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Reductions in dead space ventilation with nasal high flow depend on physiological dead space volume: metabolic hood measurements during sleep in patients with COPD and controls.

Biselli P, Fricke K, Grote L, Braun AT, Kirkness J, Smith P, Schwartz A, Schneider H.

Eur Respir J. 2018 May 30;51(5). pii: 1702251. doi: 10.1183/13993003.02251-2017. Print 2018 May.


An Official American Thoracic Society Workshop Report: Noninvasive Identification of Inspiratory Flow Limitation in Sleep Studies.

Pamidi S, Redline S, Rapoport D, Ayappa I, Palombini L, Farre R, Kirkness J, Pépin JL, Polo O, Wellman A, Kimoff RJ; American Thoracic Society Ad Hoc Committee on Inspiratory Flow Limitation.

Ann Am Thorac Soc. 2017 Jul;14(7):1076-1085. doi: 10.1513/AnnalsATS.201704-318WS.


The Efficacy of Low-Level Continuous Positive Airway Pressure for the Treatment of Snoring.

Guzman MA, Sgambati FP, Pho H, Arias RS, Hawks EM, Wolfe EM, Ötvös T, Rosenberg R, Dakheel R, Schneider H, Kirkness JP, Smith PL, Schwartz AR.

J Clin Sleep Med. 2017 May 15;13(5):703-711. doi: 10.5664/jcsm.6588.


Nasal high-flow therapy reduces work of breathing compared with oxygen during sleep in COPD and smoking controls: a prospective observational study.

Biselli PJ, Kirkness JP, Grote L, Fricke K, Schwartz AR, Smith P, Schneider H.

J Appl Physiol (1985). 2017 Jan 1;122(1):82-88. doi: 10.1152/japplphysiol.00279.2016. Epub 2016 Nov 4.


Localizing Effects of Leptin on Upper Airway and Respiratory Control during Sleep.

Yao Q, Pho H, Kirkness J, Ladenheim EE, Bi S, Moran TH, Fuller DD, Schwartz AR, Polotsky VY.

Sleep. 2016 May 1;39(5):1097-106. doi: 10.5665/sleep.5762.


Effect of Acute Intermittent CPAP Depressurization during Sleep in Obese Patients.

Jun JC, Unnikrishnan D, Schneider H, Kirkness J, Schwartz AR, Smith PL, Polotsky VY.

PLoS One. 2016 Jan 5;11(1):e0146606. doi: 10.1371/journal.pone.0146606. eCollection 2016.


Utilizing inspiratory airflows during standard polysomnography to assess pharyngeal function in children during sleep.

McGinley BM, Kirkness JP, Schneider H, Lenka A, Smith PL, Schwartz AR.

Pediatr Pulmonol. 2016 Apr;51(4):431-8. doi: 10.1002/ppul.23329. Epub 2015 Oct 16.


The effect of leptin replacement on sleep-disordered breathing in the leptin-deficient ob/ob mouse.

Pho H, Hernandez AB, Arias RS, Leitner EB, Van Kooten S, Kirkness JP, Schneider H, Smith PL, Polotsky VY, Schwartz AR.

J Appl Physiol (1985). 2016 Jan 1;120(1):78-86. doi: 10.1152/japplphysiol.00494.2015. Epub 2015 Oct 15.


The effect of increased lung volume in chronic obstructive pulmonary disease on upper airway obstruction during sleep.

Biselli P, Grossman PR, Kirkness JP, Patil SP, Smith PL, Schwartz AR, Schneider H.

J Appl Physiol (1985). 2015 Aug 1;119(3):266-71. doi: 10.1152/japplphysiol.00455.2014. Epub 2015 Jun 5.


Fluctuating flow. Vibrato, tremolo, or upper airway oscillation.

Sowho MO, Wolfe E, Murano EZ, Kirkness JP.

Ann Am Thorac Soc. 2015 Apr;12(4):613-5. doi: 10.1513/AnnalsATS.201409-437CC. No abstract available.


Obesity-related ventilatory phenotypes of sleep-disordered breathing.

Kirkness JP.

Am J Respir Crit Care Med. 2014 Oct 15;190(8):853-4. doi: 10.1164/rccm.201409-1674ED. No abstract available.


The interplay between tongue tissue volume, hyoid position, and airway patency.

Kirkness JP, Sowho M, Murano E.

Sleep. 2014 Oct 1;37(10):1585-6. doi: 10.5665/sleep.4060. No abstract available.


Sleep and respiratory physiology in adults.

Sowho M, Amatoury J, Kirkness JP, Patil SP.

Clin Chest Med. 2014 Sep;35(3):469-81. doi: 10.1016/j.ccm.2014.06.002. Epub 2014 Jul 28. Review.


Nasal insufflation treatment adherence in obstructive sleep apnea.

Sowho MO, Woods MJ, Biselli P, McGinley BM, Buenaver LF, Kirkness JP.

Sleep Breath. 2015 Mar;19(1):351-7.


Hypopnea: 'rule of thumb' or ruler and plumb?

Kirkness JP.

Sleep Breath. 2014 Dec;18(4):683-5. doi: 10.1007/s11325-014-0974-0. Epub 2014 Mar 27. No abstract available.


Leptin and the control of pharyngeal patency during sleep in severe obesity.

Shapiro SD, Chin CH, Kirkness JP, McGinley BM, Patil SP, Polotsky VY, Biselli PJ, Smith PL, Schneider H, Schwartz AR.

J Appl Physiol (1985). 2014 May 15;116(10):1334-41. doi: 10.1152/japplphysiol.00958.2013. Epub 2014 Feb 20.


A Remote-Controlled Airbag Device Can Improve Upper Airway Collapsibility by Producing Head Elevation With Jaw Closure in Normal Subjects Under Propofol Anesthesia.

Ishizaka S, Moromugi S, Kobayashi M, Kajihara H, Koga K, Sugahara H, Ishimatsu T, Kurata S, Kirkness JP, Oi K, Ayuse T.

IEEE J Transl Eng Health Med. 2014 Jul 5;2:2600109. doi: 10.1109/JTEHM.2014.2321062. eCollection 2014.


Increased phosphatidylcholine concentration in saliva reduces surface tension and improves airway patency in obstructive sleep apnoea.

Kawai M, Kirkness JP, Yamamura S, Imaizumi K, Yoshimine H, Oi K, Ayuse T.

J Oral Rehabil. 2013 Oct;40(10):758-66. doi: 10.1111/joor.12094. Epub 2013 Aug 30.


Approach for streamlining measurement of complex physiological phenotypes of upper airway collapsibility.

Wei T, Erlacher MA, Grossman P, Leitner EB, McGinley BM, Patil SP, Smith PL, Schneider H, Schwartz AR, Kirkness JP.

Comput Biol Med. 2013 Jun;43(5):600-6. doi: 10.1016/j.compbiomed.2012.12.006. Epub 2013 Mar 18.


Invited editorial on "Lung volume and upper airway collapsibility: what does it tell us about pathogenic mechanisms?".

Schwartz AR, Smith PL, Schneider H, Patil SP, Kirkness JP.

J Appl Physiol (1985). 2012 Sep 1;113(5):689-90. doi: 10.1152/japplphysiol.00716.2012. Epub 2012 Aug 2. No abstract available.


Effects of leptin and obesity on the upper airway function.

Polotsky M, Elsayed-Ahmed AS, Pichard L, Harris CC, Smith PL, Schneider H, Kirkness JP, Polotsky V, Schwartz AR.

J Appl Physiol (1985). 2012 May;112(10):1637-43. doi: 10.1152/japplphysiol.01222.2011. Epub 2012 Feb 16.


Developing quantitative physiological phenotypes of sleep apnea for epidemiological studies.

Kirkness JP, McGinley BM, Sgambati FP, Patil SP, Smith PL, Schwartz AR, Schneider H.

Conf Proc IEEE Eng Med Biol Soc. 2011;2011:8319-22. doi: 10.1109/IEMBS.2011.6092051.


Novel whole body plethysmography system for the continuous characterization of sleep and breathing in a mouse.

Hernandez AB, Kirkness JP, Smith PL, Schneider H, Polotsky M, Richardson RA, Hernandez WC, Schwartz AR.

J Appl Physiol (1985). 2012 Feb;112(4):671-80. doi: 10.1152/japplphysiol.00818.2011. Epub 2011 Dec 1.


Compensatory responses to upper airway obstruction in obese apneic men and women.

Chin CH, Kirkness JP, Patil SP, McGinley BM, Smith PL, Schwartz AR, Schneider H.

J Appl Physiol (1985). 2012 Feb;112(3):403-10. doi: 10.1152/japplphysiol.00021.2011. Epub 2011 Nov 17.


Physiologic phenotypes of sleep apnea pathogenesis.

Schwartz AR, Schneider H, Smith PL, McGinley BM, Patil SP, Kirkness JP.

Am J Respir Crit Care Med. 2011 Nov 15;184(10):1105-6. doi: 10.1164/rccm.201108-1573ED. No abstract available.


The effects of hormonal status on upper airway patency in normal female subjects during propofol anesthesia.

Hoshino Y, Ayuse T, Kobayashi M, Kurata S, Kawai M, Schneider H, Patil SP, Schwartz AR, Kirkness JP, Oi K.

J Clin Anesth. 2011 Nov;23(7):527-33. doi: 10.1016/j.jclinane.2011.02.004.


Effect of age and weight on upper airway function in a mouse model.

Polotsky M, Elsayed-Ahmed AS, Pichard L, Richardson RA, Smith PL, Schneider H, Kirkness JP, Polotsky V, Schwartz AR.

J Appl Physiol (1985). 2011 Sep;111(3):696-703. doi: 10.1152/japplphysiol.00123.2011. Epub 2011 Jun 30.


Effect of head elevation on passive upper airway collapsibility in normal subjects during propofol anesthesia.

Kobayashi M, Ayuse T, Hoshino Y, Kurata S, Moromugi S, Schneider H, Kirkness JP, Schwartz AR, Oi K.

Anesthesiology. 2011 Aug;115(2):273-81. doi: 10.1097/ALN.0b013e318223ba6d.


Performance characteristics of upper airway critical collapsing pressure measurements during sleep.

Kirkness JP, Peterson LA, Squier SB, McGinley BM, Schneider H, Meyer A, Schwartz AR, Smith PL, Patil SP.

Sleep. 2011 Apr 1;34(4):459-67.


Pitot-tube flowmeter for quantification of airflow during sleep.

Kirkness JP, Verma M, McGinley BM, Erlacher M, Schwartz AR, Smith PL, Wheatley JR, Patil SP, Amis TC, Schneider H.

Physiol Meas. 2011 Feb;32(2):223-37. doi: 10.1088/0967-3334/32/2/006. Epub 2010 Dec 22.


Effect of end-expiratory lung volume on upper airway collapsibility in sleeping men and women.

Squier SB, Patil SP, Schneider H, Kirkness JP, Smith PL, Schwartz AR.

J Appl Physiol (1985). 2010 Oct;109(4):977-85. doi: 10.1152/japplphysiol.00080.2010. Epub 2010 Jun 24.


Sex differences in the association of regional fat distribution with the severity of obstructive sleep apnea.

Simpson L, Mukherjee S, Cooper MN, Ward KL, Lee JD, Fedson AC, Potter J, Hillman DR, Eastwood P, Palmer LJ, Kirkness J.

Sleep. 2010 Apr;33(4):467-74. Erratum in: Sleep. 2010 Aug 1;33(8):preceding 1003. Hillman Fanzca, David R [corrected to Hillman, David R].


Obesity and upper airway control during sleep.

Schwartz AR, Patil SP, Squier S, Schneider H, Kirkness JP, Smith PL.

J Appl Physiol (1985). 2010 Feb;108(2):430-5. doi: 10.1152/japplphysiol.00919.2009. Epub 2009 Oct 29. Review.


The effect of gender on compensatory neuromuscular response to upper airway obstruction in normal subjects under midazolam general anesthesia.

Ayuse T, Hoshino Y, Kurata S, Ayuse T, Schneider H, Kirkness JP, Patil SP, Schwartz AR, Oi K.

Anesth Analg. 2009 Oct;109(4):1209-18. doi: 10.1213/ane.0b013e3181b0fc70.


Evolution of changes in upper airway collapsibility during slow induction of anesthesia with propofol.

Hillman DR, Walsh JH, Maddison KJ, Platt PR, Kirkness JP, Noffsinger WJ, Eastwood PR.

Anesthesiology. 2009 Jul;111(1):63-71. doi: 10.1097/ALN.0b013e3181a7ec68.


The compensatory responses to upper airway obstruction in normal subjects under propofol anesthesia.

Hoshino Y, Ayuse T, Kurata S, Ayuse T, Schneider H, Kirkness JP, Patil SP, Schwartz AR, Oi K.

Respir Physiol Neurobiol. 2009 Mar 31;166(1):24-31.


Contribution of male sex, age, and obesity to mechanical instability of the upper airway during sleep.

Kirkness JP, Schwartz AR, Schneider H, Punjabi NM, Maly JJ, Laffan AM, McGinley BM, Magnuson T, Schweitzer M, Smith PL, Patil SP.

J Appl Physiol (1985). 2008 Jun;104(6):1618-24. doi: 10.1152/japplphysiol.00045.2008. Epub 2008 Apr 17.


Upper airway neuromuscular compensation during sleep is defective in obstructive sleep apnea.

McGinley BM, Schwartz AR, Schneider H, Kirkness JP, Smith PL, Patil SP.

J Appl Physiol (1985). 2008 Jul;105(1):197-205. doi: 10.1152/japplphysiol.01214.2007. Epub 2008 Apr 10.


Oscillatory pressure wave transmission from the upper airway to the carotid artery.

Howitt L, Kairaitis K, Kirkness JP, Garlick SR, Wheatley JR, Byth K, Amis TC.

J Appl Physiol (1985). 2007 Nov;103(5):1622-7. Epub 2007 Aug 16.


A nasal cannula can be used to treat obstructive sleep apnea.

McGinley BM, Patil SP, Kirkness JP, Smith PL, Schwartz AR, Schneider H.

Am J Respir Crit Care Med. 2007 Jul 15;176(2):194-200. Epub 2007 Mar 15.


Dynamic modulation of upper airway function during sleep: a novel single-breath method.

Kirkness JP, Schwartz AR, Patil SP, Pichard LE, Marx JJ, Smith PL, Schneider H.

J Appl Physiol (1985). 2006 Nov;101(5):1489-94. Epub 2006 Jul 6.


Influence of breathing route on upper airway lining liquid surface tension in humans.

Verma M, Seto-Poon M, Wheatley JR, Amis TC, Kirkness JP.

J Physiol. 2006 Aug 1;574(Pt 3):859-66. Epub 2006 May 11.


Extraluminal tissue pressure: what does it mean?

Schwartz AR, Kirkness J, Smith P.

J Appl Physiol (1985). 2006 Jan;100(1):5-6. No abstract available.


Surface tension of upper airway mucosal lining liquid in obstructive sleep apnea/hypopnea syndrome.

Kirkness JP, Madronio M, Stavrinou R, Wheatley JR, Amis TC.

Sleep. 2005 Apr;28(4):457-63.


Application of the 'pull-off' force method for measurement of surface tension of upper airway mucosal lining liquid.

Kirkness JP, Christenson HK, Wheatley JR, Amis TC.

Physiol Meas. 2005 Oct;26(5):677-88. Epub 2005 Jun 13.


Decrement of the skin conductance response to repeated volitional inspiration.

Seto-Poon M, Madronio M, Kirkness JP, Amis TC, Byth K, Lim CL.

Clin Neurophysiol. 2005 May;116(5):1172-80. Epub 2005 Jan 21.


Older individuals have increased oro-nasal breathing during sleep.

Madronio MR, Di Somma E, Stavrinou R, Kirkness JP, Goldfinch E, Wheatley JR, Amis TC.

Eur Respir J. 2004 Jul;24(1):71-7.


Relationship between surface tension of upper airway lining liquid and upper airway collapsibility during sleep in obstructive sleep apnea hypopnea syndrome.

Kirkness JP, Madronio M, Stavrinou R, Wheatley JR, Amis TC.

J Appl Physiol (1985). 2003 Nov;95(5):1761-6. Epub 2003 Jul 11.


Upper airway extraluminal tissue pressure fluctuations during breathing in rabbits.

Kairaitis K, Parikh R, Stavrinou R, Garlick S, Kirkness JP, Wheatley JR, Amis TC.

J Appl Physiol (1985). 2003 Oct;95(4):1560-6. Epub 2003 Jun 27.

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