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Items: 1 to 50 of 53

1.

Analysis of Neutrophil Transmigration Through Epithelial Cell Monolayers.

Kirpotina LN, Kominsky DJ, Quinn MT, Swain SD.

Methods Mol Biol. 2020;2087:79-91. doi: 10.1007/978-1-0716-0154-9_6.

PMID:
31728984
2.

Isolation of Neutrophils from Nonhuman Species.

Siemsen DW, Kirpotina LN, Malachowa N, Schepetkin IA, Porter AR, Lei B, DeLeo FR, Quinn MT.

Methods Mol Biol. 2020;2087:43-59. doi: 10.1007/978-1-0716-0154-9_4.

PMID:
31728982
3.

Synthesis, anticancer activity, and molecular modeling of 1,4-naphthoquinones that inhibit MKK7 and Cdc25.

Schepetkin IA, Karpenko AS, Khlebnikov AI, Shibinska MO, Levandovskiy IA, Kirpotina LN, Danilenko NV, Quinn MT.

Eur J Med Chem. 2019 Dec 1;183:111719. doi: 10.1016/j.ejmech.2019.111719. Epub 2019 Sep 18.

PMID:
31563013
4.

Neutrophil Immunomodulatory Activity of Natural Organosulfur Compounds.

Schepetkin IA, Kirpotina LN, Khlebnikov AI, Balasubramanian N, Quinn MT.

Molecules. 2019 May 10;24(9). pii: E1809. doi: 10.3390/molecules24091809.

5.

Inhibition of T Cell Receptor Activation by Semi-Synthetic Sesquiterpene Lactone Derivatives and Molecular Modeling of Their Interaction with Glutathione and Tyrosine Kinase ZAP-70.

Khlebnikov AI, Schepetkin IA, Kishkentaeva AS, Shaimerdenova ZR, Atazhanova GA, Adekenov SM, Kirpotina LN, Quinn MT.

Molecules. 2019 Jan 19;24(2). pii: E350. doi: 10.3390/molecules24020350.

6.

Synthesis, biological evaluation, and molecular modeling of 11H-indeno[1,2-b]quinoxalin-11-one derivatives and tryptanthrin-6-oxime as c-Jun N-terminal kinase inhibitors.

Schepetkin IA, Khlebnikov AI, Potapov AS, Kovrizhina AR, Matveevskaya VV, Belyanin ML, Atochin DN, Zanoza SO, Gaidarzhy NM, Lyakhov SA, Kirpotina LN, Quinn MT.

Eur J Med Chem. 2019 Jan 1;161:179-191. doi: 10.1016/j.ejmech.2018.10.023. Epub 2018 Oct 12.

PMID:
30347329
7.

Chemical Composition and Antibacterial Activity of Essential Oils from Ferula L. Species against Methicillin-Resistant Staphylococcus aureus.

Utegenova GA, Pallister KB, Kushnarenko SV, Özek G, Özek T, Abidkulova KT, Kirpotina LN, Schepetkin IA, Quinn MT, Voyich JM.

Molecules. 2018 Jul 10;23(7). pii: E1679. doi: 10.3390/molecules23071679.

8.

The natural sesquiterpene lactones arglabin, grosheimin, agracin, parthenolide, and estafiatin inhibit T cell receptor (TCR) activation.

Schepetkin IA, Kirpotina LN, Mitchell PT, Kishkentaeva АS, Shaimerdenova ZR, Atazhanova GA, Adekenov SM, Quinn MT.

Phytochemistry. 2018 Feb;146:36-46. doi: 10.1016/j.phytochem.2017.11.010. Epub 2017 Dec 22.

9.

Novel ureidopropanamide based N-formyl peptide receptor 2 (FPR2) agonists with potential application for central nervous system disorders characterized by neuroinflammation.

Stama ML, Ślusarczyk J, Lacivita E, Kirpotina LN, Schepetkin IA, Chamera K, Riganti C, Perrone R, Quinn MT, Basta-Kaim A, Leopoldo M.

Eur J Med Chem. 2017 Dec 1;141:703-720. doi: 10.1016/j.ejmech.2017.09.023. Epub 2017 Sep 18.

10.

Functional N-Formyl Peptide Receptor 2 (FPR2) Antagonists Based on the Ureidopropanamide Scaffold Have Potential To Protect Against Inflammation-Associated Oxidative Stress.

Stama ML, Lacivita E, Kirpotina LN, Niso M, Perrone R, Schepetkin IA, Quinn MT, Leopoldo M.

ChemMedChem. 2017 Nov 22;12(22):1839-1847. doi: 10.1002/cmdc.201700429. Epub 2017 Nov 7.

11.

4-Aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-ones as N-formyl peptide receptor 1 (FPR1) antagonists.

Kirpotina LN, Schepetkin IA, Khlebnikov AI, Ruban OI, Ge Y, Ye RD, Kominsky DJ, Quinn MT.

Biochem Pharmacol. 2017 Oct 15;142:120-132. doi: 10.1016/j.bcp.2017.07.004. Epub 2017 Jul 8.

12.

Chemical composition and phagocyte immunomodulatory activity of Ferula iliensis essential oils.

Özek G, Schepetkin IA, Utegenova GA, Kirpotina LN, Andrei SR, Özek T, Başer KHC, Abidkulova KT, Kushnarenko SV, Khlebnikov AI, Damron DS, Quinn MT.

J Leukoc Biol. 2017 Jun;101(6):1361-1371. doi: 10.1189/jlb.3A1216-518RR. Epub 2017 Mar 3.

13.

Synthesis of Five- and Six-Membered N-Phenylacetamido Substituted Heterocycles as Formyl Peptide Receptor Agonists.

Vergelli C, Schepetkin IA, Ciciani G, Cilibrizzi A, Crocetti L, Giovannoni MP, Guerrini G, Iacovone A, Kirpotina LN, Ye RD, Quinn MT.

Drug Dev Res. 2017 Feb;78(1):49-62. doi: 10.1002/ddr.21370. Epub 2016 Nov 18.

14.

Modulation of Human Neutrophil Responses by the Essential Oils from Ferula akitschkensis and Their Constituents.

Schepetkin IA, Kushnarenko SV, Özek G, Kirpotina LN, Sinharoy P, Utegenova GA, Abidkulova KT, Özek T, Başer KH, Kovrizhina AR, Khlebnikov AI, Damron DS, Quinn MT.

J Agric Food Chem. 2016 Sep 28;64(38):7156-70. doi: 10.1021/acs.jafc.6b03205. Epub 2016 Sep 13.

15.

Synthesis and Pharmacological Evaluation of Indole Derivatives as Deaza Analogues of Potent Human Neutrophil Elastase Inhibitors.

Crocetti L, Schepetkin IA, Ciciani G, Giovannoni MP, Guerrini G, Iacovone A, Khlebnikov AI, Kirpotina LN, Quinn MT, Vergelli C.

Drug Dev Res. 2016 Sep;77(6):285-99. doi: 10.1002/ddr.21323. Epub 2016 Jul 30.

16.

Therapeutic Potential of Polyphenols from Epilobium Angustifolium (Fireweed).

Schepetkin IA, Ramstead AG, Kirpotina LN, Voyich JM, Jutila MA, Quinn MT.

Phytother Res. 2016 Aug;30(8):1287-97. doi: 10.1002/ptr.5648. Epub 2016 May 24. Review.

17.

2-Arylacetamido-4-phenylamino-5-substituted pyridazinones as formyl peptide receptors agonists.

Vergelli C, Schepetkin IA, Ciciani G, Cilibrizzi A, Crocetti L, Giovannoni MP, Guerrini G, Iacovone A, Kirpotina LN, Khlebnikov AI, Ye RD, Quinn MT.

Bioorg Med Chem. 2016 Apr 8. pii: S0968-0896(16)30253-X. doi: 10.1016/j.bmc.2016.04.019. [Epub ahead of print]

18.

Antagonism of human formyl peptide receptor 1 with natural compounds and their synthetic derivatives.

Schepetkin IA, Khlebnikov AI, Kirpotina LN, Quinn MT.

Int Immunopharmacol. 2016 Aug;37:43-58. doi: 10.1016/j.intimp.2015.08.036. Epub 2015 Sep 15. Review.

19.

Boronic acid-containing aminopyridine- and aminopyrimidinecarboxamide CXCR1/2 antagonists: Optimization of aqueous solubility and oral bioavailability.

Schuler AD, Engles CA, Maeda DY, Quinn MT, Kirpotina LN, Wicomb WN, Mason SN, Auten RL, Zebala JA.

Bioorg Med Chem Lett. 2015 Sep 15;25(18):3793-7. doi: 10.1016/j.bmcl.2015.07.090. Epub 2015 Jul 30.

20.

Inhibition of Human Neutrophil Responses by the Essential Oil of Artemisia kotuchovii and Its Constituents.

Schepetkin IA, Kushnarenko SV, Özek G, Kirpotina LN, Utegenova GA, Kotukhov YA, Danilova AN, Özek T, Başer KH, Quinn MT.

J Agric Food Chem. 2015 May 27;63(20):4999-5007. doi: 10.1021/acs.jafc.5b01307. Epub 2015 May 19.

21.

Boronic acid-containing CXCR1/2 antagonists: Optimization of metabolic stability, in vivo evaluation, and a proposed receptor binding model.

Maeda DY, Peck AM, Schuler AD, Quinn MT, Kirpotina LN, Wicomb WN, Auten RL, Gundla R, Zebala JA.

Bioorg Med Chem Lett. 2015 Jun 1;25(11):2280-4. doi: 10.1016/j.bmcl.2015.04.041. Epub 2015 Apr 23.

22.

Anti-Inflammatory Effects and Joint Protection in Collagen-Induced Arthritis after Treatment with IQ-1S, a Selective c-Jun N-Terminal Kinase Inhibitor.

Schepetkin IA, Kirpotina LN, Hammaker D, Kochetkova I, Khlebnikov AI, Lyakhov SA, Firestein GS, Quinn MT.

J Pharmacol Exp Ther. 2015 Jun;353(3):505-16. doi: 10.1124/jpet.114.220251. Epub 2015 Mar 17.

23.

Novel 3-(1H-indol-3-yl)-2-[3-(4-methoxyphenyl)ureido]propanamides as selective agonists of human formyl-peptide receptor 2.

Lacivita E, Schepetkin IA, Stama ML, Kirpotina LN, Colabufo NA, Perrone R, Khlebnikov AI, Quinn MT, Leopoldo M.

Bioorg Med Chem. 2015 Jul 15;23(14):3913-24. doi: 10.1016/j.bmc.2014.12.007. Epub 2014 Dec 13.

24.

Antagonism of human formyl peptide receptor 1 (FPR1) by chromones and related isoflavones.

Schepetkin IA, Kirpotina LN, Khlebnikov AI, Cheng N, Ye RD, Quinn MT.

Biochem Pharmacol. 2014 Dec 15;92(4):627-41. doi: 10.1016/j.bcp.2014.09.027. Epub 2014 Oct 17.

25.

Discovery of 2-[5-(4-Fluorophenylcarbamoyl)pyridin-2-ylsulfanylmethyl]phenylboronic Acid (SX-517): Noncompetitive Boronic Acid Antagonist of CXCR1 and CXCR2.

Maeda DY, Peck AM, Schuler AD, Quinn MT, Kirpotina LN, Wicomb WN, Fan GH, Zebala JA.

J Med Chem. 2014 Oct 23;57(20):8378-97. doi: 10.1021/jm500827t. Epub 2014 Oct 8.

26.

Neutrophil isolation from nonhuman species.

Siemsen DW, Malachowa N, Schepetkin IA, Whitney AR, Kirpotina LN, Lei B, Deleo FR, Quinn MT.

Methods Mol Biol. 2014;1124:19-37. doi: 10.1007/978-1-62703-845-4_3.

27.

Development of small molecule non-peptide formyl peptide receptor (FPR) ligands and molecular modeling of their recognition.

Schepetkin IA, Khlebnikov AI, Giovannoni MP, Kirpotina LN, Cilibrizzi A, Quinn MT.

Curr Med Chem. 2014;21(13):1478-504. Review.

28.

Immunomodulatory activity of polysaccharides isolated from Clerodendrum splendens: beneficial effects in experimental autoimmune encephalomyelitis.

Kouakou K, Schepetkin IA, Jun S, Kirpotina LN, Yapi A, Khramova DS, Pascual DW, Ovodov YS, Jutila MA, Quinn MT.

BMC Complement Altern Med. 2013 Jun 28;13:149. doi: 10.1186/1472-6882-13-149.

29.

Further studies on 2-arylacetamide pyridazin-3(2H)-ones: design, synthesis and evaluation of 4,6-disubstituted analogs as formyl peptide receptors (FPRs) agonists.

Giovannoni MP, Schepetkin IA, Cilibrizzi A, Crocetti L, Khlebnikov AI, Dahlgren C, Graziano A, Dal Piaz V, Kirpotina LN, Zerbinati S, Vergelli C, Quinn MT.

Eur J Med Chem. 2013 Jun;64:512-28. doi: 10.1016/j.ejmech.2013.03.066. Epub 2013 Apr 8.

30.

Immunomodulatory and hemagglutinating activities of acidic polysaccharides isolated from Combretum racemosum.

Schepetkin IA, Kouakou K, Yapi A, Kirpotina LN, Jutila MA, Quinn MT.

Int Immunopharmacol. 2013 Mar;15(3):628-37. doi: 10.1016/j.intimp.2013.01.015. Epub 2013 Feb 1.

31.

Immunomodulatory activity of polysaccharides isolated from Alchornea cordifolia.

Kouakou K, Schepetkin IA, Yapi A, Kirpotina LN, Jutila MA, Quinn MT.

J Ethnopharmacol. 2013 Mar 7;146(1):232-42. doi: 10.1016/j.jep.2012.12.037. Epub 2013 Jan 2.

32.

3-(1H-indol-3-yl)-2-[3-(4-nitrophenyl)ureido]propanamide enantiomers with human formyl-peptide receptor agonist activity: molecular modeling of chiral recognition by FPR2.

Schepetkin IA, Kirpotina LN, Khlebnikov AI, Leopoldo M, Lucente E, Lacivita E, De Giorgio P, Quinn MT.

Biochem Pharmacol. 2013 Feb 1;85(3):404-16. doi: 10.1016/j.bcp.2012.11.015. Epub 2012 Dec 3.

33.

Synthesis, enantioresolution, and activity profile of chiral 6-methyl-2,4-disubstituted pyridazin-3(2H)-ones as potent N-formyl peptide receptor agonists.

Cilibrizzi A, Schepetkin IA, Bartolucci G, Crocetti L, Dal Piaz V, Giovannoni MP, Graziano A, Kirpotina LN, Quinn MT, Vergelli C.

Bioorg Med Chem. 2012 Jun 15;20(12):3781-92. doi: 10.1016/j.bmc.2012.04.043. Epub 2012 Apr 27.

34.

Sublytic concentrations of Staphylococcus aureus Panton-Valentine leukocidin alter human PMN gene expression and enhance bactericidal capacity.

Graves SF, Kobayashi SD, Braughton KR, Whitney AR, Sturdevant DE, Rasmussen DL, Kirpotina LN, Quinn MT, DeLeo FR.

J Leukoc Biol. 2012 Aug;92(2):361-74. doi: 10.1189/jlb.1111575. Epub 2012 May 11.

35.

Group A Streptococcus secreted esterase hydrolyzes platelet-activating factor to impede neutrophil recruitment and facilitate innate immune evasion.

Liu M, Zhu H, Li J, Garcia CC, Feng W, Kirpotina LN, Hilmer J, Tavares LP, Layton AW, Quinn MT, Bothner B, Teixeira MM, Lei B.

PLoS Pathog. 2012;8(4):e1002624. doi: 10.1371/journal.ppat.1002624. Epub 2012 Apr 5.

36.

Identification and characterization of a novel class of c-Jun N-terminal kinase inhibitors.

Schepetkin IA, Kirpotina LN, Khlebnikov AI, Hanks TS, Kochetkova I, Pascual DW, Jutila MA, Quinn MT.

Mol Pharmacol. 2012 Jun;81(6):832-45. doi: 10.1124/mol.111.077446. Epub 2012 Mar 20.

37.

Molecular docking of 2-(benzimidazol-2-ylthio)-N-phenylacetamide-derived small-molecule agonists of human formyl peptide receptor 1.

Khlebnikov AI, Schepetkin IA, Kirpotina LN, Brive L, Dahlgren C, Jutila MA, Quinn MT.

J Mol Model. 2012 Jun;18(6):2831-43. doi: 10.1007/s00894-011-1307-x. Epub 2011 Nov 30.

38.

Polysaccharides isolated from Açaí fruit induce innate immune responses.

Holderness J, Schepetkin IA, Freedman B, Kirpotina LN, Quinn MT, Hedges JF, Jutila MA.

PLoS One. 2011 Feb 28;6(2):e17301. doi: 10.1371/journal.pone.0017301.

39.

Gastrin-releasing peptide/neuromedin B receptor antagonists PD176252, PD168368, and related analogs are potent agonists of human formyl-peptide receptors.

Schepetkin IA, Kirpotina LN, Khlebnikov AI, Jutila MA, Quinn MT.

Mol Pharmacol. 2011 Jan;79(1):77-90. doi: 10.1124/mol.110.068288. Epub 2010 Oct 13.

40.

Identification of novel small-molecule agonists for human formyl peptide receptors and pharmacophore models of their recognition.

Kirpotina LN, Khlebnikov AI, Schepetkin IA, Ye RD, Rabiet MJ, Jutila MA, Quinn MT.

Mol Pharmacol. 2010 Feb;77(2):159-70. doi: 10.1124/mol.109.060673. Epub 2009 Nov 10.

41.

Immunomodulatory activity of oenothein B isolated from Epilobium angustifolium.

Schepetkin IA, Kirpotina LN, Jakiw L, Khlebnikov AI, Blaskovich CL, Jutila MA, Quinn MT.

J Immunol. 2009 Nov 15;183(10):6754-66. doi: 10.4049/jimmunol.0901827. Epub 2009 Oct 21.

42.

Nicotinamide glycolates antagonize CXCR2 activity through an intracellular mechanism.

Maeda DY, Quinn MT, Schepetkin IA, Kirpotina LN, Zebala JA.

J Pharmacol Exp Ther. 2010 Jan;332(1):145-52. doi: 10.1124/jpet.109.159020. Epub 2009 Sep 24.

43.

6-methyl-2,4-disubstituted pyridazin-3(2H)-ones: a novel class of small-molecule agonists for formyl peptide receptors.

Cilibrizzi A, Quinn MT, Kirpotina LN, Schepetkin IA, Holderness J, Ye RD, Rabiet MJ, Biancalani C, Cesari N, Graziano A, Vergelli C, Pieretti S, Dal Piaz V, Giovannoni MP.

J Med Chem. 2009 Aug 27;52(16):5044-57. doi: 10.1021/jm900592h.

44.

Synthesis, characterization and potent superoxide dismutase-like activity of novel bis(pyrazole)-2,2'-bipyridyl mixed ligand copper(II) complexes.

Potapov AS, Nudnova EA, Domina GA, Kirpotina LN, Quinn MT, Khlebnikov AI, Schepetkin IA.

Dalton Trans. 2009 Jun 21;(23):4488-98. doi: 10.1039/b900869a. Epub 2009 Apr 7.

45.

Inhibition of the human neutrophil NADPH oxidase by Coxiella burnetii.

Siemsen DW, Kirpotina LN, Jutila MA, Quinn MT.

Microbes Infect. 2009 May-Jun;11(6-7):671-9. doi: 10.1016/j.micinf.2009.04.005. Epub 2009 Apr 18.

46.

Computational structure-activity relationship analysis of non-peptide inducers of macrophage tumor necrosis factor-alpha production.

Khlebnikov AI, Schepetkin IA, Kirpotina LN, Quinn MT.

Bioorg Med Chem. 2008 Oct 15;16(20):9302-12. doi: 10.1016/j.bmc.2008.08.078. Epub 2008 Sep 5.

47.

Macrophage immunomodulatory activity of polysaccharides isolated from Opuntia polyacantha.

Schepetkin IA, Xie G, Kirpotina LN, Klein RA, Jutila MA, Quinn MT.

Int Immunopharmacol. 2008 Oct;8(10):1455-66. doi: 10.1016/j.intimp.2008.06.003. Epub 2008 Jul 1.

48.

Identification of novel formyl peptide receptor-like 1 agonists that induce macrophage tumor necrosis factor alpha production.

Schepetkin IA, Kirpotina LN, Tian J, Khlebnikov AI, Ye RD, Quinn MT.

Mol Pharmacol. 2008 Aug;74(2):392-402. doi: 10.1124/mol.108.046946. Epub 2008 May 5.

49.

Neutrophil isolation from nonhuman species.

Siemsen DW, Schepetkin IA, Kirpotina LN, Lei B, Quinn MT.

Methods Mol Biol. 2007;412:21-34. doi: 10.1007/978-1-59745-467-4_3.

PMID:
18453103
50.

Fractionation and characterization of biologically-active polysaccharides from Artemisia tripartita.

Xie G, Schepetkin IA, Siemsen DW, Kirpotina LN, Wiley JA, Quinn MT.

Phytochemistry. 2008 Apr;69(6):1359-71. doi: 10.1016/j.phytochem.2008.01.009. Epub 2008 Mar 5.

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