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Items: 1 to 50 of 138

1.

The Amazon rain forest plant Uncaria tomentosa (cat's claw) and its specific proanthocyanidin constituents are potent inhibitors and reducers of both brain plaques and tangles.

Snow AD, Castillo GM, Nguyen BP, Choi PY, Cummings JA, Cam J, Hu Q, Lake T, Pan W, Kastin AJ, Kirschner DA, Wood SG, Rockenstein E, Masliah E, Lorimer S, Tanzi RE, Larsen L.

Sci Rep. 2019 Feb 6;9(1):561. doi: 10.1038/s41598-019-38645-0.

2.

The A2V mutation as a new tool for hindering Aβ aggregation: A neutron and x-ray diffraction study.

Cantu' L, Colombo L, Stoilova T, Demé B, Inouye H, Booth R, Rondelli V, Di Fede G, Tagliavini F, Del Favero E, Kirschner DA, Salmona M.

Sci Rep. 2017 Jul 14;7(1):5510. doi: 10.1038/s41598-017-05582-9.

3.

Myelin structure in unfixed, single nerve fibers: Scanning X-ray microdiffraction with a beam size of 200nm.

Inouye H, Kuo FH, Denninger AR, Weinhausen B, Burghammer M, Kirschner DA.

J Struct Biol. 2017 Dec;200(3):229-243. doi: 10.1016/j.jsb.2017.07.001. Epub 2017 Jul 8.

PMID:
28698109
4.

rAAV Gene Therapy in a Canavan's Disease Mouse Model Reveals Immune Impairments and an Extended Pathology Beyond the Central Nervous System.

Ahmed SS, Schattgen SA, Frakes AE, Sikoglu EM, Su Q, Li J, Hampton TG, Denninger AR, Kirschner DA, Kaspar B, Matalon R, Gao G.

Mol Ther. 2016 Jun;24(6):1030-1041. doi: 10.1038/mt.2016.68. Epub 2016 Apr 4.

5.

Evolution of myelin ultrastructure and the major structural myelin proteins.

Inouye H, Kirschner DA.

Brain Res. 2016 Jun 15;1641(Pt A):43-63. doi: 10.1016/j.brainres.2015.10.037. Epub 2015 Oct 28. Review.

PMID:
26519753
6.

Claudin-11 Tight Junctions in Myelin Are a Barrier to Diffusion and Lack Strong Adhesive Properties.

Denninger AR, Breglio A, Maheras KJ, LeDuc G, Cristiglio V, Demé B, Gow A, Kirschner DA.

Biophys J. 2015 Oct 6;109(7):1387-97. doi: 10.1016/j.bpj.2015.08.012.

7.

Plasmalogen phospholipids protect internodal myelin from oxidative damage.

Luoma AM, Kuo F, Cakici O, Crowther MN, Denninger AR, Avila RL, Brites P, Kirschner DA.

Free Radic Biol Med. 2015 Jul;84:296-310. doi: 10.1016/j.freeradbiomed.2015.03.012. Epub 2015 Mar 21.

PMID:
25801291
8.

Myelin abnormalities in the optic and sciatic nerves in mice with GM1-gangliosidosis.

Heinecke KA, Luoma A, d'Azzo A, Kirschner DA, Seyfried TN.

ASN Neuro. 2015 Feb 18;7(1). pii: 1759091415568913. doi: 10.1177/1759091415568913. Print 2015 Jan-Feb.

9.

Neutron scattering from myelin revisited: bilayer asymmetry and water-exchange kinetics.

Denninger AR, Demé B, Cristiglio V, LeDuc G, Feller WB, Kirschner DA.

Acta Crystallogr D Biol Crystallogr. 2014 Dec 1;70(Pt 12):3198-211. doi: 10.1107/S1399004714023815. Epub 2014 Nov 22.

10.

Myelin organization in the nodal, paranodal, and juxtaparanodal regions revealed by scanning x-ray microdiffraction.

Inouye H, Liu J, Makowski L, Palmisano M, Burghammer M, Riekel C, Kirschner DA.

PLoS One. 2014 Jul 1;9(7):e100592. doi: 10.1371/journal.pone.0100592. eCollection 2014.

11.

A bacteriophage capsid protein provides a general amyloid interaction motif (GAIM) that binds and remodels misfolded protein assemblies.

Krishnan R, Tsubery H, Proschitsky MY, Asp E, Lulu M, Gilead S, Gartner M, Waltho JP, Davis PJ, Hounslow AM, Kirschner DA, Inouye H, Myszka DG, Wright J, Solomon B, Fisher RA.

J Mol Biol. 2014 Jun 26;426(13):2500-19. doi: 10.1016/j.jmb.2014.04.015. Epub 2014 Apr 22.

PMID:
24768993
12.

Peripheral nervous system plasmalogens regulate Schwann cell differentiation and myelination.

da Silva TF, Eira J, Lopes AT, Malheiro AR, Sousa V, Luoma A, Avila RL, Wanders RJ, Just WW, Kirschner DA, Sousa MM, Brites P.

J Clin Invest. 2014 Jun;124(6):2560-70. doi: 10.1172/JCI72063. Epub 2014 Apr 24.

13.

A single intravenous rAAV injection as late as P20 achieves efficacious and sustained CNS Gene therapy in Canavan mice.

Ahmed SS, Li H, Cao C, Sikoglu EM, Denninger AR, Su Q, Eaton S, Liso Navarro AA, Xie J, Szucs S, Zhang H, Moore C, Kirschner DA, Seyfried TN, Flotte TR, Matalon R, Gao G.

Mol Ther. 2013 Dec;21(12):2136-47. doi: 10.1038/mt.2013.138. Epub 2013 Jul 2.

14.

Myelin structure is unaltered in chemotherapy-induced peripheral neuropathy.

Gilardini A, Avila RL, Oggioni N, Rodriguez-Menendez V, Bossi M, Canta A, Cavaletti G, Kirschner DA.

Neurotoxicology. 2012 Jan;33(1):1-7. doi: 10.1016/j.neuro.2011.10.010. Epub 2011 Nov 4.

PMID:
22079976
15.

Cotinine reduces amyloid-β aggregation and improves memory in Alzheimer's disease mice.

Echeverria V, Zeitlin R, Burgess S, Patel S, Barman A, Thakur G, Mamcarz M, Wang L, Sattelle DB, Kirschner DA, Mori T, Leblanc RM, Prabhakar R, Arendash GW.

J Alzheimers Dis. 2011;24(4):817-35. doi: 10.3233/JAD-2011-102136.

PMID:
21321389
16.

P0 (protein zero) mutation S34C underlies instability of internodal myelin in S63C mice.

Avila RL, D'Antonio M, Bachi A, Inouye H, Feltri ML, Wrabetz L, Kirschner DA.

J Biol Chem. 2010 Dec 31;285(53):42001-12. doi: 10.1074/jbc.M110.166967. Epub 2010 Oct 11.

17.

Differential effects of Phe19 and Phe20 on fibril formation by amyloidogenic peptide A beta 16-22 (Ac-KLVFFAE-NH2).

Inouye H, Gleason KA, Zhang D, Decatur SM, Kirschner DA.

Proteins. 2010 Aug 1;78(10):2306-21. doi: 10.1002/prot.22743.

PMID:
20544966
18.

Rapid assessment of internodal myelin integrity in central nervous system tissue.

Kirschner DA, Avila RL, Gamez Sazo RE, Luoma A, Enzmann GU, Agrawal D, Inouye H, Bunge MB, Kocsis J, Peters A, Whittemore SR.

J Neurosci Res. 2010 Mar;88(4):712-21. doi: 10.1002/jnr.22241.

19.

Internodal myelination during development quantitated using X-ray diffraction.

Agrawal D, Hawk R, Avila RL, Inouye H, Kirschner DA.

J Struct Biol. 2009 Dec;168(3):521-6. doi: 10.1016/j.jsb.2009.06.019. Epub 2009 Jul 1.

PMID:
19576284
20.

Constitutively active Akt induces enhanced myelination in the CNS.

Flores AI, Narayanan SP, Morse EN, Shick HE, Yin X, Kidd G, Avila RL, Kirschner DA, Macklin WB.

J Neurosci. 2008 Jul 9;28(28):7174-83. doi: 10.1523/JNEUROSCI.0150-08.2008.

21.

Fiber diffraction as a screen for amyloid inhibitors.

Kirschner DA, Gross AA, Hidalgo MM, Inouye H, Gleason KA, Abdelsayed GA, Castillo GM, Snow AD, Pozo-Ramajo A, Petty SA, Decatur SM.

Curr Alzheimer Res. 2008 Jun;5(3):288-307.

PMID:
18537544
22.

Myelin structure and composition of myelinated tissue in the African lungfish.

Kirschner DA, Karthigesan J, Bizzozero OA, Kosaras B, Inouye H.

Neuron Glia Biol. 2008 May;4(2):59-70. doi: 10.1017/S1740925X09990196.

PMID:
19737430
23.

Formation of amyloid fibrils in vitro by human gammaD-crystallin and its isolated domains.

Papanikolopoulou K, Mills-Henry I, Thol SL, Wang Y, Gross AA, Kirschner DA, Decatur SM, King J.

Mol Vis. 2008 Jan 16;14:81-9.

24.

Peripheral myelin of Xenopus laevis: role of electrostatic and hydrophobic interactions in membrane compaction.

Luo X, Cerullo J, Dawli T, Priest C, Haddadin Z, Kim A, Inouye H, Suffoletto BP, Avila RL, Lees JP, Sharma D, Xie B, Costello CE, Kirschner DA.

J Struct Biol. 2008 Apr;162(1):170-83. Epub 2007 Nov 1.

25.

Molecular Characterization of Myelin Protein Zero in Xenopus laevis Peripheral Nerve: Equilibrium between Non-covalently Associated Dimer and Monomer.

Xie B, Luo X, Zhao C, Priest CM, Chan SY, O' Connor PB, Kirschner DA, Costello CE.

Int J Mass Spectrom. 2007 Dec 1;268(2-3):304-315.

26.

Cytoplasmic domain of zebrafish myelin protein zero: adhesive role depends on beta-conformation.

Luo X, Inouye H, Gross AA, Hidalgo MM, Sharma D, Lee D, Avila RL, Salmona M, Kirschner DA.

Biophys J. 2007 Nov 15;93(10):3515-28. Epub 2007 Aug 10.

27.

Peripheral nervous system manifestations in a Sandhoff disease mouse model: nerve conduction, myelin structure, lipid analysis.

McNally MA, Baek RC, Avila RL, Seyfried TN, Strichartz GR, Kirschner DA.

J Negat Results Biomed. 2007 Jul 10;6:8.

28.

X-Ray fiber and powder diffraction of PrP prion peptides.

Inouye H, Kirschner DA.

Adv Protein Chem. 2006;73:181-215. Review.

PMID:
17190614
29.

Cytoplasmic domain of human myelin protein zero likely folded as beta-structure in compact myelin.

Luo X, Sharma D, Inouye H, Lee D, Avila RL, Salmona M, Kirschner DA.

Biophys J. 2007 Mar 1;92(5):1585-97. Epub 2006 Dec 1.

30.

Myelin structure and composition in zebrafish.

Avila RL, Tevlin BR, Lees JP, Inouye H, Kirschner DA.

Neurochem Res. 2007 Feb;32(2):197-209. Epub 2006 Sep 2. Erratum in: Neurochem Res. 2007 Feb;32(2):211-2.

PMID:
16951904
31.

Different intracellular pathomechanisms produce diverse Myelin Protein Zero neuropathies in transgenic mice.

Wrabetz L, D'Antonio M, Pennuto M, Dati G, Tinelli E, Fratta P, Previtali S, Imperiale D, Zielasek J, Toyka K, Avila RL, Kirschner DA, Messing A, Feltri ML, Quattrini A.

J Neurosci. 2006 Feb 22;26(8):2358-68.

32.

Evolution of a neuroprotective function of central nervous system myelin.

Yin X, Baek RC, Kirschner DA, Peterson A, Fujii Y, Nave KA, Macklin WB, Trapp BD.

J Cell Biol. 2006 Jan 30;172(3):469-78.

33.

Structure of core domain of fibril-forming PHF/Tau fragments.

Inouye H, Sharma D, Goux WJ, Kirschner DA.

Biophys J. 2006 Mar 1;90(5):1774-89. Epub 2005 Dec 9.

34.

Gerstmann-Sträussler-Scheinker disease amyloid protein polymerizes according to the "dock-and-lock" model.

Gobbi M, Colombo L, Morbin M, Mazzoleni G, Accardo E, Vanoni M, Del Favero E, Cantù L, Kirschner DA, Manzoni C, Beeg M, Ceci P, Ubezio P, Forloni G, Tagliavini F, Salmona M.

J Biol Chem. 2006 Jan 13;281(2):843-9. Epub 2005 Nov 10.

35.

Structure and stability of internodal myelin in mouse models of hereditary neuropathy.

Avila RL, Inouye H, Baek RC, Yin X, Trapp BD, Feltri ML, Wrabetz L, Kirschner DA.

J Neuropathol Exp Neurol. 2005 Nov;64(11):976-90.

PMID:
16254492
36.

Polyglutamine homopolymers having 8-45 residues form slablike beta-crystallite assemblies.

Sharma D, Shinchuk LM, Inouye H, Wetzel R, Kirschner DA.

Proteins. 2005 Nov 1;61(2):398-411.

PMID:
16114051
37.

Poly-(L-alanine) expansions form core beta-sheets that nucleate amyloid assembly.

Shinchuk LM, Sharma D, Blondelle SE, Reixach N, Inouye H, Kirschner DA.

Proteins. 2005 Nov 15;61(3):579-89.

PMID:
16114037
38.

Filaments of the Ure2p prion protein have a cross-beta core structure.

Baxa U, Cheng N, Winkler DC, Chiu TK, Davies DR, Sharma D, Inouye H, Kirschner DA, Wickner RB, Steven AC.

J Struct Biol. 2005 May;150(2):170-9.

PMID:
15866740
39.

Alzheimer's beta-amyloid: insights into fibril formation and structure from Congo red binding.

Inouye H, Kirschner DA.

Subcell Biochem. 2005;38:203-24. Review.

PMID:
15709480
40.

The formation of straight and twisted filaments from short tau peptides.

Goux WJ, Kopplin L, Nguyen AD, Leak K, Rutkofsky M, Shanmuganandam VD, Sharma D, Inouye H, Kirschner DA.

J Biol Chem. 2004 Jun 25;279(26):26868-75. Epub 2004 Apr 20.

41.

Structural properties of Gerstmann-Straussler-Scheinker disease amyloid protein.

Salmona M, Morbin M, Massignan T, Colombo L, Mazzoleni G, Capobianco R, Diomede L, Thaler F, Mollica L, Musco G, Kourie JJ, Bugiani O, Sharma D, Inouye H, Kirschner DA, Forloni G, Tagliavini F.

J Biol Chem. 2003 Nov 28;278(48):48146-53. Epub 2003 Sep 11.

42.

Assemblies of Alzheimer's peptides A beta 25-35 and A beta 31-35: reverse-turn conformation and side-chain interactions revealed by X-ray diffraction.

Bond JP, Deverin SP, Inouye H, el-Agnaf OM, Teeter MM, Kirschner DA.

J Struct Biol. 2003 Feb;141(2):156-70.

PMID:
12615542
43.

Molecular organization of amyloid protofilament-like assembly of betabellin 15D: helical array of beta-sandwiches.

Inouye H, Bond JE, Deverin SP, Lim A, Costello CE, Kirschner DA.

Biophys J. 2002 Sep;83(3):1716-27.

44.

Myelin protein zero exists as dimers and tetramers in native membranes of Xenopus laevis peripheral nerve.

Thompson AJ, Cronin MS, Kirschner DA.

J Neurosci Res. 2002 Mar 15;67(6):766-71.

PMID:
11891790
45.

Expression and purification of the extracellular domain of human myelin protein zero.

Bond JP, Saavedra RA, Kirschner DA.

Protein Expr Purif. 2001 Dec;23(3):398-410.

PMID:
11722176
46.

Visualization of nonstructural changes in early white matter development on diffusion-weighted MR images: evidence supporting premyelination anisotropy.

Prayer D, Barkovich AJ, Kirschner DA, Prayer LM, Roberts TP, Kucharczyk J, Moseley ME.

AJNR Am J Neuroradiol. 2001 Sep;22(8):1572-6.

47.

Laminin inhibition of beta-amyloid protein (Abeta) fibrillogenesis and identification of an Abeta binding site localized to the globular domain repeats on the laminin a chain.

Castillo GM, Lukito W, Peskind E, Raskind M, Kirschner DA, Yee AG, Snow AD.

J Neurosci Res. 2000 Nov 1;62(3):451-62.

PMID:
11054814
48.

Histidine residues underlie Congo red binding to A beta analogs.

Inouye H, Nguyen JT, Fraser PE, Shinchuk LM, Packard AB, Kirschner DA.

Amyloid. 2000 Sep;7(3):179-88.

PMID:
11019858
49.

Betabellins 15D and 16D, de Novo designed beta-sandwich proteins that have amyloidogenic properties.

Lim A, Makhov AM, Bond J, Inouye H, Connors LH, Griffith JD, Erickson BW, Kirschner DA, Costello CE.

J Struct Biol. 2000 Jun;130(2-3):363-70.

PMID:
10940239
50.

A beta fibrillogenesis: kinetic parameters for fibril formation from congo red binding.

Inouye H, Kirschner DA.

J Struct Biol. 2000 Jun;130(2-3):123-9.

PMID:
10940220

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