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Items: 1 to 50 of 69

1.

High-Throughput Patch Clamp Screening in Human α6-Containing Nicotinic Acetylcholine Receptors.

Armstrong LC, Kirsch GE, Fedorov NB, Wu C, Kuryshev YA, Sewell AL, Liu Z, Motter AL, Leggett CS, Orr MS.

SLAS Discov. 2017 Jul;22(6):686-695. doi: 10.1177/2472555217696794. Epub 2017 Mar 15.

2.

Electrophysiology-Based Assays to Detect Subtype-Selective Modulation of Human Nicotinic Acetylcholine Receptors.

Kirsch GE, Fedorov NB, Kuryshev YA, Liu Z, Armstrong LC, Orr MS.

Assay Drug Dev Technol. 2016 Aug;14(6):333-44. doi: 10.1089/adt.2015.688.

3.

Functional Characterization of Human Stem Cell-Derived Cardiomyocytes.

Kirsch GE, Obejero-Paz CA, Bruening-Wright A.

Curr Protoc Pharmacol. 2014;64:11.12.1-26. doi: 10.1002/0471141755.ph1112s64.

4.

Evaluating state dependence and subtype selectivity of calcium channel modulators in automated electrophysiology assays.

Kuryshev YA, Brown AM, Duzic E, Kirsch GE.

Assay Drug Dev Technol. 2014 Mar;12(2):110-9. doi: 10.1089/adt.2013.552. Epub 2014 Feb 28.

5.

Increased cardiac risk in concomitant methadone and diazepam treatment: pharmacodynamic interactions in cardiac ion channels.

Kuryshev YA, Bruening-Wright A, Brown AM, Kirsch GE.

J Cardiovasc Pharmacol. 2010 Oct;56(4):420-30. doi: 10.1097/FJC.0b013e3181f1d21b.

PMID:
20930594
6.

The action potential and comparative pharmacology of stem cell-derived human cardiomyocytes.

Peng S, Lacerda AE, Kirsch GE, Brown AM, Bruening-Wright A.

J Pharmacol Toxicol Methods. 2010 May-Jun;61(3):277-86. doi: 10.1016/j.vascn.2010.01.014. Epub 2010 Feb 11.

PMID:
20153443
7.

Test article concentrations in the hERG assay: losses through the perfusion, solubility and stability.

Brimecombe JC, Kirsch GE, Brown AM.

J Pharmacol Toxicol Methods. 2009 Jan-Feb;59(1):29-34. doi: 10.1016/j.vascn.2008.10.004. Epub 2008 Nov 8.

PMID:
19028590
8.

Variability in the measurement of hERG potassium channel inhibition: effects of temperature and stimulus pattern.

Kirsch GE, Trepakova ES, Brimecombe JC, Sidach SS, Erickson HD, Kochan MC, Shyjka LM, Lacerda AE, Brown AM.

J Pharmacol Toxicol Methods. 2004 Sep-Oct;50(2):93-101.

PMID:
15385083
9.

Inhibition of cardiac HERG currents by the DNA topoisomerase II inhibitor amsacrine: mode of action.

Thomas D, Hammerling BC, Wu K, Wimmer AB, Ficker EK, Kirsch GE, Kochan MC, Wible BA, Scholz EP, Zitron E, Kathöfer S, Kreye VA, Katus HA, Schoels W, Karle CA, Kiehn J.

Br J Pharmacol. 2004 Jun;142(3):485-94. Epub 2004 May 17.

10.

The common SCN5A mutation R1193Q causes LQTS-type electrophysiological alterations of the cardiac sodium channel.

Wang Q, Chen S, Chen Q, Wan X, Shen J, Hoeltge GA, Timur AA, Keating MT, Kirsch GE.

J Med Genet. 2004 May;41(5):e66. No abstract available.

11.

Mechanisms by which SCN5A mutation N1325S causes cardiac arrhythmias and sudden death in vivo.

Tian XL, Yong SL, Wan X, Wu L, Chung MK, Tchou PJ, Rosenbaum DS, Van Wagoner DR, Kirsch GE, Wang Q.

Cardiovasc Res. 2004 Feb 1;61(2):256-67.

12.

Hysteresis effect implicates calcium cycling as a mechanism of repolarization alternans.

Walker ML, Wan X, Kirsch GE, Rosenbaum DS.

Circulation. 2003 Nov 25;108(21):2704-9. Epub 2003 Oct 27.

PMID:
14581412
13.

U-type inactivation of Kv3.1 and Shaker potassium channels.

Klemic KG, Kirsch GE, Jones SW.

Biophys J. 2001 Aug;81(2):814-26.

14.

Accelerated inactivation in a mutant Na(+) channel associated with idiopathic ventricular fibrillation.

Wan X, Chen S, Sadeghpour A, Wang Q, Kirsch GE.

Am J Physiol Heart Circ Physiol. 2001 Jan;280(1):H354-60.

15.
16.

Sodium channel blockers identify risk for sudden death in patients with ST-segment elevation and right bundle branch block but structurally normal hearts.

Brugada R, Brugada J, Antzelevitch C, Kirsch GE, Potenza D, Towbin JA, Brugada P.

Circulation. 2000 Feb 8;101(5):510-5.

PMID:
10662748
17.

Ion channel defects in cardiac arrhythmia.

Kirsch GE.

J Membr Biol. 1999 Aug 1;170(3):181-90. Review. No abstract available.

PMID:
10441662
18.

Modulation of potassium channel gating by coexpression of Kv2.1 with regulatory Kv5.1 or Kv6.1 alpha-subunits.

Kramer JW, Post MA, Brown AM, Kirsch GE.

Am J Physiol. 1998 Jun;274(6):C1501-10. doi: 10.1152/ajpcell.1998.274.6.C1501.

PMID:
9696692
19.

Inactivation of Kv2.1 potassium channels.

Klemic KG, Shieh CC, Kirsch GE, Jones SW.

Biophys J. 1998 Apr;74(4):1779-89.

20.

Genetic basis and molecular mechanism for idiopathic ventricular fibrillation.

Chen Q, Kirsch GE, Zhang D, Brugada R, Brugada J, Brugada P, Potenza D, Moya A, Borggrefe M, Breithardt G, Ortiz-Lopez R, Wang Z, Antzelevitch C, O'Brien RE, Schulze-Bahr E, Keating MT, Towbin JA, Wang Q.

Nature. 1998 Mar 19;392(6673):293-6.

PMID:
9521325
21.

Mechanism of lidocaine block of late current in long Q-T mutant Na+ channels.

Dumaine R, Kirsch GE.

Am J Physiol. 1998 Feb;274(2):H477-87. doi: 10.1152/ajpheart.1998.274.2.H477.

PMID:
9486250
22.

Contribution of the NH2 terminus of Kv2.1 to channel activation.

Pascual JM, Shieh CC, Kirsch GE, Brown AM.

Am J Physiol. 1997 Dec;273(6):C1849-58. doi: 10.1152/ajpcell.1997.273.6.C1849.

PMID:
9435489
23.

Role of transmembrane segment S5 on gating of voltage-dependent K+ channels.

Shieh CC, Klemic KG, Kirsch GE.

J Gen Physiol. 1997 Jun;109(6):767-78.

24.

Cysteine mapping in the ion selectivity and toxin binding region of the cardiac Na+ channel pore.

Chen S, Hartmann HA, Kirsch GE.

J Membr Biol. 1997 Jan 1;155(1):11-25. Erratum in: J Membr Biol 1997 Mar 1;156(1):98.

PMID:
9002421
25.
26.

Multiple mechanisms of Na+ channel--linked long-QT syndrome.

Dumaine R, Wang Q, Keating MT, Hartmann HA, Schwartz PJ, Brown AM, Kirsch GE.

Circ Res. 1996 May;78(5):916-24.

PMID:
8620612
27.

Multiple residues specify external tetraethylammonium blockade in voltage-gated potassium channels.

Pascual JM, Shieh CC, Kirsch GE, Brown AM.

Biophys J. 1995 Aug;69(2):428-34.

28.

K+ pore structure revealed by reporter cysteines at inner and outer surfaces.

Pascual JM, Shieh CC, Kirsch GE, Brown AM.

Neuron. 1995 May;14(5):1055-63.

29.
31.
32.

Effects of III-IV linker mutations on human heart Na+ channel inactivation gating.

Hartmann HA, Tiedeman AA, Chen SF, Brown AM, Kirsch GE.

Circ Res. 1994 Jul;75(1):114-22.

PMID:
8013069
33.

The potassium pore and its regulation.

Brown AM, Drewe JA, Hartmann HA, Taglialatela M, De Biasi M, Soman K, Kirsch GE.

Ann N Y Acad Sci. 1993 Dec 20;707:74-80. Review. No abstract available.

PMID:
9137543
34.
35.

Segmental exchanges define 4-aminopyridine binding and the inner mouth of K+ pores.

Kirsch GE, Shieh CC, Drewe JA, Vener DF, Brown AM.

Neuron. 1993 Sep;11(3):503-12.

PMID:
8398143
36.

Histidine substitution identifies a surface position and confers Cs+ selectivity on a K+ pore.

De Biasi M, Drewe JA, Kirsch GE, Brown AM.

Biophys J. 1993 Sep;65(3):1235-42.

37.

Functional interactions between K+ pore residues located in different subunits.

Kirsch GE, Drewe JA, De Biasi M, Hartmann HA, Brown AM.

J Biol Chem. 1993 Jul 5;268(19):13799-804.

38.

Regulation of K+/Rb+ selectivity and internal TEA blockade by mutations at a single site in K+ pores.

Taglialatela M, Drewe JA, Kirsch GE, De Biasi M, Hartmann HA, Brown AM.

Pflugers Arch. 1993 Apr;423(1-2):104-12.

PMID:
7683786
39.

Inactivation determined by a single site in K+ pores.

De Biasi M, Hartmann HA, Drewe JA, Taglialatela M, Brown AM, Kirsch GE.

Pflugers Arch. 1993 Jan;422(4):354-63.

PMID:
8437886
40.

A single nonpolar residue in the deep pore of related K+ channels acts as a K+:Rb+ conductance switch.

Kirsch GE, Drewe JA, Taglialatela M, Joho RH, DeBiasi M, Hartmann HA, Brown AM.

Biophys J. 1992 Apr;62(1):136-43; discussion 143-4.

41.

Gating currents from a delayed rectifier K+ channel with altered pore structure and function.

Taglialatela M, Kirsch GE, VanDongen AM, Drewe JA, Hartmann HA, Joho RH, Stefani E, Brown AM.

Biophys J. 1992 Apr;62(1):34-6. No abstract available.

42.

Differences between the deep pores of K+ channels determined by an interacting pair of nonpolar amino acids.

Kirsch GE, Drewe JA, Hartmann HA, Taglialatela M, de Biasi M, Brown AM, Joho RH.

Neuron. 1992 Mar;8(3):499-505.

PMID:
1550675
43.

Internal and external TEA block in single cloned K+ channels.

Kirsch GE, Taglialatela M, Brown AM.

Am J Physiol. 1991 Oct;261(4 Pt 1):C583-90.

PMID:
1928322
44.

Patterns of internal and external tetraethylammonium block in four homologous K+ channels.

Taglialatela M, Vandongen AM, Drewe JA, Joho RH, Brown AM, Kirsch GE.

Mol Pharmacol. 1991 Aug;40(2):299-307.

PMID:
1875913
45.

Exchange of conduction pathways between two related K+ channels.

Hartmann HA, Kirsch GE, Drewe JA, Taglialatela M, Joho RH, Brown AM.

Science. 1991 Feb 22;251(4996):942-4.

PMID:
2000495
46.

Electrophysiological characterization of a new member of the RCK family of rat brain K+ channels.

Kirsch GE, Drewe JA, Verma S, Brown AM, Joho RH.

FEBS Lett. 1991 Jan 14;278(1):55-60.

47.

Changes in sodium channel gating produced by point mutations in a cytoplasmic linker.

Moorman JR, Kirsch GE, Brown AM, Joho RH.

Science. 1990 Nov 2;250(4981):688-91.

PMID:
2173138
48.

Coupling of ATP-sensitive K+ channels to A1 receptors by G proteins in rat ventricular myocytes.

Kirsch GE, Codina J, Birnbaumer L, Brown AM.

Am J Physiol. 1990 Sep;259(3 Pt 2):H820-6.

PMID:
2118729
49.

Inhibition of cardiac Na+ currents by isoproterenol.

Schubert B, Vandongen AM, Kirsch GE, Brown AM.

Am J Physiol. 1990 Apr;258(4 Pt 2):H977-82.

PMID:
2158748
50.

Toxin and kinetic profile of rat brain type III sodium channels expressed in Xenopus oocytes.

Joho RH, Moorman JR, VanDongen AM, Kirsch GE, Silberberg H, Schuster G, Brown AM.

Brain Res Mol Brain Res. 1990 Feb;7(2):105-13.

PMID:
2160038

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