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Items: 1 to 50 of 283

1.

VHL substrate transcription factor ZHX2 as an oncogenic driver in clear cell renal cell carcinoma.

Zhang J, Wu T, Simon J, Takada M, Saito R, Fan C, Liu XD, Jonasch E, Xie L, Chen X, Yao X, Teh BT, Tan P, Zheng X, Li M, Lawrence C, Fan J, Geng J, Liu X, Hu L, Wang J, Liao C, Hong K, Zurlo G, Parker JS, Auman JT, Perou CM, Rathmell WK, Kim WY, Kirschner MW, Kaelin WG Jr, Baldwin AS, Zhang Q.

Science. 2018 Jul 20;361(6399):290-295. doi: 10.1126/science.aap8411.

PMID:
30026228
2.

Cell size sensing in animal cells coordinates anabolic growth rates and cell cycle progression to maintain cell size uniformity.

Ginzberg MB, Chang N, D'Souza H, Patel N, Kafri R, Kirschner MW.

Elife. 2018 Jun 11;7. pii: e26957. doi: 10.7554/eLife.26957.

3.

The dynamics of gene expression in vertebrate embryogenesis at single-cell resolution.

Briggs JA, Weinreb C, Wagner DE, Megason S, Peshkin L, Kirschner MW, Klein AM.

Science. 2018 Jun 1;360(6392). pii: eaar5780. doi: 10.1126/science.aar5780. Epub 2018 Apr 26.

4.

Size uniformity of animal cells is actively maintained by a p38 MAPK-dependent regulation of G1-length.

Liu S, Ginzberg MB, Patel N, Hild M, Leung B, Li Z, Chen YC, Chang N, Wang Y, Tan C, Diena S, Trimble W, Wasserman L, Jenkins JL, Kirschner MW, Kafri R.

Elife. 2018 Mar 29;7. pii: e26947. doi: 10.7554/eLife.26947.

5.

Proteomics of phosphorylation and protein dynamics during fertilization and meiotic exit in the Xenopus egg.

Presler M, Van Itallie E, Klein AM, Kunz R, Coughlin ML, Peshkin L, Gygi SP, Wühr M, Kirschner MW.

Proc Natl Acad Sci U S A. 2017 Dec 12;114(50):E10838-E10847. doi: 10.1073/pnas.1709207114. Epub 2017 Nov 28.

6.

Mouse embryonic stem cells can differentiate via multiple paths to the same state.

Briggs JA, Li VC, Lee S, Woolf CJ, Klein A, Kirschner MW.

Elife. 2017 Oct 9;6. pii: e26945. doi: 10.7554/eLife.26945.

7.

Kinesin superfamily protein Kif26b links Wnt5a-Ror signaling to the control of cell and tissue behaviors in vertebrates.

Susman MW, Karuna EP, Kunz RC, Gujral TS, Cantú AV, Choi SS, Jong BY, Okada K, Scales MK, Hum J, Hu LS, Kirschner MW, Nishinakamura R, Yamada S, Laird DJ, Jao LE, Gygi SP, Greenberg ME, Ho HH.

Elife. 2017 Sep 8;6. pii: e26509. doi: 10.7554/eLife.26509.

8.

Proteomic and Metabolomic Characterization of a Mammalian Cellular Transition from Quiescence to Proliferation.

Lee HJ, Jedrychowski MP, Vinayagam A, Wu N, Shyh-Chang N, Hu Y, Min-Wen C, Moore JK, Asara JM, Lyssiotis CA, Perrimon N, Gygi SP, Cantley LC, Kirschner MW.

Cell Rep. 2017 Jul 18;20(3):721-736. doi: 10.1016/j.celrep.2017.06.074.

9.

Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle.

Lu Y, Wu J, Dong Y, Chen S, Sun S, Ma YB, Ouyang Q, Finley D, Kirschner MW, Mao Y.

Mol Cell. 2017 Jul 20;67(2):322-333.e6. doi: 10.1016/j.molcel.2017.06.007. Epub 2017 Jul 6.

10.

Hippo pathway mediates resistance to cytotoxic drugs.

Gujral TS, Kirschner MW.

Proc Natl Acad Sci U S A. 2017 May 2;114(18):E3729-E3738. doi: 10.1073/pnas.1703096114. Epub 2017 Apr 17.

11.

The APC/C E3 Ligase Complex Activator FZR1 Restricts BRAF Oncogenic Function.

Wan L, Chen M, Cao J, Dai X, Yin Q, Zhang J, Song SJ, Lu Y, Liu J, Inuzuka H, Katon JM, Berry K, Fung J, Ng C, Liu P, Song MS, Xue L, Bronson RT, Kirschner MW, Cui R, Pandolfi PP, Wei W.

Cancer Discov. 2017 Apr;7(4):424-441. doi: 10.1158/2159-8290.CD-16-0647. Epub 2017 Feb 7.

12.

Structural basis for dynamic regulation of the human 26S proteasome.

Chen S, Wu J, Lu Y, Ma YB, Lee BH, Yu Z, Ouyang Q, Finley DJ, Kirschner MW, Mao Y.

Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):12991-12996. Epub 2016 Oct 21.

13.

Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C.

Brown NG, VanderLinden R, Watson ER, Weissmann F, Ordureau A, Wu KP, Zhang W, Yu S, Mercredi PY, Harrison JS, Davidson IF, Qiao R, Lu Y, Dube P, Brunner MR, Grace CRR, Miller DJ, Haselbach D, Jarvis MA, Yamaguchi M, Yanishevski D, Petzold G, Sidhu SS, Kuhlman B, Kirschner MW, Harper JW, Peters JM, Stark H, Schulman BA.

Cell. 2016 Jun 2;165(6):1440-1453. doi: 10.1016/j.cell.2016.05.037.

14.

SCIENTIFIC COMMUNITY. Preprints for the life sciences.

Berg JM, Bhalla N, Bourne PE, Chalfie M, Drubin DG, Fraser JS, Greider CW, Hendricks M, Jones C, Kiley R, King S, Kirschner MW, Krumholz HM, Lehmann R, Leptin M, Pulverer B, Rosenzweig B, Spiro JE, Stebbins M, Strasser C, Swaminathan S, Turner P, Vale RD, VijayRaghavan K, Wolberger C.

Science. 2016 May 20;352(6288):899-901. doi: 10.1126/science.aaf9133. No abstract available.

PMID:
27199406
15.

The Gonium pectorale genome demonstrates co-option of cell cycle regulation during the evolution of multicellularity.

Hanschen ER, Marriage TN, Ferris PJ, Hamaji T, Toyoda A, Fujiyama A, Neme R, Noguchi H, Minakuchi Y, Suzuki M, Kawai-Toyooka H, Smith DR, Sparks H, Anderson J, Bakarić R, Luria V, Karger A, Kirschner MW, Durand PM, Michod RE, Nozaki H, Olson BJ.

Nat Commun. 2016 Apr 22;7:11370. doi: 10.1038/ncomms11370.

16.

Resonant microchannel volume and mass measurements show that suspended cells swell during mitosis.

Son S, Kang JH, Oh S, Kirschner MW, Mitchison TJ, Manalis S.

J Cell Biol. 2015 Nov 23;211(4):757-63. doi: 10.1083/jcb.201505058.

17.

Hemichordate genomes and deuterostome origins.

Simakov O, Kawashima T, Marlétaz F, Jenkins J, Koyanagi R, Mitros T, Hisata K, Bredeson J, Shoguchi E, Gyoja F, Yue JX, Chen YC, Freeman RM Jr, Sasaki A, Hikosaka-Katayama T, Sato A, Fujie M, Baughman KW, Levine J, Gonzalez P, Cameron C, Fritzenwanker JH, Pani AM, Goto H, Kanda M, Arakaki N, Yamasaki S, Qu J, Cree A, Ding Y, Dinh HH, Dugan S, Holder M, Jhangiani SN, Kovar CL, Lee SL, Lewis LR, Morton D, Nazareth LV, Okwuonu G, Santibanez J, Chen R, Richards S, Muzny DM, Gillis A, Peshkin L, Wu M, Humphreys T, Su YH, Putnam NH, Schmutz J, Fujiyama A, Yu JK, Tagawa K, Worley KC, Gibbs RA, Kirschner MW, Lowe CJ, Satoh N, Rokhsar DS, Gerhart J.

Nature. 2015 Nov 26;527(7579):459-65. doi: 10.1038/nature16150. Epub 2015 Nov 18.

18.

On the Relationship of Protein and mRNA Dynamics in Vertebrate Embryonic Development.

Peshkin L, Wühr M, Pearl E, Haas W, Freeman RM Jr, Gerhart JC, Klein AM, Horb M, Gygi SP, Kirschner MW.

Dev Cell. 2015 Nov 9;35(3):383-94. doi: 10.1016/j.devcel.2015.10.010.

19.

The Nuclear Proteome of a Vertebrate.

Wühr M, Güttler T, Peshkin L, McAlister GC, Sonnett M, Ishihara K, Groen AC, Presler M, Erickson BK, Mitchison TJ, Kirschner MW, Gygi SP.

Curr Biol. 2015 Oct 19;25(20):2663-71. doi: 10.1016/j.cub.2015.08.047. Epub 2015 Oct 1.

20.

Droplet barcoding for single-cell transcriptomics applied to embryonic stem cells.

Klein AM, Mazutis L, Akartuna I, Tallapragada N, Veres A, Li V, Peshkin L, Weitz DA, Kirschner MW.

Cell. 2015 May 21;161(5):1187-1201. doi: 10.1016/j.cell.2015.04.044.

21.

Substrate degradation by the proteasome: a single-molecule kinetic analysis.

Lu Y, Lee BH, King RW, Finley D, Kirschner MW.

Science. 2015 Apr 10;348(6231):1250834. doi: 10.1126/science.1250834.

22.

Specificity of the anaphase-promoting complex: a single-molecule study.

Lu Y, Wang W, Kirschner MW.

Science. 2015 Apr 10;348(6231):1248737. doi: 10.1126/science.1248737. Epub 2015 Apr 9.

23.

Opinion: Addressing systemic problems in the biomedical research enterprise.

Alberts B, Kirschner MW, Tilghman S, Varmus H.

Proc Natl Acad Sci U S A. 2015 Feb 17;112(7):1912-3. doi: 10.1073/pnas.1500969112. No abstract available.

24.

A noncanonical Frizzled2 pathway regulates epithelial-mesenchymal transition and metastasis.

Gujral TS, Chan M, Peshkin L, Sorger PK, Kirschner MW, MacBeath G.

Cell. 2014 Nov 6;159(4):844-56. doi: 10.1016/j.cell.2014.10.032.

25.

A nontranscriptional role for Oct4 in the regulation of mitotic entry.

Zhao R, Deibler RW, Lerou PH, Ballabeni A, Heffner GC, Cahan P, Unternaehrer JJ, Kirschner MW, Daley GQ.

Proc Natl Acad Sci U S A. 2014 Nov 4;111(44):15768-73. doi: 10.1073/pnas.1417518111. Epub 2014 Oct 16.

26.

Quantitative Lys-ϵ-Gly-Gly (diGly) proteomics coupled with inducible RNAi reveals ubiquitin-mediated proteolysis of DNA damage-inducible transcript 4 (DDIT4) by the E3 ligase HUWE1.

Thompson JW, Nagel J, Hoving S, Gerrits B, Bauer A, Thomas JR, Kirschner MW, Schirle M, Luchansky SJ.

J Biol Chem. 2014 Oct 17;289(42):28942-55. doi: 10.1074/jbc.M114.573352. Epub 2014 Aug 21.

27.

The master cell cycle regulator APC-Cdc20 regulates ciliary length and disassembly of the primary cilium.

Wang W, Wu T, Kirschner MW.

Elife. 2014 Aug 19;3:e03083. doi: 10.7554/eLife.03083.

28.

Post-Translational Modification Profiling--a High-Content Assay for Identifying Protein Modifications in Mammalian Cellular Systems.

Merbl Y, Kirschner MW.

Curr Protoc Protein Sci. 2014 Aug 1;77:27.8.1-13. doi: 10.1002/0471140864.ps2708s77. Review.

29.

Molecular ties between the cell cycle and differentiation in embryonic stem cells.

Li VC, Kirschner MW.

Proc Natl Acad Sci U S A. 2014 Jul 1;111(26):9503-8. doi: 10.1073/pnas.1408638111. Epub 2014 Jun 16.

30.

Deep proteomics of the Xenopus laevis egg using an mRNA-derived reference database.

Wühr M, Freeman RM Jr, Presler M, Horb ME, Peshkin L, Gygi S, Kirschner MW.

Curr Biol. 2014 Jul 7;24(13):1467-1475. doi: 10.1016/j.cub.2014.05.044. Epub 2014 Jun 19.

31.

APC(Cdc20) suppresses apoptosis through targeting Bim for ubiquitination and destruction.

Wan L, Tan M, Yang J, Inuzuka H, Dai X, Wu T, Liu J, Shaik S, Chen G, Deng J, Malumbres M, Letai A, Kirschner MW, Sun Y, Wei W.

Dev Cell. 2014 May 27;29(4):377-91. doi: 10.1016/j.devcel.2014.04.022.

32.

Rescuing US biomedical research from its systemic flaws.

Alberts B, Kirschner MW, Tilghman S, Varmus H.

Proc Natl Acad Sci U S A. 2014 Apr 22;111(16):5773-7. doi: 10.1073/pnas.1404402111. Epub 2014 Apr 14.

33.

Exploiting polypharmacology for drug target deconvolution.

Gujral TS, Peshkin L, Kirschner MW.

Proc Natl Acad Sci U S A. 2014 Apr 1;111(13):5048-53. doi: 10.1073/pnas.1403080111. Epub 2014 Mar 19.

34.

Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus.

Liu P, Begley M, Michowski W, Inuzuka H, Ginzberg M, Gao D, Tsou P, Gan W, Papa A, Kim BM, Wan L, Singh A, Zhai B, Yuan M, Wang Z, Gygi SP, Lee TH, Lu KP, Toker A, Pandolfi PP, Asara JM, Kirschner MW, Sicinski P, Cantley L, Wei W.

Nature. 2014 Apr 24;508(7497):541-5. doi: 10.1038/nature13079. Epub 2014 Mar 9.

35.

Microarray discovery of new OGT substrates: the medulloblastoma oncogene OTX2 is O-GlcNAcylated.

Ortiz-Meoz RF, Merbl Y, Kirschner MW, Walker S.

J Am Chem Soc. 2014 Apr 2;136(13):4845-8. doi: 10.1021/ja500451w. Epub 2014 Mar 17.

36.

Size homeostasis in adherent cells studied by synthetic phase microscopy.

Sung Y, Tzur A, Oh S, Choi W, Li V, Dasari RR, Yaqoob Z, Kirschner MW.

Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16687-92. doi: 10.1073/pnas.1315290110. Epub 2013 Sep 24.

37.

SCF-mediated Cdh1 degradation defines a negative feedback system that coordinates cell-cycle progression.

Fukushima H, Ogura K, Wan L, Lu Y, Li V, Gao D, Liu P, Lau AW, Wu T, Kirschner MW, Inuzuka H, Wei W.

Cell Rep. 2013 Aug 29;4(4):803-16. doi: 10.1016/j.celrep.2013.07.031. Epub 2013 Aug 22.

38.

Geminin deploys multiple mechanisms to regulate Cdt1 before cell division thus ensuring the proper execution of DNA replication.

Ballabeni A, Zamponi R, Moore JK, Helin K, Kirschner MW.

Proc Natl Acad Sci U S A. 2013 Jul 23;110(30):E2848-53. doi: 10.1073/pnas.1310677110. Epub 2013 Jul 8.

39.

Emi1 preferentially inhibits ubiquitin chain elongation by the anaphase-promoting complex.

Wang W, Kirschner MW.

Nat Cell Biol. 2013 Jul;15(7):797-806. doi: 10.1038/ncb2755. Epub 2013 May 26.

40.

Phosphoinositides and membrane curvature switch the mode of actin polymerization via selective recruitment of toca-1 and Snx9.

Gallop JL, Walrant A, Cantley LC, Kirschner MW.

Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7193-8. doi: 10.1073/pnas.1305286110. Epub 2013 Apr 15.

41.

Multiple phases of chondrocyte enlargement underlie differences in skeletal proportions.

Cooper KL, Oh S, Sung Y, Dasari RR, Kirschner MW, Tabin CJ.

Nature. 2013 Mar 21;495(7441):375-8. doi: 10.1038/nature11940. Epub 2013 Mar 13.

42.

Profiling of ubiquitin-like modifications reveals features of mitotic control.

Merbl Y, Refour P, Patel H, Springer M, Kirschner MW.

Cell. 2013 Feb 28;152(5):1160-72. doi: 10.1016/j.cell.2013.02.007.

43.

Dynamics extracted from fixed cells reveal feedback linking cell growth to cell cycle.

Kafri R, Levy J, Ginzberg MB, Oh S, Lahav G, Kirschner MW.

Nature. 2013 Feb 28;494(7438):480-3. doi: 10.1038/nature11897.

44.

Deubiquitinase FAM/USP9X interacts with the E3 ubiquitin ligase SMURF1 protein and protects it from ligase activity-dependent self-degradation.

Xie Y, Avello M, Schirle M, McWhinnie E, Feng Y, Bric-Furlong E, Wilson C, Nathans R, Zhang J, Kirschner MW, Huang SM, Cong F.

J Biol Chem. 2013 Feb 1;288(5):2976-85. doi: 10.1074/jbc.M112.430066. Epub 2012 Nov 26.

45.

Kinetic responses of β-catenin specify the sites of Wnt control.

Hernández AR, Klein AM, Kirschner MW.

Science. 2012 Dec 7;338(6112):1337-40. doi: 10.1126/science.1228734. Epub 2012 Nov 8.

46.

Accurate multiplexed proteomics at the MS2 level using the complement reporter ion cluster.

Wühr M, Haas W, McAlister GC, Peshkin L, Rad R, Kirschner MW, Gygi SP.

Anal Chem. 2012 Nov 6;84(21):9214-21. doi: 10.1021/ac301962s. Epub 2012 Oct 25.

47.

Direct observation of mammalian cell growth and size regulation.

Son S, Tzur A, Weng Y, Jorgensen P, Kim J, Kirschner MW, Manalis SR.

Nat Methods. 2012 Sep;9(9):910-2. doi: 10.1038/nmeth.2133. Epub 2012 Aug 5.

48.

Gap 1 phase length and mouse embryonic stem cell self-renewal.

Li VC, Ballabeni A, Kirschner MW.

Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12550-5. doi: 10.1073/pnas.1206740109. Epub 2012 Jul 16.

49.

Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation.

Jain M, Nilsson R, Sharma S, Madhusudhan N, Kitami T, Souza AL, Kafri R, Kirschner MW, Clish CB, Mootha VK.

Science. 2012 May 25;336(6084):1040-4. doi: 10.1126/science.1218595.

50.

ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner.

Hao HX, Xie Y, Zhang Y, Charlat O, Oster E, Avello M, Lei H, Mickanin C, Liu D, Ruffner H, Mao X, Ma Q, Zamponi R, Bouwmeester T, Finan PM, Kirschner MW, Porter JA, Serluca FC, Cong F.

Nature. 2012 Apr 29;485(7397):195-200. doi: 10.1038/nature11019.

PMID:
22575959

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