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Items: 16

1.

Suppression of STING associated with LKB1 loss in KRAS-driven lung cancer.

Kitajima S, Ivanova E, Guo S, Yoshida R, Campisi M, Sundararaman SK, Tange S, Mitsuishi Y, Thai TC, Masuda S, Piel BP, Sholl LM, Kirschmeier PT, Paweletz CP, Watanabe H, Yajima M, Barbie DA.

Cancer Discov. 2018 Oct 8. pii: CD-18-0689. doi: 10.1158/2159-8290.CD-18-0689. [Epub ahead of print]

PMID:
30297358
2.

A High-Throughput Immune-Oncology Screen Identifies EGFR Inhibitors as Potent Enhancers of Antigen-Specific Cytotoxic T-lymphocyte Tumor Cell Killing.

Lizotte PH, Hong RL, Luster TA, Cavanaugh ME, Taus LJ, Wang S, Dhaneshwar A, Mayman N, Yang A, Kulkarni M, Badalucco L, Fitzpatrick E, Kao HF, Kuraguchi M, Bittinger M, Kirschmeier PT, Gray NS, Barbie DA, Jänne PA.

Cancer Immunol Res. 2018 Sep 21. doi: 10.1158/2326-6066.CIR-18-0193. [Epub ahead of print]

PMID:
30242021
3.

Overcoming Resistance to Dual Innate Immune and MEK Inhibition Downstream of KRAS.

Kitajima S, Asahina H, Chen T, Guo S, Quiceno LG, Cavanaugh JD, Merlino AA, Tange S, Terai H, Kim JW, Wang X, Zhou S, Xu M, Wang S, Zhu Z, Thai TC, Takahashi C, Wang Y, Neve R, Stinson S, Tamayo P, Watanabe H, Kirschmeier PT, Wong KK, Barbie DA.

Cancer Cell. 2018 Sep 10;34(3):439-452.e6. doi: 10.1016/j.ccell.2018.08.009.

PMID:
30205046
4.

Amplification of Wild-type KRAS Imparts Resistance to Crizotinib in MET Exon 14 Mutant Non-Small Cell Lung Cancer.

Bahcall M, Awad MM, Sholl LM, Wilson FH, Xu M, Wang S, Palakurthi S, Choi J, Ivanova EV, Leonardi GC, Ulrich BC, Paweletz CP, Kirschmeier PT, Watanabe M, Baba H, Nishino M, Nagy RJ, Lanman RB, Capelletti M, Chambers ES, Redig AJ, VanderLaan PA, Costa DB, Imamura Y, Jänne PA.

Clin Cancer Res. 2018 Aug 2. doi: 10.1158/1078-0432.CCR-18-0876. [Epub ahead of print]

PMID:
30072474
5.

Recurrent ubiquitin B silencing in gynecological cancers establishes dependence on ubiquitin C.

Kedves AT, Gleim S, Liang X, Bonal DM, Sigoillot F, Harbinski F, Sanghavi S, Benander C, George E, Gokhale PC, Nguyen QD, Kirschmeier PT, Distel RJ, Jenkins J, Goldberg MS, Forrester WC.

J Clin Invest. 2017 Dec 1;127(12):4554-4568. doi: 10.1172/JCI92914. Epub 2017 Nov 13.

6.

Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids.

Jenkins RW, Aref AR, Lizotte PH, Ivanova E, Stinson S, Zhou CW, Bowden M, Deng J, Liu H, Miao D, He MX, Walker W, Zhang G, Tian T, Cheng C, Wei Z, Palakurthi S, Bittinger M, Vitzthum H, Kim JW, Merlino A, Quinn M, Venkataramani C, Kaplan JA, Portell A, Gokhale PC, Phillips B, Smart A, Rotem A, Jones RE, Keogh L, Anguiano M, Stapleton L, Jia Z, Barzily-Rokni M, Cañadas I, Thai TC, Hammond MR, Vlahos R, Wang ES, Zhang H, Li S, Hanna GJ, Huang W, Hoang MP, Piris A, Eliane JP, Stemmer-Rachamimov AO, Cameron L, Su MJ, Shah P, Izar B, Thakuria M, LeBoeuf NR, Rabinowits G, Gunda V, Parangi S, Cleary JM, Miller BC, Kitajima S, Thummalapalli R, Miao B, Barbie TU, Sivathanu V, Wong J, Richards WG, Bueno R, Yoon CH, Miret J, Herlyn M, Garraway LA, Van Allen EM, Freeman GJ, Kirschmeier PT, Lorch JH, Ott PA, Hodi FS, Flaherty KT, Kamm RD, Boland GM, Wong KK, Dornan D, Paweletz CP, Barbie DA.

Cancer Discov. 2018 Feb;8(2):196-215. doi: 10.1158/2159-8290.CD-17-0833. Epub 2017 Nov 3.

PMID:
29101162
7.

Establishment of Patient-Derived Tumor Xenograft Models of Epithelial Ovarian Cancer for Preclinical Evaluation of Novel Therapeutics.

Liu JF, Palakurthi S, Zeng Q, Zhou S, Ivanova E, Huang W, Zervantonakis IK, Selfors LM, Shen Y, Pritchard CC, Zheng M, Adleff V, Papp E, Piao H, Novak M, Fotheringham S, Wulf GM, English J, Kirschmeier PT, Velculescu VE, Paweletz C, Mills GB, Livingston DM, Brugge JS, Matulonis UA, Drapkin R.

Clin Cancer Res. 2017 Mar 1;23(5):1263-1273. doi: 10.1158/1078-0432.CCR-16-1237. Epub 2016 Aug 29.

8.

Pathological glycogenesis through glycogen synthase 1 and suppression of excessive AMP kinase activity in myeloid leukemia cells.

Bhanot H, Reddy MM, Nonami A, Weisberg EL, Bonal D, Kirschmeier PT, Salgia S, Podar K, Galinsky I, Chowdary TK, Neuberg D, Tonon G, Stone RM, Asara J, Griffin JD, Sattler M.

Leukemia. 2015 Jul;29(7):1555-1563. doi: 10.1038/leu.2015.46. Epub 2015 Feb 23.

9.

Evaluating TBK1 as a therapeutic target in cancers with activated IRF3.

Muvaffak A, Pan Q, Yan H, Fernandez R, Lim J, Dolinski B, Nguyen TT, Strack P, Wu S, Chung R, Zhang W, Hulton C, Ripley S, Hirsch H, Nagashima K, Wong KK, Jánne PA, Seidel-Dugan C, Zawel L, Kirschmeier PT, Middleton RE, Morris EJ, Wang Y.

Mol Cancer Res. 2014 Jul;12(7):1055-66. doi: 10.1158/1541-7786.MCR-13-0642. Epub 2014 Apr 21.

10.

In vivo prenylation analysis of Ras and Rho proteins.

Kirschmeier PT, Whyte D, Wilson O, Bishop WR, Pai JK.

Methods Enzymol. 2001;332:115-27. No abstract available.

PMID:
11305090
11.

Biological effects and mechanism of action of farnesyl transferase inhibitors.

Ashar HR, Armstrong L, James LJ, Carr DM, Gray K, Taveras A, Doll RJ, Bishop WR, Kirschmeier PT.

Chem Res Toxicol. 2000 Oct;13(10):949-52. Review. No abstract available.

PMID:
11080039
12.

Transduction of the human insulin gene via retroviral vectors fails to yield spliced transcripts.

Perkins AS, Kirschmeier PT, Weinstein IB.

DNA. 1989 Jan-Feb;8(1):59-68.

PMID:
2468464
13.

Construction and characterization of a retroviral vector demonstrating efficient expression of cloned cDNA sequences.

Kirschmeier PT, Housey GM, Johnson MD, Perkins AS, Weinstein IB.

DNA. 1988 Apr;7(3):219-25.

PMID:
2836147
14.

Role of protein kinase C in regulation of gene expression and relevance to tumor promotion.

Johnson MD, Housey GM, O'Brian CA, Kirschmeier PT, Weinstein IB.

Environ Health Perspect. 1987 Dec;76:89-95.

15.

Molecular cloning of gene sequences regulated by tumor promoters and mitogens through protein kinase C.

Johnson MD, Housey GM, Kirschmeier PT, Weinstein IB.

Mol Cell Biol. 1987 Aug;7(8):2821-9.

16.

Design of a retrovirus-derived vector for expression and transduction of exogenous genes in mammalian cells.

Perkins AS, Kirschmeier PT, Gattoni-Celli S, Weinstein IB.

Mol Cell Biol. 1983 Jun;3(6):1123-32.

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