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New horizons in the compression of functional decline.

Gore PG, Kingston A, Johnson GR, Kirkwood TBL, Jagger C.

Age Ageing. 2018 Nov 1;47(6):764-768. doi: 10.1093/ageing/afy145.


Predominant Asymmetrical Stem Cell Fate Outcome Limits the Rate of Niche Succession in Human Colonic Crypts.

Stamp C, Zupanic A, Sachdeva A, Stoll EA, Shanley DP, Mathers JC, Kirkwood TBL, Heer R, Simons BD, Turnbull DM, Greaves LC.

EBioMedicine. 2018 May;31:166-173. doi: 10.1016/j.ebiom.2018.04.017. Epub 2018 Apr 25.


Resolving the Enigma of the Clonal Expansion of mtDNA Deletions.

Kowald A, Kirkwood TBL.

Genes (Basel). 2018 Feb 27;9(3). pii: E126. doi: 10.3390/genes9030126.


Do reef corals age?

Bythell JC, Brown BE, Kirkwood TBL.

Biol Rev Camb Philos Soc. 2018 May;93(2):1192-1202. doi: 10.1111/brv.12391. Epub 2017 Dec 28.


Is There a Link Between Cognitive Reserve and Cognitive Function in the Oldest-Old?

Lavrencic LM, Richardson C, Harrison SL, Muniz-Terrera G, Keage HAD, Brittain K, Kirkwood TBL, Jagger C, Robinson L, Stephan BCM.

J Gerontol A Biol Sci Med Sci. 2018 Mar 14;73(4):499-505. doi: 10.1093/gerona/glx140.


Pervasive gene expression responses to a fluctuating diet in Drosophila melanogaster: The importance of measuring multiple traits to decouple potential mediators of life span and reproduction.

Zandveld J, van den Heuvel J, Mulder M, Brakefield PM, Kirkwood TBL, Shanley DP, Zwaan BJ.

Evolution. 2017 Nov;71(11):2572-2583. doi: 10.1111/evo.13327. Epub 2017 Sep 25.


Why and how are we living longer?

Kirkwood TBL.

Exp Physiol. 2017 Sep 1;102(9):1067-1074. doi: 10.1113/EP086205. Epub 2017 Aug 2. Review.


Explaining sex differences in lifespan in terms of optimal energy allocation in the baboon.

King AM, Kirkwood TBL, Shanley DP.

Evolution. 2017 Oct;71(10):2280-2297. doi: 10.1111/evo.13316. Epub 2017 Sep 14.


Is there evidence for a limit to human lifespan?

Rozing MP, Kirkwood TBL, Westendorp RGJ.

Nature. 2017 Jun 28;546(7660):E11-E12. doi: 10.1038/nature22788. No abstract available.


Longitudinal changes in global and domain specific cognitive function in the very-old: findings from the Newcastle 85+ Study.

Stephan BCM, Muniz-Terrera G, Granic A, Collerton J, Davies K, Saxby BK, Wesnes KA, Kirkwood TBL, Jagger C.

Int J Geriatr Psychiatry. 2018 Feb;33(2):298-306. doi: 10.1002/gps.4743. Epub 2017 Jun 22.


Initial level and rate of change in grip strength predict all-cause mortality in very old adults.

Granic A, Davies K, Jagger C, M Dodds R, Kirkwood TBL, Sayer AA.

Age Ageing. 2017 Nov 1;46(6):970-976. doi: 10.1093/ageing/afx087.


Grip strength and inflammatory biomarker profiles in very old adults.

Granic A, Davies K, Martin-Ruiz C, Jagger C, Kirkwood TBL, von Zglinicki T, Aihie Sayer A.

Age Ageing. 2017 Nov 1;46(6):976-982. doi: 10.1093/ageing/afx088.


Vitamin D Status, Muscle Strength and Physical Performance Decline in Very Old Adults: A Prospective Study.

Granic A, Hill TR, Davies K, Jagger C, Adamson A, Siervo M, Kirkwood TB, Mathers JC, Sayer AA.

Nutrients. 2017 Apr 13;9(4). pii: E379. doi: 10.3390/nu9040379.


Growing more positive with age: The relationship between reproduction and survival in aging flies.

van den Heuvel J, Zandveld J, Brakefield PM, Kirkwood TBL, Shanley DP, Zwaan BJ.

Exp Gerontol. 2017 Apr;90:34-42. doi: 10.1016/j.exger.2017.01.016. Epub 2017 Jan 22.


Prevalence and incidence of sarcopenia in the very old: findings from the Newcastle 85+ Study.

Dodds RM, Granic A, Davies K, Kirkwood TB, Jagger C, Sayer AA.

J Cachexia Sarcopenia Muscle. 2017 Apr;8(2):229-237. doi: 10.1002/jcsm.12157. Epub 2016 Nov 16.


Predicting Risk of Cognitive Decline in Very Old Adults Using Three Models: The Framingham Stroke Risk Profile; the Cardiovascular Risk Factors, Aging, and Dementia Model; and Oxi-Inflammatory Biomarkers.

Harrison SL, de Craen AJ, Kerse N, Teh R, Granic A, Davies K, Wesnes KA, den Elzen WP, Gussekloo J, Kirkwood TB, Robinson L, Jagger C, Siervo M, Stephan BC.

J Am Geriatr Soc. 2017 Feb;65(2):381-389. doi: 10.1111/jgs.14532. Epub 2016 Nov 14.


Serum Thyroid Function, Mortality and Disability in Advanced Old Age: The Newcastle 85+ Study.

Pearce SH, Razvi S, Yadegarfar ME, Martin-Ruiz C, Kingston A, Collerton J, Visser TJ, Kirkwood TB, Jagger C.

J Clin Endocrinol Metab. 2016 Nov;101(11):4385-4394. Epub 2016 Aug 23.


Grip Strength Decline and Its Determinants in the Very Old: Longitudinal Findings from the Newcastle 85+ Study.

Granic A, Davies K, Jagger C, Kirkwood TB, Syddall HE, Sayer AA.

PLoS One. 2016 Sep 16;11(9):e0163183. doi: 10.1371/journal.pone.0163183. eCollection 2016.


Can aging be programmed? A critical literature review.

Kowald A, Kirkwood TBL.

Aging Cell. 2016 Dec;15(6):986-998. doi: 10.1111/acel.12510. Epub 2016 Aug 17. Review.


Micronutrient intake and food sources in the very old: analysis of the Newcastle 85+ Study.

Mendonça N, Hill TR, Granic A, Davies K, Collerton J, Mathers JC, Siervo M, Wrieden WL, Seal CJ, Kirkwood TB, Jagger C, Adamson AJ.

Br J Nutr. 2016 Aug;116(4):751-61. doi: 10.1017/S0007114516002567. Epub 2016 Jul 1.


Macronutrient intake and food sources in the very old: analysis of the Newcastle 85+ Study.

Mendonça N, Hill TR, Granic A, Davies K, Collerton J, Mathers JC, Siervo M, Wrieden WL, Seal CJ, Kirkwood TB, Jagger C, Adamson AJ.

Br J Nutr. 2016 Jun;115(12):2170-80. doi: 10.1017/S0007114516001379. Epub 2016 Apr 18.


Understanding the physiology of the ageing individual: computational modelling of changes in metabolism and endurance.

van Beek JH, Kirkwood TB, Bassingthwaighte JB.

Interface Focus. 2016 Apr 6;6(2):20150079. doi: 10.1098/rsfs.2015.0079. Review.


Effect of Dietary Patterns on Muscle Strength and Physical Performance in the Very Old: Findings from the Newcastle 85+ Study.

Granic A, Jagger C, Davies K, Adamson A, Kirkwood T, Hill TR, Siervo M, Mathers JC, Sayer AA.

PLoS One. 2016 Mar 2;11(3):e0149699. doi: 10.1371/journal.pone.0149699. eCollection 2016.


Deconstructing Complex Multimorbidity in the Very Old: Findings from the Newcastle 85+ Study.

Collerton J, Jagger C, Yadegarfar ME, Davies K, Parker SG, Robinson L, Kirkwood TB.

Biomed Res Int. 2016;2016:8745670. doi: 10.1155/2016/8745670. Epub 2016 Jan 13.


Oxidative stress and life histories: unresolved issues and current needs.

Speakman JR, Blount JD, Bronikowski AM, Buffenstein R, Isaksson C, Kirkwood TB, Monaghan P, Ozanne SE, Beaulieu M, Briga M, Carr SK, Christensen LL, Cochemé HM, Cram DL, Dantzer B, Harper JM, Jurk D, King A, Noguera JC, Salin K, Sild E, Simons MJ, Smith S, Stier A, Tobler M, Vitikainen E, Peaker M, Selman C.

Ecol Evol. 2015 Nov 17;5(24):5745-57. doi: 10.1002/ece3.1790. eCollection 2015 Dec.


Dietary Patterns High in Red Meat, Potato, Gravy, and Butter Are Associated with Poor Cognitive Functioning but Not with Rate of Cognitive Decline in Very Old Adults.

Granic A, Davies K, Adamson A, Kirkwood T, Hill TR, Siervo M, Mathers JC, Jagger C.

J Nutr. 2016 Feb;146(2):265-74. doi: 10.3945/jn.115.216952. Epub 2016 Jan 6.


Respiratory health and disease in a U.K. population-based cohort of 85 year olds: The Newcastle 85+ Study.

Fisher AJ, Yadegarfar ME, Collerton J, Small T, Kirkwood TB, Davies K, Jagger C, Corris PA.

Thorax. 2016 Mar;71(3):255-66. doi: 10.1136/thoraxjnl-2015-207249. Epub 2016 Jan 5.


CMV seropositivity and T-cell senescence predict increased cardiovascular mortality in octogenarians: results from the Newcastle 85+ study.

Spyridopoulos I, Martin-Ruiz C, Hilkens C, Yadegarfar ME, Isaacs J, Jagger C, Kirkwood T, von Zglinicki T.

Aging Cell. 2016 Apr;15(2):389-92. doi: 10.1111/acel.12430. Epub 2015 Dec 22.


Dietary Patterns and Socioeconomic Status in the Very Old: The Newcastle 85+ Study.

Granic A, Davies K, Adamson A, Kirkwood T, Hill TR, Siervo M, Mathers JC, Jagger C.

PLoS One. 2015 Oct 21;10(10):e0139713. doi: 10.1371/journal.pone.0139713. eCollection 2015.


Serum 25-hydroxyvitamin D concentration and its determinants in the very old: the Newcastle 85+ Study.

Hill TR, Granic A, Davies K, Collerton J, Martin-Ruiz C, Siervo M, Mathers JC, Adamson AJ, Francis RM, Pearce SH, Razvi S, Kirkwood TBL, Jagger C.

Osteoporos Int. 2016 Mar;27(3):1199-1208. doi: 10.1007/s00198-015-3366-9. Epub 2015 Oct 14.


Evolutionary significance of ageing in the wild.

Kowald A, Kirkwood TB.

Exp Gerontol. 2015 Nov;71:89-94. doi: 10.1016/j.exger.2015.08.006. Epub 2015 Aug 17.


Antihypertensive drug use and risk of cognitive decline in the very old: an observational study - the Newcastle 85+ Study.

Peters R, Collerton J, Granic A, Davies K, Kirkwood T, Jagger C.

J Hypertens. 2015 Oct;33(10):2156-64. doi: 10.1097/HJH.0000000000000653.


Age-related frailty and its association with biological markers of ageing.

Mitnitski A, Collerton J, Martin-Ruiz C, Jagger C, von Zglinicki T, Rockwood K, Kirkwood TB.

BMC Med. 2015 Jul 13;13:161. doi: 10.1186/s12916-015-0400-x.


Integrated Stochastic Model of DNA Damage Repair by Non-homologous End Joining and p53/p21-Mediated Early Senescence Signalling.

Dolan DW, Zupanic A, Nelson G, Hall P, Miwa S, Kirkwood TB, Shanley DP.

PLoS Comput Biol. 2015 May 28;11(5):e1004246. doi: 10.1371/journal.pcbi.1004246. eCollection 2015 May.


A comparison of subjective and objective measures of physical activity from the Newcastle 85+ study.

Innerd P, Catt M, Collerton J, Davies K, Trenell M, Kirkwood TB, Jagger C.

Age Ageing. 2015 Jul;44(4):691-4. doi: 10.1093/ageing/afv062. Epub 2015 May 27.


Grip strength and mortality: a biomarker of ageing?

Sayer AA, Kirkwood TB.

Lancet. 2015 Jul 18;386(9990):226-7. doi: 10.1016/S0140-6736(14)62349-7. Epub 2015 May 13. No abstract available.


Low tobacco-related cancer incidence in offspring of long-lived siblings: a comparison with Danish national cancer registry data.

Pedersen JK, Skytthe A, McGue M, Honig LS, Franceschi C, Kirkwood TB, Passarino G, Slagboom PE, Vaupel JW, Christensen K.

Ann Epidemiol. 2015 Aug;25(8):569-574.e3. doi: 10.1016/j.annepidem.2015.03.004. Epub 2015 Mar 18.


Is there an association between metabolic syndrome and cognitive function in very old adults? The Newcastle 85+ Study.

Harrison SL, Stephan BC, Siervo M, Granic A, Davies K, Wesnes KA, Kirkwood TB, Robinson L, Jagger C.

J Am Geriatr Soc. 2015 Apr;63(4):667-75. doi: 10.1111/jgs.13358. Epub 2015 Apr 8.


The enduring effect of education-socioeconomic differences in disability trajectories from age 85 years in the Newcastle 85+ Study.

Kingston A, Davies K, Collerton J, Robinson L, Duncan R, Kirkwood TB, Jagger C.

Arch Gerontol Geriatr. 2015 May-Jun;60(3):405-11. doi: 10.1016/j.archger.2015.02.006. Epub 2015 Feb 25.


A dynamic framework for the study of optimal birth intervals reveals the importance of sibling competition and mortality risks.

Thomas MG, Shanley DP, Houston AI, McNamara JM, Mace R, Kirkwood TB.

J Evol Biol. 2015 Apr;28(4):885-95. doi: 10.1111/jeb.12613. Epub 2015 Mar 17.


Repeated-sprint cycling does not induce respiratory muscle fatigue in active adults: measurements from the powerbreathe® inspiratory muscle trainer.

Minahan C, Sheehan B, Doutreband R, Kirkwood T, Reeves D, Cross T.

J Sports Sci Med. 2015 Mar 1;14(1):233-8. eCollection 2015 Mar.


Grip strength across the life course: normative data from twelve British studies.

Dodds RM, Syddall HE, Cooper R, Benzeval M, Deary IJ, Dennison EM, Der G, Gale CR, Inskip HM, Jagger C, Kirkwood TB, Lawlor DA, Robinson SM, Starr JM, Steptoe A, Tilling K, Kuh D, Cooper C, Sayer AA.

PLoS One. 2014 Dec 4;9(12):e113637. doi: 10.1371/journal.pone.0113637. eCollection 2014.


The plastic fly: the effect of sustained fluctuations in adult food supply on life-history traits.

van den Heuvel J, Zandveld J, Mulder M, Brakefield PM, Kirkwood TB, Shanley DP, Zwaan BJ.

J Evol Biol. 2014 Nov;27(11):2322-33. doi: 10.1111/jeb.12444.


Improving retention of very old participants in longitudinal research: experiences from the Newcastle 85+ study.

Davies K, Kingston A, Robinson L, Hughes J, Hunt JM, Barker SA, Edwards J, Collerton J, Jagger C, Kirkwood TB.

PLoS One. 2014 Oct 10;9(10):e108370. doi: 10.1371/journal.pone.0108370. eCollection 2014.


Serum osmolarity and haematocrit do not modify the association between the impedance index (Ht(2)/Z) and total body water in the very old: the Newcastle 85+ study.

Siervo M, Prado C, Hooper L, Munro A, Collerton J, Davies K, Kingston A, Mathers JC, Kirkwood TB, Jagger C.

Arch Gerontol Geriatr. 2015 Jan-Feb;60(1):227-32. doi: 10.1016/j.archger.2014.09.004. Epub 2014 Sep 17.


Utility of NT-proBNP as a rule-out test for left ventricular dysfunction in very old people with limiting dyspnoea: the Newcastle 85+ Study.

Collerton J, Kingston A, Yousaf F, Davies K, Kenny A, Neely D, Martin-Ruiz C, MacGowan G, Robinson L, Kirkwood TB, Keavney B.

BMC Cardiovasc Disord. 2014 Sep 26;14:128. doi: 10.1186/1471-2261-14-128.


In memoriam Robin Holliday (November 6, 1932-April 9, 2014).

Kirkwood T.

Genetics. 2014 Sep;198(1):423-4. doi: 10.1534/genetics.114.167684. No abstract available.


Clonal expansion of early to mid-life mitochondrial DNA point mutations drives mitochondrial dysfunction during human ageing.

Greaves LC, Nooteboom M, Elson JL, Tuppen HA, Taylor GA, Commane DM, Arasaradnam RP, Khrapko K, Taylor RW, Kirkwood TB, Mathers JC, Turnbull DM.

PLoS Genet. 2014 Sep 18;10(9):e1004620. doi: 10.1371/journal.pgen.1004620. eCollection 2014 Sep.


Magnitude of fragility fracture risk in the very old--are we meeting their needs? The Newcastle 85+ Study.

Duncan R, Francis RM, Jagger C, Kingston A, McCloskey E, Collerton J, Robinson L, Kirkwood TB, Birrell F.

Osteoporos Int. 2015 Jan;26(1):123-30. doi: 10.1007/s00198-014-2837-8. Epub 2014 Sep 16.


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