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Loss of MST/Hippo signaling in a genetically engineered mouse model of fusion-positive rhabdomyosarcoma accelerates tumorigenesis.

Oristian KM, Crose LES, Kuprasertkul N, Bentley RC, Lin YT, Williams N, Kirsch DG, Linardic CM.

Cancer Res. 2018 Aug 9. pii: canres.3912.2018. doi: 10.1158/0008-5472.CAN-17-3912. [Epub ahead of print]


Blocking cyclin-dependent kinase 4/6 during single dose vs. fractionated radiation therapy leads to opposite effects on acute gastrointestinal toxicity in mice.

Lee CL, Oh P, Xu E, Ma Y, Kim Y, Daniel AR, Kirsch DG.

Int J Radiat Oncol Biol Phys. 2018 Jul 26. pii: S0360-3016(18)31645-6. doi: 10.1016/j.ijrobp.2018.07.192. [Epub ahead of print]


Notch-induced myeloid reprogramming in spontaneous pancreatic ductal adenocarcinoma by dual genetic targeting.

Cheung PF, Neff F, Neander C, Bazarna A, Savvatakis K, Liffers ST, Althoff K, Lee CL, Moding EJ, Kirsch DG, Saur D, Bazhin AV, Trajkovic-Arsic M, Heikenwälder M, Siveke JT.

Cancer Res. 2018 May 29. pii: canres.0052.2018. doi: 10.1158/0008-5472.CAN-18-0052. [Epub ahead of print]


Combining precision radiotherapy with molecular targeting and immunomodulatory agents: a guideline by the American Society for Radiation Oncology.

Bristow RG, Alexander B, Baumann M, Bratman SV, Brown JM, Camphausen K, Choyke P, Citrin D, Contessa JN, Dicker A, Kirsch DG, Krause M, Le QT, Milosevic M, Morris ZS, Sarkaria JN, Sondel PM, Tran PT, Wilson GD, Willers H, Wong RKS, Harari PM.

Lancet Oncol. 2018 May;19(5):e240-e251. doi: 10.1016/S1470-2045(18)30096-2. Review.


Current Opportunities and Future Vision of Precision Medicine in Radiation Oncology.

Kirsch DG.

Int J Radiat Oncol Biol Phys. 2018 Jun 1;101(2):267-270. doi: 10.1016/j.ijrobp.2017.04.005. No abstract available.


Rationale and emerging strategies for immune checkpoint blockade in soft tissue sarcoma.

Wisdom AJ, Mowery YM, Riedel RF, Kirsch DG.

Cancer. 2018 May 3. doi: 10.1002/cncr.31517. [Epub ahead of print] Review.


Genomic Status of MET Potentiates Sensitivity to MET and MEK Inhibition in NF1-Related Malignant Peripheral Nerve Sheath Tumors.

Peacock JD, Pridgeon MG, Tovar EA, Essenburg CJ, Bowman M, Madaj Z, Koeman J, Boguslawski EA, Grit J, Dodd RD, Khachaturov V, Cardona DM, Chen M, Kirsch DG, Maina F, Dono R, Winn ME, Graveel CR, Steensma MR.

Cancer Res. 2018 Jul 1;78(13):3672-3687. doi: 10.1158/0008-5472.CAN-17-3167. Epub 2018 May 2.


Workshop Report for Cancer Research: Defining the Shades of Gy: Utilizing the Biological Consequences of Radiotherapy in the Development of New Treatment Approaches-Meeting Viewpoint.

Ahmed MM, Coleman CN, Mendonca M, Bentzen S, Vikram B, Seltzer SM, Goodhead D, Obcemea C, Mohan R, Prise KM, Capala J, Citrin D, Kao G, Aryankalayil M, Eke I, Buchsbaum JC, Prasanna PGS, Liu FF, Le QT, Teicher B, Kirsch DG, Smart D, Tepper J, Formenti S, Haas-Kogan D, Raben D, Mitchell J.

Cancer Res. 2018 May 1;78(9):2166-2170. doi: 10.1158/0008-5472.CAN-17-3760. Epub 2018 Apr 23. No abstract available.


Correlation of High-Risk Soft Tissue Sarcoma Biomarker Expression Patterns with Outcome following Neoadjuvant Chemoradiation.

Kane JM 3rd, Magliocco A, Zhang Q, Wang D, Klimowicz A, Harris J, Simko J, DeLaney T, Kraybill W, Kirsch DG.

Sarcoma. 2018 Feb 28;2018:8310950. doi: 10.1155/2018/8310950. eCollection 2018.


Mice Lacking RIP3 Kinase are not Protected from Acute Radiation Syndrome.

Castle KD, Daniel AR, Moding EJ, Luo L, Lee CL, Kirsch DG.

Radiat Res. 2018 Jun;189(6):627-633. doi: 10.1667/RR15001.1. Epub 2018 Apr 10.


Dual-Energy CT Imaging of Tumor Liposome Delivery After Gold Nanoparticle-Augmented Radiation Therapy.

Ashton JR, Castle KD, Qi Y, Kirsch DG, West JL, Badea CT.

Theranostics. 2018 Feb 12;8(7):1782-1797. doi: 10.7150/thno.22621. eCollection 2018.


Characterizing the Potency and Impact of Carbon Ion Therapy in a Primary Mouse Model of Soft Tissue Sarcoma.

Brownstein JM, Wisdom AJ, Castle KD, Mowery YM, Guida P, Lee CL, Tommasino F, Tessa C, Scifoni E, Gao J, Luo L, Campos LDS, Ma Y, Williams N, Jung SH, Durante M, Kirsch DG.

Mol Cancer Ther. 2018 Apr;17(4):858-868. doi: 10.1158/1535-7163.MCT-17-0965. Epub 2018 Feb 7.


Efficacy and Safety of Low-Dose Iodine Plaque Brachytherapy for Juxtapapillary Choroidal Melanoma.

Oellers P, Mowery YM, Perez BA, Stinnett S, Mettu P, Vajzovic L, Light K, Steffey BA, Cai J, Dutton JJ, Buckley EG, Halperin EC, Marks LB, Kirsch DG, Mruthyunjaya P.

Am J Ophthalmol. 2018 Feb;186:32-40. doi: 10.1016/j.ajo.2017.11.008. Epub 2017 Dec 2.


Effects of chondroitin sulfate proteoglycan 4 (NG2/CSPG4) on soft-tissue sarcoma growth depend on tumor developmental stage.

Hsu SC, Nadesan P, Puviindran V, Stallcup WB, Kirsch DG, Alman BA.

J Biol Chem. 2018 Feb 16;293(7):2466-2475. doi: 10.1074/jbc.M117.805051. Epub 2017 Dec 1.


The Future of Radiobiology.

Kirsch DG, Diehn M, Kesarwala AH, Maity A, Morgan MA, Schwarz JK, Bristow R, Demaria S, Eke I, Griffin RJ, Haas-Kogan D, Higgins GS, Kimmelman AC, Kimple RJ, Lombaert IM, Ma L, Marples B, Pajonk F, Park CC, Schaue D, Tran PT, Willers H, Wouters BG, Bernhard EJ.

J Natl Cancer Inst. 2018 Apr 1;110(4):329-340. doi: 10.1093/jnci/djx231.


A precision 3D conformal treatment technique in rats: Application to whole-brain radiotherapy with hippocampal avoidance.

Yoon SW, Cramer CK, Miles DA, Reinsvold MH, Joo KM, Kirsch DG, Oldham M.

Med Phys. 2017 Nov;44(11):6008-6017. doi: 10.1002/mp.12533. Epub 2017 Sep 30.


Generation and comparison of CRISPR-Cas9 and Cre-mediated genetically engineered mouse models of sarcoma.

Huang J, Chen M, Whitley MJ, Kuo HC, Xu ES, Walens A, Mowery YM, Van Mater D, Eward WC, Cardona DM, Luo L, Ma Y, Lopez OM, Nelson CE, Robinson-Hamm JN, Reddy A, Dave SS, Gersbach CA, Dodd RD, Kirsch DG.

Nat Commun. 2017 Jul 10;8:15999. doi: 10.1038/ncomms15999.


NF1+/- Hematopoietic Cells Accelerate Malignant Peripheral Nerve Sheath Tumor Development without Altering Chemotherapy Response.

Dodd RD, Lee CL, Overton T, Huang W, Eward WC, Luo L, Ma Y, Ingram DR, Torres KE, Cardona DM, Lazar AJ, Kirsch DG.

Cancer Res. 2017 Aug 15;77(16):4486-4497. doi: 10.1158/0008-5472.CAN-16-2643. Epub 2017 Jun 23.


p53 Regulates Progenitor Cell Quiescence and Differentiation in the Airway.

McConnell AM, Yao C, Yeckes AR, Wang Y, Selvaggio AS, Tang J, Kirsch DG, Stripp BR.

Cell Rep. 2016 Nov 22;17(9):2173-2182. doi: 10.1016/j.celrep.2016.11.007.


Algorithms for differentiating between images of heterogeneous tissue across fluorescence microscopes.

Chitalia R, Mueller J, Fu HL, Whitley MJ, Kirsch DG, Brown JQ, Willett R, Ramanujam N.

Biomed Opt Express. 2016 Aug 12;7(9):3412-3424. eCollection 2016 Sep 1.


Distal airway epithelial progenitor cells are radiosensitive to High-LET radiation.

McConnell AM, Konda B, Kirsch DG, Stripp BR.

Sci Rep. 2016 Sep 23;6:33455. doi: 10.1038/srep33455.


Radiation Therapy for Soft Tissue Sarcoma: Indications and Controversies for Neoadjuvant Therapy, Adjuvant Therapy, Intraoperative Radiation Therapy, and Brachytherapy.

Larrier NA, Czito BG, Kirsch DG.

Surg Oncol Clin N Am. 2016 Oct;25(4):841-60. doi: 10.1016/j.soc.2016.05.012. Epub 2016 Aug 6. Review.


X-Ray Psoralen Activated Cancer Therapy (X-PACT).

Oldham M, Yoon P, Fathi Z, Beyer WF, Adamson J, Liu L, Alcorta D, Xia W, Osada T, Liu C, Yang XY, Dodd RD, Herndon JE 2nd, Meng B, Kirsch DG, Lyerly HK, Dewhirst MW, Fecci P, Walder H, Spector NL.

PLoS One. 2016 Sep 1;11(9):e0162078. doi: 10.1371/journal.pone.0162078. eCollection 2016.


An extra copy of p53 suppresses development of spontaneous Kras-driven but not radiation-induced cancer.

Moding EJ, Min HD, Castle KD, Ali M, Woodlief L, Williams N, Ma Y, Kim Y, Lee CL, Kirsch DG.

JCI Insight. 2016 Jul 7;1(10). pii: e86698.


Opportunities for Radiosensitization in the Stereotactic Body Radiation Therapy (SBRT) Era.

Moding EJ, Mowery YM, Kirsch DG.

Cancer J. 2016 Jul-Aug;22(4):267-73. doi: 10.1097/PPO.0000000000000203. Review.


Mesenchymal Tumors Can Derive from Ng2/Cspg4-Expressing Pericytes with β-Catenin Modulating the Neoplastic Phenotype.

Sato S, Tang YJ, Wei Q, Hirata M, Weng A, Han I, Okawa A, Takeda S, Whetstone H, Nadesan P, Kirsch DG, Wunder JS, Alman BA.

Cell Rep. 2016 Jul 26;16(4):917-927. doi: 10.1016/j.celrep.2016.06.058. Epub 2016 Jul 14.


A Novel Imaging System Distinguishes Neoplastic from Normal Tissue During Resection of Soft Tissue Sarcomas and Mast Cell Tumors in Dogs.

Bartholf DeWitt S, Eward WC, Eward CA, Lazarides AL, Whitley MJ, Ferrer JM, Brigman BE, Kirsch DG, Berg J.

Vet Surg. 2016 Aug;45(6):715-22. doi: 10.1111/vsu.12487. Epub 2016 Jun 9.


Preoperative or postoperative radiotherapy versus surgery alone for retroperitoneal sarcoma: a case-control, propensity score-matched analysis of a nationwide clinical oncology database.

Nussbaum DP, Rushing CN, Lane WO, Cardona DM, Kirsch DG, Peterson BL, Blazer DG Rd.

Lancet Oncol. 2016 Jul;17(7):966-975. doi: 10.1016/S1470-2045(16)30050-X. Epub 2016 May 17.


Improving the Predictive Value of Preclinical Studies in Support of Radiotherapy Clinical Trials.

Coleman CN, Higgins GS, Brown JM, Baumann M, Kirsch DG, Willers H, Prasanna PG, Dewhirst MW, Bernhard EJ, Ahmed MM.

Clin Cancer Res. 2016 Jul 1;22(13):3138-47. doi: 10.1158/1078-0432.CCR-16-0069. Epub 2016 May 6. Review.


Application of single-cell RNA sequencing in optimizing a combinatorial therapeutic strategy in metastatic renal cell carcinoma.

Kim KT, Lee HW, Lee HO, Song HJ, Jeong da E, Shin S, Kim H, Shin Y, Nam DH, Jeong BC, Kirsch DG, Joo KM, Park WY.

Genome Biol. 2016 Apr 29;17:80. doi: 10.1186/s13059-016-0945-9.


MicroRNA-182 drives metastasis of primary sarcomas by targeting multiple genes.

Sachdeva M, Mito JK, Lee CL, Zhang M, Li Z, Dodd RD, Cason D, Luo L, Ma Y, Van Mater D, Gladdy R, Lev DC, Cardona DM, Kirsch DG.

J Clin Invest. 2016 Apr 1;126(4):1606. doi: 10.1172/JCI86573. Epub 2016 Apr 1. No abstract available.


A Fluorescence-Guided Laser Ablation System for Removal of Residual Cancer in a Mouse Model of Soft Tissue Sarcoma.

Lazarides AL, Whitley MJ, Strasfeld DB, Cardona DM, Ferrer JM, Mueller JL, Fu HL, Bartholf DeWitt S, Brigman BE, Ramanujam N, Kirsch DG, Eward WC.

Theranostics. 2016 Jan 1;6(2):155-66. doi: 10.7150/thno.13536. eCollection 2016.


Margin reduction from image guided radiation therapy for soft tissue sarcoma: Secondary analysis of Radiation Therapy Oncology Group 0630 results.

Li XA, Chen X, Zhang Q, Kirsch DG, Petersen I, DeLaney TF, Freeman CR, Trotti A, Hitchcock Y, Bedi M, Haddock M, Salerno K, Dundas G, Wang D.

Pract Radiat Oncol. 2016 Jul-Aug;6(4):e135-40. doi: 10.1016/j.prro.2015.11.012. Epub 2015 Nov 17.


Structured Illumination Microscopy and a Quantitative Image Analysis for the Detection of Positive Margins in a Pre-Clinical Genetically Engineered Mouse Model of Sarcoma.

Fu HL, Mueller JL, Whitley MJ, Cardona DM, Willett RM, Kirsch DG, Brown JQ, Ramanujam N.

PLoS One. 2016 Jan 22;11(1):e0147006. doi: 10.1371/journal.pone.0147006. eCollection 2016.


Externally applied high-dose-rate brachytherapy for deeply invasive cutaneous squamous cell carcinoma in an older patient.

Whitley MJ, Cardones AR, Craciunescu OI, Kirsch DG.

Pract Radiat Oncol. 2016 Jul-Aug;6(4):e141-4. doi: 10.1016/j.prro.2015.11.008. Epub 2015 Nov 17. No abstract available.


A mouse-human phase 1 co-clinical trial of a protease-activated fluorescent probe for imaging cancer.

Whitley MJ, Cardona DM, Lazarides AL, Spasojevic I, Ferrer JM, Cahill J, Lee CL, Snuderl M, Blazer DG 3rd, Hwang ES, Greenup RA, Mosca PJ, Mito JK, Cuneo KC, Larrier NA, O'Reilly EK, Riedel RF, Eward WC, Strasfeld DB, Fukumura D, Jain RK, Lee WD, Griffith LG, Bawendi MG, Kirsch DG, Brigman BE.

Sci Transl Med. 2016 Jan 6;8(320):320ra4. doi: 10.1126/scitranslmed.aad0293.


Treatment Planning and Delivery of Whole Brain Irradiation with Hippocampal Avoidance in Rats.

Cramer CK, Yoon SW, Reinsvold M, Joo KM, Norris H, Hood RC, Adamson JD, Klein RC, Kirsch DG, Oldham M.

PLoS One. 2015 Dec 4;10(12):e0143208. doi: 10.1371/journal.pone.0143208. eCollection 2015.


Spectrotemporal CT data acquisition and reconstruction at low dose.

Clark DP, Lee CL, Kirsch DG, Badea CT.

Med Phys. 2015 Nov;42(11):6317-36. doi: 10.1118/1.4931407.


Acute DNA damage activates the tumour suppressor p53 to promote radiation-induced lymphoma.

Lee CL, Castle KD, Moding EJ, Blum JM, Williams N, Luo L, Ma Y, Borst LB, Kim Y, Kirsch DG.

Nat Commun. 2015 Sep 24;6:8477. doi: 10.1038/ncomms9477.


MicroRNA-16 suppresses metastasis in an orthotopic, but not autochthonous, mouse model of soft tissue sarcoma.

Sachdeva M, Whitley MJ, Mito JK, Ma Y, Lev DC, Cardona DM, Kirsch DG.

Dis Model Mech. 2015 Sep;8(9):1169. doi: 10.1242/dmm.022582. No abstract available.


Tailoring Adjuvant Radiation Therapy by Intraoperative Imaging to Detect Residual Cancer.

Whitley MJ, Weissleder R, Kirsch DG.

Semin Radiat Oncol. 2015 Oct;25(4):313-21. doi: 10.1016/j.semradonc.2015.05.005. Epub 2015 May 14. Review.


Biomarkers for Predicting Radiation Response.

Kirsch DG.

Semin Radiat Oncol. 2015 Oct;25(4):225-6. doi: 10.1016/j.semradonc.2015.05.011. Epub 2015 May 22. No abstract available.


Epigenetic silencing of Kruppel like factor-3 increases expression of pro-metastatic miR-182.

Sachdeva M, Dodd RD, Huang Z, Grenier C, Ma Y, Lev DC, Cardona DM, Murphy SK, Kirsch DG.

Cancer Lett. 2015 Dec 1;369(1):202-11. doi: 10.1016/j.canlet.2015.08.016. Epub 2015 Aug 24.


Cell Death Identification in Anticancer Therapy-Letter.

Brown JM, Wouters BG, Kirsch DG.

Cancer Res. 2015 Sep 1;75(17):3681. doi: 10.1158/0008-5472.CAN-15-0908. Epub 2015 Aug 18. No abstract available.


Concepts and challenges in cancer risk prediction for the space radiation environment.

Barcellos-Hoff MH, Blakely EA, Burma S, Fornace AJ Jr, Gerson S, Hlatky L, Kirsch DG, Luderer U, Shay J, Wang Y, Weil MM.

Life Sci Space Res (Amst). 2015 Jul;6:92-103. doi: 10.1016/j.lssr.2015.07.006. Epub 2015 Jul 17. Review.


Analysis of perioperative radiation therapy in the surgical treatment of primary and recurrent retroperitoneal sarcoma.

Lane WO, Cramer CK, Nussbaum DP, Speicher PJ, Gulack BC, Czito BG, Kirsch DG, Tyler DS, Blazer DG 3rd.

J Surg Oncol. 2015 Sep;112(4):352-8. doi: 10.1002/jso.23996. Epub 2015 Aug 4.


Myogenic transcription factors regulate pro-metastatic miR-182.

Dodd RD, Sachdeva M, Mito JK, Eward WC, Brigman BE, Ma Y, Dodd L, Kim Y, Lev D, Kirsch DG.

Oncogene. 2016 Apr 7;35(14):1868-75. doi: 10.1038/onc.2015.252. Epub 2015 Aug 3.


A Plasmonic Gold Nanostar Theranostic Probe for In Vivo Tumor Imaging and Photothermal Therapy.

Liu Y, Ashton JR, Moding EJ, Yuan H, Register JK, Fales AM, Choi J, Whitley MJ, Zhao X, Qi Y, Ma Y, Vaidyanathan G, Zalutsky MR, Kirsch DG, Badea CT, Vo-Dinh T.

Theranostics. 2015 May 23;5(9):946-60. doi: 10.7150/thno.11974. eCollection 2015.

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