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Items: 1 to 50 of 158

1.

Melanoma Extracellular Vesicles Generate Immunosuppressive Myeloid Cells by Upregulating PD-L1 via TLR4 Signaling.

Fleming V, Hu X, Weller C, Weber R, Groth C, Riester Z, Hüser L, Sun Q, Nagibin V, Kirschning C, Bronte V, Utikal J, Altevogt P, Umansky V.

Cancer Res. 2019 Sep 15;79(18):4715-4728. doi: 10.1158/0008-5472.CAN-19-0053. Epub 2019 Jul 23.

PMID:
31337655
2.

Circulating growth/differentiation factor 15 is associated with human CD56bright natural killer cell dysfunction and nosocomial infection in severe systemic inflammation.

Kleinertz H, Hepner-Schefczyk M, Ehnert S, Claus M, Halbgebauer R, Boller L, Huber-Lang M, Cinelli P, Kirschning C, Flohé S, Sander A, Waydhas C, Vonderhagen S, Jäger M, Dudda M, Watzl C, Flohé SB.

EBioMedicine. 2019 May;43:380-391. doi: 10.1016/j.ebiom.2019.04.018. Epub 2019 Apr 13.

3.

Glycosylation of HIV Env Impacts IgG Subtype Responses to Vaccination.

Heß R, Storcksdieck Genannt Bonsmann M, Lapuente D, Maaske A, Kirschning C, Ruland J, Lepenies B, Hannaman D, Tenbusch M, Überla K.

Viruses. 2019 Feb 13;11(2). pii: E153. doi: 10.3390/v11020153.

4.

Mycobacteria exploit nitric oxide-induced transformation of macrophages into permissive giant cells.

Gharun K, Senges J, Seidl M, Lösslein A, Kolter J, Lohrmann F, Fliegauf M, Elgizouli M, Alber M, Vavra M, Schachtrup K, Illert AL, Gilleron M, Kirschning CJ, Triantafyllopoulou A, Henneke P.

EMBO Rep. 2018 Dec;19(12). pii: e47190. doi: 10.15252/embr.201847190. No abstract available.

5.

Antibiotic treatment-induced secondary IgA deficiency enhances susceptibility to Pseudomonas aeruginosa pneumonia.

Robak OH, Heimesaat MM, Kruglov AA, Prepens S, Ninnemann J, Gutbier B, Reppe K, Hochrein H, Suter M, Kirschning CJ, Marathe V, Buer J, Hornef MW, Schnare M, Schneider P, Witzenrath M, Bereswill S, Steinhoff U, Suttorp N, Sander LE, Chaput C, Opitz B.

J Clin Invest. 2018 Aug 1;128(8):3535-3545. doi: 10.1172/JCI97065. Epub 2018 Jul 16.

6.

Mycobacteria exploit nitric oxide-induced transformation of macrophages into permissive giant cells.

Gharun K, Senges J, Seidl M, Lösslein A, Kolter J, Lohrmann F, Fliegauf M, Elgizouli M, Alber M, Vavra M, Schachtrup K, Illert AL, Gilleron M, Kirschning CJ, Triantafyllopoulou A, Henneke P.

EMBO Rep. 2017 Dec;18(12):2144-2159. doi: 10.15252/embr.201744121. Epub 2017 Nov 2. Erratum in: EMBO Rep. 2018 Dec;19(12):.

7.

Decreased Secondary Lesion Growth and Attenuated Immune Response after Traumatic Brain Injury in Tlr2/4-/- Mice.

Krieg SM, Voigt F, Knuefermann P, Kirschning CJ, Plesnila N, Ringel F.

Front Neurol. 2017 Aug 30;8:455. doi: 10.3389/fneur.2017.00455. eCollection 2017.

8.

Porphyromonas gingivalis Stimulates TLR2-PI3K Signaling to Escape Immune Clearance and Induce Bone Resorption Independently of MyD88.

Makkawi H, Hoch S, Burns E, Hosur K, Hajishengallis G, Kirschning CJ, Nussbaum G.

Front Cell Infect Microbiol. 2017 Aug 8;7:359. doi: 10.3389/fcimb.2017.00359. eCollection 2017.

9.

The IL-1R/TLR signaling pathway is essential for efficient CD8+ T-cell responses against hepatitis B virus in the hydrodynamic injection mouse model.

Ma Z, Liu J, Wu W, Zhang E, Zhang X, Li Q, Zelinskyy G, Buer J, Dittmer U, Kirschning CJ, Lu M.

Cell Mol Immunol. 2017 Dec;14(12):997-1008. doi: 10.1038/cmi.2017.43. Epub 2017 Jul 31.

10.

Toll-Like Receptor 2 and Mincle Cooperatively Sense Corynebacterial Cell Wall Glycolipids.

Schick J, Etschel P, Bailo R, Ott L, Bhatt A, Lepenies B, Kirschning C, Burkovski A, Lang R.

Infect Immun. 2017 Jun 20;85(7). pii: e00075-17. doi: 10.1128/IAI.00075-17. Print 2017 Jul.

11.

Combined toll-like receptor 3/7/9 deficiency on host cells results in T-cell-dependent control of tumour growth.

Klein JC, Moses K, Zelinskyy G, Sody S, Buer J, Lang S, Helfrich I, Dittmer U, Kirschning CJ, Brandau S.

Nat Commun. 2017 Mar 16;8:14600. doi: 10.1038/ncomms14600.

12.

RAIDD Mediates TLR3 and IRF7 Driven Type I Interferon Production.

Maney SK, Xu HC, Huang J, Pandyra AA, Ehlting C, Aguilar-Valenzuela R, Pozdeev VI, McIlwain DR, Zimmermann A, Bode JG, Hengel H, Kirschning CJ, Kim IR, Hiscott J, Brenner D, Häussinger D, Ohashi PS, Mak TW, Lang KS, Lang PA.

Cell Physiol Biochem. 2016;39(4):1271-80. doi: 10.1159/000447832. Epub 2016 Sep 8.

13.

Endosomal recognition of Lactococcus lactis G121 and its RNA by dendritic cells is key to its allergy-protective effects.

Stein K, Brand S, Jenckel A, Sigmund A, Chen ZJ, Kirschning CJ, Kauth M, Heine H.

J Allergy Clin Immunol. 2017 Feb;139(2):667-678.e5. doi: 10.1016/j.jaci.2016.06.018. Epub 2016 Jul 15.

PMID:
27544739
14.

CCL2 expression is mediated by type I IFN receptor and recruits NK and T cells to the lung during MVA infection.

Lehmann MH, Torres-Domínguez LE, Price PJ, Brandmüller C, Kirschning CJ, Sutter G.

J Leukoc Biol. 2016 Jun;99(6):1057-64. doi: 10.1189/jlb.4MA0815-376RR. Epub 2016 Mar 18. Review.

PMID:
26992431
15.

Type I Interferon Signaling Prevents IL-1β-Driven Lethal Systemic Hyperinflammation during Invasive Bacterial Infection of Soft Tissue.

Castiglia V, Piersigilli A, Ebner F, Janos M, Goldmann O, Damböck U, Kröger A, Weiss S, Knapp S, Jamieson AM, Kirschning C, Kalinke U, Strobl B, Müller M, Stoiber D, Lienenklaus S, Kovarik P.

Cell Host Microbe. 2016 Mar 9;19(3):375-87. doi: 10.1016/j.chom.2016.02.003.

16.

Staphylococcus aureus-derived lipoteichoic acid induces temporary T-cell paralysis independent of Toll-like receptor 2.

Kaesler S, Skabytska Y, Chen KM, Kempf WE, Volz T, Köberle M, Wölbing F, Hein U, Hartung T, Kirschning C, Röcken M, Biedermann T.

J Allergy Clin Immunol. 2016 Sep;138(3):780-790.e6. doi: 10.1016/j.jaci.2015.11.043. Epub 2016 Mar 3.

PMID:
26949056
17.

Streptococci Engage TLR13 on Myeloid Cells in a Site-Specific Fashion.

Kolter J, Feuerstein R, Spoeri E, Gharun K, Elling R, Trieu-Cuot P, Goldmann T, Waskow C, Chen ZJ, Kirschning CJ, Deshmukh SD, Henneke P.

J Immunol. 2016 Mar 15;196(6):2733-41. doi: 10.4049/jimmunol.1501014. Epub 2016 Feb 12.

18.

Human TLR8 senses UR/URR motifs in bacterial and mitochondrial RNA.

Krüger A, Oldenburg M, Chebrolu C, Beisser D, Kolter J, Sigmund AM, Steinmann J, Schäfer S, Hochrein H, Rahmann S, Wagner H, Henneke P, Hornung V, Buer J, Kirschning CJ.

EMBO Rep. 2015 Dec;16(12):1656-63. doi: 10.15252/embr.201540861. Epub 2015 Nov 6.

19.

Species and mediator specific TLR4 antagonism in primary human and murine immune cells by βGlcN(1↔1)αGlc based lipid A mimetics.

Chebrolu C, Artner D, Sigmund AM, Buer J, Zamyatina A, Kirschning CJ.

Mol Immunol. 2015 Oct;67(2 Pt B):636-41. doi: 10.1016/j.molimm.2015.07.037. Epub 2015 Aug 28.

PMID:
26319313
20.

Innate immune response to Streptococcus pyogenes depends on the combined activation of TLR13 and TLR2.

Fieber C, Janos M, Koestler T, Gratz N, Li XD, Castiglia V, Aberle M, Sauert M, Wegner M, Alexopoulou L, Kirschning CJ, Chen ZJ, von Haeseler A, Kovarik P.

PLoS One. 2015 Mar 10;10(3):e0119727. doi: 10.1371/journal.pone.0119727. eCollection 2015.

21.

CEACAM1 induces B-cell survival and is essential for protective antiviral antibody production.

Khairnar V, Duhan V, Maney SK, Honke N, Shaabani N, Pandyra AA, Seifert M, Pozdeev V, Xu HC, Sharma P, Baldin F, Marquardsen F, Merches K, Lang E, Kirschning C, Westendorf AM, Häussinger D, Lang F, Dittmer U, Küppers R, Recher M, Hardt C, Scheffrahn I, Beauchemin N, Göthert JR, Singer BB, Lang PA, Lang KS.

Nat Commun. 2015 Feb 18;6:6217. doi: 10.1038/ncomms7217.

22.

Prophylactic and therapeutic vaccination with a nanoparticle-based peptide vaccine induces efficient protective immunity during acute and chronic retroviral infection.

Knuschke T, Bayer W, Rotan O, Sokolova V, Wadwa M, Kirschning CJ, Hansen W, Dittmer U, Epple M, Buer J, Westendorf AM.

Nanomedicine. 2014 Nov;10(8):1787-98. doi: 10.1016/j.nano.2014.06.014. Epub 2014 Jul 9.

PMID:
25014891
23.

Chemokine (C-C Motif) receptor 1 is required for efficient recruitment of neutrophils during respiratory infection with modified vaccinia virus Ankara.

Price PJ, Luckow B, Torres-Domínguez LE, Brandmüller C, Zorn J, Kirschning CJ, Sutter G, Lehmann MH.

J Virol. 2014 Sep;88(18):10840-50. doi: 10.1128/JVI.01524-14. Epub 2014 Jul 9.

24.

Multiple roles of Myd88 in the immune response to the plague F1-V vaccine and in protection against an aerosol challenge of Yersinia pestis CO92 in mice.

Dankmeyer JL, Fast RL, Cote CK, Worsham PL, Fritz D, Fisher D, Kern SJ, Merkel T, Kirschning CJ, Amemiya K.

J Immunol Res. 2014;2014:341820. doi: 10.1155/2014/341820. Epub 2014 Jun 4.

25.

TLR-independent and P2X7-dependent signaling mediate Alu RNA-induced NLRP3 inflammasome activation in geographic atrophy.

Kerur N, Hirano Y, Tarallo V, Fowler BJ, Bastos-Carvalho A, Yasuma T, Yasuma R, Kim Y, Hinton DR, Kirschning CJ, Gelfand BD, Ambati J.

Invest Ophthalmol Vis Sci. 2013 Nov 11;54(12):7395-401. doi: 10.1167/iovs.13-12500.

26.

Molecular cloning and characterization of a novel anti-TLR9 intrabody.

Reimer E, Somplatzki S, Zegenhagen D, Hänel S, Fels A, Bollhorst T, Hovest LG, Bauer S, Kirschning CJ, Böldicke T.

Cell Mol Biol Lett. 2013 Sep;18(3):433-46. doi: 10.2478/s11658-013-0098-8. Epub 2013 Jul 26.

27.

Nonpathogenic bacteria alleviating atopic dermatitis inflammation induce IL-10-producing dendritic cells and regulatory Tr1 cells.

Volz T, Skabytska Y, Guenova E, Chen KM, Frick JS, Kirschning CJ, Kaesler S, Röcken M, Biedermann T.

J Invest Dermatol. 2014 Jan;134(1):96-104. doi: 10.1038/jid.2013.291. Epub 2013 Jun 28.

28.
29.

Priming of NK cell anti-viral effector mechanisms by direct recognition of human cytomegalovirus.

Muntasell A, Costa-Garcia M, Vera A, Marina-Garcia N, Kirschning CJ, López-Botet M.

Front Immunol. 2013 Feb 21;4:40. doi: 10.3389/fimmu.2013.00040. eCollection 2013.

30.

The Mincle-activating adjuvant TDB induces MyD88-dependent Th1 and Th17 responses through IL-1R signaling.

Desel C, Werninghaus K, Ritter M, Jozefowski K, Wenzel J, Russkamp N, Schleicher U, Christensen D, Wirtz S, Kirschning C, Agger EM, Prazeres da Costa C, Lang R.

PLoS One. 2013;8(1):e53531. doi: 10.1371/journal.pone.0053531. Epub 2013 Jan 7.

31.

Primary sterile necrotic cells fail to cross-prime CD8(+) T cells.

Gamrekelashvili J, Ormandy LA, Heimesaat MM, Kirschning CJ, Manns MP, Korangy F, Greten TF.

Oncoimmunology. 2012 Oct 1;1(7):1017-1026.

32.

TLR13 recognizes bacterial 23S rRNA devoid of erythromycin resistance-forming modification.

Oldenburg M, Krüger A, Ferstl R, Kaufmann A, Nees G, Sigmund A, Bathke B, Lauterbach H, Suter M, Dreher S, Koedel U, Akira S, Kawai T, Buer J, Wagner H, Bauer S, Hochrein H, Kirschning CJ.

Science. 2012 Aug 31;337(6098):1111-5. doi: 10.1126/science.1220363. Epub 2012 Jul 19.

33.

Priming of natural killer cells by nonmucosal mononuclear phagocytes requires instructive signals from commensal microbiota.

Ganal SC, Sanos SL, Kallfass C, Oberle K, Johner C, Kirschning C, Lienenklaus S, Weiss S, Staeheli P, Aichele P, Diefenbach A.

Immunity. 2012 Jul 27;37(1):171-86. doi: 10.1016/j.immuni.2012.05.020. Epub 2012 Jun 28.

34.

TLR9-dependent and independent pathways drive activation of the immune system by Propionibacterium acnes.

Tchaptchet S, Gumenscheimer M, Kalis C, Freudenberg N, Hölscher C, Kirschning CJ, Lamers M, Galanos C, Freudenberg MA.

PLoS One. 2012;7(6):e39155. doi: 10.1371/journal.pone.0039155. Epub 2012 Jun 22.

35.

Bacterial RNA mediates activation of caspase-1 and IL-1β release independently of TLRs 3, 7, 9 and TRIF but is dependent on UNC93B.

Eigenbrod T, Franchi L, Muñoz-Planillo R, Kirschning CJ, Freudenberg MA, Núñez G, Dalpke A.

J Immunol. 2012 Jul 1;189(1):328-36. doi: 10.4049/jimmunol.1103258. Epub 2012 May 25.

36.

Poke weed mitogen requires Toll-like receptor ligands for proliferative activity in human and murine B lymphocytes.

Bekeredjian-Ding I, Foermer S, Kirschning CJ, Parcina M, Heeg K.

PLoS One. 2012;7(1):e29806. doi: 10.1371/journal.pone.0029806. Epub 2012 Jan 4.

37.

Transient P2X7 receptor activation triggers macrophage death independent of Toll-like receptors 2 and 4, caspase-1, and pannexin-1 proteins.

Hanley PJ, Kronlage M, Kirschning C, del Rey A, Di Virgilio F, Leipziger J, Chessell IP, Sargin S, Filippov MA, Lindemann O, Mohr S, Königs V, Schillers H, Bähler M, Schwab A.

J Biol Chem. 2012 Mar 23;287(13):10650-63. doi: 10.1074/jbc.M111.332676. Epub 2012 Jan 10.

38.

Fever induction by systemic stimulation with macrophage-activating lipopeptide-2 depends upon TLR2 but not CD36.

Welsch J, Hübschle T, Murgott J, Kirschning C, Rummel C, Gerstberger R, Roth J.

Innate Immun. 2012 Jun;18(3):541-59. doi: 10.1177/1753425911426892. Epub 2011 Oct 31.

PMID:
22042912
39.

Expression of type I interferon by splenic macrophages suppresses adaptive immunity during sepsis.

Schwandt T, Schumak B, Gielen GH, Jüngerkes F, Schmidbauer P, Klocke K, Staratschek-Jox A, van Rooijen N, Kraal G, Ludwig-Portugall I, Franken L, Wehner S, Kalff JC, Weber O, Kirschning C, Coch C, Kalinke U, Wenzel J, Kurts C, Zawatzky R, Holzmann B, Layland L, Schultze JL, Burgdorf S, den Haan JM, Knolle PA, Limmer A.

EMBO J. 2012 Jan 4;31(1):201-13. doi: 10.1038/emboj.2011.380. Epub 2011 Oct 28.

40.

The NLRP3 inflammasome contributes to brain injury in pneumococcal meningitis and is activated through ATP-dependent lysosomal cathepsin B release.

Hoegen T, Tremel N, Klein M, Angele B, Wagner H, Kirschning C, Pfister HW, Fontana A, Hammerschmidt S, Koedel U.

J Immunol. 2011 Nov 15;187(10):5440-51. doi: 10.4049/jimmunol.1100790. Epub 2011 Oct 14.

41.

Dissection of a type I interferon pathway in controlling bacterial intracellular infection in mice.

Lippmann J, Müller HC, Naujoks J, Tabeling C, Shin S, Witzenrath M, Hellwig K, Kirschning CJ, Taylor GA, Barchet W, Bauer S, Suttorp N, Roy CR, Opitz B.

Cell Microbiol. 2011 Nov;13(11):1668-82. doi: 10.1111/j.1462-5822.2011.01646.x. Epub 2011 Aug 24.

42.

CCL17 controls mast cells for the defense against filarial larval entry.

Specht S, Frank JK, Alferink J, Dubben B, Layland LE, Denece G, Bain O, Förster I, Kirschning CJ, Martin C, Hoerauf A.

J Immunol. 2011 Apr 15;186(8):4845-52. doi: 10.4049/jimmunol.1000612. Epub 2011 Mar 11.

43.

Borrelia burgdorferi infection regulates CD1 expression in human cells and tissues via IL1-β.

Yakimchuk K, Roura-Mir C, Magalhaes KG, de Jong A, Kasmar AG, Granter SR, Budd R, Steere A, Pena-Cruz V, Kirschning C, Cheng TY, Moody DB.

Eur J Immunol. 2011 Mar;41(3):694-705. doi: 10.1002/eji.201040808. Epub 2011 Jan 18.

44.

Left ventricular dilation in toll-like receptor 2 deficient mice after myocardial ischemia/reperfusion through defective scar formation.

Mersmann J, Habeck K, Latsch K, Zimmermann R, Jacoby C, Fischer JW, Hartmann C, Schrader J, Kirschning CJ, Zacharowski K.

Basic Res Cardiol. 2011 Jan;106(1):89-98. doi: 10.1007/s00395-010-0127-y. Epub 2010 Oct 22.

PMID:
20967453
45.

Polyinosinic-polycytidylic acid treatment of Friend retrovirus-infected mice improves functional properties of virus-specific T cells and prevents virus-induced disease.

Gibbert K, Dietze KK, Zelinskyy G, Lang KS, Barchet W, Kirschning CJ, Dittmer U.

J Immunol. 2010 Nov 15;185(10):6179-89. doi: 10.4049/jimmunol.1000858. Epub 2010 Oct 13.

46.

Toll-like receptor 2 signaling triggers fatal arrhythmias upon myocardial ischemia-reperfusion.

Mersmann J, Koch A, Tran N, Zimmermann R, Granja TF, Larmann J, Herzog C, Theilmeier G, Bornstein SR, Kirschning CJ, Zacharowski K.

Crit Care Med. 2010 Oct;38(10):1927-32. doi: 10.1097/CCM.0b013e3181ef455b.

PMID:
20855990
47.

Toll-like receptor 3 mediates expression of clusterin/apolipoprotein J in vascular smooth muscle cells stimulated with RNA released from necrotic cells.

Baiersdörfer M, Schwarz M, Seehafer K, Lehmann C, Heit A, Wagner H, Kirschning CJ, Koch-Brandt C.

Exp Cell Res. 2010 Dec 10;316(20):3489-500. doi: 10.1016/j.yexcr.2010.07.022. Epub 2010 Aug 5.

PMID:
20692254
48.

Generation of anti-TLR2 intrabody mediating inhibition of macrophage surface TLR2 expression and TLR2-driven cell activation.

Kirschning CJ, Dreher S, Maass B, Fichte S, Schade J, Köster M, Noack A, Lindenmaier W, Wagner H, Böldicke T.

BMC Biotechnol. 2010 Apr 13;10:31. doi: 10.1186/1472-6750-10-31.

49.

Toll-like receptors 2 and 4 in renal ischemia/reperfusion injury.

Rusai K, Sollinger D, Baumann M, Wagner B, Strobl M, Schmaderer C, Roos M, Kirschning C, Heemann U, Lutz J.

Pediatr Nephrol. 2010 May;25(5):853-60. doi: 10.1007/s00467-009-1422-4. Epub 2010 Feb 4.

PMID:
20130923
50.

Immunomodulating effects of OM-89, a bacterial extract from Escherichia coli, in murine and human leukocytes.

Bessler WG, Puce K, vor dem Esche U, Kirschning C, Huber M.

Arzneimittelforschung. 2009;59(11):571-7. doi: 10.1055/s-0031-1296446.

PMID:
20066966

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