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Activated Stromal Cells Transfer Mitochondria to Rescue Acute Lymphoblastic Leukaemia Cells from Oxidative Stress.

Burt R, Dey A, Aref S, Aguiar M, Akarca A, Bailey K, Day W, Hooper S, Kirkwood A, Kirschner K, Lee S, Lo Celso C, Manji J, Mansour MR, Marafioti T, Mitchell RJ, Muirhead RC, Ng KCY, Pospori C, Puccio I, Zuborne-Alapi K, Sahai E, Fielding AK.

Blood. 2019 Sep 9. pii: blood.2019001398. doi: 10.1182/blood.2019001398. [Epub ahead of print]


A systematic review of the efficacy of CNS prophylaxis with stand-alone intrathecal chemotherapy in diffuse large B cell lymphoma patients treated with anthracycline-based chemotherapy in the rituximab era.

Eyre TA, Djebbari F, Kirkwood AA, Collins GP.

Haematologica. 2019 Sep 5. pii: haematol.2019.229948. doi: 10.3324/haematol.2019.229948. [Epub ahead of print]


Reduced cognitive performance in aged rats correlates with increased excitation/inhibition ratio in the dentate gyrus in response to lateral entorhinal input.

Tran T, Bridi M, Koh MT, Gallagher M, Kirkwood A.

Neurobiol Aging. 2019 Jul 23;82:120-127. doi: 10.1016/j.neurobiolaging.2019.07.010. [Epub ahead of print]


Stand-alone intrathecal central nervous system (CNS) prophylaxis provide unclear benefit in reducing CNS relapse risk in elderly DLBCL patients treated with R-CHOP and is associated increased infection-related toxicity.

Eyre TA, Kirkwood AA, Wolf J, Hildyard C, Mercer C, Plaschkes H, Griffith J, Fields P, Gunawan A, Oliver R, Booth S, Martinez-Calle N, McMillan A, Bishton M, Fox CP, Collins GP, Hatton CSR.

Br J Haematol. 2019 Jun 20. doi: 10.1111/bjh.16070. [Epub ahead of print]


A retrospective comparison of venetoclax alone or in combination with an anti-CD20 monoclonal antibody in R/R CLL.

Mato AR, Roeker LE, Eyre TA, Nabhan C, Lamanna N, Hill BT, Brander DM, Barr PM, Lansigan F, Cheson BD, Singavi AK, Yazdy MS, Shah NN, Allan JN, Bhavsar EB, Rhodes J, Kennard K, Schuster SJ, Williams AM, Skarbnik AP, Goy AH, Goodfriend JM, Dorsey C, Coombs CC, Tuncer H, Ujjani CS, Jacobs R, Winter AM, Pagel JM, Bailey N, Schuh A, Shadman M, Sitlinger A, Weissbrot H, Muralikrishnan S, Zelenetz A, Kirkwood AA, Fox CP.

Blood Adv. 2019 May 28;3(10):1568-1573. doi: 10.1182/bloodadvances.2019000180.


Tumor Lysis, Adverse Events, and Dose Adjustments in 297 Venetoclax-Treated CLL Patients in Routine Clinical Practice.

Roeker LE, Fox CP, Eyre TA, Brander DM, Allan JN, Schuster SJ, Nabhan C, Hill BT, Shah NN, Lansigan F, Yazdy M, Cheson BD, Lamanna N, Singavi AK, Coombs CC, Barr PM, Skarbnik AP, Shadman M, Ujjani CS, Tuncer HH, Winter AM, Rhodes J, Dorsey C, Morse H, Kabel C, Pagel JM, Williams AM, Jacobs R, Goy A, Muralikrishnan S, Pearson L, Sitlinger A, Bailey N, Schuh A, Kirkwood AA, Mato AR.

Clin Cancer Res. 2019 Jul 15;25(14):4264-4270. doi: 10.1158/1078-0432.CCR-19-0361. Epub 2019 Apr 19.


Developing and evaluating a tool to measure general practice productivity: a multimethod study.

Dawson J, Rigby-Brown A, Adams L, Baker R, Fernando J, Forrest A, Kirkwood A, Murray R, West M, Wike P, Wilde M.

Southampton (UK): NIHR Journals Library; 2019 Mar.


Developmental and Full-Life Cycle Exposures to Guanylurea and Guanylurea-Metformin Mixtures Results in Adverse Effects on Japanese Medaka (Oryzias latipes).

Ussery E, Bridges KN, Pandelides Z, Kirkwood AE, Guchardi J, Holdway D.

Environ Toxicol Chem. 2019 May;38(5):1023-1028. doi: 10.1002/etc.4403. Epub 2019 Apr 5.


The incidence of invasive fungal infections in children, adolescents and young adults with acute lymphoblastic leukaemia/lymphoma treated with the UKALL2011 protocol: a multicentre retrospective study.

O'Reilly MA, Govender D, Kirkwood AA, Vora A, Samarasinghe S, Khwaja A, Grandage V, Rao A, Ancliff P, Pavasovic V, Cheng D, Carpenter B, Daw S, Hough R, O'Connor D.

Br J Haematol. 2019 Jul;186(2):327-329. doi: 10.1111/bjh.15798. Epub 2019 Feb 15. No abstract available.


Efficacy of venetoclax monotherapy in patients with relapsed chronic lymphocytic leukaemia in the post-BCR inhibitor setting: a UK wide analysis.

Eyre TA, Kirkwood AA, Gohill S, Follows G, Walewska R, Walter H, Cross M, Forconi F, Shah N, Chasty R, Hart A, Broom A, Marr H, Patten PEM, Dann A, Arumainathan A, Munir T, Shankara P, Bloor A, Johnston R, Orchard K, Schuh AH, Fox CP; the UK CLL Forum.

Br J Haematol. 2019 May;185(4):656-669. doi: 10.1111/bjh.15802. Epub 2019 Feb 15.


Ionic current correlations are ubiquitous across phyla.

Tran T, Unal CT, Severin D, Zaborszky L, Rotstein HG, Kirkwood A, Golowasch J.

Sci Rep. 2019 Feb 8;9(1):1687. doi: 10.1038/s41598-018-38405-6.


Global patterns and drivers of ecosystem functioning in rivers and riparian zones.

Tiegs SD, Costello DM, Isken MW, Woodward G, McIntyre PB, Gessner MO, Chauvet E, Griffiths NA, Flecker AS, Acuña V, Albariño R, Allen DC, Alonso C, Andino P, Arango C, Aroviita J, Barbosa MVM, Barmuta LA, Baxter CV, Bell TDC, Bellinger B, Boyero L, Brown LE, Bruder A, Bruesewitz DA, Burdon FJ, Callisto M, Canhoto C, Capps KA, Castillo MM, Clapcott J, Colas F, Colón-Gaud C, Cornut J, Crespo-Pérez V, Cross WF, Culp JM, Danger M, Dangles O, de Eyto E, Derry AM, Villanueva VD, Douglas MM, Elosegi A, Encalada AC, Entrekin S, Espinosa R, Ethaiya D, Ferreira V, Ferriol C, Flanagan KM, Fleituch T, Follstad Shah JJ, Frainer Barbosa A, Friberg N, Frost PC, Garcia EA, García Lago L, García Soto PE, Ghate S, Giling DP, Gilmer A, Gonçalves JF Jr, Gonzales RK, Graça MAS, Grace M, Grossart HP, Guérold F, Gulis V, Hepp LU, Higgins S, Hishi T, Huddart J, Hudson J, Imberger S, Iñiguez-Armijos C, Iwata T, Janetski DJ, Jennings E, Kirkwood AE, Koning AA, Kosten S, Kuehn KA, Laudon H, Leavitt PR, Lemes da Silva AL, Leroux SJ, LeRoy CJ, Lisi PJ, MacKenzie R, Marcarelli AM, Masese FO, McKie BG, Oliveira Medeiros A, Meissner K, Miliša M, Mishra S, Miyake Y, Moerke A, Mombrikotb S, Mooney R, Moulton T, Muotka T, Negishi JN, Neres-Lima V, Nieminen ML, Nimptsch J, Ondruch J, Paavola R, Pardo I, Patrick CJ, Peeters ETHM, Pozo J, Pringle C, Prussian A, Quenta E, Quesada A, Reid B, Richardson JS, Rigosi A, Rincón J, Rîşnoveanu G, Robinson CT, Rodríguez-Gallego L, Royer TV, Rusak JA, Santamans AC, Selmeczy GB, Simiyu G, Skuja A, Smykla J, Sridhar KR, Sponseller R, Stoler A, Swan CM, Szlag D, Teixeira-de Mello F, Tonkin JD, Uusheimo S, Veach AM, Vilbaste S, Vought LBM, Wang CP, Webster JR, Wilson PB, Woelfl S, Xenopoulos MA, Yates AG, Yoshimura C, Yule CM, Zhang YX, Zwart JA.

Sci Adv. 2019 Jan 9;5(1):eaav0486. doi: 10.1126/sciadv.aav0486. eCollection 2019 Jan.


Allogeneic stem cell transplantation as part of front line therapy for Mantle cell lymphoma.

Rule S, Cook G, Russell NH, Hunter A, Robinson S, Morley N, Sureda A, Patrick P, Clifton-Hadley L, Adedayo T, Kirkwood A, Peggs KS.

Br J Haematol. 2019 Mar;184(6):999-1005. doi: 10.1111/bjh.15723. Epub 2018 Dec 17.


Effects of environmentally relevant metformin exposure on Japanese medaka (Oryzias latipes).

Ussery E, Bridges KN, Pandelides Z, Kirkwood AE, Bonetta D, Venables BJ, Guchardi J, Holdway D.

Aquat Toxicol. 2018 Dec;205:58-65. doi: 10.1016/j.aquatox.2018.10.003. Epub 2018 Oct 9.


Determinants of ovarian function after response-adapted therapy in patients with advanced Hodgkin's lymphoma (RATHL): a secondary analysis of a randomised phase 3 trial.

Anderson RA, Remedios R, Kirkwood AA, Patrick P, Stevens L, Clifton-Hadley L, Roberts T, Hatton C, Kalakonda N, Milligan DW, McKay P, Rowntree C, Scott FM, Johnson PWM.

Lancet Oncol. 2018 Oct;19(10):1328-1337. doi: 10.1016/S1470-2045(18)30500-X. Epub 2018 Sep 13.


Light Affects Mood and Learning through Distinct Retina-Brain Pathways.

Fernandez DC, Fogerson PM, Lazzerini Ospri L, Thomsen MB, Layne RM, Severin D, Zhan J, Singer JH, Kirkwood A, Zhao H, Berson DM, Hattar S.

Cell. 2018 Sep 20;175(1):71-84.e18. doi: 10.1016/j.cell.2018.08.004. Epub 2018 Aug 30.


Enhanced postsynaptic inhibitory strength in hippocampal principal cells in high-performing aged rats.

Tran T, Gallagher M, Kirkwood A.

Neurobiol Aging. 2018 Oct;70:92-101. doi: 10.1016/j.neurobiolaging.2018.06.008. Epub 2018 Jun 12.


Toxicity, recovery, and resilience in a 3D dopaminergic neuronal in vitro model exposed to rotenone.

Harris G, Eschment M, Orozco SP, McCaffery JM, Maclennan R, Severin D, Leist M, Kleensang A, Pamies D, Maertens A, Hogberg HT, Freeman D, Kirkwood A, Hartung T, Smirnova L.

Arch Toxicol. 2018 Aug;92(8):2587-2606. doi: 10.1007/s00204-018-2250-8. Epub 2018 Jun 28.


Delayed injury of hippocampal interneurons after neonatal hypoxia-ischemia and therapeutic hypothermia in a murine model.

Chavez-Valdez R, Emerson P, Goffigan-Holmes J, Kirkwood A, Martin LJ, Northington FJ.

Hippocampus. 2018 Aug;28(8):617-630. doi: 10.1002/hipo.22965.


Two distinct mechanisms for experience-dependent homeostasis.

Bridi MCD, de Pasquale R, Lantz CL, Gu Y, Borrell A, Choi SY, He K, Tran T, Hong SZ, Dykman A, Lee HK, Quinlan EM, Kirkwood A.

Nat Neurosci. 2018 Jun;21(6):843-850. doi: 10.1038/s41593-018-0150-0. Epub 2018 May 14.


Prognostic impact of the absence of biallelic deletion at the TRG locus for pediatric patients with T-cell acute lymphoblastic leukemia treated on the Medical Research Council UK Acute Lymphoblastic Leukemia 2003 trial.

Farah N, Kirkwood AA, Rahman S, Leon T, Jenkinson S, Gale RE, Patrick K, Hancock J, Samarasinghe S, Linch DC, Moorman AV, Goulden N, Vora A, Mansour MR.

Haematologica. 2018 Jul;103(7):e288-e292. doi: 10.3324/haematol.2017.185801. Epub 2018 Mar 8. No abstract available.


Early morphological response is significantly associated with, but does not accurately predict, relapse in teenagers and young adults aged 10-24 years with acute lymphoblastic leukaemia (ALL): results from UKALL2003.

Furness CL, Kirkwood A, Rowntree C, Vora A, Mitchell C, Samarasinghe S, Goulden N, Moorman A, Hough R.

Br J Haematol. 2019 Feb;184(4):663-666. doi: 10.1111/bjh.15150. Epub 2018 Feb 22. No abstract available.


Endogenous Gαq-Coupled Neuromodulator Receptors Activate Protein Kinase A.

Chen Y, Granger AJ, Tran T, Saulnier JL, Kirkwood A, Sabatini BL.

Neuron. 2017 Dec 6;96(5):1070-1083.e5. doi: 10.1016/j.neuron.2017.10.023. Epub 2017 Nov 16.


Donohue syndrome: A review of literature, case series, and anesthetic considerations.

Kirkwood A, Stuart G, Harding L.

Paediatr Anaesth. 2018 Jan;28(1):23-27. doi: 10.1111/pan.13273. Epub 2017 Nov 17. Review.


Brief Novel Visual Experience Fundamentally Changes Synaptic Plasticity in the Mouse Visual Cortex.

Li S, Wang L, Tie X, Sohya K, Lin X, Kirkwood A, Jiang B.

J Neurosci. 2017 Sep 27;37(39):9353-9360. doi: 10.1523/JNEUROSCI.0334-17.2017. Epub 2017 Aug 18.


Assessing landscape and contaminant point-sources as spatial determinants of water quality in the Vermilion River System, Ontario, Canada.

Strangway C, Bowman MF, Kirkwood AE.

Environ Sci Pollut Res Int. 2017 Oct;24(28):22587-22601. doi: 10.1007/s11356-017-9933-1. Epub 2017 Aug 14.


Antimicrobial stewardship for hospitalized patients with viral respiratory tract infections.

Lowe CF, Payne M, Puddicombe D, Mah A, Wong D, Kirkwood A, Hull MW, Leung V.

Am J Infect Control. 2017 Aug 1;45(8):872-875. doi: 10.1016/j.ajic.2017.03.025. Epub 2017 May 16.


Use of the 2008 Basel Consensus Statements to Assess, Realign, and Monitor Pharmacy Practice at a Tertiary Care Hospital in Northern Uganda: Illustrative Case Study, Part 2.

Stacey D, Vaillancourt R, Brander L, Chenel N, McMahon E, Wiebe J, Kirkwood A, Shaka G, Cheng D.

Can J Hosp Pharm. 2017 Jan-Feb;70(1):35-46. Epub 2017 Feb 28. No abstract available.


Advanced stage nodular lymphocyte predominant Hodgkin lymphoma in children and adolescents: clinical characteristics and treatment outcome - a report from the SFCE & CCLG groups.

Shankar AG, Roques G, Kirkwood AA, Lambilliotte A, Freund K, Leblanc T, Hayward J, Abbou S, Ramsay AD, Schmitt C, Gorde-Grosjean S, Pacquement H, Haouy S, Boudjemaa S, Aladjidi N, Hall GW, Landman-Parker J.

Br J Haematol. 2017 Apr;177(1):106-115. doi: 10.1111/bjh.14518. Epub 2017 Feb 21.


Prevalence of antibiotic resistance genes in bacterial communities associated with Cladophora glomerata mats along the nearshore of Lake Ontario.

Ibsen M, Fernando DM, Kumar A, Kirkwood AE.

Can J Microbiol. 2017 May;63(5):439-449. doi: 10.1139/cjm-2016-0803. Epub 2017 Feb 13.


Experience-dependent homeostasis of 'noise' at inhibitory synapses preserves information coding in adult visual cortex.

Gao M, Whitt JL, Huang S, Lee A, Mihalas S, Kirkwood A, Lee HK.

Philos Trans R Soc Lond B Biol Sci. 2017 Mar 5;372(1715). pii: 20160156. doi: 10.1098/rstb.2016.0156.


Sorafenib for the Treatment of Advanced Hepatocellular Cancer - a UK Audit.

King J, Palmer DH, Johnson P, Ross P, Hubner RA, Sumpter K, Darby S, Braconi C, Iwuji C, Swinson D, Collins P, Patel K, Nobes J, Muazzam I, Blesing C, Kirkwood A, Nash S, Meyer T.

Clin Oncol (R Coll Radiol). 2017 Apr;29(4):256-262. doi: 10.1016/j.clon.2016.11.012. Epub 2016 Dec 10.


Impact of PharmaNet-Based Admission Medication Reconciliation on Best Possible Medication Histories for Warfarin.

Au D, Wu H, San C, Chua D, Su V, Kirkwood A.

Can J Hosp Pharm. 2016 Sep-Oct;69(5):348-355. Epub 2016 Oct 31.


Neuregulin-Dependent Regulation of Fast-Spiking Interneuron Excitability Controls the Timing of the Critical Period.

Gu Y, Tran T, Murase S, Borrell A, Kirkwood A, Quinlan EM.

J Neurosci. 2016 Oct 5;36(40):10285-10295.


Screening microalgae isolated from urban storm- and wastewater systems as feedstock for biofuel.

Massimi R, Kirkwood AE.

PeerJ. 2016 Sep 1;4:e2396. doi: 10.7717/peerj.2396. eCollection 2016.


CDK5 downregulation enhances synaptic plasticity.

Posada-Duque RA, Ramirez O, Härtel S, Inestrosa NC, Bodaleo F, González-Billault C, Kirkwood A, Cardona-Gómez GP.

Cell Mol Life Sci. 2017 Jan;74(1):153-172. doi: 10.1007/s00018-016-2333-8. Epub 2016 Aug 9.


Pegylated-asparaginase during induction therapy for adult acute lymphoblastic leukaemia: toxicity data from the UKALL14 trial.

Patel B, Kirkwood AA, Dey A, Marks DI, McMillan AK, Menne TF, Micklewright L, Patrick P, Purnell S, Rowntree CJ, Smith P, Fielding AK.

Leukemia. 2017 Jan;31(1):58-64. doi: 10.1038/leu.2016.219. Epub 2016 Aug 2.


Ki-67 index and response to chemotherapy in patients with neuroendocrine tumours.

Childs A, Kirkwood A, Edeline J, Luong TV, Watkins J, Lamarca A, Alrifai D, Nsiah-Sarbeng P, Gillmore R, Mayer A, Thirlwell C, Sarker D, Valle JW, Meyer T.

Endocr Relat Cancer. 2016 Jul;23(7):563-70. doi: 10.1530/ERC-16-0099.


Adapted Treatment Guided by Interim PET-CT Scan in Advanced Hodgkin's Lymphoma.

Johnson P, Federico M, Kirkwood A, Fosså A, Berkahn L, Carella A, d'Amore F, Enblad G, Franceschetto A, Fulham M, Luminari S, O'Doherty M, Patrick P, Roberts T, Sidra G, Stevens L, Smith P, Trotman J, Viney Z, Radford J, Barrington S.

N Engl J Med. 2016 Jun 23;374(25):2419-29. doi: 10.1056/NEJMoa1510093.


Relapsed or poorly responsive nodular lymphocyte predominant Hodgkin lymphoma in children and adolescents - a report from the United Kingdom's Children's Cancer and Leukaemia Study Group.

Shankar AG, Kirkwood AA, Depani S, Bianchi E, Hayward J, Ramsay AD, Hall GW.

Br J Haematol. 2016 May;173(3):421-31. doi: 10.1111/bjh.13979. Epub 2016 Mar 21.


Metabotropic Glutamate Receptors Induce a Form of LTP Controlled by Translation and Arc Signaling in the Hippocampus.

Wang H, Ardiles AO, Yang S, Tran T, Posada-Duque R, Valdivia G, Baek M, Chuang YA, Palacios AG, Gallagher M, Worley P, Kirkwood A.

J Neurosci. 2016 Feb 3;36(5):1723-9. doi: 10.1523/JNEUROSCI.0878-15.2016.


PET-CT for staging and early response: results from the Response-Adapted Therapy in Advanced Hodgkin Lymphoma study.

Barrington SF, Kirkwood AA, Franceschetto A, Fulham MJ, Roberts TH, Almquist H, Brun E, Hjorthaug K, Viney ZN, Pike LC, Federico M, Luminari S, Radford J, Trotman J, Fosså A, Berkahn L, Molin D, D'Amore F, Sinclair DA, Smith P, O'Doherty MJ, Stevens L, Johnson PW.

Blood. 2016 Mar 24;127(12):1531-8. doi: 10.1182/blood-2015-11-679407. Epub 2016 Jan 8.


Brief Dark Exposure Reduces Tonic Inhibition in Visual Cortex.

Huang S, Hokenson K, Bandyopadhyay S, Russek SJ, Kirkwood A.

J Neurosci. 2015 Dec 2;35(48):15916-20. doi: 10.1523/JNEUROSCI.1813-15.2015.


The addition of rituximab to fludarabine and cyclophosphamide chemotherapy results in a significant improvement in overall survival in patients with newly diagnosed mantle cell lymphoma: results of a randomized UK National Cancer Research Institute trial.

Rule S, Smith P, Johnson PW, Bolam S, Follows G, Gambell J, Hillmen P, Jack A, Johnson S, Kirkwood AA, Kruger A, Pocock C, Seymour JF, Toncheva M, Walewski J, Linch D.

Haematologica. 2016 Feb;101(2):235-40. doi: 10.3324/haematol.2015.128710. Epub 2015 Nov 26.


Distinct Eligibility Traces for LTP and LTD in Cortical Synapses.

He K, Huertas M, Hong SZ, Tie X, Hell JW, Shouval H, Kirkwood A.

Neuron. 2015 Nov 4;88(3):528-38. doi: 10.1016/j.neuron.2015.09.037. Epub 2015 Oct 22.


Defective Age-Dependent Metaplasticity in a Mouse Model of Alzheimer's Disease.

Megill A, Tran T, Eldred K, Lee NJ, Wong PC, Hoe HS, Kirkwood A, Lee HK.

J Neurosci. 2015 Aug 12;35(32):11346-57. doi: 10.1523/JNEUROSCI.5289-14.2015.


A Multicenter Randomized Trial of Ibandronate Compared With Single-Dose Radiotherapy for Localized Metastatic Bone Pain in Prostate Cancer.

Hoskin P, Sundar S, Reczko K, Forsyth S, Mithal N, Sizer B, Bloomfield D, Upadhyay S, Wilson P, Kirkwood A, Stratford M, Jitlal M, Hackshaw A.

J Natl Cancer Inst. 2015 Aug 4;107(10). pii: djv197. doi: 10.1093/jnci/djv197. Print 2015 Oct.


Impact of PTEN abnormalities on outcome in pediatric patients with T-cell acute lymphoblastic leukemia treated on the MRC UKALL2003 trial.

Jenkinson S, Kirkwood AA, Goulden N, Vora A, Linch DC, Gale RE.

Leukemia. 2016 Jan;30(1):39-47. doi: 10.1038/leu.2015.206. Epub 2015 Jul 29.


Early Changes in Circulating Tumor Cells Are Associated with Response and Survival Following Treatment of Metastatic Neuroendocrine Neoplasms.

Khan MS, Kirkwood AA, Tsigani T, Lowe H, Goldstein R, Hartley JA, Caplin ME, Meyer T.

Clin Cancer Res. 2016 Jan 1;22(1):79-85. doi: 10.1158/1078-0432.CCR-15-1008. Epub 2015 Jul 21.

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