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TLR2 Stimulation Increases Cellular Metabolism in CD8+ T Cells and Thereby Enhances CD8+ T Cell Activation, Function, and Antiviral Activity.

Zhang E, Ma Z, Li Q, Yan H, Liu J, Wu W, Guo J, Zhang X, Kirschning CJ, Xu H, Lang PA, Yang D, Dittmer U, Yan H, Lu M.

J Immunol. 2019 Oct 21. pii: ji1900065. doi: 10.4049/jimmunol.1900065. [Epub ahead of print]


Mycobacteria exploit nitric oxide-induced transformation of macrophages into permissive giant cells.

Gharun K, Senges J, Seidl M, Lösslein A, Kolter J, Lohrmann F, Fliegauf M, Elgizouli M, Alber M, Vavra M, Schachtrup K, Illert AL, Gilleron M, Kirschning CJ, Triantafyllopoulou A, Henneke P.

EMBO Rep. 2018 Dec;19(12). pii: e47190. doi: 10.15252/embr.201847190. No abstract available.


Antibiotic treatment-induced secondary IgA deficiency enhances susceptibility to Pseudomonas aeruginosa pneumonia.

Robak OH, Heimesaat MM, Kruglov AA, Prepens S, Ninnemann J, Gutbier B, Reppe K, Hochrein H, Suter M, Kirschning CJ, Marathe V, Buer J, Hornef MW, Schnare M, Schneider P, Witzenrath M, Bereswill S, Steinhoff U, Suttorp N, Sander LE, Chaput C, Opitz B.

J Clin Invest. 2018 Aug 1;128(8):3535-3545. doi: 10.1172/JCI97065. Epub 2018 Jul 16.


Mycobacteria exploit nitric oxide-induced transformation of macrophages into permissive giant cells.

Gharun K, Senges J, Seidl M, Lösslein A, Kolter J, Lohrmann F, Fliegauf M, Elgizouli M, Alber M, Vavra M, Schachtrup K, Illert AL, Gilleron M, Kirschning CJ, Triantafyllopoulou A, Henneke P.

EMBO Rep. 2017 Dec;18(12):2144-2159. doi: 10.15252/embr.201744121. Epub 2017 Nov 2. Erratum in: EMBO Rep. 2018 Dec;19(12):.


Decreased Secondary Lesion Growth and Attenuated Immune Response after Traumatic Brain Injury in Tlr2/4-/- Mice.

Krieg SM, Voigt F, Knuefermann P, Kirschning CJ, Plesnila N, Ringel F.

Front Neurol. 2017 Aug 30;8:455. doi: 10.3389/fneur.2017.00455. eCollection 2017.


Porphyromonas gingivalis Stimulates TLR2-PI3K Signaling to Escape Immune Clearance and Induce Bone Resorption Independently of MyD88.

Makkawi H, Hoch S, Burns E, Hosur K, Hajishengallis G, Kirschning CJ, Nussbaum G.

Front Cell Infect Microbiol. 2017 Aug 8;7:359. doi: 10.3389/fcimb.2017.00359. eCollection 2017.


The IL-1R/TLR signaling pathway is essential for efficient CD8+ T-cell responses against hepatitis B virus in the hydrodynamic injection mouse model.

Ma Z, Liu J, Wu W, Zhang E, Zhang X, Li Q, Zelinskyy G, Buer J, Dittmer U, Kirschning CJ, Lu M.

Cell Mol Immunol. 2017 Dec;14(12):997-1008. doi: 10.1038/cmi.2017.43. Epub 2017 Jul 31.


Combined toll-like receptor 3/7/9 deficiency on host cells results in T-cell-dependent control of tumour growth.

Klein JC, Moses K, Zelinskyy G, Sody S, Buer J, Lang S, Helfrich I, Dittmer U, Kirschning CJ, Brandau S.

Nat Commun. 2017 Mar 16;8:14600. doi: 10.1038/ncomms14600.


RAIDD Mediates TLR3 and IRF7 Driven Type I Interferon Production.

Maney SK, Xu HC, Huang J, Pandyra AA, Ehlting C, Aguilar-Valenzuela R, Pozdeev VI, McIlwain DR, Zimmermann A, Bode JG, Hengel H, Kirschning CJ, Kim IR, Hiscott J, Brenner D, Häussinger D, Ohashi PS, Mak TW, Lang KS, Lang PA.

Cell Physiol Biochem. 2016;39(4):1271-80. doi: 10.1159/000447832. Epub 2016 Sep 8.


Endosomal recognition of Lactococcus lactis G121 and its RNA by dendritic cells is key to its allergy-protective effects.

Stein K, Brand S, Jenckel A, Sigmund A, Chen ZJ, Kirschning CJ, Kauth M, Heine H.

J Allergy Clin Immunol. 2017 Feb;139(2):667-678.e5. doi: 10.1016/j.jaci.2016.06.018. Epub 2016 Jul 15.


CCL2 expression is mediated by type I IFN receptor and recruits NK and T cells to the lung during MVA infection.

Lehmann MH, Torres-Domínguez LE, Price PJ, Brandmüller C, Kirschning CJ, Sutter G.

J Leukoc Biol. 2016 Jun;99(6):1057-64. doi: 10.1189/jlb.4MA0815-376RR. Epub 2016 Mar 18. Review.


Streptococci Engage TLR13 on Myeloid Cells in a Site-Specific Fashion.

Kolter J, Feuerstein R, Spoeri E, Gharun K, Elling R, Trieu-Cuot P, Goldmann T, Waskow C, Chen ZJ, Kirschning CJ, Deshmukh SD, Henneke P.

J Immunol. 2016 Mar 15;196(6):2733-41. doi: 10.4049/jimmunol.1501014. Epub 2016 Feb 12.


Human TLR8 senses UR/URR motifs in bacterial and mitochondrial RNA.

Krüger A, Oldenburg M, Chebrolu C, Beisser D, Kolter J, Sigmund AM, Steinmann J, Schäfer S, Hochrein H, Rahmann S, Wagner H, Henneke P, Hornung V, Buer J, Kirschning CJ.

EMBO Rep. 2015 Dec;16(12):1656-63. doi: 10.15252/embr.201540861. Epub 2015 Nov 6.


Species and mediator specific TLR4 antagonism in primary human and murine immune cells by βGlcN(1↔1)αGlc based lipid A mimetics.

Chebrolu C, Artner D, Sigmund AM, Buer J, Zamyatina A, Kirschning CJ.

Mol Immunol. 2015 Oct;67(2 Pt B):636-41. doi: 10.1016/j.molimm.2015.07.037. Epub 2015 Aug 28.


Innate immune response to Streptococcus pyogenes depends on the combined activation of TLR13 and TLR2.

Fieber C, Janos M, Koestler T, Gratz N, Li XD, Castiglia V, Aberle M, Sauert M, Wegner M, Alexopoulou L, Kirschning CJ, Chen ZJ, von Haeseler A, Kovarik P.

PLoS One. 2015 Mar 10;10(3):e0119727. doi: 10.1371/journal.pone.0119727. eCollection 2015.


Prophylactic and therapeutic vaccination with a nanoparticle-based peptide vaccine induces efficient protective immunity during acute and chronic retroviral infection.

Knuschke T, Bayer W, Rotan O, Sokolova V, Wadwa M, Kirschning CJ, Hansen W, Dittmer U, Epple M, Buer J, Westendorf AM.

Nanomedicine. 2014 Nov;10(8):1787-98. doi: 10.1016/j.nano.2014.06.014. Epub 2014 Jul 9.


Chemokine (C-C Motif) receptor 1 is required for efficient recruitment of neutrophils during respiratory infection with modified vaccinia virus Ankara.

Price PJ, Luckow B, Torres-Domínguez LE, Brandmüller C, Zorn J, Kirschning CJ, Sutter G, Lehmann MH.

J Virol. 2014 Sep;88(18):10840-50. doi: 10.1128/JVI.01524-14. Epub 2014 Jul 9.


Multiple roles of Myd88 in the immune response to the plague F1-V vaccine and in protection against an aerosol challenge of Yersinia pestis CO92 in mice.

Dankmeyer JL, Fast RL, Cote CK, Worsham PL, Fritz D, Fisher D, Kern SJ, Merkel T, Kirschning CJ, Amemiya K.

J Immunol Res. 2014;2014:341820. doi: 10.1155/2014/341820. Epub 2014 Jun 4.


TLR-independent and P2X7-dependent signaling mediate Alu RNA-induced NLRP3 inflammasome activation in geographic atrophy.

Kerur N, Hirano Y, Tarallo V, Fowler BJ, Bastos-Carvalho A, Yasuma T, Yasuma R, Kim Y, Hinton DR, Kirschning CJ, Gelfand BD, Ambati J.

Invest Ophthalmol Vis Sci. 2013 Nov 11;54(12):7395-401. doi: 10.1167/iovs.13-12500.


Molecular cloning and characterization of a novel anti-TLR9 intrabody.

Reimer E, Somplatzki S, Zegenhagen D, Hänel S, Fels A, Bollhorst T, Hovest LG, Bauer S, Kirschning CJ, Böldicke T.

Cell Mol Biol Lett. 2013 Sep;18(3):433-46. doi: 10.2478/s11658-013-0098-8. Epub 2013 Jul 26.


Nonpathogenic bacteria alleviating atopic dermatitis inflammation induce IL-10-producing dendritic cells and regulatory Tr1 cells.

Volz T, Skabytska Y, Guenova E, Chen KM, Frick JS, Kirschning CJ, Kaesler S, Röcken M, Biedermann T.

J Invest Dermatol. 2014 Jan;134(1):96-104. doi: 10.1038/jid.2013.291. Epub 2013 Jun 28.


Priming of NK cell anti-viral effector mechanisms by direct recognition of human cytomegalovirus.

Muntasell A, Costa-Garcia M, Vera A, Marina-Garcia N, Kirschning CJ, López-Botet M.

Front Immunol. 2013 Feb 21;4:40. doi: 10.3389/fimmu.2013.00040. eCollection 2013.


Primary sterile necrotic cells fail to cross-prime CD8(+) T cells.

Gamrekelashvili J, Ormandy LA, Heimesaat MM, Kirschning CJ, Manns MP, Korangy F, Greten TF.

Oncoimmunology. 2012 Oct 1;1(7):1017-1026.


TLR13 recognizes bacterial 23S rRNA devoid of erythromycin resistance-forming modification.

Oldenburg M, Krüger A, Ferstl R, Kaufmann A, Nees G, Sigmund A, Bathke B, Lauterbach H, Suter M, Dreher S, Koedel U, Akira S, Kawai T, Buer J, Wagner H, Bauer S, Hochrein H, Kirschning CJ.

Science. 2012 Aug 31;337(6098):1111-5. doi: 10.1126/science.1220363. Epub 2012 Jul 19.


TLR9-dependent and independent pathways drive activation of the immune system by Propionibacterium acnes.

Tchaptchet S, Gumenscheimer M, Kalis C, Freudenberg N, Hölscher C, Kirschning CJ, Lamers M, Galanos C, Freudenberg MA.

PLoS One. 2012;7(6):e39155. doi: 10.1371/journal.pone.0039155. Epub 2012 Jun 22.


Bacterial RNA mediates activation of caspase-1 and IL-1β release independently of TLRs 3, 7, 9 and TRIF but is dependent on UNC93B.

Eigenbrod T, Franchi L, Muñoz-Planillo R, Kirschning CJ, Freudenberg MA, Núñez G, Dalpke A.

J Immunol. 2012 Jul 1;189(1):328-36. doi: 10.4049/jimmunol.1103258. Epub 2012 May 25.


Poke weed mitogen requires Toll-like receptor ligands for proliferative activity in human and murine B lymphocytes.

Bekeredjian-Ding I, Foermer S, Kirschning CJ, Parcina M, Heeg K.

PLoS One. 2012;7(1):e29806. doi: 10.1371/journal.pone.0029806. Epub 2012 Jan 4.


Dissection of a type I interferon pathway in controlling bacterial intracellular infection in mice.

Lippmann J, Müller HC, Naujoks J, Tabeling C, Shin S, Witzenrath M, Hellwig K, Kirschning CJ, Taylor GA, Barchet W, Bauer S, Suttorp N, Roy CR, Opitz B.

Cell Microbiol. 2011 Nov;13(11):1668-82. doi: 10.1111/j.1462-5822.2011.01646.x. Epub 2011 Aug 24.


CCL17 controls mast cells for the defense against filarial larval entry.

Specht S, Frank JK, Alferink J, Dubben B, Layland LE, Denece G, Bain O, Förster I, Kirschning CJ, Martin C, Hoerauf A.

J Immunol. 2011 Apr 15;186(8):4845-52. doi: 10.4049/jimmunol.1000612. Epub 2011 Mar 11.


Left ventricular dilation in toll-like receptor 2 deficient mice after myocardial ischemia/reperfusion through defective scar formation.

Mersmann J, Habeck K, Latsch K, Zimmermann R, Jacoby C, Fischer JW, Hartmann C, Schrader J, Kirschning CJ, Zacharowski K.

Basic Res Cardiol. 2011 Jan;106(1):89-98. doi: 10.1007/s00395-010-0127-y. Epub 2010 Oct 22.


Polyinosinic-polycytidylic acid treatment of Friend retrovirus-infected mice improves functional properties of virus-specific T cells and prevents virus-induced disease.

Gibbert K, Dietze KK, Zelinskyy G, Lang KS, Barchet W, Kirschning CJ, Dittmer U.

J Immunol. 2010 Nov 15;185(10):6179-89. doi: 10.4049/jimmunol.1000858. Epub 2010 Oct 13.


Toll-like receptor 2 signaling triggers fatal arrhythmias upon myocardial ischemia-reperfusion.

Mersmann J, Koch A, Tran N, Zimmermann R, Granja TF, Larmann J, Herzog C, Theilmeier G, Bornstein SR, Kirschning CJ, Zacharowski K.

Crit Care Med. 2010 Oct;38(10):1927-32. doi: 10.1097/CCM.0b013e3181ef455b.


Toll-like receptor 3 mediates expression of clusterin/apolipoprotein J in vascular smooth muscle cells stimulated with RNA released from necrotic cells.

Baiersdörfer M, Schwarz M, Seehafer K, Lehmann C, Heit A, Wagner H, Kirschning CJ, Koch-Brandt C.

Exp Cell Res. 2010 Dec 10;316(20):3489-500. doi: 10.1016/j.yexcr.2010.07.022. Epub 2010 Aug 5.


Generation of anti-TLR2 intrabody mediating inhibition of macrophage surface TLR2 expression and TLR2-driven cell activation.

Kirschning CJ, Dreher S, Maass B, Fichte S, Schade J, Köster M, Noack A, Lindenmaier W, Wagner H, Böldicke T.

BMC Biotechnol. 2010 Apr 13;10:31. doi: 10.1186/1472-6750-10-31.


Recipient Toll-like receptors contribute to chronic graft dysfunction by both MyD88- and TRIF-dependent signaling.

Wang S, Schmaderer C, Kiss E, Schmidt C, Bonrouhi M, Porubsky S, Gretz N, Schaefer L, Kirschning CJ, Popovic ZV, Gröne HJ.

Dis Model Mech. 2010 Jan-Feb;3(1-2):92-103. doi: 10.1242/dmm.003533. Epub 2009 Dec 28.


Maternal TLR signaling is required for prenatal asthma protection by the nonpathogenic microbe Acinetobacter lwoffii F78.

Conrad ML, Ferstl R, Teich R, Brand S, Blümer N, Yildirim AO, Patrascan CC, Hanuszkiewicz A, Akira S, Wagner H, Holst O, von Mutius E, Pfefferle PI, Kirschning CJ, Garn H, Renz H.

J Exp Med. 2009 Dec 21;206(13):2869-77. doi: 10.1084/jem.20090845. Epub 2009 Dec 7.


Not interferon, but interleukin-6 controls early gene expression in hepatitis B virus infection.

Hösel M, Quasdorff M, Wiegmann K, Webb D, Zedler U, Broxtermann M, Tedjokusumo R, Esser K, Arzberger S, Kirschning CJ, Langenkamp A, Falk C, Büning H, Rose-John S, Protzer U.

Hepatology. 2009 Dec;50(6):1773-82. doi: 10.1002/hep.23226.


Conventional bone marrow-derived dendritic cells contribute to toll-like receptor-independent production of alpha/beta interferon in response to inactivated parapoxvirus ovis.

Siegemund S, Hartl A, von Buttlar H, Dautel F, Raue R, Freudenberg MA, Fejer G, Büttner M, Köhler G, Kirschning CJ, Sparwasser T, Alber G.

J Virol. 2009 Sep;83(18):9411-22. doi: 10.1128/JVI.02362-08. Epub 2009 Jul 1.


Experimental models of acute infection and Toll-like receptor driven septic shock.

Ferstl R, Spiller S, Fichte S, Dreher S, Kirschning CJ.

Methods Mol Biol. 2009;517:313-27. doi: 10.1007/978-1-59745-541-1_19.


Extracellular and intracellular pattern recognition receptors cooperate in the recognition of Helicobacter pylori.

Rad R, Ballhorn W, Voland P, Eisenächer K, Mages J, Rad L, Ferstl R, Lang R, Wagner H, Schmid RM, Bauer S, Prinz C, Kirschning CJ, Krug A.

Gastroenterology. 2009 Jun;136(7):2247-57. doi: 10.1053/j.gastro.2009.02.066. Epub 2009 Mar 6.


Rare TLR2 mutations reduce TLR2 receptor function and can increase atopy risk.

Kormann MS, Ferstl R, Depner M, Klopp N, Spiller S, Illig T, Vogelberg C, von Mutius E, Kirschning CJ, Kabesch M.

Allergy. 2009 Apr;64(4):636-42. doi: 10.1111/j.1398-9995.2008.01891.x. Epub 2009 Feb 12.


Refining HPV 16 L1 purification from E. coli: reducing endotoxin contaminations and their impact on immunogenicity.

Schädlich L, Senger T, Kirschning CJ, Müller M, Gissmann L.

Vaccine. 2009 Mar 4;27(10):1511-22. doi: 10.1016/j.vaccine.2009.01.014. Epub 2009 Jan 25.


Mammalian target of rapamycin (mTOR) orchestrates the defense program of innate immune cells.

Schmitz F, Heit A, Dreher S, Eisenächer K, Mages J, Haas T, Krug A, Janssen KP, Kirschning CJ, Wagner H.

Eur J Immunol. 2008 Nov;38(11):2981-92. doi: 10.1002/eji.200838761.


Innate immunity to pneumococcal infection of the central nervous system depends on toll-like receptor (TLR) 2 and TLR4.

Klein M, Obermaier B, Angele B, Pfister HW, Wagner H, Koedel U, Kirschning CJ.

J Infect Dis. 2008 Oct 1;198(7):1028-36. doi: 10.1086/591626.


MyD88/IL-18-dependent pathways rather than TLRs control early parasitaemia in non-lethal Plasmodium yoelii infection.

Cramer JP, Lepenies B, Kamena F, Hölscher C, Freudenberg MA, Burchard GD, Wagner H, Kirschning CJ, Liu X, Seeberger PH, Jacobs T.

Microbes Infect. 2008 Oct;10(12-13):1259-65. doi: 10.1016/j.micinf.2008.07.024. Epub 2008 Jul 22.


TLR4-induced IFN-gamma production increases TLR2 sensitivity and drives Gram-negative sepsis in mice.

Spiller S, Elson G, Ferstl R, Dreher S, Mueller T, Freudenberg M, Daubeuf B, Wagner H, Kirschning CJ.

J Exp Med. 2008 Aug 4;205(8):1747-54. doi: 10.1084/jem.20071990. Epub 2008 Jul 21. Erratum in: J Exp Med. 2008 Sep 1;205(9):2177.


Group A streptococcus activates type I interferon production and MyD88-dependent signaling without involvement of TLR2, TLR4, and TLR9.

Gratz N, Siller M, Schaljo B, Pirzada ZA, Gattermeier I, Vojtek I, Kirschning CJ, Wagner H, Akira S, Charpentier E, Kovarik P.

J Biol Chem. 2008 Jul 18;283(29):19879-87. doi: 10.1074/jbc.M802848200. Epub 2008 May 14.


Containment of aerogenic Mycobacterium tuberculosis infection in mice does not require MyD88 adaptor function for TLR2, -4 and -9.

Hölscher C, Reiling N, Schaible UE, Hölscher A, Bathmann C, Korbel D, Lenz I, Sonntag T, Kröger S, Akira S, Mossmann H, Kirschning CJ, Wagner H, Freudenberg M, Ehlers S.

Eur J Immunol. 2008 Mar;38(3):680-94. doi: 10.1002/eji.200736458.


Human Langerhans cells selectively activated via Toll-like receptor 2 agonists acquire migratory and CD4+T cell stimulatory capacity.

Peiser M, Koeck J, Kirschning CJ, Wittig B, Wanner R.

J Leukoc Biol. 2008 May;83(5):1118-27. doi: 10.1189/jlb.0807567. Epub 2008 Feb 5.


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