fournier A, Tsusaka T, Adelmant G, Shimazu T, Matano S, Kirsh O, Amouroux R, Dohmae N, Suzuki T, Filion GJ, Deng W, de Dieuleveult M, Fritsch L, Kudithipudi S, Jeltsch A, Leonhardt H, Hajkova P, Marto JA, Arita K, Shinkai Y, Defossez PA.

Mol Cell. 2017 Aug 17;67(4):550-565.e5. doi: 10.1016/j.molcel.2017.07.012. Epub 2017 Aug 10.


Loss of the Methyl-CpG-Binding Protein ZBTB4 Alters Mitotic Checkpoint, Increases Aneuploidy, and Promotes Tumorigenesis.

Roussel-Gervais A, Naciri I, Kirsh O, Kasprzyk L, Velasco G, Grillo G, Dubus P, Defossez PA.

Cancer Res. 2017 Jan 1;77(1):62-73. doi: 10.1158/0008-5472.CAN-16-1181. Epub 2016 Nov 4.


E4F1 controls a transcriptional program essential for pyruvate dehydrogenase activity.

Lacroix M, Rodier G, Kirsh O, Houles T, Delpech H, Seyran B, Gayte L, Casas F, Pessemesse L, Heuillet M, Bellvert F, Portais JC, Berthet C, Bernex F, Brivet M, Boutron A, Le Cam L, Sardet C.

Proc Natl Acad Sci U S A. 2016 Sep 27;113(39):10998-1003. doi: 10.1073/pnas.1602754113. Epub 2016 Sep 12.


E4F1-mediated control of pyruvate dehydrogenase activity is essential for skin homeostasis.

Goguet-Rubio P, Seyran B, Gayte L, Bernex F, Sutter A, Delpech H, Linares LK, Riscal R, Repond C, Rodier G, Kirsh O, Touhami J, Noel J, Vincent C, Pirot N, Pavlovic G, Herault Y, Sitbon M, Pellerin L, Sardet C, Lacroix M, Le Cam L.

Proc Natl Acad Sci U S A. 2016 Sep 27;113(39):11004-9. doi: 10.1073/pnas.1602751113. Epub 2016 Sep 12.


Screening of a kinase library reveals novel pro-senescence kinases and their common NF-κB-dependent transcriptional program.

Ferrand M, Kirsh O, Griveau A, Vindrieux D, Martin N, Defossez PA, Bernard D.

Aging (Albany NY). 2015 Nov;7(11):986-1003.


Description of an optimized ChIP-seq analysis pipeline dedicated to genome wide identification of E4F1 binding sites in primary and transformed MEFs.

Houlès T, Rodier G, Le Cam L, Sardet C, Kirsh O.

Genom Data. 2015 Jul 14;5:368-70. doi: 10.1016/j.gdata.2015.07.004. eCollection 2015 Sep.


The transcription factor E4F1 coordinates CHK1-dependent checkpoint and mitochondrial functions.

Rodier G, Kirsh O, Baraibar M, Houlès T, Lacroix M, Delpech H, Hatchi E, Arnould S, Severac D, Dubois E, Caramel J, Julien E, Friguet B, Le Cam L, Sardet C.

Cell Rep. 2015 Apr 14;11(2):220-33. doi: 10.1016/j.celrep.2015.03.024. Epub 2015 Apr 2.


E4F1 deficiency results in oxidative stress-mediated cell death of leukemic cells.

Hatchi E, Rodier G, Lacroix M, Caramel J, Kirsh O, Jacquet C, Schrepfer E, Lagarrigue S, Linares LK, Lledo G, Tondeur S, Dubus P, Sardet C, Le Cam L.

J Exp Med. 2011 Jul 4;208(7):1403-17. doi: 10.1084/jem.20101995. Epub 2011 Jun 27.


Coupling mitosis to DNA replication: the emerging role of the histone H4-lysine 20 methyltransferase PR-Set7.

Brustel J, Tardat M, Kirsh O, Grimaud C, Julien E.

Trends Cell Biol. 2011 Aug;21(8):452-60. doi: 10.1016/j.tcb.2011.04.006. Epub 2011 May 31. Review.


The histone H4 Lys 20 methyltransferase PR-Set7 regulates replication origins in mammalian cells.

Tardat M, Brustel J, Kirsh O, Lefevbre C, Callanan M, Sardet C, Julien E.

Nat Cell Biol. 2010 Nov;12(11):1086-93. doi: 10.1038/ncb2113. Epub 2010 Oct 17.


FLI-1 functionally interacts with PIASxalpha, a member of the PIAS E3 SUMO ligase family.

van den Akker E, Ano S, Shih HM, Wang LC, Pironin M, Palvimo JJ, Kotaja N, Kirsh O, Dejean A, Ghysdael J.

J Biol Chem. 2005 Nov 11;280(45):38035-46. Epub 2005 Sep 7.


Deconstructing PML-induced premature senescence.

Bischof O, Kirsh O, Pearson M, Itahana K, Pelicci PG, Dejean A.

EMBO J. 2002 Jul 1;21(13):3358-69.


The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase.

Kirsh O, Seeler JS, Pichler A, Gast A, Müller S, Miska E, Mathieu M, Harel-Bellan A, Kouzarides T, Melchior F, Dejean A.

EMBO J. 2002 Jun 3;21(11):2682-91.

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